Cited by 738Inflammasome and immune disordersImmune Response and InflammationIL-33, ST2, and ILC Pathways

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Mechanism of NLRP3 inflammasome activation

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Sutterwala, Fayyaz S., Haasken, Stefanie, Cassel, Suzanne L.·2014·Annals of the New York Academy of Sciences

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Abstract

Inflammasomes continue to generate interest in an increasing number of disciplines owing to their unique ability to integrate a myriad of signals from pathogen- and damage-associated molecular patterns into a proinflammatory response. This potent caspase-1-dependent process is capable of activating the innate immune system, initiating pyroptosis (an inflammatory form of programmed cell death), and shaping adaptive immunity. The NLRP3 inflammasome is the most thoroughly studied of the inflammasome complexes that have been described thus far, perhaps owing to its disparate assortment of agonists. This review highlights our current understanding of the mechanisms of both priming and activation of the NLRP3 inflammasome.

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Authors: Sutterwala, F. S., Haasken, S., & Cassel, S. L.
Affiliations: University of Iowa (US)
Corresponding author: Sutterwala, Fayyaz S.
ORCID: Sutterwala, Fayyaz S.
Venue: Annals of the New York Academy of Sciences
Publisher: Wiley
Published: 2014-05-19
Volume: 1319
Issue: 1
Pages: 82-95
ISSN: 0077-8923 (ISSN-L)
1749-6632
DOI: 10.1111/nyas.12458
PMC: PMC4074217
OpenAlex: W1636793459
Cited by: 736
References: 82
Citations by year: 2026: 25 · 2025: 54 · 2024: 58 · 2023: 68 · 2022: 85 · 2021: 88 · 2020: 81 · 2019: 52 · 2018: 60 · 2017: 57 · 2016: 57 · 2015: 42 · 2014: 8
FWCI: 5.18
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Annals of the New York Academy of Sciences (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (AI087630, AI104706, AI007511)
Asthma and Allergy foundation of America
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Immunology and Microbiology › Immunology › IL-33, ST2, and ILC Pathways
Keywords: NLRP3 inflammasome, inflammasome activation, inflammasome priming, caspase-1, pyroptosis, innate immunity, damage-associated molecular patterns, pathogen-associated molecular patterns
MeSH terms: NLR Family, Pyrin Domain-Containing 3 Protein, Animals, Carrier Proteins, Cell Survival, Humans, Cell Death, Adaptive Immunity, Inflammasomes

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Mechanism of NLRP3 inflammasome activation

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