Nutritional interventions for Alzheimer's prevention: a clinical precision medicine approach

Schelke, Matthew W.; Hackett, Katherine; Chen, Jaclyn L.; Shih, Chiashin; Shum, Jessica; Montgomery, Mary E.; Chiang, Gloria C.; Berkowitz, Cara; Seifan, Alon; Krikorian, Robert; Isaacson, Richard Scott

doi:10.1111/nyas.13070

Cited by 51Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsNutritional Studies and Diet

Nutritional interventions for Alzheimer's prevention: a clinical precision medicine approach

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Schelke, Matthew W., Hackett, Katherine, Chen, Jaclyn L., Shih, Chiashin, Shum, Jessica, Montgomery, Mary E., Chiang, Gloria C., Berkowitz, Cara +3 more·2016·Annals of the New York Academy of Sciences

DOI 10.1111/nyas.13070PMC PMC5674531

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Abstract

Alzheimer's disease (AD) is a major source of morbidity and mortality, with the disease burden expected to rise as the population ages. No disease‐modifying agent is currently available, but recent research suggests that nutritional and lifestyle modifications can delay or prevent the onset of AD. However, preventive nutritional interventions are not universally applicable and depend on the clinical profile of the individual patient. This article reviews existing nutritional modalities for AD prevention that act through improvement of insulin resistance, correction of dyslipidemia, and reduction of oxidative stress, and discusses how they may be modified on the basis of individual biomarkers, genetics, and behavior. In addition, we report preliminary results of clinical application of these personalized interventions at the first AD prevention clinic in the United States. The use of these personalized interventions represents an important application of precision medicine techniques for the prevention of AD that can be adopted by clinicians across disciplines.

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Alzheimer's disease patients are predisposed to complications including increased oxidative stress, morbidity, mortality, microvascular disease, dyslipidemia, and insulin resistance.
“AD patients are predisposed to some complications including increased oxidative stress (Sultana et al., 2011), morbidity, mortality (Schelke et al., 2016), microvascular disease, dyslipidemia, and insulin resistance (Sridhar et al., 2015).”
From Effect of Probiotic Supplementation on Cognitive Function and Metabolic Status in Alzheimer's Disease: A Randomized, Double-Blind and Controlled Trial (2016) · cites this paper as Schelke et al., 2016

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Authors: Schelke, M. W., Hackett, K., Chen, J. L., Shih, C., Shum, J., Montgomery, M. E., Chiang, G. C., Berkowitz, C., Seifan, A., Krikorian, R., & Isaacson, R. S.
Affiliations: Weill Cornell Medicine (US)
Weill Cornell Medical Center (US)
Neurology, Compass Health Systems Miami Florida
University of Cincinnati Medical Center (US)
Corresponding author: Isaacson, Richard Scott
ORCID: Schelke, Matthew W.
Hackett, Katherine
Chiang, Gloria C.
Berkowitz, Cara
Seifan, Alon
Isaacson, Richard Scott
Venue: Annals of the New York Academy of Sciences
Publisher: Wiley
Published: 2016-03
Volume: 1367
Issue: 1
Pages: 50-56
ISSN: 0077-8923 (ISSN-L)
1749-6632
DOI: 10.1111/nyas.13070
PMC: PMC5674531
OpenAlex: W2344811506
Cited by: 51
References: 64
Citations by year: 2026: 1 · 2025: 5 · 2024: 6 · 2023: 1 · 2022: 8 · 2021: 6 · 2020: 6 · 2019: 3 · 2018: 8 · 2017: 4 · 2016: 3
FWCI: 0.86
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 56 d)
Locations: Annals of the New York Academy of Sciences (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (UL1TR000457)
National Center for Advancing Translational Sciences
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
Keywords: Alzheimer's disease prevention, dietary intervention, precision medicine, personalized nutrition, insulin resistance, dyslipidemia, oxidative stress, biomarkers, genetic risk factors, lifestyle modification, disease-modifying therapy
MeSH terms: Alzheimer Disease, Humans, Insulin Resistance, Nutritional Status, Oxidative Stress, Risk Reduction Behavior, Precision Medicine

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Nutritional interventions for Alzheimer's prevention: a clinical precision medicine approach

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