Blueberry supplementation improves memory in older adults
Open accessAbstract
The prevalence of dementia is increasing with expansion of the older adult population. In the absence of effective therapy, preventive approaches are essential to address this public health problem. Blueberries contain polyphenolic compounds, most prominently anthocyanins, which have antioxidant and anti-inflammatory effects. In addition, anthocyanins have been associated with increased neuronal signaling in brain centers, mediating memory function as well as improved glucose disposal, benefits that would be expected to mitigate neurodegeneration. This study investigated the effects of daily consumption of wild blueberry juice in a sample of nine older adults with early memory changes. At 12 weeks, improved paired associate learning (p = 0.009) and word list recall (p = 0.04) were observed. In addition, there were trends suggesting reduced depressive symptoms (p = 0.08) and lower glucose levels (p = 0.10). We also compared the memory performances of the blueberry subjects with a demographically matched sample who consumed a berry placebo beverage in a companion trial of identical design and observed comparable results for paired associate learning. The findings of this preliminary study suggest that moderate-term blueberry supplementation can confer neurocognitive benefit and establish a basis for more comprehensive human trials to study preventive potential and neuronal mechanisms.
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In elderly individuals with mild cognitive impairment, daily dietary introduction of an anthocyanin-rich fruit juice significantly improved verbal fluency, short-term memory, and long-term memory over a 12-week period.
“In these patients, the dietary introduction of a daily anthocyanin-rich fruit juice significantly improved verbal fluency, as well as short-term and long-term memory, over a 12-week period [119], which is consistent with other reports [120,121].”
From Mediterranean diet nutrients to turn the tide against insulin resistance and related diseases (2020) · cites this paper as [121]
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- Authors
- Krikorian, R., Shidler, M. D., Nash, T. A., Kalt, W., Vinqvist-Tymchuk, M. R., Shukitt-Hale, B., & Joseph, J. A.
- Affiliations
- University of Cincinnati Medical Center (US)
- Agriculture and Agri-Food Canada (CA)
- Agriculture and Agri-Food Canada, AFHRC, 32 Main Street, Kentville, Nova Scotia, B4N 1J5 Canada
- USDA Human Nutrition Research Center on Aging and Tufts University, 711 Washington Street, Boston, Massachusetts 02111-1524
- Tufts University (US)
- Corresponding author
- Krikorian, Robert
- Venue
- Journal of Agricultural and Food Chemistry
- Publisher
- American Chemical Society (ACS)
- Published
- 2010-01-04
- Volume
- 58
- Issue
- 7
- Pages
- 3996-4000
- ISSN
- 0021-8561 (ISSN-L)
- 1520-5118
- PMC
- PMC2850944
- OpenAlex
- W1968286822
- Cited by
- 582
- References
- 40
- Citations by year
- 2026: 29 · 2025: 35 · 2024: 38 · 2023: 30 · 2022: 29 · 2021: 48 · 2020: 38 · 2019: 44 · 2018: 32 · 2017: 40 · 2016: 41 · 2015: 30 · 2014: 43 · 2013: 31 · 2012: 53
- FWCI
- 19.60
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Agricultural and Food Chemistry (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (R21AG024484)
- Topics
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- memory, older adults, dementia prevention, anthocyanins, polyphenols, paired-associate learning, word list recall, depressive symptoms, blood glucose, neurocognitive function, neurodegeneration
- MeSH terms
- Aged, Aged, 80 and over, Female, Humans, Male, Memory, Plant Extracts, Dietary Supplements, Blueberry Plants
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