Cited by 57Probiotics and Fermented FoodsGut microbiota and healthMyasthenia Gravis and Thymoma

Gut microbiota and probiotics: Novel immune system modulators in myasthenia gravis?

Rinaldi, Elena, Consonni, Alessandra, Guidesi, Elena, Elli, Marina, Mantegazza, Renato, Baggi, Fulvio·2018·Annals of the New York Academy of Sciences

Abstract

Gut microorganisms (microbiota) live in symbiosis with the host and influence human nutrition, metabolism, physiology, and immune development and function. The microbiota prevents pathogen infection to the host, and in turn the host provides a niche for survival. The alteration of gut bacteria composition (dysbiosis) could contribute to the development of immune-mediated diseases by influencing the immune system activation and driving the pro- and anti-inflammatory responses in order to promote or counteract immune reactions. Probiotics are nonpathogenic microorganisms able to interact with the gut microbiota and provide health benefits; their use has recently been exploited to dampen immunological response in several experimental models of autoimmune diseases. Here, we focus on the relationships among commensal bacteria, probiotics, and the gut, describing the main interactions occurring with the immune system and recent data supporting the clinical efficacy of probiotic administration in rheumatoid arthritis, multiple sclerosis, and myasthenia gravis (MG) animal models. The encouraging results suggest that selected strains of probiotics should be evaluated in clinical trials as adjuvant therapy to restore the disrupted tolerance in myasthenia gravis.

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Crossref · 10.1111/nyas.13567

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57 of 57 references verified0 citation errors · 0 not checkable

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  • Probiotics can increase the number of macrophages and dendritic cells in lamina propria and enhance their function in the intestine for a period of time.

    “Probiotics can increase the number of macrophages and dendritic cells (DCs) in lamina propria and enhance their function in the intestine for a period of time.”

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Authors
Rinaldi, E., Consonni, A., Guidesi, E., Elli, M., Mantegazza, R., & Baggi, F.
Affiliations
  • Fondazione IRCCS Istituto Neurologico Carlo Besta (IT)
  • AAT‐Advanced Analytical Technologies Fiorenzuola d'Arda Piacenza Italy
Corresponding author
Rinaldi, Elena
Venue
Annals of the New York Academy of Sciences
Publisher
Wiley
Published
2018-01-17
Volume
1413
Issue
1
Pages
49-58
ISSN
  • 0077-8923 (ISSN-L)
  • 1749-6632
OpenAlex
W2789526819
Cited by
57
References
57
Citations by year
2026: 5 · 2025: 10 · 2024: 7 · 2023: 8 · 2022: 7 · 2021: 6 · 2020: 5 · 2019: 7 · 2018: 2
FWCI
0.51
Type
journal article
Language
en
Open access
closed
Locations
  • Annals of the New York Academy of Sciences (publishedVersion)
  • PubMed (publishedVersion)
Funders
Italian Ministry of Health (Project code PE-2011 02346818)
Topics
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Medicine › Neurology › Myasthenia Gravis and Thymoma
Keywords
gut microbiota, probiotics, myasthenia gravis, dysbiosis, immunomodulation, autoimmune disease, rheumatoid arthritis, multiple sclerosis, commensal bacteria, immune tolerance, adjuvant therapy, animal models
MeSH terms
Gastrointestinal Microbiome, Animals, Arthritis, Rheumatoid, Disease Models, Animal, Humans, Immunologic Factors, Multiple Sclerosis, Myasthenia Gravis, Symbiosis, Probiotics, Dysbiosis

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