High frequency of intestinal T H 17 cells correlates with microbiota alterations and disease activity in multiple sclerosis
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The headquarter of our immune system resides in the gut and modulates autoimmune disease activation in multiple sclerosis.
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Ustekinumab, an IL-12/23 inhibitor, showed no efficacy in relapsing remitting MS.
“In therapeutic interventions the inhibitor of IL-12+23, ustekinumab, showed no efficacy in relapsing remitting MS (RRMS) [146].”
From TH17 cell heterogeneity and its role in tissue inflammation (2023) · cites this paper as [146]
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- Authors
- Cosorich, I., Dalla-Costa, G., Sorini, C., Ferrarese, R., Messina, M. J., Dolpady, J., Radice, E., Mariani, A., Testoni, P. A., Canducci, F., Comi, G., Martinelli, V., & Falcone, M.
- Affiliations
- Vita-Salute San Raffaele University (IT)
- Clinical Neurology Unit, IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy.
- IRCCS Ospedale San Raffaele (IT)
- University of Insubria (IT)
- Corresponding author
- Cosorich, Ilaria
- Martinelli, Vittorio
- Falcone, Marika
- ORCID
- Venue
- Science Advances
- Published
- 2017-07-07
- Volume
- 3
- Issue
- 7
- Pages
- e1700492-e1700492
- ISSN
- 2375-2548 (ISSN-L)
- PMC
- PMC5507635
- OpenAlex
- W2734586792
- Cited by
- 338
- References
- 48
- Citations by year
- 2026: 29 · 2025: 34 · 2024: 51 · 2023: 41 · 2022: 48 · 2021: 46 · 2020: 30 · 2019: 31 · 2018: 25 · 2017: 3
- FWCI
- 19.11
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc
- Locations
- Science Advances (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele (submittedVersion)
- Funders
- Fondazione Italiana Sclerosi Multipla (award330486)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Keywords
- multiple sclerosis, Th17 cells, intestinal immune cells, gut microbiota, microbiota alterations, disease activity, autoimmune disease, gut-immune axis
- MeSH terms
- Gastrointestinal Microbiome, Adult, Biopsy, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Multiple Sclerosis, Peyer's Patches, Severity of Illness Index, Biomarkers, T-Lymphocyte Subsets, Lymphocyte Count, Immunity, Mucosal, Th17 Cells
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