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Current understanding of periodontal disease pathogenesis and targets for host‐modulation therapy
Open accessAbstract
Recent advances indicate that periodontitis is driven by reciprocally reinforced interactions between a dysbiotic microbiome and dysregulated inflammation. Inflammation is not only a consequence of dysbiosis but, via mediating tissue dysfunction and damage, fuels further growth of selectively dysbiotic communities of bacteria (inflammophiles), thereby generating a self‐sustained feed‐forward loop that perpetuates the disease. These considerations provide a strong rationale for developing adjunctive host‐modulation therapies for the treatment of periodontitis. Such host‐modulation approaches aim to inhibit harmful inflammation and promote its resolution or to interfere directly with downstream effectors of connective tissue and bone destruction. This paper reviews diverse strategies targeted to modulate the host periodontal response and discusses their mechanisms of action, perceived safety, and potential for clinical application.
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Metadata
- Authors
- Hajishengallis, G., Chavakis, T., & Lambris, J. D.
- Venue
- Periodontology 2000
- Publisher
- Wiley
- Published
- 2020-08-25
- Volume
- 84
- Issue
- 1
- Pages
- 14-34
- ISSN
- 0906-6713 (ISSN-L)
- 1600-0757
- OpenAlex
- W3080228553
- Cited by
- 502
- References
- 264
- FWCI
- 40.14
- Type
- journal article
- Language
- en
- Open access
- green
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Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.