Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 265

The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.

N ‐acetylcysteine attenuates the decline in muscle Na + ,K + ‐pump activity and delays fatigue during prolonged exercise in humans

Open access
McKenna, Michael J., Medved, Ivan, Goodman, Craig A., Brown, Malcolm J., Bjorksten, Andrew R., Murphy, Kate T., Petersen, Aaron C., Sostaric, Simon, Gong, Xiaofei·2006·The Journal of Physiology
DOI 10.1113/jphysiol.2006.115352
Open this paper in CoChat — free account

Abstract

Reactive oxygen species (ROS) have been linked with both depressed Na + ,K + ‐pump activity and skeletal muscle fatigue. This study investigated N ‐acetylcysteine (NAC) effects on muscle Na + ,K + ‐pump activity and potassium (K + ) regulation during prolonged, submaximal endurance exercise. Eight well‐trained subjects participated in a double‐blind, randomised, crossover design, receiving either NAC or saline (CON) intravenous infusion at 125 mg kg −1 h −1 for 15 min, then 25 mg kg −1 h −1 for 20 min prior to and throughout exercise. Subjects cycled for 45 min at 71% , then continued at 92% until fatigue. Vastus lateralis muscle biopsies were taken before exercise, at 45 min and fatigue and analysed for maximal in vitro Na + ,K + ‐pump activity (K + ‐stimulated 3‐O‐methyfluorescein phosphatase; 3‐O‐MFPase). Arterialized venous blood was sampled throughout exercise and analysed for plasma K + and other electrolytes. Time to fatigue at 92% was reproducible in preliminary trials ( c.v. 5.6 ± 0.6%) and was prolonged with NAC by 23.8 ± 8.3% (NAC 6.3 ± 0.5 versus CON 5.2 ± 0.6 min, P < 0.05). Maximal 3‐O‐MFPase activity decreased from rest by 21.6 ± 2.8% at 45 min and by 23.9 ± 2.3% at fatigue ( P < 0.05). NAC attenuated the percentage decline in maximal 3‐O‐MFPase activity (%Δactivity) at 45 min ( P < 0.05) but not at fatigue. When expressed relative to work done, the %Δactivity‐to‐work ratio was attenuated by NAC at 45 min and fatigue ( P < 0.005). The rise in plasma [K + ] during exercise and the Δ[K + ]‐to‐work ratio at fatigue were attenuated by NAC ( P < 0.05). These results confirm that the antioxidant NAC attenuates muscle fatigue, in part via improved K + regulation, and point to a role for ROS in muscle fatigue.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1113/jphysiol.2006.115352

Cites

1 of 1 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 1 references

Cited by

Metadata

Authors
McKenna, M. J., Medved, I., Goodman, C. A., Brown, M. J., Bjorksten, A. R., Murphy, K. T., Petersen, A. C., Sostaric, S., & Gong, X.
Venue
The Journal of Physiology
Publisher
Wiley
Published
2006-09-22
Volume
576
Issue
1
Pages
279-288
ISSN
  • 0022-3751 (ISSN-L)
  • 1469-7793
DOI
10.1113/jphysiol.2006.115352
OpenAlex
W2144193033
Cited by
265
References
1
FWCI
16.83
Type
journal article
Language
en
Open access
bronze

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.