The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
The sigma‐1 receptor modulates NMDA receptor synaptic transmission and plasticity via SK channels in rat hippocampus
Open accessAbstract
The sigma receptor (σR), once considered a subtype of the opioid receptor, is now described as a distinct pharmacological entity. Modulation of N‐methyl‐d‐aspartate receptor (NMDAR) functions by σR‐1 ligands is well documented; however, its mechanism is not fully understood. Using patch‐clamp whole‐cell recordings in CA1 pyramidal cells of rat hippocampus and (+)pentazocine, a high‐affinity σR‐1 agonist, we found that σR‐1 activation potentiates NMDAR responses and long‐term potentiation (LTP) by preventing a small conductance Ca 2+‐activated K+current (SK channels), known to shunt NMDAR responses, to open. Therefore, the block of SK channels and the resulting increased Ca 2+influx through the NMDAR enhances NMDAR responses and LTP. These results emphasize the importance of the σR‐1 as postsynaptic regulator of synaptic transmission.
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The pharmacology of sigma-1 receptors.
Maurice, T., & Su, T.-P. (2009) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2009.07.001 · Cited by 654
The sigma-1 receptor chaperone as an inter-organelle signaling modulator
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The Sigma-1 Receptor as a Pluripotent Modulator in Living Systems
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The sigma-1 receptor: roles in neuronal plasticity and disease
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Sigma-1 receptor: a potential therapeutic target for traumatic brain injury
Shi, M., Chen, F., Chen, Z., Yang, W., Yue, S., Zhang, J., & Chen, X. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.685201 · Cited by 58
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Mutational Analysis of Sigma-1 Receptor’s Role in Synaptic Stability
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Metadata
- Authors
- Martina, M., Turcotte, M. B., Halman, S., & Bergeron, R.
- Venue
- The Journal of Physiology
- Publisher
- Wiley
- Published
- 2006-12-21
- Volume
- 578
- Issue
- 1
- Pages
- 143-157
- ISSN
- 0022-3751 (ISSN-L)
- 1469-7793
- OpenAlex
- W1561309798
- Cited by
- 187
- References
- 6
- FWCI
- 2.46
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
