Does Short-Term High Dose Probiotic Supplementation Containing Lactobacillus casei Attenuate Exertional-Heat Stress Induced Endotoxaemia and Cytokinaemia?

Gill, Samantha K.; Allerton, Dean M.; Ansley-Robson, Paula; Hemmings, Krystal; Cox, Martin; Costa, Ricardo J.S.

doi:10.1123/ijsnem.2015-0186

Cited by 67Probiotics and Fermented FoodsThermoregulation and physiological responsesExercise and Physiological Responses

Does Short-Term High Dose Probiotic Supplementation Containing Lactobacillus casei Attenuate Exertional-Heat Stress Induced Endotoxaemia and Cytokinaemia?

Gill, Samantha K., Allerton, Dean M., Ansley-Robson, Paula, Hemmings, Krystal, Cox, Martin, Costa, Ricardo J.S.·2016·International Journal of Sport Nutrition and Exercise Metabolism

DOI 10.1123/ijsnem.2015-0186

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Abstract

The study aimed to determine if short-term high dose probiotic supplementation containing Lactobacillus casei (L.casei) attenuates the commonly reported exertional-heat stress (EHS) induced endotoxinaemia and cytokinaemia. Eight endurance trained male volunteers (mean± SD: age 26 ± 6 y, nude body mass 70.2 ± 8.8 kg, height 1.75 ± 0.05 m, VO 2max 59 ± 5 ml·kg-1·min-1) completed a blinded randomized cross-over design, whereby oral ingestion of a commercially available probiotic beverage containing L.casei (volume equivalent for ×10 11 colony forming units·day-1) (PRO) or placebo (PLA) was consumed for 7 consecutive days before exposure to EHS, which comprised of 2h running exercise at 60% VO 2max in hot ambient conditions (34.0 °C and 32% RH). Blood samples were collected at baseline (7 days before EHS), pre-EHS, post-EHS (1 hr, 2 hr, 4 hr, and at 24 hr). Plasma samples were analyzed for gram-negative bacterial endotoxin, cytokine profile (IL-6, IL-1β, TNF-α, IFN-γ, IL-8, and IL-10) and plasma osmolality. Plasma osmolality did not differ between trials. Seven days of L.casei supplementation did not show significant changes in resting circulatory endotoxin concentration or plasma cytokine profile compared with PLA. A main effect of time was observed for IL-6, TNF-α, IL-10 and IL-8; whereby levels increased in response to EHS (p < .05). Relative to pre-EHS concentrations, higher plasma concentrations of endotoxin (p = .05), and a trend for higher plasma TNF-α concentration (p = .09) was observed on PRO compared with PLA throughout recovery. Short-term high dose supplementation of a probiotic beverage containing L.casei before EHS did not attenuate EHS induced endotoxaemia and cytokinaemia; nor is it more positively favorable over a placebo.

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Short-term, high-dose single-strain L. casei supplementation did not markedly change resting circulatory endotoxin concentration or plasma cytokine profile compared with placebo in male runners under heat stress.
“In short-term, high dose single-strain probiotic supplementation (L. casei), male runners under heat stress did not exhibit any marked changes in resting circulatory endotoxin concentration or plasma cytokine profile compared with placebo [76].”
From International Society of Sports Nutrition Position Stand: Probiotics (2019) · cites this paper as [76]
The duration of probiotic supplementation has been variable in the studies reviewed; the shortest duration lasted 7 days and the longest lasted 150 days.
“Similar to the type of probiotic used, the duration of supplementation has also been variable in the studies reviewed (Table 3). The shortest duration lasted 7 days [75, 76] and the longest lasted 150 days [68].”
From International Society of Sports Nutrition Position Stand: Probiotics (2019) · cites this paper as [76]
Such strategies may only apply to chronic interventions, as recent research has demonstrated no impact of acute (7 days) probiotic use on endotoxin levels following endurance exercise.
“Although this supports previous findings [26,48], such strategies may only apply to chronic interventions, as recent research has demonstrated no impact of acute (7 days) probiotic use on endotoxin levels following endurance exercise at 60%VO2max under ambient or heat-stressed conditions [49].”
From An Exploratory Investigation of Endotoxin Levels in Novice Long Distance Triathletes, and the Effects of a Multi-Strain Probiotic/Prebiotic, Antioxidant Intervention (2016) · cites this paper as [49]

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Authors: Gill, S. K., Allerton, D. M., Ansley-Robson, P., Hemmings, K., Cox, M., & Costa, R. J. S.
Affiliations: Coventry University (GB)
Corresponding author: Costa, Ricardo J.S.
ORCID: Allerton, Dean M.
Costa, Ricardo J.S.
Venue: International Journal of Sport Nutrition and Exercise Metabolism
Publisher: Human Kinetics
Published: 2016-06
Volume: 26
Issue: 3
Pages: 268-275
ISSN: 1526-484X (ISSN-L)
1543-2742
DOI: 10.1123/ijsnem.2015-0186
OpenAlex: W2178513736
Cited by: 67
References: 0
Citations by year: 2026: 3 · 2025: 5 · 2024: 6 · 2023: 4 · 2022: 11 · 2021: 8 · 2020: 8 · 2019: 10 · 2018: 4 · 2017: 6 · 2016: 2
FWCI: 5.35
Type: journal article
Language: en
Open access: closed
Locations: International Journal of Sport Nutrition and Exercise Metabolism (publishedVersion)
PubMed (publishedVersion)
Coventry University Open Collections (Coventry university) (submittedVersion)
Pure (Coventry University) (submittedVersion)
The Open Collections (Coventry University) (submittedVersion)
Topics: Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Health Sciences › Medicine › Physiology › Thermoregulation and physiological responses
Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
Keywords: probiotic supplementation, Lactobacillus casei, exertional heat stress, endotoxemia, plasma cytokines, interleukin-6, TNF-α, IL-10, interleukin-8, endurance exercise, heat exposure, plasma osmolality, probiotic beverages
MeSH terms: Adult, Energy Intake, Drinking, Endotoxins, Hot Temperature, Humans, Lacticaseibacillus casei, Male, Oxygen Consumption, Physical Endurance, Running, Cytokines, Treatment Outcome, Cross-Over Studies, Heat-Shock Response, Endotoxemia, Probiotics, Young Adult

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Does Short-Term High Dose Probiotic Supplementation Containing Lactobacillus casei Attenuate Exertional-Heat Stress Induced Endotoxaemia and Cytokinaemia?

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