Selective Inhibition of Casein Kinase 1ϵ Minimally Alters Circadian Clock Period

Molecular components of the mammalian circadian clock

Ko, C. H., & Takahashi, J. S. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl207 · Cited by 1,657 · see citing works

The Meter of Metabolism

Green, C. B., Takahashi, J. S., & Bass, J. (2008) · Cell · doi:10.1016/j.cell.2008.08.022 · Cited by 902 · cited 2× · see citing works

Post-translational modifications regulate the ticking of the circadian clock

Gallego, M., & Virshup, D. M. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2106 · Cited by 863 · see citing works

Functional consequences of a CKIδ mutation causing familial advanced sleep phase syndrome

Xu, Y., Padiath, Q. S., Shapiro, R. E., Jones, C. R., Wu, S. C., Saigoh, N., Saigoh, K., Ptáček, L. J., & Fu, Y.-H. (2005) · Nature · doi:10.1038/nature03453 · Cited by 861 · see citing works

Positional Syntenic Cloning and Functional Characterization of the Mammalian Circadian Mutation tau

Lowrey, P. L., Shimomura, K., Antoch, M. P., Yamazaki, S., Zemenides, P. D., Ralph, M. R., Menaker, M., & Takahashi, J. S. (2000) · Science · doi:10.1126/science.288.5465.483 · Cited by 860 · see citing works

double-time Is a Novel Drosophila Clock Gene that Regulates PERIOD Protein Accumulation

Price, J. L., Blau, J., Rothenfluh, A., Abodeely, M., Kloss, B., & Young, M. W. (1998) · Cell · doi:10.1016/s0092-8674(00)81224-6 · Cited by 839 · see citing works

A Mutation of the Circadian System in Golden Hamsters

Ralph, M. R., & Menaker, M. (1988) · Science · doi:10.1126/science.3413487 · Cited by 700 · see citing works

The Drosophila Clock Gene double-time Encodes a Protein Closely Related to Human Casein Kinase Iε

Kloss, B., Price, J. L., Sáez, L., Blau, J., Rothenfluh, A., Wesley, C. S., & Young, M. W. (1998) · Cell · doi:10.1016/s0092-8674(00)81225-8 · Cited by 682 · see citing works

The casein kinase 1 family: participation in multiple cellular processes in eukaryotes

Knippschild, U., Gocht, A., Wolff, S., Huber, N., Löhler, J., & Stöter, M. (2005) · Cellular Signalling · doi:10.1016/j.cellsig.2004.12.011 · Cited by 601 · see citing works

Rhythmic CLOCK-BMAL1 binding to multiple E-box motifs drives circadian Dbp transcription and chromatin transitions

Ripperger, J. A., & Schibler, U. (2006) · Nature Genetics · doi:10.1038/ng1738 · Cited by 593 · see citing works

Familial advanced sleep-phase syndrome: a short-period circadian rhythm variant in humans

Jones, C. R., Campbell, S. S., Zone, S. E., Cooper, F., DeSano, A., Murphy, P. J., Jones, B., Czajkowski, L., & Ptček, L. J. (1999) · Nature Medicine · doi:10.1038/12502 · Cited by 567 · see citing works

Peripheral Circadian Oscillators in Mammals: Time and Food

Schibler, U., Ripperger, J. A., & Brown, S. A. (2003) · Journal of Biological Rhythms · doi:10.1177/0748730403018003007 · Cited by 525 · see citing works

Control of Mammalian Circadian Rhythm by CKIε-Regulated Proteasome-Mediated PER2 Degradation

Eide, E. J., Woolf, M. F., Kang, H., Woolf, P., Hurst, W., Camacho, F., Vielhaber, E. L., Giovanni, A., & Virshup, D. M. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.7.2795-2807.2005 · Cited by 495 · see citing works

Orchestrating time: arrangements of the brain circadian clock

Antle, M. C., & Silver, R. (2005) · Trends in Neurosciences · doi:10.1016/j.tins.2005.01.003 · Cited by 463 · see citing works

Influence of nonspecific brain and plasma binding on CNS exposure: implications for rational drug discovery

Kalvass, J. C., & Maurer, T. S. (2002) · Biopharmaceutics & Drug Disposition · doi:10.1002/bdd.325 · Cited by 422 · see citing works

Setting Clock Speed in Mammals: The CK1ɛ tau Mutation in Mice Accelerates Circadian Pacemakers by Selectively Destabilizing PERIOD Proteins

Meng, Q., Logunova, L., Maywood, E. S., Gallego, M., Lebiecki, J., Brown, T. M., Sládek, M., Semikhodskii, A. G., Glossop, N. R. J., Piggins, H. D., et al. (2008) · Neuron · doi:10.1016/j.neuron.2008.01.019 · Cited by 372 · see citing works

Phosphate groups as substrate determinants for casein kinase I action.

Flotow, H., Graves, P. R., Wang, A. Q., Fiol, C. J., Roeske, R. W., & Roach, P. J. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)77295-5 · Cited by 337 · see citing works

Nuclear Entry of the Circadian Regulator mPER1 Is Controlled by Mammalian Casein Kinase I ɛ

Vielhaber, E. L., Eide, E. J., Rivers, A. M., Gao, Z.-H., & Virshup, D. M. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.13.4888-4899.2000 · Cited by 308 · see citing works

Development and validation of a 96-well equilibrium dialysis apparatus for measuring plasma protein binding

Banker, M. J., Clark, T. H., & Williams, J. A. (2003) · Journal of Pharmaceutical Sciences · doi:10.1002/jps.10332 · Cited by 305 · see citing works

Control of Intracellular Dynamics of Mammalian Period Proteins by Casein Kinase I ε (CKIε) and CKIδ in Cultured Cells

Akashi, M., Tsuchiya, Y., Yoshino, T., & Nishida, E. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.6.1693-1703.2002 · Cited by 292 · see citing works

CKI, there's more than one: casein kinase I family members in Wnt and Hedgehog signalingPreprint

Price, M. A. (2006) · Genes & Development · doi:10.1101/gad.1394306 · Cited by 257 · see citing works

Real-time luminescence reporting of circadian gene expression in mammals

Yamazaki, S., & Takahashi, J. S. (2005) · Methods in Enzymology · doi:10.1016/s0076-6879(05)93012-7 · Cited by 200 · see citing works

Wnt-5a induces Dishevelled phosphorylation and dopaminergic differentiation via a CK1-dependent mechanism

Bryja, V., Schulte, G., Rawal, N., Grahn, A., & Arenas, E. (2007) · Journal of Cell Science · doi:10.1242/jcs.03368 · Cited by 186 · see citing works

When Clocks Go Bad: Neurobehavioural Consequences of Disrupted Circadian Timing

Barnard, A. R., & Nolan, P. M. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.1000040 · Cited by 181 · see citing works

An opposite role for tau in circadian rhythms revealed by mathematical modeling

Gallego, M., Eide, E. J., Woolf, M. F., Virshup, D. M., & Forger, D. B. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604511103 · Cited by 176 · see citing works

An Inhibitor of Casein Kinase Iϵ Induces Phase Delays in Circadian Rhythms under Free-Running and Entrained Conditions

Badura, L., Swanson, T., Adamowicz, W., Adams, J., Cianfrogna, J., Fisher, K., Holland, J., Kleiman, R., Nelson, F., Reynolds, L., et al. (2007) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.107.122846 · Cited by 176 · see citing works

Human casein kinase Iδ phosphorylation of human circadian clock proteins period 1 and 2

Camacho, F., Cilio, M., Guo, Y., Virshup, D. M., Patel, K., Khorkova, O., Styren, S. D., Morse, B., Yao, Z., & Keesler, G. A. (2001) · FEBS Letters · doi:10.1016/s0014-5793(00)02434-0 · Cited by 153 · see citing works

A role for the circadian genes in drug addiction

Falcón, E., & McClung, C. A. (2009) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.06.054 · Cited by 135 · see citing works

Ligand modulation of REV-ERBα function resets the peripheral circadian clock in a phasic manner

Meng, Q., McMaster, A., Beesley, S., Lu, W., Gibbs, J. E., Parks, D. J., Collins, J. L., Farrow, S. N., Donn, R. P., Ray, D. W., et al. (2008) · Journal of Cell Science · doi:10.1242/jcs.035048 · Cited by 126 · see citing works

The Casein Kinase I Family in Wnt Signaling

McKay, R. M., Peters, J. M., & Graff, J. M. (2001) · Developmental Biology · doi:10.1006/dbio.2001.0308 · Cited by 111 · see citing works

Regulation of Casein Kinase Iϵ Activity by Wnt Signaling

Swiatek, W., Tsai, I.-C., Klimowski, L., Pepler, A., Barnette, J. E., Yost, H. J., & Virshup, D. M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m304682200 · Cited by 106 · see citing works

Synthesis and Selective Cyclooxygenase-2 Inhibitory Activity of a Series of Novel, Nitric Oxide Donor-Containing Pyrazoles

Ranatunge, R. R., Augustyniak, M. E., Bandarage, U. K., Earl, R. A., Ellis, J. L., Garvey, D. S., Janero, D. R., Letts, L. G., Martino, A. M., Murty, M. G., et al. (2004) · Journal of Medicinal Chemistry · doi:10.1021/jm030276s · Cited by 77 · see citing works

RAP, an integrated program for monitoring bioluminescence and analyzing circadian rhythms in real time

Okamoto, K., Onai, K., & Ishiura, M. (2004) · Analytical Biochemistry · doi:10.1016/j.ab.2004.11.007 · Cited by 44 · see citing works

A role for casein kinase 1 epsilon in the locomotor stimulant response to methamphetamine

Bryant, C. D., Graham, M. E., Distler, M. G., Munoz, M. B., Li, D., Vezina, P., Sokoloff, G., & Palmer, A. A. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1417-z · Cited by 41 · see citing works

Mechanisms and function of substrate recruitment by F-box proteins

Skaar, J. R., Pagan, J. K., & Pagano, M. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3582 · Cited by 671 · see citing works

Genetics of Circadian Rhythms in Mammalian Model Organisms

Lowrey, P. L., & Takahashi, J. S. (2011) · Advances in genetics · doi:10.1016/b978-0-12-387690-4.00006-4 · Cited by 578 · see citing works

Circadian rhythm as a therapeutic target

Ruan, W., Yuan, X., & Eltzschig, H. K. (2021) · Nature Reviews Drug Discovery · doi:10.1038/s41573-020-00109-w · Cited by 501 · see citing works

The CK1 Family: Contribution to Cellular Stress Response and Its Role in Carcinogenesis

Knippschild, U., Krüger, M., Richter, J., Xu, P., García-Reyes, B., Peifer, C., Halekotte, J., Bakulev, V. A., & Bischof, J. (2014) · Frontiers in Oncology · doi:10.3389/fonc.2014.00096 · Cited by 276 · see citing works

Regulating the Suprachiasmatic Nucleus (SCN) Circadian Clockwork: Interplay between Cell-Autonomous and Circuit-Level MechanismsPreprint

Herzog, E. D., Hermanstyne, T. O., Smyllie, N. J., & Hastings, M. H. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a027706 · Cited by 268 · see citing works

Casein kinase 1: Complexity in the family

Cheong, J. K., & Virshup, D. M. (2010) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2010.12.004 · Cited by 256 · see citing works

Entrainment of disrupted circadian behavior through inhibition of casein kinase 1 (CK1) enzymes

Meng, Q., Maywood, E. S., Bechtold, D. A., Lu, W., Li, J., Gibbs, J. E., Dupré, S. M., Chesham, J. E., Rajamohan, F., Knafels, J. D., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1005101107 · Cited by 253 · see citing works

High-Throughput Chemical Screen Identifies a Novel Potent Modulator of Cellular Circadian Rhythms and Reveals CKIα as a Clock Regulatory Kinase

Hirota, T., Lee, J. W., Lewis, W. G., Zhang, E. E., Breton, G., Liu, X., Garcia, M. E., Peters, E. C., Etchegaray, J., Traver, D. J., et al. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000559 · Cited by 248 · see citing works

Macromolecular Assemblies of the Mammalian Circadian Clock

Aryal, R. P., Kwak, P. B., Tamayo, A. G., Gebert, M., Chiu, P., Walz, T., & Weitz, C. J. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.07.017 · Cited by 246 · see citing works

Functional genomics identifies therapeutic targets for MYC-driven cancer

Toyoshima, M., Howie, H. L., Imakura, M., Walsh, R. M., Annis, J. E., Chang, A. N., Frazier, J. P., Chau, B. N., Loboda, A. P., Linsley, P. S., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1121119109 · Cited by 245 · see citing works

Biological functions of casein kinase 1 isoforms and putative roles in tumorigenesis

Schittek, B., & Sinnberg, T. W. (2014) · Molecular Cancer · doi:10.1186/1476-4598-13-231 · Cited by 245 · see citing works

Circadian dysfunction in disease

Bechtold, D. A., Gibbs, J. E., & Loudon, A. S. I. (2010) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2010.01.002 · Cited by 206 · see citing works

THE CROSSTALK BETWEEN PHYSIOLOGY AND CIRCADIAN CLOCK PROTEINS

Duguay, D., & Cermakian, N. (2009) · Chronobiology International · doi:10.3109/07420520903497575 · Cited by 201 · see citing works

Identification of diverse modulators of central and peripheral circadian clocks by high-throughput chemical screening

Chen, Z., Yoo, S. H., Park, Y. S., Kim, K.-H., Wei, S., Buhr, E. D., Ye, Z., Pan, H., & Takahashi, J. S. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1118034108 · Cited by 189 · see citing works

Dissociation of circadian and circatidal timekeeping in the marine crustacean Eurydice pulchra

Zhang, L., Hastings, M. H., Green, E. W., Tauber, E., Sladek, M., Webster, S. G., Kyriacou, C. P., & Wilcockson, D. C. (2013) · Current Biology · doi:10.1016/j.cub.2013.08.038 · Cited by 187 · see citing works

The period of the circadian oscillator is primarily determined by the balance between casein kinase 1 and protein phosphatase 1

Lee, H.-M., Chen, R., Kim, H., Etchegaray, J., Weaver, D. R., & Lee, C. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1107178108 · Cited by 185 · see citing works

Molecular mechanism of the repressive phase of the mammalian circadian clock

Cao, X., Yang, Y., Selby, C. P., Liu, Z., & Sancar, A. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2021174118 · Cited by 183 · see citing works

Kinases and phosphatases in the mammalian circadian clock

Reischl, S., & Kramer, A. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.02.038 · Cited by 167 · see citing works

Circadian rhythms and mood regulation: insights from pre-clinical models

McClung, C. A. (2011) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2011.07.008 · Cited by 169 · see citing works

Essential roles of CKIδ and CKIε in the mammalian circadian clock

Lee, H.-M., Chen, R., Lee, Y., Yoo, S. H., & Lee, C. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0906651106 · Cited by 172 · see citing works

Protein kinases CK1 and CK2 as new targets for neurodegenerative diseases

Pérez, D. I., Gil, C., & Martı́nez, A. (2010) · Medicinal Research Reviews · doi:10.1002/med.20207 · Cited by 155 · see citing works

Development and Therapeutic Potential of Small-Molecule Modulators of Circadian Systems

Chen, Z., Yoo, S. H., & Takahashi, J. S. (2017) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010617-052645 · Cited by 153 · see citing works

Circadian and circalunar clock interactions in a marine annelid

Zantke, J., Ishikawa-Fujiwara, T., Arboleda, E., Lohs, C., Schipany, K., Hallay, N., Straw, A. D., Todo, T., & Tessmar-Raible, K. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.08.031 · Cited by 148 · see citing works

Biologically Driven Synthesis of Pyrazolo[3,4-d]pyrimidines As Protein Kinase Inhibitors: An Old Scaffold As a New Tool for Medicinal Chemistry and Chemical Biology Studies

Schenone, S., Radi, M., Musumeci, F., Brullo, C., & Botta, M. (2014) · Chemical Reviews · doi:10.1021/cr400270z · Cited by 148 · see citing works

Cell-based screen identifies a new potent and highly selective CK2 inhibitor for modulation of circadian rhythms and cancer cell growth

Oshima, T., Niwa, Y., Kuwata, K., Srivastava, A., Hyoda, T., Tsuchiya, Y., Kumagai, M., Tsuyuguchi, M., Tamaru, T., Sugiyama, A., et al. (2019) · Science Advances · doi:10.1126/sciadv.aau9060 · Cited by 137 · see citing works

Casein kinase: the triple meaning of a misnomer

Venerando, A., Ruzzene, M., & Pinna, L. A. (2014) · Biochemical Journal · doi:10.1042/bj20140178 · Cited by 134 · see citing works

Polymorphism in the PER3 Promoter Associates with Diurnal Preference and Delayed Sleep Phase Disorder

Archer, S. N., Carpen, J. D., Gibson, M., Lim, G. H., Johnston, J. D., Skene, D. J., & von Schantz, M. (2010) · SLEEP · doi:10.1093/sleep/33.5.695 · Cited by 134 · see citing works

The DUF1669 domain of FAM83 family proteins anchor casein kinase 1 isoforms

Fulcher, L. J., Bozatzi, P., Tachie-Menson, T., Wu, K. Z. L., Cummins, T. D., Bufton, J. C., Pinkas, D. M., Dunbar, K. J., Shrestha, S., Wood, N. T., et al. (2018) · Science Signaling · doi:10.1126/scisignal.aao2341 · Cited by 131 · see citing works

Non-kinase targets of protein kinase inhibitors

Munoz, L. (2017) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.266 · Cited by 121 · see citing works

IC261 induces cell cycle arrest and apoptosis of human cancer cells via CK1δ/ɛ and Wnt/β-catenin independent inhibition of mitotic spindle formation

Cheong, J. K., Hung, N. T., Wang, H., Tan, P. B. O., Voorhoeve, P. M., Lee, S. H., & Virshup, D. M. (2011) · Oncogene · doi:10.1038/onc.2010.627 · Cited by 123 · see citing works

The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks

Andreatta, G., & Tessmar-Raible, K. (2020) · Journal of Molecular Biology · doi:10.1016/j.jmb.2020.03.009 · Cited by 111 · see citing works

Silencing c-Myc translation as a therapeutic strategy through targeting PI3Kδ and CK1ε in hematological malignancies

Deng, C., Lipstein, M. R., Scotto, L., Serrano, X. O. J., Mangone, M. A., Li, S., Vendôme, J., Hao, Y., Xu, X., Deng, S., et al. (2016) · Blood · doi:10.1182/blood-2016-08-731240 · Cited by 108 · see citing works

The phosphorylation switch that regulates ticking of the circadian clock

Narasimamurthy, R., & Virshup, D. M. (2021) · Molecular Cell · doi:10.1016/j.molcel.2021.01.006 · Cited by 105 · see citing works

Small molecule modifiers of circadian clocks

Chen, Z., Yoo, S. H., & Takahashi, J. S. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1207-y · Cited by 102 · see citing works

Metabolic and chemical architecture of the mammalian circadian clock

Laothamatas, I., Rasmussen, E. S., Green, C. B., & Takahashi, J. S. (2023) · Cell chemical biology · doi:10.1016/j.chembiol.2023.08.014 · Cited by 95 · see citing works

Model-driven experimental approach reveals the complex regulatory distribution of p53 by the circadian factor Period 2

Gotoh, T., Kim, J. K., Liu, J., Vila-Caballer, M., Stauffer, P. E., Tyson, J. J., & Finkielstein, C. V. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1607984113 · Cited by 90 · see citing works

Casein kinases as potential therapeutic targets

Cozza, G., & Pinna, L. A. (2015) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2016.1091883 · Cited by 92 · see citing works

Development of highly selective casein kinase 1δ/1ε (CK1δ/ε) inhibitors with potent antiproliferative properties

Bibian, M., Rahaim, R. J. J., Choi, J. Y., Noguchi, Y., Schürer, S. C., Chen, W., Nakanishi, S., Licht, K., Rosenberg, L. H., Li, L., et al. (2013) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2013.05.075 · Cited by 90 · see citing works

Circadian Clocks and Mood-Related Behaviors

Albrecht, U. (2013) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-25950-0_9 · Cited by 86 · see citing works

Hrr25/CK1δ-directed release of Ltv1 from pre-40S ribosomes is necessary for ribosome assembly and cell growth

Ghalei, H., Schaub, F. X., Doherty, J. R., Noguchi, Y., Roush, W. R., Cleveland, J. L., Stroupe, M. E., & Karbstein, K. (2015) · The Journal of Cell Biology · doi:10.1083/jcb.201409056 · Cited by 86 · see citing works

Speed control: cogs and gears that drive the circadian clock

Zheng, X., & Sehgal, A. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2012.05.007 · Cited by 83 · see citing works

Structure, regulation, and (patho-)physiological functions of the stress-induced protein kinase CK1 delta (CSNK1D)

Xu, P., Ianes, C., Gärtner, F., Liu, C., Burster, T., Bakulev, V. A., Rachidi, N., Knippschild, U., & Bischof, J. (2019) · Gene · doi:10.1016/j.gene.2019.144005 · Cited by 79 · see citing works

The application of flow microreactors to the preparation of a family of casein kinase I inhibitors

Venturoni, F., Nikbin, N., Ley, S. V., & Baxendale, I. R. (2010) · Organic & Biomolecular Chemistry · doi:10.1039/b925327k · Cited by 79 · see citing works

Setting the pace: host rhythmic behaviour and gene expression patterns in the facultatively symbiotic cnidarian Aiptasia are determined largely by Symbiodinium

Sorek, M., Schnytzer, Y., Ben‐Asher, H. W., Caspi, V. C., Chen, C.-S., Miller, D. J., & Levy, O. (2018) · Microbiome · doi:10.1186/s40168-018-0465-9 · Cited by 73 · see citing works

Therapeutic applications of circadian rhythms for the cardiovascular system

Tsimakouridze, E. V., Alibhai, F. J., & Martino, T. A. (2015) · Frontiers in Pharmacology · doi:10.3389/fphar.2015.00077 · Cited by 70 · see citing works

Targeting Casein Kinase 1 (CK1) in Hematological Cancers

Janovská, P., Normant, E., Miskin, H. P., & Bryja, V. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21239026 · Cited by 70 · see citing works

Synthetic Lethal Screens as a Means to Understand and Treat MYC-Driven CancersPreprint

Cermelli, S., Jang, I. S., Bernard, B. M., & Grandori, C. (2014) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a014209 · Cited by 68 · see citing works

Assessment of circadian rhythms in humans: comparison of real-time fibroblast reporter imaging with plasma melatonin

Hasan, S., Santhi, N., Lazar, A. S., Slak, A., Lo, J., von Schantz, M., Archer, S. N., Johnston, J. D., & Dijk, D. (2012) · The FASEB Journal · doi:10.1096/fj.11-201699 · Cited by 68 · see citing works

The dual PI3Kδ/CK1ε inhibitor umbralisib exhibits unique immunomodulatory effects on CLL T cells

Maharaj, K. K., Powers, J. J., Achille, A. N., Mediavilla-Varela, M., Gamal, W. M., Burger, K. L., Fonseca, R., Jiang, K., Miskin, H. P., Maryanski, D., et al. (2020) · Blood Advances · doi:10.1182/bloodadvances.2020001800 · Cited by 63 · see citing works

Structural Basis for the Interaction between Casein Kinase 1 Delta and a Potent and Selective Inhibitor

Long, A., Zhao, H., & Huang, X. Y. (2011) · Journal of Medicinal Chemistry · doi:10.1021/jm201387s · Cited by 59 · see citing works

Casein Kinase 1 Delta (CK1δ) Regulates Period Length of the Mouse Suprachiasmatic Circadian Clock In Vitro

Etchegaray, J., Yu, E. A., Indic, P., Dallmann, R., & Weaver, D. R. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010303 · Cited by 59 · see citing works

Tidal and diel orchestration of behaviour and gene expression in an intertidal mollusc

Schnytzer, Y., Simon-Blecher, N., Li, J., Waldman Ben-Asher, H., Salmon-Divon, M., Achituv, Y., Hughes, M. E., & Levy, O. (2018) · Scientific Reports · doi:10.1038/s41598-018-23167-y · Cited by 58 · see citing works

A Design Principle for a Posttranslational Biochemical Oscillator

Jolley, C. C., Ode, K. L., & Ueda, H. R. (2012) · Cell Reports · doi:10.1016/j.celrep.2012.09.006 · Cited by 60 · see citing works

Csnk1e Is a Genetic Regulator of Sensitivity to Psychostimulants and Opioids

Bryant, C. D., Parker, C. C., Zhou, L., Olker, C. J., Chandrasekaran, R. Y., Wager, T. T., Bolivar, V. J., Loudon, A. S. I., Vitaterna, M. H., Turek, F. W., et al. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.287 · Cited by 60 · see citing works

A Small Molecule Modulates Circadian Rhythms through Phosphorylation of the Period Protein

Lee, J. W., Hirota, T., Peters, E. C., Garcia, M. E., Gonzalez, R., Cho, C. Y., Wu, X., Schultz, P. G., & Kay, S. A. (2011) · Angewandte Chemie International Edition · doi:10.1002/anie.201103915 · Cited by 60 · see citing works

Inhibition of the Casein-Kinase-1-Epsilon/Delta Prevents Relapse-Like Alcohol Drinking

Perreau‐Lenz, S., Vengeliene, V., Noori, H. R., Merlo‐Pich, E., Corsi, M., Corti, C., & Spanagel, R. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.62 · Cited by 60 · see citing works

Chemical chronobiology: Toward drugs manipulating time

Wallach, T. E., & Kramer, A. (2015) · FEBS Letters · doi:10.1016/j.febslet.2015.04.059 · Cited by 60 · see citing works

Time to target the circadian clock for drug discovery

Sjulstok, E., Takahashi, J. S., & Green, C. B. (2022) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2022.04.009 · Cited by 58 · see citing works

Small molecule modulators targeting protein kinase CK1 and CK2

Qiao, Y., Chen, T., Yang, H., Chen, Y., Lin, H., Qu, W., Feng, F., Liu, W., Guo, Q., Liu, Z., et al. (2019) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2019.111581 · Cited by 57 · see citing works

A Novel Mechanism Controlling Resetting Speed of the Circadian Clock to Environmental Stimuli

Pilorz, V., Cunningham, P. S., Jackson-Crawford, A., West, A. C., Wager, T. T., Loudon, A. S. I., & Bechtold, D. A. (2014) · Current Biology · doi:10.1016/j.cub.2014.02.027 · Cited by 53 · see citing works

Inhibition of IgE-mediated allergic reactions by pharmacologically targeting the circadian clock

Nakamura, Y., Nakano, N., Ishimaru, K., Ando, N., Katoh, R., Suzuki‐Inoue, K., Koyanagi, S., Ogawa, H., Okumura, K., Shibata, S., et al. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.08.052 · Cited by 55 · see citing works

Casein kinase 1 is a therapeutic target in chronic lymphocytic leukemia

Janovská, P., Verner, J., Kohoutek, J., Bryjová, L., Gregorová, M., Dzimková, M., Škabrahová, H., Radaszkiewicz, T. W., Ovesná, P., Blanářová, O. V., et al. (2018) · Blood · doi:10.1182/blood-2017-05-786947 · Cited by 54 · see citing works

Pharmacologic and genetic approaches define human pancreatic β cell mitogenic targets of DYRK1A inhibitors

Ackeifi, C. A., Swartz, E., Kumar, K., Liu, H., Suebsuwong, C., Karaköse, E., Scott, D. K., Garcı́a-Ocaña, A., Sánchez, R., DeVita, R. J., et al. (2019) · JCI Insight · doi:10.1172/jci.insight.132594 · Cited by 54 · see citing works

Site-specific phosphorylation of casein kinase 1 δ (CK1δ) regulates its activity towards the circadian regulator PER2

Eng, G. W. L., Edison, & Virshup, D. M. (2017) · PLoS ONE · doi:10.1371/journal.pone.0177834 · Cited by 53 · see citing works

Profiling molecular and behavioral circadian rhythms in the non-symbiotic sea anemone Nematostella vectensis

Oren, M., Tarrant, A. M., Alon, S., Simon‐Blecher, N., Elbaz, I., Appelbaum, L., & Levy, O. (2015) · Scientific Reports · doi:10.1038/srep11418 · Cited by 52 · see citing works

Molecular Targets for Small-Molecule Modulators of Circadian Clocks

He, B., & Chen, Z. (2016) · Current Drug Metabolism · doi:10.2174/1389200217666160111124439 · Cited by 51 · see citing works

Pharmacological Interventions to Circadian Clocks and Their Molecular Bases

Miller, S., & Hirota, T. (2020) · Journal of Molecular Biology · doi:10.1016/j.jmb.2020.01.003 · Cited by 50 · see citing works

Adipose tissue, adipocytes and the circadian timing system

Johnston, J. D., Frost, G. S., & Otway, D. T. (2009) · Obesity Reviews · doi:10.1111/j.1467-789x.2009.00665.x · Cited by 49 · see citing works

Modeling and Validating Chronic Pharmacological Manipulation of Circadian Rhythms

Kim, J. K., Forger, D. B., Marconi, M., Wood, D., Doran, A. C., Wager, T. T., Chang, C., & Walton, K. (2013) · CPT Pharmacometrics & Systems Pharmacology · doi:10.1038/psp.2013.34 · Cited by 49 · see citing works

Distinct control of PERIOD2 degradation and circadian rhythms by the oncoprotein and ubiquitin ligase MDM2

Liu, J., Zou, X., Gotoh, T., Brown, A. M., Jiang, L., Wisdom, E. L., Kim, J. K., & Finkielstein, C. V. (2018) · Science Signaling · doi:10.1126/scisignal.aau0715 · Cited by 47 · see citing works

Controlling the Circadian Clock with High Temporal Resolution through Photodosing

Kolarski, D., Sugiyama, A., Breton, G., Rakers, C., Ono, D., Schulte, A. M., Tama, F., Itami, K., Szymański, W., Hirota, T., et al. (2019) · Journal of the American Chemical Society · doi:10.1021/jacs.9b05445 · Cited by 47 · see citing works

Discovery of N6-phenyl-1H-pyrazolo[3,4-d]pyrimidine-3,6-diamine derivatives as novel CK1 inhibitors using common-feature pharmacophore model based virtual screening and hit-to-lead optimization

Yang, L., Li, G., Yan, H., Sun, Q., Ma, S., Ji, P., Wang, Z.-R., Feng, S., Zou, J., & Yang, S. (2012) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2012.08.007 · Cited by 44 · see citing works

CK1δ and CK1ε are components of human 40S subunit precursors required for cytoplasmic 40S maturation

Zemp, I., Wandrey, F., Rao, S., Ashiono, C., Wyler, E., Montellese, C., & Kutay, U. (2014) · Journal of Cell Science · doi:10.1242/jcs.138719 · Cited by 44 · see citing works

Structural Basis for the Potent and Selective Inhibition of Casein Kinase 1 Epsilon

Long, A. M., Zhao, H., & Huang, X. Y. (2012) · Journal of Medicinal Chemistry · doi:10.1021/jm301336n · Cited by 42 · see citing works

High-Throughput Screening and Chemical Biology: New Approaches for Understanding Circadian Clock Mechanisms

Hirota, T., & Kay, S. A. (2009) · Chemistry & Biology · doi:10.1016/j.chembiol.2009.09.002 · Cited by 42 · see citing works

Manipulating the Circadian and Sleep Cycles to Protect Against Metabolic Disease

Nohara, K., Yoo, S. H., & Chen, Z. (. (2015) · Frontiers in Endocrinology · doi:10.3389/fendo.2015.00035 · Cited by 40 · see citing works

Combined Pharmacological and Genetic Manipulations Unlock Unprecedented Temporal Elasticity and Reveal Phase-Specific Modulation of the Molecular Circadian Clock of the Mouse Suprachiasmatic Nucleus

Patton, A. P., Chesham, J. E., & Hastings, M. H. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.0958-16.2016 · Cited by 40 · see citing works

Casein Kinase 1δ/ε Inhibitor PF-5006739 Attenuates Opioid Drug-Seeking Behavior

Wager, T. T., Chandrasekaran, R. Y., Bradley, J. A., Rubitski, D. M., Berke, H., Mente, S., Butler, T. W., Doran, A. C., Chang, C., Fisher, K. E., et al. (2014) · ACS Chemical Neuroscience · doi:10.1021/cn500201x · Cited by 39 · see citing works

Casein Kinase 1δ/ε Inhibitor, PF670462 Attenuates the Fibrogenic Effects of Transforming Growth Factor-β in Pulmonary Fibrosis

Keenan, C. R., Langenbach, S. Y., Jativa, F., Harris, T., Li, M., Chen, Q., Xia, Y., Gao, X., Schuliga, M. J., Jaffar, J., et al. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00738 · Cited by 38 · see citing works

Systems approach reveals photosensitivity and PER2 level as determinants of clock‐modulator efficacy

Kim, D. W., Chang, C., Chen, X., Doran, A. C., Gaudreault, F., Wager, T. T., DeMarco, G. J., & Kim, J. K. (2019) · Molecular Systems Biology · doi:10.15252/msb.20198838 · Cited by 38 · see citing works

Casein kinase 1 enables nucleus accumbens amphetamine‐induced locomotion by regulating AMPA receptor phosphorylation

Li, D., Herrera, S., Bubula, N., Nikitina, E., Palmer, A. A., Hanck, D. A., Loweth, J. A., & Vezina, P. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07308.x · Cited by 37 · see citing works

Molecular basis for the regulation of the circadian clock kinases CK1δ and CK1ε

Yu, Y., Xu, T., Zhang, Y., & Qin, X. (2017) · Cellular Signalling · doi:10.1016/j.cellsig.2016.12.010 · Cited by 35 · see citing works

Ligand–Protein Interactions of Selective Casein Kinase 1δ Inhibitors

Mente, S., Arnold, E. P., Butler, T. W., Subramanyam, C., Chandrasekaran, R. Y., Cherry, K., DiRico, K. J., Doran, A. C., Fisher, K. E., Galatsis, P., et al. (2013) · Journal of Medicinal Chemistry · doi:10.1021/jm4006324 · Cited by 35 · see citing works

Casein Kinase 1δ Activity: A Key Element in the Zebrafish Circadian Timing System

Storz, S. S., Tovin, A., Mracek, P., Alon, S., Foulkes, N. S., & Gothilf, Y. (2013) · PLoS ONE · doi:10.1371/journal.pone.0054189 · Cited by 33 · see citing works

Oncogenic and Circadian Effects of Small Molecules Directly and Indirectly Targeting the Core Circadian Clock

Lin, H.-H., Robertson, K. L., Bisbee, H. A., & Farkas, M. E. (2020) · Integrative Cancer Therapies · doi:10.1177/1534735420924094 · Cited by 32 · see citing works

Desynchrony between brain and peripheral clocks caused by CK1δ/ε disruption in GABA neurons does not lead to adverse metabolic outcomes

van der Vinne, V., Swoap, S. J., Vajtay, T. J., & Weaver, D. R. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1712324115 · Cited by 32 · see citing works

Development of dual casein kinase 1δ/1ε (CK1δ/ε) inhibitors for treatment of breast cancer

Monastyrskyi, A., Nilchan, N., Quereda, V., Noguchi, Y., Ruiz, C. H., Grant, W. M., Cameron, M. D., Duckett, D. R., & Roush, W. R. (2017) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2017.12.020 · Cited by 32 · see citing works

Antibodies for assessing circadian clock proteins in the rodent suprachiasmatic nucleus

LeSauter, J., Lambert, C. M., Robotham, M. R., Model, Z., Silver, R., & Weaver, D. R. (2012) · PLoS ONE · doi:10.1371/journal.pone.0035938 · Cited by 31 · see citing works

Circadian clock modulating small molecules repurposing as inhibitors of SARS-CoV-2 Mpro for pharmacological interventions in COVID-19 pandemic

Sultan, A., Ali, R., Sultan, T., Ali, S., Khan, N. J., & Parganiha, A. (2021) · Chronobiology International · doi:10.1080/07420528.2021.1903027 · Cited by 31 · see citing works

Casein Kinase 1 Epsilon Regulates Glioblastoma Cell Survival

Varghese, R. T., Young, S., Pham, L., Liang, Y., Pridham, K. J., Guo, S., Murphy, S. F., Kelly, D. F., & Sheng, Z. (2018) · Scientific Reports · doi:10.1038/s41598-018-31864-x · Cited by 30 · see citing works

Chronic treatment with a selective inhibitor of casein kinase I δ/ε yields cumulative phase delays in circadian rhythms

Sprouse, J. S., Reynolds, L. S., Kleiman, R. J., Tate, B. A., Swanson, T. A., & Pickard, G. E. (2010) · Psychopharmacology · doi:10.1007/s00213-010-1860-5 · Cited by 30 · see citing works

Epiblastin A Induces Reprogramming of Epiblast Stem Cells Into Embryonic Stem Cells by Inhibition of Casein Kinase 1

Ursu, A., Illich, D. J., Takemoto, Y., Porfetye, A. T., Zhang, M., Brockmeyer, A., Janning, P., Watanabe, N., Osada, H., Vetter, I. R., et al. (2016) · Cell chemical biology · doi:10.1016/j.chembiol.2016.02.015 · Cited by 29 · see citing works

The circadian machinery links metabolic disorders and depression: A review of pathways, proteins and potential pharmacological interventions

Pitsillou, E., Liang, J. J., Hung, A., & Karagiannis, T. C. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118809 · Cited by 29 · see citing works

Modeling the Effect of APC Truncation on Destruction Complex Function in Colorectal Cancer Cells

Barua, D., & Hlavacek, W. S. (2013) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1003217 · Cited by 28 · see citing works

Modelling the dual role of Per phosphorylation and its effect on the period and phase of the mammalian circadian clock

Leloup, J., & Goldbeter, A. (2011) · IET Systems Biology · doi:10.1049/iet-syb.2009.0068 · Cited by 29 · see citing works

The Circadian Clock Gene Csnk1e Regulates Rapid Eye Movement Sleep Amount, and Nonrapid Eye Movement Sleep Architecture in Mice

Zhou, L., Bryant, C. D., Loudon, A. S. I., Palmer, A. A., Vitaterna, M. H., & Turek, F. W. (2014) · SLEEP · doi:10.5665/sleep.3590 · Cited by 28 · see citing works

Identification of circadian rhythms in Nannochloropsis species using bioluminescence reporter lines

Poliner, E., CUMMINGS, C. J., Newton, L. A., & Farré, E. M. (2019) · The Plant Journal · doi:10.1111/tpj.14314 · Cited by 26 · see citing works

Endogenous casein kinase‐1 modulates NMDA receptor activity of hypothalamic presympathetic neurons and sympathetic outflow in hypertension

Li, D., Zhou, J., & Pan, H. (2015) · The Journal of Physiology · doi:10.1113/jp270831 · Cited by 26 · see citing works

Oncogenic RAS-induced CK1α drives nuclear FOXO proteolysis

Zhang, F., Virshup, D. M., & Cheong, J. K. (2017) · Oncogene · doi:10.1038/onc.2017.334 · Cited by 24 · see citing works

Pharmacological Manipulation of the Circadian Clock: A Possible Approach to the Management of Bipolar Disorder

Porcu, A., Gonzalez, R., & McCarthy, M. J. (2019) · CNS Drugs · doi:10.1007/s40263-019-00673-9 · Cited by 22 · see citing works

Selective Inhibition of Casein Kinase 1 Minimally Alters Circadian Clock Period□S

Walton, K. M., Fisher, K., Rubitski, D. M., Marconi, M., Meng, Q., Adams, J., Bass, M., Ch, R., Butler, T., Griffor, M., et al. (2009)

Entrainment of disrupted circadian behavior through inhibition of casein kinase 1 (CK1) enzymes

Meng, Q., Maywood, E. S., Bechtold, D. A., Lu, W., Li, J., Gibbs, J. E., Dupré, S. M., Chesham, J. E., Rajamohan, F., Knafels, J. D., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1005101107 · Cited by 253 · see citing works

An Inhibitor of Casein Kinase Iϵ Induces Phase Delays in Circadian Rhythms under Free-Running and Entrained Conditions

Badura, L., Swanson, T., Adamowicz, W., Adams, J., Cianfrogna, J., Fisher, K., Holland, J., Kleiman, R., Nelson, F., Reynolds, L., et al. (2007) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.107.122846 · Cited by 176 · see citing works

Chronic treatment with a selective inhibitor of casein kinase I δ/ε yields cumulative phase delays in circadian rhythms

Sprouse, J. S., Reynolds, L. S., Kleiman, R. J., Tate, B. A., Swanson, T. A., & Pickard, G. E. (2010) · Psychopharmacology · doi:10.1007/s00213-010-1860-5 · Cited by 30 · see citing works

Casein Kinase 1 Delta Regulates the Pace of the Mammalian Circadian Clock

Etchegaray, J., Machida, K., Noton, E., Constance, C. M., Dallmann, R., Napoli, M. N. D., DeBruyne, J. P., Lambert, C. M., Yu, E. A., Reppert, S. M., et al. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.00338-09 · Cited by 237 · see citing works