Cited by 2,763Receptor Mechanisms and SignalingNeurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology Research

The DOI matches its Crossref record; 404 of the 409 references it cites were found in a registry or an index.

The Physiology, Signaling, and Pharmacology of Dopamine Receptors

Beaulieu, Jean-Martin, Gainetdinov, Raul R.·2011·Pharmacological Reviews

DOI 10.1124/pr.110.002642

Open this paper in CoChat — free account

Abstract

G protein-coupled dopamine receptors (D1, D2, D3, D4, and D5) mediate all of the physiological functions of the catecholaminergic neurotransmitter dopamine, ranging from voluntary movement and reward to hormonal regulation and hypertension. Pharmacological agents targeting dopaminergic neurotransmission have been clinically used in the management of several neurological and psychiatric disorders, including Parkinson's disease, schizophrenia, bipolar disorder, Huntington's disease, attention deficit hyperactivity disorder (ADHD(1)), and Tourette's syndrome. Numerous advances have occurred in understanding the general structural, biochemical, and functional properties of dopamine receptors that have led to the development of multiple pharmacologically active compounds that directly target dopamine receptors, such as antiparkinson drugs and antipsychotics. Recent progress in understanding the complex biology of dopamine receptor-related signal transduction mechanisms has revealed that, in addition to their primary action on cAMP-mediated signaling, dopamine receptors can act through diverse signaling mechanisms that involve alternative G protein coupling or through G protein-independent mechanisms via interactions with ion channels or proteins that are characteristically implicated in receptor desensitization, such as β-arrestins. One of the future directions in managing dopamine-related pathologic conditions may involve a transition from the approaches that directly affect receptor function to a precise targeting of postreceptor intracellular signaling modalities either directly or through ligand-biased signaling pharmacology. In this comprehensive review, we discuss dopamine receptor classification, their basic structural and genetic organization, their distribution and functions in the brain and the periphery, and their regulation and signal transduction mechanisms. In addition, we discuss the abnormalities of dopamine receptor expression, function, and signaling that are documented in human disorders and the current pharmacology and emerging trends in the development of novel therapeutic agents that act at dopamine receptors and/or on related signaling events.

Integrity signals

Registry

Crossref · 10.1124/pr.110.002642

Cites

404 of 404 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Neurocircuitry of Addiction
Koob, G. F., & Volkow, N. D. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.110 · Cited by 5,340
Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
Cross, D. A. E., Alessi, D. R., Cohen, P., Andjelkovich, M., & Hemmings, B. A. (1995) · Nature · doi:10.1038/378785a0 · Cited by 5,244
EVIDENCE FOR THE EXISTENCE OF MONOAMINE-CONTAINING NEURONS IN THE CENTRAL NERVOUS SYSTEM. I. DEMONSTRATION OF MONOAMINES IN THE CELL BODIES OF BRAIN STEM NEURONS.
Dahlstroem, A., & Fuxé, K. (1964) · PubMed · Cited by 5,133
Multiple receptors for dopamine
Kebabian, J. W., & Calne, D. B. (1979) · Nature · doi:10.1038/277093a0 · Cited by 3,756
Dopamine receptors: from structure to function
MISSALE, C., NASH, S. R., ROBINSON, S. W., JABER, M., & CARON, M. G. (1998) · Physiological Reviews · doi:10.1152/physrev.1998.78.1.189 · Cited by 3,633
Seven-transmembrane receptors
Pierce, K. L., Premont, R. T., & Lefkowitz, R. J. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm908 · Cited by 2,712
NEURAL MECHANISMS OF ADDICTION: The Role of Reward-Related Learning and Memory
Hyman, S. E., Malenka, R. C., & Nestler, E. J. (2006) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.29.051605.113009 · Cited by 2,647
Molecular cloning and characterization of a novel dopamine receptor (D3) as a target for neuroleptics
Sokoloff, P., Bruno Giros, A., Martres, M., Bouthenet, M.-L., & Schwartz, J. (1990) · Nature · doi:10.1038/347146a0 · Cited by 2,608
Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter
Giros, B., Jaber, M., Jones, S. R., Wightman, R. M., & Caron, M. G. (1996) · Nature · doi:10.1038/379606a0 · Cited by 2,476
Dopamine Receptor Binding Predicts Clinical and Pharmacological Potencies of Antischizophrenic Drugs
Creese, I., Burt, D. R., & Snyder, S. H. (1976) · Science · doi:10.1126/science.3854 · Cited by 2,220

Show all 409 references

Sorted by citations

Items 201–300 of 1,006

Physicochemical Insights on Terahertz Wave Diminished Side Effects of Drugs from Slow Dissociation
Li, Y., Zhu, Z. H., Sun, L., Xiang, Z., Chang, C., & Fan, C. (2022) · ACS Nano · doi:10.1021/acsnano.2c02952 · Cited by 104
S100 Calcium Binding Proteins and Ion Channels
Hermann, A., Donato, R., Weiger, T. M., & Chazin, W. (2012) · Frontiers in Pharmacology · doi:10.3389/fphar.2012.00067 · Cited by 104
Reciprocal Regulation of Endocytosis and Metabolism
Antonescu, C. N., McGraw, T. E., & Klip, A. (2014) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a016964 · Cited by 104
Dopaminergic Signaling in the Cochlea: Receptor Expression Patterns and Deletion Phenotypes
Maison, S. F., Liu, X.-P., Eatock, R. A., Sibley, D. R., Grandy, D. K., & Liberman, M. C. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.4720-11.2012 · Cited by 103
Postsynaptic D2 dopamine receptor supersensitivity in the striatum of mice lacking TAAR1
Espinoza, S., Ghisi, V., Emanuele, M., Leo, D., Sukhanov, I., Sotnikova, T. D., Chieregatti, E., & Gainetdinov, R. R. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.02.010 · Cited by 103
Self-citation
Estradiol increases the sensitivity of ventral tegmental area dopamine neurons to dopamine and ethanol
Vandegrift, B. J., You, C., Satta, R., Brodie, M. S., & Lasek, A. W. (2017) · PLoS ONE · doi:10.1371/journal.pone.0187698 · Cited by 103
Dopamine signalling in locusts and other insects
Verlinden, H. (2018) · Insect Biochemistry and Molecular Biology · doi:10.1016/j.ibmb.2018.04.005 · Cited by 103
Role of Descending Dopaminergic Pathways in Pain Modulation
Li, C., Liu, S., Lu, X., & Tao, F. (2019) · Current Neuropharmacology · doi:10.2174/1570159x17666190430102531 · Cited by 103
Pharmacosynthetics: Reimagining the pharmacogenetic approach
Farrell, M. S., & Roth, B. L. (2012) · Brain Research · doi:10.1016/j.brainres.2012.09.043 · Cited by 103
Two-Photon Optical Interrogation of Individual Dendritic Spines with Caged Dopamine
Araya, R., Andino-Pavlovsky, V., Yuste, R., & Etchenique, R. (2013) · ACS Chemical Neuroscience · doi:10.1021/cn4000692 · Cited by 103
The role of GPCRs in neurodegenerative diseases: avenues for therapeutic intervention
Huang, Y., Todd, N., & Thathiah, A. (2017) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2017.02.001 · Cited by 104
Nucleus Accumbens Microcircuit Underlying D2-MSN-Driven Increase in Motivation
Soares‐Cunha, C., Coimbra, B., Domingues, A. V., de Vasconcelos, N. A. P., Sousa, N., & Rodrigues, A. J. (2018) · eNeuro · doi:10.1523/eneuro.0386-18.2018 · Cited by 102
Catecholamines and cognition after traumatic brain injury
Jenkins, P. O., Mehta, M. A., & Sharp, D. J. (2016) · Brain · doi:10.1093/brain/aww128 · Cited by 102
Activation of Dopamine Receptor 2 Prompts Transcriptomic and Metabolic Plasticity in Glioblastoma
Caragher, S. P., Shireman, J. M., Huang, M., Miska, J. M., Atashi, F., Baisiwala, S., Park, C. H., Saathoff, M. R., Warnke, L., Xiao, T., et al. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.1589-18.2018 · Cited by 101
Dopamine Synthesis and D3 Receptor Activation in Pancreatic β-Cells Regulates Insulin Secretion and Intracellular [Ca2+] Oscillations
Ustione, A., & Piston, D. W. (2012) · Molecular Endocrinology · doi:10.1210/me.2012-1226 · Cited by 101
Drugs that Disturb Sleep and Wakefulness
Schweitzer, P. K., & Randazzo, A. C. (2016) · Elsevier eBooks · doi:10.1016/b978-0-323-24288-2.00045-3 · Cited by 101
Impaired β-arrestin recruitment and reduced desensitization by non-catechol agonists of the D1 dopamine receptor
Gray, D. L., Allen, J., Mente, S., O’Connor, R. E., DeMarco, G. J., Efremov, I. V., Tierney, P. L., Volfson, D., Davoren, J. E., Guilmette, E. R., et al. (2018) · Nature Communications · doi:10.1038/s41467-017-02776-7 · Cited by 100
Neural substrates of trait impulsivity, anhedonia, and irritability: Mechanisms of heterotypic comorbidity between externalizing disorders and unipolar depression
Zisner, A. R., & Beauchaine, T. P. (2016) · Development and Psychopathology · doi:10.1017/s0954579416000754 · Cited by 101
Dopamine elevates and lowers astroglial Ca2+ through distinct pathways depending on local synaptic circuitry
Jennings, A., Tyurikova, O., Bard, L., Zheng, K., Semyanov, A. V., Henneberger, C., & Rusakov, D. A. (2016) · Glia · doi:10.1002/glia.23103 · Cited by 102
Antipsychotic Induced Dopamine Supersensitivity Psychosis: A Comprehensive Review
Yin, J., Barr, A. M., Ramos‐Miguel, A., & Procyshyn, R. M. (2016) · Current Neuropharmacology · doi:10.2174/1570159x14666160606093602 · Cited by 99
Visualization and ligand-induced modulation of dopamine receptor dimerization at the single molecule level
Tabor, A., Weisenburger, S., Banerjee, A., Purkayastha, N., Kaindl, J. M., Hübner, H., Wei, L., Grömer, T. W., Kornhuber, J., Tschammer, N., et al. (2016) · Scientific Reports · doi:10.1038/srep33233 · Cited by 99
Antibodies to Surface Dopamine-2 Receptor and N-Methyl-D-Aspartate Receptor in the First Episode of Acute Psychosis in Children
Pathmanandavel, K., Starling, J., Merheb, V., Ramanathan, S., Sinmaz, N., Dale, R. C., & Brilot, F. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.07.014 · Cited by 98
Gastroparesis, metoclopramide, and tardive dyskinesia: Risk revisited
Al‐Saffar, A., Lennernäs, H., & Hellström, P. M. (2019) · Neurogastroenterology & Motility · doi:10.1111/nmo.13617 · Cited by 98
Genome-wide Association Analysis of Parkinson’s Disease and Schizophrenia Reveals Shared Genetic Architecture and Identifies Novel Risk Loci
Smeland, O. B., Shadrin, A. A., Bahrami, S., Broce, I., Tesli, M., Frei, O., Wirgenes, K. V., O’Connell, K. S., Krull, F., Bettella, F., et al. (2020) · Biological Psychiatry · doi:10.1016/j.biopsych.2020.01.026 · Cited by 98
Involvement of Dopamine Receptors in Binge Methamphetamine-Induced Activation of Endoplasmic Reticulum and Mitochondrial Stress Pathways
Beauvais, G., Atwell, K., Jayanthi, S., Ladenheim, B., & Cadet, J. L. (2011) · PLoS ONE · doi:10.1371/journal.pone.0028946 · Cited by 98
Co-deposition of carbon dots and reduced graphene oxide nanosheets on carbon-fiber microelectrode surface for selective detection of dopamine
Fang, J., Xie, Z., Wallace, G. G., & Wang, X. (2017) · Applied Surface Science · doi:10.1016/j.apsusc.2017.03.257 · Cited by 98
A GABAergic Feedback Shapes Dopaminergic Input on the Drosophila Mushroom Body to Promote Appetitive Long-Term Memory
Pavlowsky, A., Schor, J., Plaçais, P.-Y., & Préat, T. (2018) · Current Biology · doi:10.1016/j.cub.2018.04.040 · Cited by 97
Obesity and dietary fat influence dopamine neurotransmission: exploring the convergence of metabolic state, physiological stress, and inflammation on dopaminergic control of food intake
Wallace, C. W., & Fordahl, S. C. (2021) · Nutrition Research Reviews · doi:10.1017/s0954422421000196 · Cited by 98
Chronic Stress Effects on Tumor: Pathway and Mechanism
Hong, H., Ji, M. J., & Lai, D. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.738252 · Cited by 97
The Signaling and Pharmacology of the Dopamine D1 Receptor
Jones-Tabah, J., Mohammad, H., Paulus, E., Clarke, P. B. S., & Hébert, T. E. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.806618 · Cited by 97
A systematic review of psychostimulant treatment of negative symptoms of schizophrenia: Challenges and therapeutic opportunities
Lindenmayer, J., Nasrallah, H. A., Pucci, M. L., James, S., & Citrome, L. (2013) · Schizophrenia Research · doi:10.1016/j.schres.2013.03.019 · Cited by 97
Bitopic Ligands and Metastable Binding Sites: Opportunities for G Protein-Coupled Receptor (GPCR) Medicinal Chemistry
Fronik, P., Gaiser, B. I., & Pedersen, D. S. (2017) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.6b01601 · Cited by 97
The steroid hormone 20-hydroxyecdysone binds to dopamine receptor to repress lepidopteran insect feeding and promote pupation
Kang, X.-L., Zhang, J.-Y., Wang, D., Zhao, Y.-M., Han, X.-L., Wang, J.-X., & Zhao, X.-F. (2019) · PLOS Genetics · doi:10.1371/journal.pgen.1008331 · Cited by 96
Executive (dys)function after traumatic brain injury: special considerations for behavioral pharmacology
Ozga, J. E., Povroznik, J. M., Engler-Chiurazzi, E. B., & Haar, C. V. (2018) · Behavioural Pharmacology · doi:10.1097/fbp.0000000000000430 · Cited by 96
Dopamine Uses the DRD5-ARRB2-PP2A Signaling Axis to Block the TRAF6-Mediated NF-κB Pathway and Suppress Systemic Inflammation
Wu, Y., Hu, Y., Wang, B., Li, S., Ma, C., Liu, X., Moynagh, P. N., Zhou, J., & Yang, S. (2020) · Molecular Cell · doi:10.1016/j.molcel.2020.01.022 · Cited by 96
Dopamine Modulates Dynamic Decision-Making during Foraging
Heron, C. J. L., Kolling, N., Plant, O., Kienast, A., Janska, R., Ang, Y., Fallon, S. J., Husain, M., & Apps, M. A. J. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.2586-19.2020 · Cited by 97
Detection of phasic dopamine by D1 and D2 striatal medium spiny neurons
Yapo, C., Nair, A. G., Clement, L., Castro, L. R., Kotaleski, J. H., & Vincent, P. (2017) · The Journal of Physiology · doi:10.1113/jp274475 · Cited by 94
The neurobiology of human aggressive behavior: Neuroimaging, genetic, and neurochemical aspects
Cupaioli, F. A., Zucca, F. A., Caporale, C., Lesch, K., Passamonti, L., & Zecca, L. (2020) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110059 · Cited by 94
Expression and therapeutic targeting of dopamine receptor-1 (D1R) in breast cancer
Borcherding, D. C., Tong, W. S., Hugo, E. R., Barnard, D. F., Fox, S. R., LaSance, K., Shaughnessy, E., & Ben‐Jonathan, N. (2015) · Oncogene · doi:10.1038/onc.2015.369 · Cited by 94
The role of dopamine in the pathophysiology and treatment of apathy
Chong, T. T. ‐., & Husain, M. (2016) · Progress in brain research · doi:10.1016/bs.pbr.2016.05.007 · Cited by 93
Adrenergic and Dopaminergic Modulation of Immunity in Multiple Sclerosis: Teaching Old Drugs New Tricks?
Cosentino, M., & Marino, F. (2012) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-012-9410-z · Cited by 93
Antipsychotic Drug Effects in Schizophrenia: A Review of Longitudinal fMRI Investigations and Neural Interpretations
Abbott, C., Jaramillo, A. A., Wilcox, C. E., & Hamilton, D. A. (2013) · Current Medicinal Chemistry · doi:10.2174/092986713804870864 · Cited by 93
Molecular basis of dopamine replacement therapy and its side effects in Parkinson’s disease
You, H., Mariani, L., Mangone, G., de Nailly, D. L. F., Charbonnier‐Beaupel, F., & Corvol, J. (2018) · Cell and Tissue Research · doi:10.1007/s00441-018-2813-2 · Cited by 92
Dopamine D3 Receptor Antagonists as Potential Therapeutics for the Treatment of Neurological Diseases
Maramai, S., Gemma, S., Brogi, S., Campiani, G., Butini, S., Stark, H., & Brindisi, M. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00451 · Cited by 92
Monoamines in glioblastoma: complex biology with therapeutic potential
Caragher, S. P., Hall, R. R., Ahsan, R., & Ahmed, A. U. (2017) · Neuro-Oncology · doi:10.1093/neuonc/nox210 · Cited by 91
Heterogeneity in striatal dopamine circuits: Form and function in dynamic reward seeking
Collins, A. L., & Saunders, B. T. (2020) · Journal of Neuroscience Research · doi:10.1002/jnr.24587 · Cited by 93
Antioxidant Properties of Second-Generation Antipsychotics: Focus on Microglia
Caruso, G., Grasso, M., Fidilio, A., Tascedda, F., Drago, F., & Caraci, F. (2020) · Pharmaceuticals · doi:10.3390/ph13120457 · Cited by 91
Genetic evidence for role of integration of fast and slow neurotransmission in schizophrenia
Devor, A., Andreassen, O. A., Wang, Y., Mäki‐Marttunen, T., Smeland, O. B., Fan, C.-C., Schork, A. J., Holland, D., Thompson, W. K., Witoelar, A., et al. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.33 · Cited by 91
Long‐term, calorie‐restricted intake of a high‐fat diet in rats reduces impulse control and ventral striatal D2 receptor signalling – two markers of addiction vulnerability
Adams, W. K., Sussman, J. L., Kaur, S., D'souza, A. M., Kieffer, T. J., & Winstanley, C. A. (2015) · European Journal of Neuroscience · doi:10.1111/ejn.13117 · Cited by 91
The Class-A GPCR Dopamine D2 Receptor Forms Transient Dimers Stabilized by Agonists: Detection by Single-Molecule Tracking
Kasai, R. S., Ito, S., Awane, R., Fujiwara, T. K., & Kusumi, A. (2017) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-017-0829-y · Cited by 90
Optical Control of Dopamine Receptors Using a Photoswitchable Tethered Inverse Agonist
Donthamsetti, P., Winter, N., Schönberger, M., Levitz, J., Stanley, C., Javitch, J. A., Isacoff, E. Y., & Trauner, D. H. (2017) · Journal of the American Chemical Society · doi:10.1021/jacs.7b07659 · Cited by 90
Translational evidence for lithium-induced brain plasticity and neuroprotection in the treatment of neuropsychiatric disorders
Puglisi‐Allegra, S., Ruggieri, S. A., & Fornai, F. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01492-7 · Cited by 90
A literature review of dopamine in binge eating
Yu, Y. H., Miller, R. M., & Groth, S. W. (2022) · Journal of Eating Disorders · doi:10.1186/s40337-022-00531-y · Cited by 90
Paraoxonase-2 (PON2) in brain and its potential role in neuroprotection
Costa, L. G., de Laat, R., Dao, K., Pellacani, C., Cole, T. B., & Furlong, C. E. (2013) · NeuroToxicology · doi:10.1016/j.neuro.2013.08.011 · Cited by 90
A pilot study on the effect of cognitive training on BDNF serum levels in individuals with Parkinson’s disease
Angelucci, F., Peppe, A., Carlesimo, G. A., Serafini, F., Zabberoni, S., Barban, F., Shofany, J., Caltagirone, C., & da Costa, A. L. C. (2015) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2015.00130 · Cited by 90
The afferent signaling complex: Regulation of type I spiral ganglion neuron responses in the auditory periphery
Reijntjes, D. O. J., & Pyott, S. J. (2016) · Hearing Research · doi:10.1016/j.heares.2016.03.011 · Cited by 90
Zinc in the Monoaminergic Theory of Depression: Its Relationship to Neural Plasticity
Doboszewska, U., Właź, P., Nowak, G., Radziwoń-Zaleska, M., Cui, R., & Młyniec, K. (2017) · Neural Plasticity · doi:10.1155/2017/3682752 · Cited by 90
Intrinsic and Antipsychotic Drug-Induced Metabolic Dysfunction in Schizophrenia
Freyberg, Z., Aslanoglou, D., Shah, R. N., & Ballon, J. S. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00432 · Cited by 90
Therapeutic potential of targeting G protein-gated inwardly rectifying potassium (GIRK) channels in the central nervous system
Jeremic, D., Sanchez-Rodriguez, I., Jimenez-Diaz, L., & Navarro-Lopez, J. D. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.107808 · Cited by 89
Neurogenesis in neurological and psychiatric diseases and brain injury: From bench to bedside
Ruan, L., Lau, B. W.-M., Wang, J., Huang, L., Zhuge, Q., Wang, B. Z., Jin, K., & So, K. (2014) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.12.006 · Cited by 89
A Critical Role for Dopamine D5 Receptors in Pain Chronicity in Male Mice
Megat, S., Shiers, S. I., Moy, J. K., Barragán‐Iglesias, P., Pradhan, G., Seal, R. P., Dussor, G. O., & Price, T. J. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.2110-17.2017 · Cited by 89
Repurposing psychiatric drugs as anti-cancer agents
Huang, J., Zhao, D., Liu, Z., & Liu, F. (2018) · Cancer Letters · doi:10.1016/j.canlet.2018.01.058 · Cited by 89
Quinoline- and Isoquinoline-Sulfonamide Analogs of Aripiprazole: Novel Antipsychotic Agents?
Zajdel, P., Partyka, A., Marciniec, K., Bojarski, A. J., Pawłowski, M., & Wesołowska, A. (2013) · Future Medicinal Chemistry · doi:10.4155/fmc.13.158 · Cited by 89
Quantification of receptor tyrosine kinase transactivation through direct dimerization and surface density measurements in single cells
Swift, J. L., Godin, A. G., Doré, K., Freland, L., Bouchard, N., Nimmo, C. M., Sergeev, M., Koninck, Y. D., Wiseman, P. W., & Beaulieu, J. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1018280108 · Cited by 89
Self-citation
A Highly Sensitive A-Kinase Activity Reporter for Imaging Neuromodulatory Events in Awake Mice
Ma, L., Jongbloets, B. C., Xiong, W.-H., Melander, J. B., Qin, M., Lameyer, T. J., Harrison, M. F., Zemelman, B. V., Mao, T., & Zhong, H. (2018) · Neuron · doi:10.1016/j.neuron.2018.07.020 · Cited by 91
A comparison of D2 receptor specific binding in obese and normal‐weight individuals using PET with (N‐[11C]methyl)benperidol
Eisenstein, S. A., Antenor‐Dorsey, J. A. V., Gredysa, D. M., Koller, J. M., Bihun, E. C., Ranck, S. A., Arbeláez, A. M., Klein, S., Perlmutter, J. S., Moerlein, S. M., et al. (2013) · Synapse · doi:10.1002/syn.21680 · Cited by 88
D1-D2 Dopamine Receptor Synergy Promotes Calcium Signaling via Multiple Mechanisms
Chun, L. S., Free, R. B., Doyle, T. B., Huang, X., Rankin, M. L., & Sibley, D. R. (2013) · Molecular Pharmacology · doi:10.1124/mol.113.085175 · Cited by 88
The role of serotonergic, adrenergic and dopaminergic receptors in antidepressant-like effect
Pytka, K., Podkowa, K., Rapacz, A., Podkowa, A., Żmudzka, E., Olczyk, A., Sapa, J., & Filipek, B. (2015) · Pharmacological Reports · doi:10.1016/j.pharep.2015.08.007 · Cited by 88
Crosstalk between receptor tyrosine kinases (RTKs) and G protein-coupled receptors (GPCR) in the brain: Focus on heteroreceptor complexes and related functional neurotrophic effects
Liberto, V. D., Mudò, G., & Belluardo, N. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.11.018 · Cited by 87
The modulatory role of dopamine receptors in brain neuroinflammation
Xia, Q.-P., Cheng, Z.-Y., & He, L. (2019) · International Immunopharmacology · doi:10.1016/j.intimp.2019.105908 · Cited by 87
Advances in biomedical study of the myopia-related signaling pathways and mechanisms
Yang, J., Ouyang, X., Fu, H. Y., Hou, X., Liu, Y., Xie, Y., Yu, H., & Wang, G. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112472 · Cited by 87
Dopamine transporter mutant animals: a translational perspective
Efimova, E. V., Gainetdinov, R. R., Budygin, E. A., & Sotnikova, T. D. (2016) · Journal of Neurogenetics · doi:10.3109/01677063.2016.1144751 · Cited by 86
Self-citation
Understanding the role of dopamine in cancer: past, present and future
Grant, C. E., Flis, A. L., & Ryan, B. M. (2022) · Carcinogenesis · doi:10.1093/carcin/bgac045 · Cited by 86
Cocaine Self-Administration Produces Pharmacodynamic Tolerance: Differential Effects on the Potency of Dopamine Transporter Blockers, Releasers, and Methylphenidate
Ferris, M. J., Calipari, E. S., Mateo, Y., Melchior, J. R., Roberts, D. C. S., & Jones, S. R. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.17 · Cited by 86
Dopamine and learned food preferences
Sclafani, A. J., Touzani, K., & Bodnar, R. J. (2011) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.04.039 · Cited by 86
Modulation of Synaptic Plasticity in the Cortex Needs to Understand All the Players
Meunier, C. N. J., Chameau, P. J. P., & Fossier, P. (2017) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2017.00002 · Cited by 86
Current Concepts on the Physiopathological Relevance of Dopaminergic Receptors
Ledonne, A., & Mercuri, N. B. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00027 · Cited by 86
Age-Related Dopaminergic Innervation Augments T Helper 2-Type Allergic Inflammation in the Postnatal Lung
Wang, W., Cohen, J. A., Wallrapp, A., Trieu, K. G., Barrios, J., Shao, F., Krishnamoorthy, N., Kuchroo, V. K., Jones, M. R., Fine, A., et al. (2019) · Immunity · doi:10.1016/j.immuni.2019.10.002 · Cited by 86
On the pathophysiology and treatment of akinetic mutism
Arnts, H., van Erp, W. S., Lavrijsen, J. C. M., van Gaal, S., Groenewegen, H. J., & van den Munckhof, P. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.02.006 · Cited by 85
The nucleus accumbens in reward and aversion processing: insights and implications
Xu, Y., Lin, Y., Yu, M., & Zhou, K. (2024) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2024.1420028 · Cited by 86
Impact on intracortical myelination trajectory of long acting injection versus oral risperidone in first-episode schizophrenia
Bartzokis, G., Lu, P. H., Raven, E. P., Amar, C. P., DeTore, N. R., Couvrette, A., Mintz, J., Ventura, J., Casaus, L. R., Luo, J. S., et al. (2012) · Schizophrenia Research · doi:10.1016/j.schres.2012.06.036 · Cited by 85
Critical periods of brain development
(2020) · Handbook of Clinical Neurology · doi:10.1016/b978-0-444-64150-2.00009-5 · Cited by 84
The Prospective Value of Dopamine Receptors on Bio-Behavior of Tumor
Wang, X., Wang, Z.-B., Luo, C., Mao, X., Li, X., Yin, J., Zhang, W., Zhou, H., & Liu, Z. (2019) · Journal of Cancer · doi:10.7150/jca.27780 · Cited by 84
Carbon nanofiber-PEDOT composite films as novel microelectrode for neural interfaces and biosensing
Saunier, V., Emmanuel Flahaut, B., Blatché, M.-C., Bergaud, C., & Maziz, A. (2020) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2020.112413 · Cited by 84
Developmental Profile of the Aberrant Dopamine D2 Receptor Response in Striatal Cholinergic Interneurons in DYT1 Dystonia
Sciamanna, G., Tassone, A., Martella, G., Mandolesi, G., Puglisi, F., Cuomo, D., Madeo, G., Ponterio, G., Standaert, D. G., Bonsi, P., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024261 · Cited by 84
Dopamine D3 receptor: A neglected participant in Parkinson Disease pathogenesis and treatment?
Yang, P., Perlmutter, J. S., Benzinger, T. L. S., Morris, J. C., & Xu, J. (2019) · Ageing Research Reviews · doi:10.1016/j.arr.2019.100994 · Cited by 83
Recent advances in inorganic functional nanomaterials based flexible electrochemical sensors
Yuan, F., Xia, Y., Lu, Q., Xu, Q. H., Shu, Y., & Hu, X. (2022) · Talanta · doi:10.1016/j.talanta.2022.123419 · Cited by 83
Selective deletion of forebrain glycogen synthase kinase 3β reveals a central role in serotonin-sensitive anxiety and social behaviour
Latapy, C., Rioux, V., Guitton, M. J., & Beaulieu, J. (2012) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2012.0094 · Cited by 84
Self-citation
Evidence for Noncanonical Neurotransmitter Activation: Norepinephrine as a Dopamine D2-Like Receptor Agonist
Sánchez‐Soto, M., Bonifazi, A., Cai, N. S., Ellenberger, M. P., Newman, A. H., Ferré, S., & Yano, H. (2016) · Molecular Pharmacology · doi:10.1124/mol.115.101808 · Cited by 83
Pridopidine activates neuroprotective pathways impaired in Huntington Disease
Geva, M., Kusko, R. L., Soares, H. D., Fowler, K. D., Birnberg, T., Barash, S., Wagner, A. M., Fine, T., Lysaght, A. C., Weiner, B., et al. (2016) · Human Molecular Genetics · doi:10.1093/hmg/ddw238 · Cited by 83
Dopamine Receptor Activation Increases HIV Entry into Primary Human Macrophages
Gaskill, P. J., Yano, H., Kalpana, G. V., Javitch, J. A., & Berman, J. W. (2014) · PLoS ONE · doi:10.1371/journal.pone.0108232 · Cited by 82
Chronic Cocaine Dampens Dopamine Signaling during Cocaine Intoxication and Unbalances D1over D2Receptor Signaling
Park, K., Volkow, N. D., Pan, Y., & Du, C. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.1935-13.2013 · Cited by 83
Implication of dopamine D3 receptor activation in the reversion of Parkinson’s disease-related motivational deficits
Carnicella, S., Drui, G., Boulet, S., Carcenac, C., Favier, M., Duran, T., & Savasta, M. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.43 · Cited by 82
Neurobiological substrates of personality: A critical overview.
Yarkoni, T. (2014) · American Psychological Association eBooks · doi:10.1037/14343-003 · Cited by 81
Dopamine, the antipsychotic molecule: A perspective on mechanisms underlying antipsychotic response variability
Amato, D., Vernon, A. C., & Papaleo, F. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.09.027 · Cited by 81
Dopamine receptor D2, but not D1, mediates descending dopaminergic pathway–produced analgesic effect in a trigeminal neuropathic pain mouse model
Liu, S., Tang, Y., Shu, H., Tatum, D., Bai, Q., Crawford, J. A., Xing, Y., Lobo, M. K., Bellinger, L. L., Kramer, P. R., et al. (2018) · Pain · doi:10.1097/j.pain.0000000000001414 · Cited by 81
A dynamic and screening-compatible nanoluciferase-based complementation assay enables profiling of individual GPCR–G protein interactions
Laschet, C., Dupuis, N., & Hanson, J. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.006231 · Cited by 81
Global gene expression profiling of healthy human brain and its application in studying neurological disorders
Negi, S., & Guda, C. (2017) · Scientific Reports · doi:10.1038/s41598-017-00952-9 · Cited by 80
Phosphodiesterase inhibition and modulation of corticostriatal and hippocampal circuits: Clinical overview and translational considerations
Heckman, P. R. A., Blokland, A., Bollen, E., & Prickaerts, J. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.02.007 · Cited by 80
Dopamine D2 receptor signalling controls inflammation in acute pancreatitis via a PP2A‐dependent Akt/NF‐κB signalling pathway
Han, X., Li, B., Ye, X., Mulatibieke, T., Wu, J., Dai, J., Wu, D., Ni, J., Zhang, R., Xue, J., et al. (2017) · British Journal of Pharmacology · doi:10.1111/bph.14057 · Cited by 79

Authors: Beaulieu, J.-M., & Gainetdinov, R. R.
Affiliations: Université Laval (CA)
Italian Institute of Technology (IT)
ORCID: Beaulieu, Jean-Martin
Gainetdinov, Raul R.
Venue: Pharmacological Reviews
Publisher: Elsevier BV
Published: 2011-03
Volume: 63
Issue: 1
Pages: 182-217
ISSN: 0031-6997 (ISSN-L)
DOI: 10.1124/pr.110.002642
OpenAlex: W2097744565
Cited by: 2,763
References: 409
Citations by year: 2026: 157 · 2025: 183 · 2024: 172 · 2023: 193 · 2022: 201 · 2021: 197 · 2020: 198 · 2019: 220 · 2018: 200 · 2017: 187 · 2016: 205 · 2015: 175 · 2014: 194 · 2013: 136 · 2012: 101
FWCI: 13.93
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Pharmacological Reviews (publishedVersion)
PubMed (publishedVersion)
Funders: Canadian Institutes of Health Research (NSA93798)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: dopamine receptors, dopamine D1/D5 receptors, G protein-coupled receptors, signal transduction, cAMP signaling, G protein-independent signaling, beta-arrestin, receptor desensitization, antiparkinsonian drugs, antipsychotic drugs
MeSH terms: Animals, Gene Expression Regulation, Humans, Ligands, Receptors, Dopamine, Signal Transduction, Dopamine Agonists, Dopamine Antagonists, Molecular Targeted Therapy

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The Physiology, Signaling, and Pharmacology of Dopamine Receptors

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks