Cited by 2,763Receptor Mechanisms and SignalingNeurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology Research

The DOI matches its Crossref record; 404 of the 409 references it cites were found in a registry or an index.

The Physiology, Signaling, and Pharmacology of Dopamine Receptors

Beaulieu, Jean-Martin, Gainetdinov, Raul R.·2011·Pharmacological Reviews

DOI 10.1124/pr.110.002642

Open this paper in CoChat — free account

Abstract

G protein-coupled dopamine receptors (D1, D2, D3, D4, and D5) mediate all of the physiological functions of the catecholaminergic neurotransmitter dopamine, ranging from voluntary movement and reward to hormonal regulation and hypertension. Pharmacological agents targeting dopaminergic neurotransmission have been clinically used in the management of several neurological and psychiatric disorders, including Parkinson's disease, schizophrenia, bipolar disorder, Huntington's disease, attention deficit hyperactivity disorder (ADHD(1)), and Tourette's syndrome. Numerous advances have occurred in understanding the general structural, biochemical, and functional properties of dopamine receptors that have led to the development of multiple pharmacologically active compounds that directly target dopamine receptors, such as antiparkinson drugs and antipsychotics. Recent progress in understanding the complex biology of dopamine receptor-related signal transduction mechanisms has revealed that, in addition to their primary action on cAMP-mediated signaling, dopamine receptors can act through diverse signaling mechanisms that involve alternative G protein coupling or through G protein-independent mechanisms via interactions with ion channels or proteins that are characteristically implicated in receptor desensitization, such as β-arrestins. One of the future directions in managing dopamine-related pathologic conditions may involve a transition from the approaches that directly affect receptor function to a precise targeting of postreceptor intracellular signaling modalities either directly or through ligand-biased signaling pharmacology. In this comprehensive review, we discuss dopamine receptor classification, their basic structural and genetic organization, their distribution and functions in the brain and the periphery, and their regulation and signal transduction mechanisms. In addition, we discuss the abnormalities of dopamine receptor expression, function, and signaling that are documented in human disorders and the current pharmacology and emerging trends in the development of novel therapeutic agents that act at dopamine receptors and/or on related signaling events.

Integrity signals

Registry

Crossref · 10.1124/pr.110.002642

Cites

404 of 404 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Neurocircuitry of Addiction
Koob, G. F., & Volkow, N. D. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.110 · Cited by 5,340
Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
Cross, D. A. E., Alessi, D. R., Cohen, P., Andjelkovich, M., & Hemmings, B. A. (1995) · Nature · doi:10.1038/378785a0 · Cited by 5,244
EVIDENCE FOR THE EXISTENCE OF MONOAMINE-CONTAINING NEURONS IN THE CENTRAL NERVOUS SYSTEM. I. DEMONSTRATION OF MONOAMINES IN THE CELL BODIES OF BRAIN STEM NEURONS.
Dahlstroem, A., & Fuxé, K. (1964) · PubMed · Cited by 5,133
Multiple receptors for dopamine
Kebabian, J. W., & Calne, D. B. (1979) · Nature · doi:10.1038/277093a0 · Cited by 3,756
Dopamine receptors: from structure to function
MISSALE, C., NASH, S. R., ROBINSON, S. W., JABER, M., & CARON, M. G. (1998) · Physiological Reviews · doi:10.1152/physrev.1998.78.1.189 · Cited by 3,633
Seven-transmembrane receptors
Pierce, K. L., Premont, R. T., & Lefkowitz, R. J. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm908 · Cited by 2,712
NEURAL MECHANISMS OF ADDICTION: The Role of Reward-Related Learning and Memory
Hyman, S. E., Malenka, R. C., & Nestler, E. J. (2006) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.29.051605.113009 · Cited by 2,647
Molecular cloning and characterization of a novel dopamine receptor (D3) as a target for neuroleptics
Sokoloff, P., Bruno Giros, A., Martres, M., Bouthenet, M.-L., & Schwartz, J. (1990) · Nature · doi:10.1038/347146a0 · Cited by 2,608
Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter
Giros, B., Jaber, M., Jones, S. R., Wightman, R. M., & Caron, M. G. (1996) · Nature · doi:10.1038/379606a0 · Cited by 2,476
Dopamine Receptor Binding Predicts Clinical and Pharmacological Potencies of Antischizophrenic Drugs
Creese, I., Burt, D. R., & Snyder, S. H. (1976) · Science · doi:10.1126/science.3854 · Cited by 2,220

Show all 409 references

Sorted by citations

Items 601–700 of 1,006

SU-8 based pyrolytic carbon for the electrochemical detection of dopamine
Peltola, E., Heikkinen, J. J., Sovanto, K., Sainio, S., Aarva, A., Franssila, S., Jokinen, V. P., & Laurila, T. T. (2017) · Journal of Materials Chemistry B · doi:10.1039/c7tb02469j · Cited by 41
Inhibition of phosphodiesterases as a strategy to achieve neuroprotection in Huntington's disease
Cardinale, A., & Fusco, F. R. (2018) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12834 · Cited by 41
Dopamine Receptor Subtypes Differentially Regulate Autophagy
Wang, D., Ji, X., Liu, J., Li, Z., & Zhang, X. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19051540 · Cited by 41
In situ electrodeposition of cholesterol oxidase-modified polydopamine thin film on nanostructured screen printed electrodes for free cholesterol determination
Salazar, P., Martín, M. E., & González–Mora, J. L. (2019) · Journal of Electroanalytical Chemistry · doi:10.1016/j.jelechem.2019.02.032 · Cited by 41
Contrasting patterns of ERK activation in the tail of the striatum in response to aversive and rewarding signals
Gangarossa, G., Castell, L., Castro, L. R., Tarot, P., Veyrunes, F., Vincent, P., Bertaso, F., & Valjent, E. (2019) · Journal of Neurochemistry · doi:10.1111/jnc.14804 · Cited by 41
Positive allosteric modulators of the dopamine D1 receptor: A new mechanism for the treatment of neuropsychiatric disorders
Svensson, K. A., Hao, J., & Bruns, R. F. (2019) · Advances in pharmacology · doi:10.1016/bs.apha.2019.06.001 · Cited by 41
Current Perspectives on Selective Dopamine D3 Receptor Antagonists/Partial Agonists as Pharmacotherapeutics for Opioid and Psychostimulant Use Disorders
Newman, A. H., Xi, Z., & Heidbreder, C. A. (2022) · Current topics in behavioral neurosciences · doi:10.1007/7854_2022_347 · Cited by 41
Dopamine receptor D2 regulates GLUA1-containing AMPA receptor trafficking and central sensitization through the PI3K signaling pathway in a male rat model of chronic migraine
Zhang, W., Lei, M., Wen, Q., Zhang, D., Qin, G., Zhou, J., & Chen, L. (2022) · The Journal of Headache and Pain · doi:10.1186/s10194-022-01469-x · Cited by 41
Sleep loss and addiction
López-Muciño, L. A., García‐García, F., Cueto‐Escobedo, J., Acosta-Hernández, M. E., Venebra-Muñoz, A., & Rodríguez‐Alba, J. C. (2022) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2022.104832 · Cited by 41
Novel Analogues of ( R )-5-(Methylamino)-5,6-dihydro-4 H -imidazo[4,5,1- ij ]quinolin-2(1 H )-one (Sumanirole) Provide Clues to Dopamine D2/D3 Receptor Agonist Selectivity
Zou, M., Keck, T. M., Kumar, V., Donthamsetti, P., Michino, M., Burzynski, C., Schweppe, C. A., Bonifazi, A., Free, R. B., Sibley, D. R., et al. (2016) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5b01612 · Cited by 41
Dopamine Receptor Subtypes Mediate Opposing Effects on Form Deprivation Myopia in Pigmented Guinea Pigs
Zhang, S., Yang, J., Reinach, P. S., Wang, F., Zhang, L., Fan, M., Ying, H., Pan, M., Qu, J., & Zhou, X. (2018) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.17-21574 · Cited by 41
Cocaine-seeking is associated with PKC-dependent reduction of excitatory signaling in accumbens shell D2 dopamine receptor-expressing neurons
Ortinski, P. I., Briand, L. A., Pierce, R. C., & Schmidt, H. D. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.01.002 · Cited by 40
Discovery of GPCR ligands for probing signal transduction pathways
Brogi, S., Tafi, A., Désaubry, L., & Nebigil, C. G. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00255 · Cited by 40
Molecular Determinants of Biased Agonism at the Dopamine D2Receptor
Weichert, D., Banerjee, A., Hiller, C., Kling, R. C., Hübner, H., & Gmeiner, P. (2015) · Journal of Medicinal Chemistry · doi:10.1021/jm501889t · Cited by 40
Restructuring of basal ganglia circuitry and associated behaviors triggered by low striatal D2 receptor expression: implications for substance use disorders
Dobbs, L. K., Lemos, J. C., & Alvarez, V. A. (2016) · Genes Brain & Behavior · doi:10.1111/gbb.12361 · Cited by 40
Calcium, Dopamine and Neuronal Calcium Sensor 1: Their Contribution to Parkinson’s Disease
Catoni, C., Calí, T., & Brini, M. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00055 · Cited by 40
Visual Hallucinations and the Role of Medications in Parkinson’s Disease: Triggers, Pathophysiology, and Management
Powell, A., Ireland, C., & Lewis, S. J. G. (2020) · Journal of Neuropsychiatry · doi:10.1176/appi.neuropsych.19110316 · Cited by 40
LEAP2 Impairs the Capability of the Growth Hormone Secretagogue Receptor to Regulate the Dopamine 2 Receptor Signaling
Mustafá, E. R., González, S. C., Damian, M., Cantel, S., Denoyelle, S., Wagner, R., Schiöth, H. B., Fehrentz, J., Banères, J., Perelló, M., et al. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.712437 · Cited by 40
Catecholamines Mediate Psychologic Stress–Induced Cancer Progression
Bernabé, D. G. (2021) · Cancer Research · doi:10.1158/0008-5472.can-21-3077 · Cited by 40
Neuroanatomical, Biochemical, and Functional Modifications in Brain Induced by Treatment with Antidepressants
Khushboo, Siddiqi, N. J., Pereira, M. D. L., & Sharma, B. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-02780-z · Cited by 40
Sleep deprivation differentially affects dopamine receptor subtypes in mouse striatum
Lim, M. M., Xu, J., Holtzman, D. M., & Mach, R. H. (2011) · Neuroreport · doi:10.1097/wnr.0b013e32834846a0 · Cited by 40
Dopamine D3 receptor deletion or blockade attenuates cocaine-induced conditioned place preference in mice
Song, R., Zhang, H., Peng, X., Su, R., Yang, R., Li, J., Xi, Z., & Gardner, E. L. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.04.042 · Cited by 40
Protective Effect of Curcumin by Modulating BDNF/DARPP32/CREB in Arsenic-Induced Alterations in Dopaminergic Signaling in Rat Corpus Striatum
Srivastava, P., Dhuriya, Y. K., Gupta, R., Shukla, R. K., Yadav, R. S., Dwivedi, H. N., Pant, A. B., & Khanna, V. K. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0288-2 · Cited by 40
Circuits regulating pleasure and happiness – focus on potential biomarkers for circuitry including the habenuloid complex
LOONEN, A. J. M., & Ivanova, S. А. (2022) · Acta Neuropsychiatrica · doi:10.1017/neu.2022.15 · Cited by 39
Striatal μ-opioid receptor activation triggers direct-pathway GABAergic plasticity and induces negative affect
Wang, W., Xie, X., Zhuang, X., Huang, Y., Tan, T., Gangal, H., Huang, Z., Purvines, W., Wang, X., Stefanov, A., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112089 · Cited by 39
PET studies in nonhuman primate models of cocaine abuse: Translational research related to vulnerability and neuroadaptations
Gould, R. W., Duke, A. N., & Nader, M. A. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.02.004 · Cited by 39
Selective determination of dopamine with an amperometric biosensor using electrochemically pretreated and activated carbon/tyrosinase/Nafion®-modified glassy carbon electrode
Rahman, S. F., Min, K., Park, S.-H., Park, J.-H., Yoo, J. C., & Park, D.-H. (2016) · Biotechnology and Bioprocess Engineering · doi:10.1007/s12257-016-0382-3 · Cited by 39
A Complete Assessment of Dopamine Receptor- Ligand Interactions through Computational Methods
Bueschbell, B., Barreto, C. A. V., Preto, A. J., Schiedel, A. C., & Moreira, I. S. (2019) · Molecules · doi:10.3390/molecules24071196 · Cited by 39
Designing Functionally Selective Noncatechol Dopamine D1 Receptor Agonists with Potent In Vivo Antiparkinsonian Activity
Martini, M. L., Ray, C., Yu, X., Liu, J., Pogorelov, V. M., Wetsel, W. C., Huang, X., McCorvy, J. D., Caron, M. G., & Jin, J. J. (2019) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.9b00410 · Cited by 39
Treadmill exercise improves memory by up-regulating dopamine and down-regulating D2 dopamine receptor in traumatic brain injury rats
Ko, I., Kim, C., & Kim, H. K. (2019) · Journal of Exercise Rehabilitation · doi:10.12965/jer.1938316.158 · Cited by 39
Physiological feeding rates and cilia suppression in blue mussels (Mytilus edulis) with increased levels of dissolved carbon dioxide
Meseck, S. L., Sennefelder, G., Krisak, M., & Wikfors, G. H. (2020) · Ecological Indicators · doi:10.1016/j.ecolind.2020.106675 · Cited by 39
Retinal Dopamine D2 Receptors Participate in the Development of Myopia in Mice
Huang, F., Shu, Z., Huang, Q., Chen, K., Yan, W., Wu, W., Yang, J., Wang, Q., Wang, F., Zhang, C., et al. (2022) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.63.1.24 · Cited by 39
Emerging Roles of FTO in Neuropsychiatric Disorders
Chang, R., Huang, Z., Zhao, S., Zou, J., Li, Y., & Tan, S. (2022) · BioMed Research International · doi:10.1155/2022/2677312 · Cited by 39
Ion channels and schizophrenia: a gene set-based analytic approach to GWAS data for biological hypothesis testing
Askland, K. D., Read, C., O’Connell, C. P., & Moore, J. H. (2011) · Human Genetics · doi:10.1007/s00439-011-1082-x · Cited by 39
Dopamine enhances the response of sunitinib in the treatment of drug-resistant breast cancer: Involvement of eradicating cancer stem-like cells
Wang, S., Mou, Z.-Z., Ma, Y., Li, J., Li, J., Ji, X., Wu, K., Li, L., Lu, W., & Zhou, T. (2015) · Biochemical Pharmacology · doi:10.1016/j.bcp.2015.03.013 · Cited by 39
Cytosolic Sulfotransferase 1A3 Is Induced by Dopamine and Protects Neuronal Cells from Dopamine Toxicity
Sidharthan, N. P., Minchin, R. F., & Butcher, N. J. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.493239 · Cited by 39
Bias Analyses of Preclinical and Clinical D2 Dopamine Ligands: Studies with Immediate and Complex Signaling Pathways
Brust, T. F., Hayes, M. P., Roman, D. L., Burris, K. D., & Watts, V. J. (2014) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.114.220293 · Cited by 39
Repurposing dopaminergic drugs for MS — the evidence mounts
Marino, F., & Cosentino, M. (2016) · Nature Reviews Neurology · doi:10.1038/nrneurol.2016.33 · Cited by 38
Activation of the Hippocampal DRD2 Alleviates Neuroinflammation, Synaptic Plasticity Damage and Cognitive Impairment After Sleep Deprivation
Gao, H., Zhang, Y., Luo, D., Xu, J., Tan, S., Li, Y., Qi, W., Zhai, Q., & Wang, Q. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03514-5 · Cited by 38
Current Review of the Function and Regulation of Tuberoinfundibular Dopamine Neurons
Qi-Lytle, X., Sayers, S., & Wagner, E. J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms25010110 · Cited by 38
A microchip electrophoresis-mass spectrometric platform for fast separation and identification of enantiomers employing the partial filling technique
Li, X., Xiao, D., Ou, X., McCullum, C., & Liu, Y. (2013) · Journal of Chromatography A · doi:10.1016/j.chroma.2013.10.020 · Cited by 38
Intranasal Delivery of a Peptide with Antidepressant-Like Effect
Brown, V., & Liu, F. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.61 · Cited by 38
Stimulation of dopamine D 1 receptor improves learning capacity in cooperating cleaner fish
Messias, J. P. M., Santos, T. P., Pinto, M., & Soares, M. C. (2016) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2015.2272 · Cited by 40
Cross interaction of dopaminergic and adrenergic systems in neural modulation.
Lei, S. (2014) · Europe PMC (PubMed Central) · Cited by 38
Disentangling the diverse roles of dopamine D2 receptors in striatal function and behavior
Gallo, E. F. (2019) · Neurochemistry International · doi:10.1016/j.neuint.2019.01.022 · Cited by 38
Deficit in working memory and abnormal behavioral tactics in dopamine transporter knockout rats during training in the 8-arm maze
Kurzina, N. P., Aristova, I., Volnova, A. B., & Gainetdinov, R. R. (2020) · Behavioural Brain Research · doi:10.1016/j.bbr.2020.112642 · Cited by 38
Self-citation
Dopamine D1 receptor agonist A-68930 ameliorates Aβ1-42-induced cognitive impairment and neuroinflammation in mice
Cheng, Z.-Y., Xia, Q.-P., Hu, Y., Wang, C., & He, L. (2020) · International Immunopharmacology · doi:10.1016/j.intimp.2020.106963 · Cited by 38
Dopamine improves chemotherapeutic efficacy for pancreatic cancer by regulating macrophage-derived inflammations
Liu, Q., Zhang, R., Zhang, X., Liu, J., Wu, H., Li, Y., Cui, M., Li, T., Song, H., Gao, J., et al. (2021) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-020-02816-0 · Cited by 38
Dopamine Modulation of Motor and Sensory Cortical Plasticity among Vertebrates
Macêdo-Lima, M., & Remage‐Healey, L. (2021) · Integrative and Comparative Biology · doi:10.1093/icb/icab019 · Cited by 38
Role of Amine Neurotransmitters and Their Receptors in Skin Pigmentation: Therapeutic Implication
Enkhtaivan, E., & Lee, C. H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22158071 · Cited by 38
One-pot synthesis of boron and nitrogen co-doped silicon-carbon dots for fluorescence enhancement and on-site colorimetric detection of dopamine with high selectivity
Wang, Y., Li, L., Jiang, M., Yang, X., Yu, X., & Xu, L. (2021) · Applied Surface Science · doi:10.1016/j.apsusc.2021.151457 · Cited by 38
Atlas of type 2 dopamine receptors in the human brain: Age and sex dependent variability in a large PET cohort
Malén, T., Karjalainen, T., Isojärvi, J., Vehtari, A., Bürkner, P., Putkinen, V., Kaasinen, V., Hietala, J. A., Nuutila, P., Rinne, J. O., et al. (2022) · NeuroImage · doi:10.1016/j.neuroimage.2022.119149 · Cited by 40
Dopamine and norepinephrine are embracing their immune side and so should we
Gaskill, P. J., & Khoshbouei, H. (2022) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2022.102626 · Cited by 38
Tributyltin exposure influences predatory behavior, neurotransmitter content and receptor expression in Sebastiscus marmoratus
Yu, A., Wang, X., Zuo, Z., Cai, J., & Wang, C. (2012) · Aquatic Toxicology · doi:10.1016/j.aquatox.2012.12.008 · Cited by 38
Subthalamic deep brain stimulation differently alters striatal dopaminergic receptor levels in rats
Carcenac, C., Favier, M., Vachez, Y. M., Lacombe, E., Carnicella, S., Savasta, M., & Boulet, S. (2015) · Movement Disorders · doi:10.1002/mds.26146 · Cited by 38
Chronic behavioral stress exaggerates motor deficit and neuroinflammation in the MPTP mouse model of Parkinson’s disease
Lauretti, E., Meco, A. D., Merali, S., & Praticò, D. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.1 · Cited by 38
Modulation of Dopaminergic Pathways to Treat Erectile Dysfunction
Simonsen, U., Comerma-Steffensen, S., & Andersson, K. (2016) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.12653 · Cited by 38
Involvement of PKA/DARPP-32/PP1α and β- arrestin/Akt/GSK-3β Signaling in Cadmium-Induced DA-D2 Receptor-Mediated Motor Dysfunctions: Protective Role of Quercetin
Gupta, R., Shukla, R. K., Pandey, A., Sharma, T., Dhuriya, Y. K., Srivastava, P., Singh, M. P., Siddiqi, M. I., Pant, A. B., & Khanna, V. K. (2018) · Scientific Reports · doi:10.1038/s41598-018-20342-z · Cited by 38
Pharmacogenomic Biomarkers and Their Applications in Psychiatry
Kam, H., & Jeong, H. (2020) · Genes · doi:10.3390/genes11121445 · Cited by 37
A role for dopamine in C. elegans avoidance behavior induced by mitochondrial stress
Chou, S., Chen, Y., Liao, C., & Pan, C. (2022) · Neuroscience Research · doi:10.1016/j.neures.2022.01.005 · Cited by 37
The dopamine D2 receptor dimer and its interaction with homobivalent antagonists: homology modeling, docking and molecular dynamics
Kaczor, A. A., Jörg, M., & Capuano, B. (2016) · Journal of Molecular Modeling · doi:10.1007/s00894-016-3065-2 · Cited by 37
Blockade of neuronal dopamine D2 receptor attenuates morphine tolerance in mice spinal cord
Dai, W., Xiong, F., Yan, B., Cao, Z., Liu, W., Liu, J.-H., & Yu, B. (2016) · Scientific Reports · doi:10.1038/srep38746 · Cited by 37
Behavioral Modulation by Spontaneous Activity of Dopamine Neurons
Ichinose, T., Tanimoto, H., & Yamagata, N. (2017) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2017.00088 · Cited by 37
Exercise Ameliorates Motor Deficits and Improves Dopaminergic Functions in the Rat Hemi-Parkinson’s Model
Chen, Y.-H., Kuo, T., Kao, J., Huang, E. Y., Hsieh, T.-H., Chou, Y., & Hoffer, B. J. (2018) · Scientific Reports · doi:10.1038/s41598-018-22462-y · Cited by 37
Reduced level of docosahexaenoic acid shifts GPCR neuroreceptors to less ordered membrane regions
Javanainen, M., Enkavi, G., Guixà-González, R., Kulig, W., Martinez‐Seara, H., Levental, I., & Vattulainen, I. (2019) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1007033 · Cited by 37
DRD3 (dopamine receptor D3) but not DRD2 activates autophagy through MTORC1 inhibition preserving protein synthesis
Barroso‐Chinea, P., Luis-Ravelo, D., Fumagallo-Reading, F., Castro‐Hernández, J., Salas-Hernández, J., Rodríguez-Núñez, J., Febles-Casquero, A., Cruz‐Muros, I., Afonso‐Oramas, D., Abreu-González, P., et al. (2019) · Autophagy · doi:10.1080/15548627.2019.1668606 · Cited by 37
Directing Technology Addiction Research in Information Systems
Serenko, A., & Turel, O. (2020) · ACM SIGMIS Database the DATABASE for Advances in Information Systems · doi:10.1145/3410977.3410982 · Cited by 37
Pt nanoparticle decorated carbon nanotubes nanocomposite based sensing platform for the monitoring of cell-secreted dopamine
Li, J., Huang, X. H., Shi, W., Jiang, M., Tian, L., Su, M., Wu, J., Liu, Q., Yu, C., & Gu, H. (2020) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2020.129311 · Cited by 37
In Parkinson's patient-derived dopamine neurons, the triplication of α-synuclein locus induces distinctive firing pattern by impeding D2 receptor autoinhibition
Lin, M., Mackie, P. M., Shaerzadeh, F., Gamble‐George, J., Miller, D. R., Martyniuk, C. J., & Khoshbouei, H. (2021) · Acta Neuropathologica Communications · doi:10.1186/s40478-021-01203-9 · Cited by 37
The Prevention and Treatment of Delirium in Elderly Patients Following Hip Fracture Surgery
Martocchia, A., Curto, M., Comite, F., Scaccianoce, S., Girardi, P., Ferracuti, S., Nicoletti, F., Falaschi, P., & Bentham Science Publisher Orthogeriatric Group (2015) · Recent Patents on CNS Drug Discovery · doi:10.2174/1574889810666150216152624 · Cited by 37
Dopamine modulates hemocyte phagocytosis via a D1-like receptor in the rice stem borer, Chilo suppressalis
Wu, S., Xu, G., STANLEY, D. W., Huang, J., & Yè, G. (2015) · Scientific Reports · doi:10.1038/srep12247 · Cited by 37
Shared Behavioral and Neurocircuitry Disruptions in Drug Addiction, Obesity, and Binge Eating Disorder: Focus on Group I mGluRs in the Mesolimbic Dopamine Pathway
Yohn, S. E., Galbraith, J., Calipari, E. S., & Conn, P. J. (2019) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.8b00601 · Cited by 36
Exploring neurotransmitters and their receptors for breast cancer prevention and treatment
Li, R. Q., Zhao, X. H., Zhu, Q., Liu, T., Hondermarck, H., Thorne, R. F., Zhang, X. D., & Gao, J. N. (2023) · Theranostics · doi:10.7150/thno.81403 · Cited by 36
Dopamine D2 receptors in pyramidal neurons in the medial prefrontal cortex regulate social behavior
Chen, H. H., Xiong, X.-X., Jin, S.-Y., He, X., He, X., Yang, J.-M., Gao, T., & Chen, Y. (2023) · Pharmacological Research · doi:10.1016/j.phrs.2023.107042 · Cited by 36
Treatment of antipsychotic-induced hyperprolactinemia: an umbrella review of systematic reviews and meta-analyses
Jiang, Q., Tian, L., Zhao, L., Sun, Y., Mao, Z., Xing, Y., Wang, C., & Bo, Q. (2024) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2024.1337274 · Cited by 36
Using click chemistry toward novel 1,2,3-triazole-linked dopamine D3 receptor ligands
Keck, T. M., Banala, A. K., Slack, R. D., Burzynski, C., Bonifazi, A., Bakare, O. M., Moore, M., Deschamps, J. R., Rais, R., Slusher, B. S., et al. (2015) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2015.01.017 · Cited by 36
New functional activity of aripiprazole revealed: Robust antagonism of D2 dopamine receptor-stimulated Gβγ signaling
Brust, T. F., Hayes, M. P., Roman, D. L., & Watts, V. J. (2014) · Biochemical Pharmacology · doi:10.1016/j.bcp.2014.10.014 · Cited by 36
Dopamine directly increases mitochondrial mass and thermogenesis in brown adipocytes
Kohlie, R., Perwitz, N., Resch, J., Schmid, S. M., Lehnert, H., Klein, J. C., & Iwen, K. A. (2016) · Journal of Molecular Endocrinology · doi:10.1530/jme-16-0159 · Cited by 36
An anatomical and physiological basis for the cardiovascular autonomic nervous system consequences of sport-related brain injury
Fountaine, M. F. L. (2017) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2017.11.016 · Cited by 36
Dopamine D1 Receptors Contribute Critically to the Apomorphine-Induced Inhibition of Form-Deprivation Myopia in Mice
Huang, F., Zhang, L., Wang, Q., Yang, Y., Li, Q., Wu, Y. J., Chen, J., Qu, J., & Zhou, X. (2018) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.17-22578 · Cited by 36
Balance between dopamine and adenosine signals regulates the PKA/Rap1 pathway in striatal medium spiny neurons
Zhang, X., Nagai, T., Ahammad, R. U., Kuroda, K., Nakamuta, S., Nakano, T., Yukinawa, N., Funahashi, Y., Yamahashi, Y., Amano, M., et al. (2018) · Neurochemistry International · doi:10.1016/j.neuint.2018.10.008 · Cited by 36
REST-DRD2 mechanism impacts glioblastoma stem cell–mediated tumorigenesis
Marisetty, A., Lu, L., Veo, B. L., Liu, B., Coarfa, C., Kamal, M. M., Kassem, D. H., Irshad, K., Lu, Y., Gumin, J., et al. (2019) · Neuro-Oncology · doi:10.1093/neuonc/noz030 · Cited by 36
Modulation of Neuro-Dopamine Homeostasis in Juvenile Female Atlantic Cod (Gadus morhua) Exposed to Polycyclic Aromatic Hydrocarbons and Perfluoroalkyl Substances
Khan, E. A., Bertotto, L. B., Dale, K., Lille‐Langøy, R., Yadetie, F., Karlsen, O. A., Goksøyr, A., Schlenk, D., & Arukwe, A. (2019) · Environmental Science & Technology · doi:10.1021/acs.est.9b00637 · Cited by 36
Dopamine D3 receptor dysfunction prevents anti-nociceptive effects of morphine in the spinal cord
Brewer, K. L., Baran, C. A., Whitfield, B. R., Jensen, A. M., & Clemens, S. (2014) · Frontiers in Neural Circuits · doi:10.3389/fncir.2014.00062 · Cited by 36
The effects of cannabis use on salience attribution: a systematic review
Wijayendran, S. B., O’Neill, A., & Bhattacharyya, S. (2016) · Acta Neuropsychiatrica · doi:10.1017/neu.2016.58 · Cited by 36
Abnormal Trajectory of Intracortical Myelination in Schizophrenia Implicates White Matter in Disease Pathophysiology and the Therapeutic Mechanism of Action of Antipsychotics
Tishler, T. A., Bartzokis, G., Lu, P. H., Raven, E. P., Khanoyan, M., Kirkpatrick, C. J., Pyle, M., Villablanca, J. P., Altshuler, L. L., Mintz, J., et al. (2017) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2017.03.007 · Cited by 36
D2 receptors and cognitive flexibility in marmosets: tri-phasic dose–response effects of intra-striatal quinpirole on serial reversal performance
Horst, N. K., Jupp, B., Roberts, A., & Robbins, T. W. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0272-9 · Cited by 36
Diamond-like carbon (DLC) thin film bioelectrodes: Effect of thermal post-treatments and the use of Ti adhesion layer
Laurila, T. T., Rautiainen, A., Sintonen, S., Jiang, H., Kaivosoja, E., & Koskinen, J. (2013) · Materials Science and Engineering C · doi:10.1016/j.msec.2013.09.035 · Cited by 35
Deficiency of the RIIβ subunit of PKA affects locomotor activity and energy homeostasis in distinct neuronal populations
Zheng, R., Yang, L., Sikorski, M. A., Enns, L. C., Czyzyk, T. A., Ladiges, W., & McKnight, G. S. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1219542110 · Cited by 35
Dopamine D1 receptors and phosphorylation of dopamine- and cyclic AMP-regulated phosphoprotein-32 in the medial preoptic area are involved in experience-induced enhancement of male sexual behavior in rats.
McHenry, J. A., Bell, G. A., Parrish, B. P., & Hull, E. M. (2012) · Behavioral Neuroscience · doi:10.1037/a0028707 · Cited by 35
Towards trans-diagnostic mechanisms in psychiatry: Neurobehavioral profile of rats with a loss of function point mutation in the dopamine transporter gene
Vengeliene, V., Bespalov, A., Roßmanith, M., Horschitz, S., Berger, S. M., Relo, A. L., Noori, H. R., Schneider, P., Enkel, T., Bartsch, D., et al. (2017) · Disease Models & Mechanisms · doi:10.1242/dmm.027623 · Cited by 35
Effects of endogenous and exogenous D1/D5 dopamine receptor activation on LTP in ventral and dorsal CA1 hippocampal synapses
Papaleonidopoulos, V., Kouvaros, S., & Papatheodoropoulos, C. (2018) · Synapse · doi:10.1002/syn.22033 · Cited by 35
Dopamine Triggers CTCF-Dependent Morphological and Genomic Remodeling of Astrocytes
Galloway, A. L., Adeluyi, A., O’Donovan, B., Fisher, M. L., Rao, C. N., Critchfield, P., Sajish, M., Turner, J. R., & Ortinski, P. I. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.3349-17.2018 · Cited by 35
Polydopamine as the Antigen Delivery Nanocarrier for Enhanced Immune Response in Tumor Immunotherapy
Wang, N., Yang, Y., Wang, X., Tian, X., Qin, W., Wang, X., Liang, J., Zhang, H., & Leng, X. (2019) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.9b00359 · Cited by 35
Dopamine increases HIV entry into macrophages by increasing calcium release via an alternative signaling pathway
Nickoloff-Bybel, E. A., Mackie, P. M., Runner, K., Matt, S. M., Khoshbouei, H., & Gaskill, P. J. (2019) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2019.08.191 · Cited by 35
Modulation of dopamine D1 receptors via histamine H3 receptors is a novel therapeutic target for Huntington's disease
Moreno‐Delgado, D., Puigdellívol, M., Moreno, E., Rodríguez-Ruiz, M., Botta, J. A., Gasperini, P., Chiarlone, A., Howell, L. A., Scarselli, M., Casadó, V., et al. (2020) · eLife · doi:10.7554/elife.51093 · Cited by 35
Endocannabinoid and dopaminergic system: the pas de deux underlying human motivation and behaviors
Laksmidewi, A. A. A. P., & Soejitno, A. (2021) · Journal of Neural Transmission · doi:10.1007/s00702-021-02326-y · Cited by 35
Molecular Engineered Carbon-Based Sensor for Ultrafast and Specific Detection of Neurotransmitters
Suriyaprakash, J., Bala, K., Shan, L., Wu, L., & Gupta, N. (2021) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.1c18137 · Cited by 35
Combining NGN2 programming and dopaminergic patterning for a rapid and efficient generation of hiPSC-derived midbrain neurons
Sheta, R., Teixeira, M., Idi, W., Pierre, M., Jacquet, A. D. R., Émond, V., Zorca, C. E., Vanderperre, B., Durcan, T. M., Fon, E. A., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-22158-4 · Cited by 35
The complex molecular pharmacology of the dopamine D2 receptor: Implications for pramipexole, ropinirole, and rotigotine
Ferraiolo, M., & Hermans, E. (2023) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2023.108392 · Cited by 36

Authors: Beaulieu, J.-M., & Gainetdinov, R. R.
Affiliations: Université Laval (CA)
Italian Institute of Technology (IT)
ORCID: Beaulieu, Jean-Martin
Gainetdinov, Raul R.
Venue: Pharmacological Reviews
Publisher: Elsevier BV
Published: 2011-03
Volume: 63
Issue: 1
Pages: 182-217
ISSN: 0031-6997 (ISSN-L)
DOI: 10.1124/pr.110.002642
OpenAlex: W2097744565
Cited by: 2,763
References: 409
Citations by year: 2026: 157 · 2025: 183 · 2024: 172 · 2023: 193 · 2022: 201 · 2021: 197 · 2020: 198 · 2019: 220 · 2018: 200 · 2017: 187 · 2016: 205 · 2015: 175 · 2014: 194 · 2013: 136 · 2012: 101
FWCI: 13.93
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Pharmacological Reviews (publishedVersion)
PubMed (publishedVersion)
Funders: Canadian Institutes of Health Research (NSA93798)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: dopamine receptors, dopamine D1/D5 receptors, G protein-coupled receptors, signal transduction, cAMP signaling, G protein-independent signaling, beta-arrestin, receptor desensitization, antiparkinsonian drugs, antipsychotic drugs
MeSH terms: Animals, Gene Expression Regulation, Humans, Ligands, Receptors, Dopamine, Signal Transduction, Dopamine Agonists, Dopamine Antagonists, Molecular Targeted Therapy

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The Physiology, Signaling, and Pharmacology of Dopamine Receptors

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks