Parallel findings in age-related macular degeneration and Alzheimer’s disease

Ohno-Matsui, Kyoko

doi:10.1016/j.preteyeres.2011.02.004

Cited by 280Retinal Diseases and TreatmentsAlzheimer's disease research and treatmentsRetinal Imaging and Analysis

Parallel findings in age-related macular degeneration and Alzheimer’s disease

Ohno-Matsui, Kyoko·2011·Progress in Retinal and Eye Research

DOI 10.1016/j.preteyeres.2011.02.004

Open this paper in CoChat — free account

Abstract

Age is a common risk factor for Alzheimer's disease (AD) and age-related macular degeneration (AMD). Because of the increasing age of the population, these two age-related diseases have recently received a great deal of attention. In addition to age as a risk factor, AD and AMD have many characteristics in common. An important characteristic common to both diseases is the presence of amyloid β (Aβ) in the senile plaques of the AD brain and in the drusen of AMD patients. We have focused on the role of Aβ as a key regulator of the progression from drusen to AMD, and our results have shown that Aβ causes an imbalance of angiogenesis-related factors in the retinal pigment epithelial (RPE) cells. Mice that lack the Aβ-degrading enzyme neprilysin develop RPE degeneration, and the sub-RPE deposits that are formed have features similar to those of AMD in humans. These data suggest that a common pathogenic mechanism might exist between AMD and AD. Thus, therapeutic approaches that have targeted Aβ in patients with AD can also be applied to AMD. In this review, we summarise recent findings on the shared characteristics and perspectives between AMD and AD, beginning with the mechanism of Aβ deposition and including a discussion of Aβ-targeted therapeutic approaches for both AD and AMD.

Integrity signals

Registry

Crossref · 10.1016/j.preteyeres.2011.02.004

Cites

195 of 195 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

With advancing age, the outer retina displays elevated inflammation and widespread deposition of extracellular debris, including amyloid species.
“With advancing age, the outer retina of the eye displays elevated inflammation and widespread deposition of extracellular debris, including amyloid species [55, 88].”
From Fecal microbiota transfer between young and aged mice reverses hallmarks of the aging gut, eye, and brain (2022) · cites this paper as [88]

Alzheimer's disease: the amyloid cascade hypothesis
Hardy, J. A., & Higgins, G. A. (1992) · Science · doi:10.1126/science.1566067 · Cited by 7,484 · see citing works
Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein
Glenner, G. G., & Wong, C. W. (1984) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(84)80190-4 · Cited by 5,404 · see citing works
Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid β-peptide
Haass, C., & Selkoe, D. J. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2101 · Cited by 4,744 · see citing works
Alzheimer’s disease
Querfurth, H. W., & LaFerla, F. M. (2010) · New England Journal of Medicine · doi:10.1056/nejmra0909142 · Cited by 4,569 · see citing works
Inflammation and Alzheimer’s disease
Akiyama, H. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00124-x · Cited by 4,514 · see citing works
Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound‐B
Klunk, W. E., Engler, H., Nordberg, A., Wang, Y., Blomqvist, G., Holt, D. P., Bergström, M., Savitcheva, I., Huang, G., Estrada, S., et al. (2004) · Annals of Neurology · doi:10.1002/ana.20009 · Cited by 4,496 · see citing works
Complement factor H polymorphism in age-related macular degeneration
Klein, R. J., Zeiss, C., Chew, E. Y., Tsai, J.-Y., Sackler, R. S., Haynes, C., Henning, A. K., SanGiovanni, J. P., Mane, S. M., Mayne, S. T., et al. (2005) · Science · doi:10.1126/science.1109557 · Cited by 4,492 · see citing works
Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis
Kayed, R., Head, E., Thompson, J. L., McIntire, T. M., Milton, S. C., Cotman, C. W., & Glabe, C. G. (2003) · Science · doi:10.1126/science.1079469 · Cited by 4,064 · see citing works
Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators
Issemann, I., & Green, S. (1990) · Nature · doi:10.1038/347645a0 · Cited by 3,519 · see citing works
A Randomized, Placebo-Controlled, Clinical Trial of High-Dose Supplementation With Vitamins C and E, Beta Carotene, and Zinc for Age-Related Macular Degeneration and Vision Loss: AREDS Report No. 8
(2001) · Archives of Ophthalmology · doi:10.1001/archopht.119.10.1417 · Cited by 3,285 · see citing works
Prevalence of Age-Related Macular Degeneration in the United States
The Eye Diseases Prevalence Research Group* (2004) · Archives of Ophthalmology · doi:10.1001/archopht.122.4.564 · Cited by 2,742 · see citing works
Complement factor H polymorphism and age-related macular degeneration
Edwards, A. O., Ritter, R., Abel, K. J., Manning, A., Panhuysen, C., & Farrer, L. A. (2005) · Science · doi:10.1126/science.1110189 · Cited by 2,449 · see citing works
Complement factor H variant increases the risk of age-related macular degeneration
Haines, J. L., Hauser, M. A., Schmidt, S., Scott, W. K., Olson, L. M., Gallins, P., Spencer, K. L., Kwan, S. Y., Noureddine, M., Gilbert, J. R., et al. (2005) · Science · doi:10.1126/science.1110359 · Cited by 2,424 · see citing works
Alzheimer Disease in the US Population: Prevalence Estimates Using the 2000 Census
Hebert, L. E., Scherr, P. A., Bienias, J. L., Bennett, D. A., & Evans, D. A. (2003) · Archives of Neurology · doi:10.1001/archneur.60.8.1119 · Cited by 2,168 · see citing works
The Role of Oxidative Stress in the Pathogenesis of Age-Related Macular Degeneration
Beatty, S., Koh, H.-H., Phil, M., Henson, D., & Boulton, M. (2000) · Survey of Ophthalmology · doi:10.1016/s0039-6257(00)00140-5 · Cited by 2,051 · see citing works
RAGE and amyloid-β peptide neurotoxicity in Alzheimer's disease
Yan, S. D., Chen, X., Fu, J., Chen, M., Zhu, H., Roher, A., Slattery, T., Zhao, L., Nagashima, M., Morser, J., et al. (1996) · Nature · doi:10.1038/382685a0 · Cited by 2,012 · see citing works
A common haplotype in the complement regulatory gene factor H ( HF1/CFH ) predisposes individuals to age-related macular degeneration
Hageman, G. S., Anderson, D. H., Johnson, L. V., Hancox, L. S., Taiber, A. J., Hardisty, L. I., Hageman, J. L., Stockman, H. A., Borchardt, J. D., Gehrs, K. M., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501536102 · Cited by 1,961 · see citing works
Aβ Oligomers – a decade of discovery
Walsh, D. M., & Selkoe, D. J. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04426.x · Cited by 1,938 · see citing works
Statins and the risk of dementia
Jick, H., Zornberg, G. L., Jick, S. S., Seshadri, S. S., & Drachman, D. (2000) · The Lancet · doi:10.1016/s0140-6736(00)03155-x · Cited by 1,763 · see citing works
Pigment Epithelium-Derived Factor: A Potent Inhibitor of Angiogenesis
Dawson, D. W., Volpert, O. V., Gillis, P., Crawford, S. E., Xu, H.-J., Benedict, W., & Bouck, N. (1999) · Science · doi:10.1126/science.285.5425.245 · Cited by 1,500 · see citing works
How common are the "common" neurologic disorders?
Hirtz, D., Thurman, D. J., Gwinn-Hardy, K., Mohamed, M., Chaudhuri, A. R., & Zalutsky, R. (2007) · Neurology · doi:10.1212/01.wnl.0000252807.38124.a3 · Cited by 1,365 · see citing works
Inflammation in Neurodegenerative Disease—A Double-Edged Sword
Wyss-Coray, T., & Mucke, L. (2002) · Neuron · doi:10.1016/s0896-6273(02)00794-8 · Cited by 1,235 · see citing works
HOW COMMON ARE THE “COMMON” NEUROLOGIC DISORDERS?
Kaplin, A. I., & Williams, M. (2007) · Neurology · doi:10.1212/01.wnl.0000278071.91524.4d · Cited by 1,132 · see citing works
Variation in factor B (BF) and complement component 2 (C2) genes is associated with age-related macular degeneration
The AMD Genetics Clinical Study Group, Gold, B., Merriam, J. E., Zernant, J., Hancox, L. S., Taiber, A. J., Gehrs, K., Cramer, K., Neel, J., Bergeron, J., et al. (2006) · Nature Genetics · doi:10.1038/ng1750 · Cited by 1,075 · see citing works
IL-1 is required for tumor invasiveness and angiogenesis
Voronov, E., Shouval, D. S., Krelin, Y., Cagnano, E., Benharroch, D., Iwakura, Y., Dinarello, C. A., & Apte, R. N. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0437939100 · Cited by 1,023 · see citing works
Drusen associated with aging and age-related macular degeneration contain proteins common to extracellular deposits associated with atherosclerosis, elastosis, amyloidosis, and dense deposit disease
Mullins, R. F., Russell, S. R., Anderson, D. H., & Hageman, G. S. (2000) · The FASEB Journal · doi:10.1096/fasebj.14.7.835 · Cited by 937 · see citing works
Oxidative stress in Alzheimer’s disease
Smith, M. A., Rottkamp, C. A., Nunomura, A., Raina, A. K., & Perry, G. (2000) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/s0925-4439(00)00040-5 · Cited by 895 · see citing works
Metabolic Regulation of Brain Aβ by Neprilysin
Iwata, N., Tsubuki, S., Takaki, Y., Shirotani, K., Lu, B., Gerard, N., Gerard, C., Hama, E., Lee, H., & Saido, T. (2001) · Science · doi:10.1126/science.1059946 · Cited by 894 · see citing works
Immunochemical identification of the serine protease inhibitor α1-antichymotrypsin in the brain amyloid deposits of Alzheimer's disease
Abraham, C. R., Selkoe, D. J., & Potter, H. (1988) · Cell · doi:10.1016/0092-8674(88)90462-x · Cited by 893 · see citing works
HTRA1 Promoter Polymorphism in Wet Age-Related Macular Degeneration
DeWan, A., Liu, M., Hartman, S., Zhang, S. S.-M., Liu, D. T. L., Zhao, C., Tam, P. O. S., Chan, W. M., Lam, D. S. C., Snyder, M., et al. (2006) · Science · doi:10.1126/science.1133807 · Cited by 876 · see citing works
Ubiquitin Is a Component of Paired Helical Filaments in Alzheimer's Disease
Mori, H., Kondo, J., & Ihara, Y. (1987) · Science · doi:10.1126/science.3029875 · Cited by 843 · see citing works
Clinical risk factors for age-related macular degeneration: a systematic review and meta-analysis
Chakravarthy, U., Wong, T. Y., Fletcher, A., Piault, E., Evans, C., Zlateva, G., Buggage, R., Pleil, A., & Mitchell, P. (2010) · BMC Ophthalmology · doi:10.1186/1471-2415-10-31 · Cited by 842 · see citing works
Peroxisomes and oxidative stress
Schrader, M., & Fahimi, H. D. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2006.09.006 · Cited by 838 · see citing works
Complement C3 variant and the risk of age-related macular degeneration
Yates, J. R. W., Sepp, T., Matharu, B. K., Khan, J. C., Thurlby, D. A., Shahid, H., Clayton, D. G., Hayward, C., Morgan, J., Wright, A. F., et al. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa072618 · Cited by 829 · see citing works
Complement activation by beta-amyloid in Alzheimer disease.
Rogers, J., Cooper, N. R., Webster, S., Schultz, J., McGeer, P. L., Styren, S. D., Civin, W. H., Brachova, L., Bradt, B., & Ward, P. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.21.10016 · Cited by 817 · see citing works
Advanced glycation end products contribute to amyloidosis in Alzheimer disease
Vitek, M. P., Bhattacharya, K., Glendening, J. M., Stopa, E., Vlassara, H., Bucala, R., Manogue, K., & Cerami, A. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.11.4766 · Cited by 806 · see citing works
A Variant of the HTRA1 Gene Increases Susceptibility to Age-Related Macular Degeneration
Yang, Z., Camp, N. J., Sun, H., Tong, Z., Gibbs, D., Cameron, D. J., Chen, H., Zhao, Y., Pearson, E., Li, X., et al. (2006) · Science · doi:10.1126/science.1133811 · Cited by 796 · see citing works
The pivotal role of the complement system in aging and age-related macular degeneration: Hypothesis re-visited
Anderson, D. H., Radeke, M. J., Gallo, N. B., Chapin, E. A., Johnson, P. T., Curletti, C. R., Hancox, L. S., Hu, J., Ebright, J. N., Malek, G., et al. (2010) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2009.11.003 · Cited by 727 · see citing works
Identification of amyloid plaques in retinas from Alzheimer's patients and noninvasive in vivo optical imaging of retinal plaques in a mouse model
Koronyo-Hamaoui, M., Koronyo, Y., Ljubimov, A. V., Miller, C. A., Ko, M. K., Black, K. L., Schwartz, M., & Farkas, D. L. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2010.06.020 · Cited by 672 · see citing works
Drusen complement components C3a and C5a promote choroidal neovascularization
Nozaki, M., Raisler, B. J., Sakurai, E., Sarma, J. V., Barnum, S. R., Lambris, J. D., Chen, Y., Zhang, K., Ambati, B. K., Baffi, J. Z., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408835103 · Cited by 650 · see citing works
Age‐related macular degeneration—emerging pathogenetic and therapeutic concepts
Gehrs, K. M., Anderson, D. H., Johnson, L. V., & Hageman, G. S. (2006) · Annals of Medicine · doi:10.1080/07853890600946724 · Cited by 633 · see citing works
Effect of Eculizumab on Hemolysis and Transfusion Requirements in Patients with Paroxysmal Nocturnal Hemoglobinuria
Hillmen, P., Hall, C., Marsh, J. C. W., Elebute, M. O., Bombara, M. P., Petro, B. E., Cullen, M. J., Richards, S. J., Rollins, S. A., Mojcik, C. F., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa031688 · Cited by 632 · see citing works
Complement activation and inflammatory processes in Drusen formation and age related macular degeneration
Johnson, L. V., Leitner, W. P., Staples, M. K., & Anderson, D. H. (2001) · Experimental Eye Research · doi:10.1006/exer.2001.1094 · Cited by 621 · see citing works
CX3CR1-dependent subretinal microglia cell accumulation is associated with cardinal features of age-related macular degeneration
Combadière, C., Feumi, C., Raoul, W., Keller, N., Rodéro, M., Pézard, A., Lavalette, S., Houssier, M., Jonet, L., Picard, E., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31692 · Cited by 618 · cited 2× · see citing works
“Although the role of retinal microglia in AMD is unclear, Combadiere et al. (2007) demonstrated that all retinal microglial cells express receptors for CX3C, a chemokine receptor 1 (CX3CR1).”
Background
Amyloid β-Protein Assembly and Alzheimer Disease
Roychaudhuri, R., Yang, M., Hoshi, M. M., & Teplow, D. B. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.r800036200 · Cited by 617 · see citing works
Preserved Cognition in Patients With Early Alzheimer Disease and Amnestic Mild Cognitive Impairment During Treatment With Rosiglitazone
Watson, G. S., Cholerton, B. A., Reger, M. A., Baker, L. D., Plymate, S. R., Asthana, S., Fishel, M. A., Kulstad, J. J., Green, P. S., Cook, D. G., et al. (2005) · American Journal of Geriatric Psychiatry · doi:10.1176/appi.ajgp.13.11.950 · Cited by 607 · see citing works
Evidence of neuronal oxidative damage in Alzheimer's disease.
Good, P. F., Werner, P., Hsu, A., Olanow, C. W., & Perl, D. P. (1996) · Europe PMC (PubMed Central) · Cited by 600 · see citing works
Synchrotron-based infrared and X-ray imaging shows focalized accumulation of Cu and Zn co-localized with β-amyloid deposits in Alzheimer’s disease
Miller, L. M., Wang, Q., Telivala, T. P., Smith, R., Lanzirotti, A., & Judith Miklossy, A. (2005) · Journal of Structural Biology · doi:10.1016/j.jsb.2005.09.004 · Cited by 588 · see citing works
PEDF: A pigment epithelium-derived factor with potent neuronal differentiative activity
Tombran‐Tink, J., Chader, G. G., & Johnson, L. V. (1991) · Experimental Eye Research · doi:10.1016/0014-4835(91)90248-d · Cited by 578 · see citing works
Interleukin-1 Mediates Pathological Effects of Microglia on Tau Phosphorylation and on Synaptophysin Synthesis in Cortical Neurons through a p38-MAPK Pathway
Li, Y., Liu, L., Barger, S. W., & Griffin, W. S. T. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-05-01605.2003 · Cited by 563 · see citing works
Aging human RPE: morphometric analysis of macular, equatorial, and peripheral cells.
Feeney-Burns, L., Hilderbrand, E. S., & Eldridge, S. (1984) · PubMed · Cited by 561 · see citing works
Oxidative stress-induced mitochondrial DNA damage in human retinal pigment epithelial cells: a possible mechanism for RPE aging and age-related macular degeneration
Liang, F.-Q., & Godley, B. F. (2003) · Experimental Eye Research · doi:10.1016/s0014-4835(03)00023-x · Cited by 557 · see citing works
Synapse Formation and Function Is Modulated by the Amyloid Precursor Protein
Priller, C., Bauer, T., Mitteregger, G., Krebs, B., Kretzschmar, H. A., & Herms, J. W. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.1450-06.2006 · Cited by 548 · see citing works
Interleukin‐6 and α‐2‐macroglobulin indicate an acute‐phase state in Alzheimer's disease cortices
Bauer, J., Strauss, S., Schreiter-Gasser, U., Ganter, U., Schlegel, P., Witt, I., Yolk, B., & Berger, M. (1991) · FEBS Letters · doi:10.1016/0014-5793(91)80737-n · Cited by 483 · see citing works
The Role of Inflammation in the Pathogenesis of Age-related Macular Degeneration
Donoso, L. A., Kim, D. S., Frost, A. T., Callahan, A., & Hageman, G. S. (2006) · Survey of Ophthalmology · doi:10.1016/j.survophthal.2005.12.001 · Cited by 480 · see citing works
Complement-targeted therapeutics
Ricklin, D., & Lambris, J. D. (2007) · Nature Biotechnology · doi:10.1038/nbt1342 · Cited by 478 · see citing works
Delayed onset of Alzheimer's disease with nonsteroidal anti-inflammatory and histamine H2 blocking drugs
Breitner, J. C. S. (1995) · Neurobiology of Aging · doi:10.1016/0197-4580(95)00049-k · Cited by 466 · see citing works
Expression and function of serum amyloid A, a major acute-phase protein, in normal and disease states
Urieli-Shoval, S., Linke, R., & Matzner, Y. (2000) · Current Opinion in Hematology · doi:10.1097/00062752-200001000-00012 · Cited by 463 · see citing works
Immunological and Aetiological Aspects of Macular Degeneration
Penfold, P. L., Madigan, M. C., Gillies, M. C., & Provis, J. M. (2001) · Progress in Retinal and Eye Research · doi:10.1016/s1350-9462(00)00025-2 · Cited by 460 · see citing works
Immunoglobulins and complement factors in senile plaques: An immunoperoxidase study
Eikelenboom, P., & Stam, F. C. (1982) · Acta Neuropathologica · doi:10.1007/bf00685397 · Cited by 454 · see citing works
The Alzheimer's Aβ-peptide is deposited at sites of complement activation in pathologic deposits associated with aging and age-related macular degeneration
Johnson, L. V., Leitner, W. P., Rivest, A. J., Staples, M. K., Radeke, M. J., & Anderson, D. H. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.192203399 · Cited by 447 · see citing works
Inflammation, microglia, and alzheimer's disease
Cameron, B., & Landreth, G. E. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.10.006 · Cited by 440 · see citing works
Dietary factors and Alzheimer's disease
Luchsinger, J. A., & Mayeux, R. P. (2004) · The Lancet Neurology · doi:10.1016/s1474-4422(04)00878-6 · Cited by 434 · see citing works
Microglia and Inflammation in Alzheimers Disease
Mandrekar-Colucci, S., & Landreth, G. E. (2010) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152710791012071 · Cited by 421 · see citing works
Lipofuscin and melanin of human retinal pigment epithelium. Fluorescence, enzyme cytochemical, and ultrastructural studies.
Feeney, L. (1978) · PubMed · Cited by 397 · see citing works
Transferrin and Transferrin Receptor Function in Brain Barrier Systems
Moos, T., & Morgan, E. H. (2000) · Cellular and Molecular Neurobiology · doi:10.1023/a:1006948027674 · Cited by 394 · see citing works
Glatiramer acetate fights against Alzheimer’s disease by inducing dendritic-like microglia expressing insulin-like growth factor 1
Butovsky, O., Koronyo-Hamaoui, M., Kunis, G., Ophir, E., Landa, G., Cohen, H., & Schwartz, M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604681103 · Cited by 388 · see citing works
Abundant Lipid and Protein Components of Drusen
Wang, L., Clark, M. E., Crossman, D. K., Kojima, K., Messinger, J. D., Mobley, J. A., & Curcio, C. A. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010329 · Cited by 383 · see citing works
Activation of the classical complement pathway in brain tissue of Alzheimer patients
McGeer, P. L., Akiyama, H., Itagaki, S., & McGeer, E. G. (1989) · Neuroscience Letters · doi:10.1016/0304-3940(89)90843-4 · Cited by 383 · see citing works
Systemic Complement Activation in Age-Related Macular Degeneration
Scholl, H. P. N., Issa, P. C., Walier, M., Janzer, S., Pollok‐Kopp, B., Börncke, F., Fritsche, L. G., Chong, V. N., Fimmers, R., Wienker, T. F., et al. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002593 · Cited by 366 · see citing works
Increased intrathecal levels of the angiogenic factors VEGF and TGF-β in Alzheimer’s disease and vascular dementia
Tarkowski, E., Issa, R., Sjögren, M., Wallin, A., Blennow, K., Tarkowski, A., & Kumar, P. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00285-8 · Cited by 360 · see citing works
Fish consumption, long-chain omega-3 fatty acids and risk of cognitive decline or Alzheimer disease: a complex association
Fotuhi, M., Mohassel, P., & Yaffe, K. (2009) · Nature Reviews Neurology · doi:10.1038/ncpneuro1044 · Cited by 344 · see citing works
Morphological and functional retinal impairment in Alzheimer's disease patients
Parisi, V., Restuccia, R., Fattapposta, F., Mina, C., Bucci, M. G., & Pierelli, F. (2001) · Clinical Neurophysiology · doi:10.1016/s1388-2457(01)00620-4 · Cited by 344 · see citing works
19F and 1H MRI detection of amyloid β plaques in vivo
Higuchi, M., Iwata, N., Matsuba, Y., Sato, K., Sasamoto, K., & Saido, T. C. (2005) · Nature Neuroscience · doi:10.1038/nn1422 · Cited by 339 · see citing works
Up-Regulated Production and Activation of the Complement System in Alzheimer's Disease Brain
Yasojima, K., Schwab, C., McGeer, E. G., & McGeer, P. L. (1999) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65340-0 · Cited by 328 · see citing works
Relationship of Drusen and Abnormalities of the Retinal Pigment Epithelium to the Prognosis of Neovascular Macular Degeneration
Bressler, S. B. (1990) · Archives of Ophthalmology · doi:10.1001/archopht.1990.01070120090035 · Cited by 325 · see citing works
Characterization of β amyloid assemblies in drusen: the deposits associated with aging and age-related macular degeneration
Anderson, D. H., Talaga, K. C., Rivest, A. J., Barron, E., Hageman, G. S., & Johnson, L. V. (2004) · Experimental Eye Research · doi:10.1016/j.exer.2003.10.011 · Cited by 319 · see citing works
Neprilysin Degrades Both Amyloid β Peptides 1–40 and 1–42 Most Rapidly and Efficiently among Thiorphan- and Phosphoramidon-sensitive Endopeptidases
Shirotani, K., Tsubuki, S., Iwata, N., Takaki, Y., Yamao‐Harigaya, W., Maruyama, K., Kiryu‐Seo, S., Kiyama, H., Iwata, H., Tomita, T., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008511200 · Cited by 312 · see citing works
Role of complement in neurodegeneration and neuroinflammation
Bonifati, D. M., & Kishore, U. (2006) · Molecular Immunology · doi:10.1016/j.molimm.2006.03.007 · Cited by 310 · see citing works
Amyloid-β Deposits Lead to Retinal Degeneration in a Mouse Model of Alzheimer Disease
Ning, A., Cui, J., To, E., Ashe, K. H., & Matsubara, J. (2008) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.08-1849 · Cited by 303 · see citing works
Plasma complement components and activation fragments: Associations with age-related macular degeneration genotypes and phenotypes
Reynolds, R., Hartnett, M. E., Atkinson, J. P., Giclas, P. C., Rosner, B., & Seddon, J. M. (2009) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.09-3928 · Cited by 294 · see citing works
Copper and Zinc Binding to Amyloid‐β: Coordination, Dynamics, Aggregation, Reactivity and Metal‐Ion Transfer
Faller, P. (2009) · ChemBioChem · doi:10.1002/cbic.200900321 · Cited by 285 · see citing works
Dietary ω-3 Fatty Acid and Fish Intake in the Primary Prevention of Age-Related Macular Degeneration: A Systematic Review and Meta-analysis
Chong, E. W.-T. (2008) · Archives of Ophthalmology · doi:10.1001/archopht.126.6.826 · Cited by 279 · see citing works
Apolipoprotein B in Cholesterol-Containing Drusen and Basal Deposits of Human Eyes with Age-Related Maculopathy
Malek, G., Li, C.-M., Guidry, C., Medeiros, N. E., & Curcio, C. A. (2003) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)63836-9 · Cited by 270 · see citing works
Amyloid β‐Peptide(1‐42) Contributes to the Oxidative Stress and Neurodegeneration Found in Alzheimer Disease Brain
Butterfield, D. A., & Debra Boyd-kimball, A. (2004) · Brain Pathology · doi:10.1111/j.1750-3639.2004.tb00087.x · Cited by 263 · see citing works
Novel mechanism for age‐related macular degeneration: An equilibrium shift between the angiogenesis factors VEGF and PEDF
Ohno‐Matsui, K., Morita, I., Tombran‐Tink, J., Mrazek, D., Onodera, M., Uetama, T., Hayano, M., Murota, S., & Mochizuki, M. (2001) · Journal of Cellular Physiology · doi:10.1002/jcp.10026 · Cited by 261 · see citing works
Self-citation
Local cellular sources of apolipoprotein E in the human retina and retinal pigmented epithelium: implications for the process of drusen formation
Anderson, D. H., Ozaki, S., Nealon, M., Neitz, J., Mullins, R. F., Hageman, G. S., & Johnson, L. V. (2001) · American Journal of Ophthalmology · doi:10.1016/s0002-9394(00)00961-2 · Cited by 255 · see citing works
Amyloid-beta is found in drusen from some age-related macular degeneration retinas, but not in drusen from normal retinas.
Dentchev, T., Milam, A. H., Lee, V. M. ‐., Trojanowski, J. Q., & Dunaief, J. L. (2003) · PubMed · Cited by 252 · see citing works
Isolation and characterization of amyloid P component from Alzheimer's disease and other types of cerebral amyloidosis.
Coria, F., Castaño, E., Prelli, F. C., Larrondo-Lillo, M., van Duinen, S. G., Shelanski, M. L., & Frangione, B. (1988) · PubMed · Cited by 245 · see citing works
A reinvestigation of the fatty acid content of bovine, rat and frog retinal rod outer segments
Stone, W. L., Farnsworth, C. C., & Dratz, E. A. (1979) · Experimental Eye Research · doi:10.1016/0014-4835(79)90114-3 · Cited by 237 · see citing works
Cholesterol metabolism and transport in the pathogenesis of Alzheimer’s disease
Martins, I. J., Berger, T. R., Sharman, M. J., Verdile, G., Fuller, S. J., & Martins, R. N. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06408.x · Cited by 232 · see citing works
β-Amyloid Deposition and Functional Impairment in the Retina of the APPswe/PS1ΔE9 Transgenic Mouse Model of Alzheimer’s Disease
Perez, S. E., Lumayag, S., Kovacs, B., Mufson, E. J., & Xu, S. (2009) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.08-2384 · Cited by 231 · see citing works
Vascular endothelial growth factor, interleukin 8, platelet-derived endothelial cell growth factor, and basic fibroblast growth factor promote angiogenesis and metastasis in human melanoma xenografts.
Rofstad, E. K., & Halsør, E. F. (2000) · PubMed · Cited by 229 · see citing works
MHC class II‐positive microglia in human brain: Association with alzheimer lesions
Perlmutter, L. S., Scott, S. A., Barrón, E., & Chui, H. C. (1992) · Journal of Neuroscience Research · doi:10.1002/jnr.490330407 · Cited by 228 · see citing works
Distribution, markers, and functions of retinal microglia
Chen, L., Yang, P., & Kijlstra, A. (2002) · Ocular Immunology and Inflammation · doi:10.1076/ocii.10.1.27.10328 · Cited by 226 · see citing works
The role of macrophage-derived IL-1 in induction and maintenance of angiogenesis
Carmi, Y., Voronov, E., Dotan, S., Lahat, N., Rahat, M. A., Fogel, M., Huszar, M., White, M. R., Dinarello, C. A., & Apte, R. N. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0901511 · Cited by 224 · see citing works
Dietary antioxidants and primary prevention of age related macular degeneration: systematic review and meta-analysis
Chong, E. W. T., Wong, T. Y., Kreis, A., Simpson, J. A., & Guymer, R. H. (2007) · BMJ · doi:10.1136/bmj.39350.500428.47 · Cited by 223 · see citing works
Individuals homozygous for the age-related macular degeneration risk-conferring variant of complement factor H have elevated levels of CRP in the choroid
Johnson, P. T., Betts, K. E., Radeke, M. J., Hageman, G. S., Anderson, D. H., & Johnson, L. V. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606234103 · Cited by 223 · see citing works
CLAC: a novel Alzheimer amyloid plaque component derived from a transmembrane precursor, CLAC‐P/collagen type XXV
Hashimoto, T., Wakabayashi, T., Watanabe, A., Kowa, H., Hosoda, R., Nakamura, A., Kanazawa, I., Arai, T., Takio, K., Mann, D. M. A., et al. (2002) · The EMBO Journal · doi:10.1093/emboj/21.7.1524 · Cited by 223 · see citing works
Reduced prevalence of AD in users of NSAIDs and H2 receptor antagonists
Anthony, J. C., Breitner, J., Zandi, P., Meyer, M., Jurasová, I., Norton, M., & Stone, S. (2000) · Neurology · doi:10.1212/wnl.54.11.2066 · Cited by 222 · see citing works
Decreased Thickness and Integrity of the Macular Elastic Layer of Bruch's Membrane Correspond to the Distribution of Lesions Associated with Age-Related Macular Degeneration
Chong, N. H. V., Keonin, J., Luthert, P. J., Frennesson, C. I., Weingeist, D. M., Wolf, R. L., Mullins, R. F., & Hageman, G. S. (2005) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)62248-1 · Cited by 218 · see citing works
Microglia in the Mouse Retina Alter the Structure and Function of Retinal Pigmented Epithelial Cells: A Potential Cellular Interaction Relevant to AMD
Ma, W., Zhao, L., Fontainhas, A. M., Fariss, R. N., & Wong, W. T. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007945 · Cited by 213 · see citing works
ACAT1 gene ablation increases 24(S)-hydroxycholesterol content in the brain and ameliorates amyloid pathology in mice with AD
Bryleva, E. Y., Rogers, M. A., Chang, C. C. Y., Buen, F., Harris, B. T., Rousselet, E., Seidah, N. G., Oddo, S., LaFerla, F. M., Spencer, T. A., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0913828107 · Cited by 209 · see citing works
Age-Related Macular Degeneration
Ciulla, T. A., Danis, R. P., & Harris, A. (1998) · Survey of Ophthalmology · doi:10.1016/s0039-6257(98)00014-9 · Cited by 208 · see citing works
The role of complement and activated microglia in the pathogenesis of Alzheimer's disease
Eikelenboom, P., & Veerhuis, R. (1996) · Neurobiology of Aging · doi:10.1016/0197-4580(96)00108-x · Cited by 206 · see citing works
Region‐specific reduction of Aβ‐degrading endopeptidase, neprilysin, in mouse hippocampus upon aging
Iwata, N., Takaki, Y., Fukami, S., Tsubuki, S., & Saido, T. C. (2002) · Journal of Neuroscience Research · doi:10.1002/jnr.10390 · Cited by 203 · see citing works
Oxidative stress and Alzheimer’s disease: dietary polyphenols as potential therapeutic agents
Darvesh, A. S., Carroll, R. T., Bishayee, A., Geldenhuys, W. J., & der Schyf, C. J. V. (2010) · Expert Review of Neurotherapeutics · doi:10.1586/ern.10.42 · Cited by 203 · see citing works
Drusen deposits associated with aging and age-related macular degeneration contain nonfibrillar amyloid oligomers
Luibl, V. (2006) · Journal of Clinical Investigation · doi:10.1172/jci25843 · Cited by 203 · see citing works
The potential role of amyloid in the pathogenesis of age-related macular degeneration
Yoshida, T. (2005) · Journal of Clinical Investigation · doi:10.1172/jci24635 · Cited by 202 · see citing works
Expression of Peroxisome Proliferator-Activated Receptor α (PPARα) in Primary Cultures of Human Vascular Endothelial Cells
Inoue, I., Shino, K., Noji, S., Awata, T., & Katayama, S. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.8622 · Cited by 199 · see citing works
Mitochondrial function and redox control in the aging eye: Role of MsrA and other repair systems in cataract and macular degenerations
Brennan, L., & Kantorow, M. (2008) · Experimental Eye Research · doi:10.1016/j.exer.2008.05.018 · Cited by 193 · see citing works
Disruption of the retinoid signalling pathway causes a deposition of amyloid β in the adult rat brain
Corcoran, J. P. T., So, P. L., & Maden, M. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03563.x · Cited by 190 · see citing works
Vascular endothelial growth factor in Alzheimer's disease and experimental cerebral ischemia
Kalaria, R. N., Cohen, D., Premkumar, D. R., Nag, S., LaManna, J. C., & Lust, W. D. (1998) · Molecular Brain Research · doi:10.1016/s0169-328x(98)00190-9 · Cited by 190 · see citing works
Advanced Glycation End Products in Age-related Macular Degeneration
Ishibashi, T. (1998) · Archives of Ophthalmology · doi:10.1001/archopht.116.12.1629 · Cited by 184 · see citing works
Amyloid-Peptide Vaccinations Reduce β-Amyloid Plaques but Exacerbate Vascular Deposition and Inflammation in the Retina of Alzheimer’s Transgenic Mice
Liu, B., Rasool, S., Yang, Z., Glabe, C. G., Schreiber, S. S., Ge, J., & Tan, Z. (2009) · The American Journal of Pathology · doi:10.2353/ajpath.2009.090159 · Cited by 182 · see citing works
Oxidation and age-related macular degeneration: insights from molecular biology
Khandhadia, S., & Lotery, A. J. (2010) · Expert Reviews in Molecular Medicine · doi:10.1017/s146239941000164x · Cited by 180 · see citing works
Peroxisome proliferator-activated receptor-gamma ligands inhibit choroidal neovascularization.
Murata, T., He, S., Hangai, M., Ishibashi, T., Xi, X. P., Kim, S., Hsueh, W. A., Ryan, S. J., Law, R. E., & Hinton, D. R. (2000) · PubMed · Cited by 179 · see citing works
Lipid peroxidation and advanced glycation end products in the brain in normal aging and in Alzheimer's disease
Dei, R., Takeda, A., Niwa, H., Li, M., Nakagomi, Y., Watanabe, M., Inagaki, T., Washimi, Y., Yasuda, Y., Horie, K., et al. (2002) · Acta Neuropathologica · doi:10.1007/s00401-002-0523-y · Cited by 179 · see citing works
Plasma biomarkers for mild cognitive impairment and Alzheimer's disease
Song, F., Poljak, A., Smythe, G. A., & Sachdev, P. S. (2009) · Brain Research Reviews · doi:10.1016/j.brainresrev.2009.05.003 · Cited by 173 · see citing works
Co-accumulation of vascular endothelial growth factor with β-amyloid in the brain of patients with Alzheimer’s disease
Yang, S., Bae, D., Kang, H. J., Gwag, B. J., Gho, Y. S., & Chae, C. (2003) · Neurobiology of Aging · doi:10.1016/s0197-4580(03)00111-8 · Cited by 170 · see citing works
Molecular composition of drusen as related to substructural phenotype.
Hageman, G. S., & Mullins, R. F. (1999) · PubMed · Cited by 167 · see citing works
Molecular composition of drusen and possible involvement of anti‐retinal autoimmunity in two different forms of macular degeneration in cynomolgus monkey ( Macaca fascicularis )
Umeda, S., SUZUKI, M. T., Okamoto, H., Ono, F., Mizota, A., Terao, K., Yoshikawa, Y., Tanaka, Y., & Iwata, T. (2005) · The FASEB Journal · doi:10.1096/fj.04-3525fje · Cited by 163 · see citing works
Mitochondrial ATP-synthase in the entorhinal cortex is a target of oxidative stress at stages I/II of Alzheimer’s disease pathology
Terni, B., Boada, J., Portero‐Otin, M., Pamplona, R., & Ferrer, I. (2010) · Brain Pathology · doi:10.1111/j.1750-3639.2009.00266.x · Cited by 159 · see citing works
Compstatin: A Complement Inhibitor on its Way to Clinical Application
Ricklin, D., & Lambris, J. D. (2008) · Advances in experimental medicine and biology · doi:10.1007/978-0-387-78952-1_20 · Cited by 157 · see citing works
Evidence of angiogenic vessels in Alzheimer’s disease
Desai, B. S., Schneider, J. A., Li, J.-L., Carvey, P. M., & Hendey, B. (2009) · Journal of Neural Transmission · doi:10.1007/s00702-009-0226-9 · Cited by 153 · see citing works
Soluble and Mature Amyloid Fibrils in Drusen Deposits
Isas, J. M., Luibl, V., Johnson, L. V., Kayed, R., Wetzel, R. B., Glabe, C. G., Langen, R., & Chen, J. (2010) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.09-4207 · Cited by 153 · see citing works
Statin and aspirin therapy are associated with decreased rates of choroidal neovascularization among patients with age-related macular degeneration
WILSON, H., Schwartz, D. M., Bhatt, H. R. F., McCulloch, C. E., & Duncan, J. L. (2004) · American Journal of Ophthalmology · doi:10.1016/s0002-9394(03)01286-8 · Cited by 153 · see citing works
Nine-Year Incidence and Risk Factors for Age-Related Macular Degeneration in a Defined Japanese PopulationThe Hisayama Study
Yasuda, M., Kiyohara, Y., Hata, Y., Arakawa, S., Yonemoto, K., Doi, Y., Iida, M., & Ishibashi, T. (2009) · Ophthalmology · doi:10.1016/j.ophtha.2009.04.017 · Cited by 152 · see citing works
Butovsky, O. et al. Glatiramer acetate fights against Alzheimer's disease by inducing dendritic-like microglia expressing insulin-like growth factor 1. Proc. Natl Acad. Sci. USA 103, 11784-11789
Butovsky, O., Koronyo‐Hamaoui, M., Kunis, G., Ophir, E., Landa, G., Cohen, H., & Schwartz, M. (2006) · Cited by 144 · see citing works
Immuno-electron microscopic localization of immunoglobulins in amyloid fibrils of senile plaques
Ishii, T., & Haga, S. (1976) · Acta Neuropathologica · doi:10.1007/bf00685368 · Cited by 142 · see citing works
Amyloid precursor protein processing and retinal pathology in mouse models of Alzheimer’s disease
Dutescu, R. M., Li, Q., Crowston, J. G., Masters, C. L., Baird, P. N., & Culvenor, J. G. (2009) · Graefe s Archive for Clinical and Experimental Ophthalmology · doi:10.1007/s00417-009-1060-3 · Cited by 139 · see citing works
Senile plaque composition and posttranslational modification of amyloid-β peptide and associated proteins
Atwood, C., Martins, R. N., Smith, M. A., & Perry, G. L. (2002) · Peptides · doi:10.1016/s0196-9781(02)00070-0 · Cited by 137 · see citing works
Peroxisome Proliferator-Activated Receptor-γ Agonists Increase Vascular Endothelial Growth Factor Expression in Human Vascular Smooth Muscle Cells
Yamakawa, K., Hosoi, M., Koyama, H., Tanaka, S., Fukumoto, S., Morii, H., & Nishizawà, Y. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.2665 · Cited by 136 · see citing works
Viewing Ageing Eyes: Diverse Sites of Amyloid Beta Accumulation in the Ageing Mouse Retina and the Up-Regulation of Macrophages
Hoh Kam, J., Lenassi, E., & Jeffery, G. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013127 · Cited by 131 · see citing works
Structure of Compstatin in Complex with Complement Component C3c Reveals a New Mechanism of Complement Inhibition
Janssen, B. J. C., Halff, E. F., Lambris, J. D., & Gros, P. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m704587200 · Cited by 130 · see citing works
C3 R102G polymorphism increases risk of age-related macular degeneration
Spencer, K. L., Olson, L. M., Anderson, B. M., Schnetz‐Boutaud, N. C., Scott, W. K., Gallins, P. J., Agarwal, A., Postel, E. A., Pericak‐Vance, M. A., & Haines, J. L. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn075 · Cited by 130 · see citing works
Demonstration of CRP immunoreactivity in brains of Alzheimer's disease: immunohistochemical study using formic acid pretreatment of tissue sections
Iwamoto, N., Nishiyama, E., Ohwada, J., & Arai, H. (1994) · Neuroscience Letters · doi:10.1016/0304-3940(94)90035-3 · Cited by 129 · see citing works
High concentration of zinc in sub-retinal pigment epithelial deposits
Lengyel, I., Flinn, J. M., Pető, T., Linkous, D. H., Cano, K., Bird, A. C., Lanzirotti, A., Frederickson, C. J., & van Kuijk, F. J. G. M. (2007) · Experimental Eye Research · doi:10.1016/j.exer.2006.12.015 · Cited by 127 · see citing works
Early stages of age-related macular degeneration: an immunofluorescence and electron microscopy study.
van der Schaft, T. L., Mooy, C. M., de Bruijn, W. C., & de Jong, P. T. (1993) · British Journal of Ophthalmology · doi:10.1136/bjo.77.10.657 · Cited by 126 · see citing works
α1-Antitrypsin and α1-antichymotrypsin are in the lesions of Alzheimerʼs disease
Gollin, P. A., Kalaria, R. N., Eikelenboom, P., Rozemüller, A. J. M., & Perry, G. L. (1992) · Neuroreport · doi:10.1097/00001756-199202000-00020 · Cited by 124 · see citing works
Expression of complement system components during aging and amyloid deposition in APP transgenic mice
Reichwald, J., Danner, S., Wiederhold, K., & Staufenbiel, M. (2009) · Journal of Neuroinflammation · doi:10.1186/1742-2094-6-35 · Cited by 122 · see citing works
Immunohistochemical localization of vitronectin, its receptor and beta-3 integrin in Alzheimer brain tissue
Akiyama, H., Kawamata, T., Dedhar, S., & McGeer, P. L. (1991) · Journal of Neuroimmunology · doi:10.1016/0165-5728(91)90067-h · Cited by 120 · see citing works
Complement activation in very early Alzheimer disease
Zanjani, H., Finch, C. E., Kemper, C., Atkinson, J., McKeel, D., Morris, J. C., & Price, J. L. (2005) · Alzheimer Disease & Associated Disorders · doi:10.1097/01.wad.0000165506.60370.94 · Cited by 115 · see citing works
Senile cerebral amyloid. Prealbumin as a common constituent in the neuritic plaque, in the neurofibrillary tangle, and in the microangiopathic lesion.
Shirahama, T., Skinner, M. M., Westermark, P., Rubinow, A., Cohen, A. S., Brun, A., & Kemper, T. L. (1982) · PubMed Central · Cited by 114 · see citing works
Detection of complement alternative pathway mRNA and proteins in the Alzheimer’s disease brain
Strohmeyer, R., Shen, Y., & Rogers, J. (2000) · Molecular Brain Research · doi:10.1016/s0169-328x(00)00149-2 · Cited by 114 · see citing works
Amyloid‐β(1‐42) alters structure and function of retinal pigmented epithelial cells
Bruban, J., Glotin, A., Dinet, V., Chalour, N., Sennlaub, F., Jonet, L., An, N., Faussat, A. M., & Mascarelli, F. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2009.00456.x · Cited by 114 · see citing works
Early Age-Related Macular Degeneration, Cognitive Function, and Dementia: The Cardiovascular Health Study
Baker, M. L. (2009) · Archives of Ophthalmology · doi:10.1001/archophthalmol.2009.30 · Cited by 114 · see citing works
Accumulation of tissue inhibitor of metalloproteinases-3 in human eyes with Sorsby's fundus dystrophy or retinitis pigmentosa
Fariss, R. N., Apte, S., Luthert, P. J., Bird, A. C., & Milam, A. H. (1998) · British Journal of Ophthalmology · doi:10.1136/bjo.82.11.1329 · Cited by 114 · see citing works
Non-Steroidal Anti-Inflammatory Drugs and Alzheimers Disease: The Epidemiological Evidence
Szekely, C. A., & Zandi, P. P. (2010) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152710791012026 · Cited by 114 · see citing works
RAGE Ligand Upregulation of VEGF Secretion in ARPE-19 Cells
Ma, W., Lee, S. E., Guo, J., Qu, W., Hudson, B. I., Schmidt, A. M., & Barile, G. R. (2007) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.06-0738 · Cited by 107 · see citing works
Amyloid‐β up‐regulates complement factor B in retinal pigment epithelial cells through cytokines released from recruited macrophages/microglia: Another mechanism of complement activation in age‐related macular degeneration
Wang, J., Ohno‐Matsui, K., Yoshida, T., Shimada, N., Ichinose, S., Sato, T., Mochizuki, M., & Morita, I. (2009) · Journal of Cellular Physiology · doi:10.1002/jcp.21742 · Cited by 105 · see citing works
Self-citation
Metabolism of amyloid β peptide and pathogenesis of Alzheimer's disease
Saido, T. C., & Iwata, N. (2006) · Neuroscience Research · doi:10.1016/j.neures.2005.12.015 · Cited by 101 · see citing works
Solution structure of Compstatin, a potent complement inhibitor
Morikis, D., Assa‐Munt, N., Sahu, A., & Lambris, J. D. (1998) · Protein Science · doi:10.1002/pro.5560070311 · Cited by 101 · see citing works
Immunosuppressive Properties of the Pigmented Epithelial Cells and the Subretinal Space
Zamiri, P., Sugita, S., & Streilein, J. W. (2007) · KARGER eBooks · doi:10.1159/000099259 · Cited by 100 · see citing works
Molecular genetics of AMD and current animal models
Edwards, A. O., & Malek, G. (2007) · Angiogenesis · doi:10.1007/s10456-007-9064-2 · Cited by 98 · see citing works
Targeting age-related macular degeneration with Alzheimer’s disease based immunotherapies: Anti-amyloid-β antibody attenuates pathologies in an age-related macular degeneration mouse model
Ding, J., Lin, J. C., Mace, B. E., Herrmann, R., Sullivan, P. M., & Rickman, C. B. (2007) · Vision Research · doi:10.1016/j.visres.2007.07.025 · Cited by 97 · see citing works
INCREASED GLYCEROL-3-PHOSPHORYLCHOUNE IN POST-MORTEM ALZHEIMER'S BRAIN
Bárány, M., Chang, Y., Arús, C., Rustan, T. D., & Frey, W. (1985) · The Lancet · doi:10.1016/s0140-6736(85)92114-2 · Cited by 96 · see citing works
Detection of Specific Extracellular Matrix Molecules in Drusen, Bruch's Membrane, and Ciliary Body
Newsome, D. A., Hewitt, A. T., Huh, W., Robey, P. G., & Hassell, J. R. (1987) · American Journal of Ophthalmology · doi:10.1016/0002-9394(87)90227-3 · Cited by 96 · see citing works
Amyloid-β Immunotherapy for Alzheimers Disease
Fu, H., Liu, B., Frost, J. L., & Lemere, C. A. (2010) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152710791012017 · Cited by 91 · see citing works
The monoclonal antibody, Alz 50, recognizes tau proteins in Alzheimer's disease brain
Nukina, N., Kosik, K. S., & Selkoe, D. J. (1988) · Neuroscience Letters · doi:10.1016/0304-3940(88)90455-7 · Cited by 90 · see citing works
Peroxisome Proliferator‐Activated Receptors and Lipid Metabolisma
KELLER, H., Mahfoudi, A., Dreyer, C., Hihi, A. K., Medin, J. A., Ozato, K., & Wahli, W. (1993) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1993.tb32279.x · Cited by 89 · see citing works
Microarray Analysis Identifies Changes in Inflammatory Gene Expression in Response to Amyloid-β Stimulation of Cultured Human Retinal Pigment Epithelial Cells
Kurji, K. H., Cui, J. Z., Lin, T. R., Harriman, D. I., Prasad, S. S., Kojic, L., & Matsubara, J. A. (2010) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.09-3622 · Cited by 87 · see citing works
Expression of ?2-macroglobulin receptor/low density lipoprotein receptor-related protein (LRP) in rat microglial cells
Marzolo, M., Rommy von Bernhardi, M., Bu, G., & Inestrosa, N. C. (2000) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(20000501)60:3 · Cited by 87 · see citing works
Neprylisin decreases uniformly in Alzheimer's disease and in normal aging
Russo, R., Borghi, R., Markesbery, W. R., Tabaton, M., & Piccini, A. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.09.054 · Cited by 87 · see citing works
Association of complement factor H Y402H gene polymorphism with Alzheimer's disease
Zetterberg, M., Landgren, S., Andersson, M. E., Palmér, M. S., Gustafson, D., Skoog, I. G., Minthon, L., Thelle, D. S., Wallin, A., Bogdanović, N., et al. (2007) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30668 · Cited by 87 · see citing works
Altered Function of Factor I Caused by Amyloid β: Implication for Pathogenesis of Age-Related Macular Degeneration from Drusen
Wang, J., Ohno‐Matsui, K., Yoshida, T., Kojima, A., Shimada, N., Nakahama, K., Safranova, O., Iwata, N., Saido, T. C., Mochizuki, M., et al. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.1.712 · Cited by 81 · see citing works
Self-citation
Changes in the ageing brain in health and disease
Anderton, B. H. (1997) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.1997.0162 · Cited by 78 · see citing works
Emerging Pharmacologic Therapies for Wet Age-Related Macular Degeneration
Zhang, N., & Hui, P. (2009) · Ophthalmologica · doi:10.1159/000228926 · Cited by 67 · see citing works
Neuronal Lipofuscin Accumulation in Ageing and Alzheimer Dementia: A Pathogenic Mechanism?
Dowson, J. H. (1982) · The British Journal of Psychiatry · doi:10.1192/bjp.140.2.142 · Cited by 67 · see citing works
Differential Accumulation of Secreted AβPP Metabolites in Ocular Fluids1
Prakasam, A., Muthuswamy, A., Ablonczy, Z., Greig, N. H., Fauq, A. H., Rao, K. S. J., Pappolla, M. A., & Sambamurti, K. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-100210 · Cited by 65 · see citing works
Suppression of Drusen Formation by Compstatin, a Peptide Inhibitor of Complement C3 activation, on Cynomolgus Monkey with Early-Onset Macular Degeneration
Chi, Z., Yoshida, T., Lambris, J. D., & Iwata, T. (2010) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-5635-4_9 · Cited by 64 · see citing works
Low-Dose Aspirin and Medical Record–Confirmed Age-related Macular Degeneration in a Randomized Trial of Women
Christen, W. G., Glynn, R. J., Chew, E. Y., & Buring, J. E. (2009) · Ophthalmology · doi:10.1016/j.ophtha.2009.05.031 · Cited by 63 · see citing works
β-amyloid deposits in transgenic mice expressing human β-amyloid precursor protein have the same characteristics as those in Alzheimer's disease
Terai, K., Iwai, A., Kawabata, S., Tasaki, Y., Watanabe, T., Miyata, K., & Yamaguchi, T. (2001) · Neuroscience · doi:10.1016/s0306-4522(01)00095-1 · Cited by 58 · see citing works
Complement proteins and complement inhibitors in Alzheimer's disease
McGeer, P. L., & McGeer, E. G. (1992) · Research in Immunology · doi:10.1016/0923-2494(92)80045-m · Cited by 57 · see citing works
Statin and aspirin therapy are associated with decreased rates of choroidal neovascularization among patients with age-related macular degeneration
Girgis, R., & McKee, H. D. R. (2004) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2004.05.063 · Cited by 55 · see citing works
Laminins in the adult and aged brain
Jucker, M., Tian, M., & Ingram, D. K. (1996) · Molecular and Chemical Neuropathology · doi:10.1007/bf02815224 · Cited by 55 · see citing works
ACAT as a Drug Target for Alzheimer’s Disease
Huttunen, H. J., & Kovacs, D. M. (2008) · Neurodegenerative Diseases · doi:10.1159/000113705 · Cited by 50 · see citing works
Weekly Vaccination with Copaxone (Glatiramer Acetate) as a Potential Therapy for Dry Age-Related Macular Degeneration
Landa, G., Butovsky, O., Shoshani, J., Schwartz, M., & Pollack, A. (2008) · Current Eye Research · doi:10.1080/02713680802484637 · Cited by 50 · see citing works
The Cellular Biochemistry of Cholesterol and Statins: Insights into the Pathophysiology and Therapy of Alzheimer's Disease
Wolozin, B. L., Brown, J. A., Theisler, C. M., & Silberman, S. (2004) · CNS Drug Reviews · doi:10.1111/j.1527-3458.2004.tb00009.x · Cited by 48 · see citing works
New Mechanism of Rosiglitazone to Reduce Neointimal Hyperplasia
Lee, C.-S., Kwon, Y., Yang, H., Kim, S. H., Kim, T.-Y., Hur, J., Park, K. W., Cho, H.-J., Kang, H., Park, Y.-B., et al. (2009) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.108.176230 · Cited by 47 · see citing works
Induced expression of neuronal membrane attack complex and cell death by Alzheimer's β-amyloid peptide
Shen, Y., Sullivan, T., Lee, C., Meri, S., Shiosaki, K., & Lin, C. W. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00346-1 · Cited by 46 · see citing works
β amyloid angiogenic activity in vitro and in vivo
Boscolo, E., Folin, M., Nico, B., Grandi, C., Mangieri, D., Longo, V., Scienza, R., Zampieri, P., Conconi, M. T., Parnigotto, P., et al. (2007) · International Journal of Molecular Medicine · doi:10.3892/ijmm.19.4.581 · Cited by 46 · see citing works
Apolipoprotein E Gene and Early Age-Related MaculopathyThe Atherosclerosis Risk in Communities Study
Wong, T. Y., SHANKAR, A., Klein, R., Bray, M. S., Couper, D. J., KLEIN, B., SHARRETT, A., & Folsom, A. R. (2006) · Ophthalmology · doi:10.1016/j.ophtha.2005.10.048 · Cited by 38 · see citing works
Alzheimer s disease and heparan sulfate proteoglycan
Fukuchi, K.-I. (1998) · Frontiers in bioscience · doi:10.2741/a277 · Cited by 34 · see citing works
Tau-2 immunoreactivity of corpora amylacea in the human retina and optic nerve.
Loeffler, K. U., Edward, D. P., & Tso, M. O. M. (1993) · PubMed · Cited by 33 · see citing works
A Targeted Inhibitor of the Complement Alternative Pathway Reduces RPE Injury and Angiogenesis in Models of Age-Related Macular Degeneration
Rohrer, B., Long, Q., Coughlin, B. A., Renner, B., Huang, Y. J., Kunchithapautham, K., Ferreira, V. P., Pangburn, M. K., Gilkeson, G. S., Thurman, J. M., et al. (2010) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-5635-4_10 · Cited by 30 · see citing works
Association study of the CFH Y402H polymorphism with Alzheimer's disease
Fur, I. L., Laumet, G. O., Richard, F., Fiévet, N., Berr, C., Rouaud, O., Delcourt, C., Amouyel, P., & Lambert, J. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.03.003 · Cited by 30 · see citing works
Qualitative Spectral OCT/SLO Analysis of Drusen Change in Dry Age-Related Macular Degeneration Patients Treated with Copaxone
Landa, G., Rosen, R. B., Patel, A. P., Lima, V. C., Tai, K. W., Perez, V. R., Aizman, A., & Garcia, P. (2011) · Journal of Ocular Pharmacology and Therapeutics · doi:10.1089/jop.2010.0109 · Cited by 25 · see citing works
Complement Factor H Y402H Polymorphism is not Associated with Late-onset Alzheimer’s Disease
Hamilton, G., Proitsi, P., Williams, J. H., O’Donovan, M. C., Owen, M. J., Powell, J. F., & Lovestone, S. (2007) · NeuroMolecular Medicine · doi:10.1007/s12017-007-8013-y · Cited by 21 · see citing works
Asymmetric expression patterns of brain transthyretin in normal mice and a transgenic mouse model of Alzheimer's disease
Tsai, K., Yang, C.-H., Lee, P.-C., Wang, W., Chiu, M., & Shen, C. ‐. J. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2008.12.045 · Cited by 21 · see citing works
Decay Accelerating Factor (CD55)–Mediated Attenuation of Complement: Therapeutic Implications for Age-Related Macular Degeneration
Kelly, N., Cashman, S. M., Sweigard, J. H., & Kumar‐Singh, R. (2010) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.10-5887 · Cited by 19 · see citing works
Distribution of apolipoprotein E in senile plaques in brains with Alzheimer's disease: investigation with the confocal laser scan microscope
Nishiyama, E., Iwamoto, N., Ohwada, J., & Arai, H. (1997) · Brain Research · doi:10.1016/s0006-8993(96)01329-7 · Cited by 18 · see citing works
Assessment of the VEGF, bFGF, aFGF and IL8 angiogenic activity in urinary bladder carcinoma, using the mice cutaneous angiogenesis test.
Rogala, E., Skopińska-Różewska, E., Sommer, E., Pastewka, K., Chorostowska‐Wynimko, J., Sokolnicka, I., & Kazoń, M. (2001) · PubMed · Cited by 12 · see citing works
Characterisation of an epitope specific to the neuron-specific isoform of human enolase recognised by a monoclonal antibody raised against a synthetic peptide corresponding to the C-terminus of β/A4-protein
Harrington, C. R., Quinn, G. B., Hurt, J., Day, I. N. M., & Wischik, C. M. (1993) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(93)90005-s · Cited by 6 · see citing works
The complement system and plasma protein levels in Alzheimer's disease.
Ricchieri, G., Argentiero, V., Ongaro, G., & Tavolato, B. F. (1983) · PubMed · Cited by 3 · see citing works

Flagged first, then by citations

3 of the 198 references couldn’t be matched to a known paper.

Sorted by citations

Inflammation and its role in age-related macular degeneration
Kauppinen, A., Paterno, J. J., Błasiak, J., Salminen, A., & Kaarniranta, K. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2147-8 · Cited by 660 · see citing works
Epidemiology of age-related macular degeneration (AMD): associations with cardiovascular disease phenotypes and lipid factors
Pennington, K. L., & DeAngelis, M. M. (2016) · Eye and Vision · doi:10.1186/s40662-016-0063-5 · Cited by 484 · see citing works
Fecal microbiota transfer between young and aged mice reverses hallmarks of the aging gut, eye, and brain
Parker, A., Romano, S., Ansorge, R., Aboelnour, A., Le Gall, G., Savva, G. M., Pontifex, M. G., Telatin, A., Baker, D., Jones, E., et al. (2022) · Microbiome · doi:10.1186/s40168-022-01243-w · Cited by 368 · see citing works
A deep learning model for detection of Alzheimer's disease based on retinal photographs: a retrospective, multicentre case-control study
Cheung, C. Y.-L., Ran, A. R., Wang, S., Chan, V. T. T., Sham, K., Hilal, S., Venketasubramanian, N., Cheng, C., Sabanayagam, C., Tham, Y. C., et al. (2022) · The Lancet Digital Health · doi:10.1016/s2589-7500(22)00169-8 · Cited by 272 · see citing works
Ocular indicators of Alzheimer’s: exploring disease in the retina
Hart, N. J., Koronyo, Y., Black, K. L., & Koronyo‐Hamaoui, M. (2016) · Acta Neuropathologica · doi:10.1007/s00401-016-1613-6 · Cited by 260 · see citing works
Defects in retinal pigment epithelial cell proteolysis and the pathology associated with age-related macular degeneration.
Ferrington, D. A., Sinha, D., & Kaarniranta, K. (2016) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2015.09.002 · Cited by 241 · see citing works
Altered glucose metabolism in Alzheimer's disease: Role of mitochondrial dysfunction and oxidative stress
Dewanjee, S., Chakraborty, P., Bhattacharya, H., Chacko, L., Singh, B., Chaudhary, A., Javvaji, K., Pradhan, S. R., Vallamkondu, J., Dey, A., et al. (2022) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2022.09.032 · Cited by 235 · see citing works
The Aging Eye: Common Degenerative Mechanisms Between the Alzheimer's Brain and Retinal Disease
Sivak, J. M. (2013) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.12-10827 · Cited by 217 · see citing works
Retinal Nerve Fiber Layer Thickness in Patients With Alzheimer Disease
Kırbaş, S., Türkyılmaz, K., Anlar, Ö., Tüfekçi, A., & Durmuş, M. (2012) · Journal of Neuro-Ophthalmology · doi:10.1097/wno.0b013e318267fd5f · Cited by 217 · see citing works
Macroglia-Microglia Interactions via TSPO Signaling Regulates Microglial Activation in the Mouse Retina
Wang, M., Wang, X., Zhao, L., Ma, W., Rodríguez, I. R., Fariss, R. N., & Wong, W. T. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.3153-13.2014 · Cited by 201 · see citing works
Lysosomal alkalization and dysfunction in human fibroblasts with the Alzheimer’s disease-linked presenilin 1 A246E mutation can be reversed with cAMP
Coffey, E. E., Beckel, J. M., Laties, A. M., & Mitchell, C. H. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.01.001 · Cited by 183 · see citing works
Nicotinamide Ameliorates Disease Phenotypes in a Human iPSC Model of Age-Related Macular Degeneration
Saini, J. S., Corneo, B., Miller, J. D., Kiehl, T. R., Wang, Q., Boles, N. C., Blenkinsop, T. A., Stern, J. H., & Temple, S. (2017) · Cell stem cell · doi:10.1016/j.stem.2016.12.015 · Cited by 187 · see citing works
The vast complexity of primary open angle glaucoma: Disease genes, risks, molecular mechanisms and pathobiology
Janssen, S. F., Gorgels, T. G. M. F., Ramdas, W. D., Klaver, C. C. W., van Duijn, C. M., Jansonius, N. M., & Bergen, A. A. B. (2013) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2013.09.001 · Cited by 185 · see citing works
The mitochondrial-Derived peptide humanin protects RPE cells from oxidative stress, senescence, and mitochondrial dysfunction
Sreekumar, P. G., Ishikawa, K., Spee, C., Mehta, H. H., Wan, J., Yen, K., Cohen, P., Kannan, R., & Hinton, D. R. (2016) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.15-17053 · Cited by 179 · see citing works
Molecular and bioenergetic differences between cells with African versus European inherited mitochondrial DNA haplogroups: Implications for population susceptibility to diseases
Kenney, M. C., Chwa, M., Atilano, S. R., Falatoonzadeh, P., Ramírez, C., Malik, D., Tarek, M., Cáceres‐del‐Carpio, J., Nesburn, A. B., Boyer, D. S., et al. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2013.10.016 · Cited by 177 · see citing works
Choroidal Thinning as a New Finding in Alzheimer's Disease: Evidence from Enhanced Depth Imaging Spectral Domain Optical Coherence Tomography
Gharbiya, M., Trebbastoni, A., Parisi, F., Manganiello, S., Cruciani, F., D’Antonio, F., Vico, U. D., Imbriano, L., Campanelli, A., & de Lena, C. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-132039 · Cited by 174 · see citing works
Clearance of misfolded and aggregated proteins by aggrephagy and implications for aggregation diseases
Hyttinen, J. M. T., Amadio, M., Viiri, J., Pascale, A., Salminen, A., & Kaarniranta, K. (2014) · Ageing Research Reviews · doi:10.1016/j.arr.2014.07.002 · Cited by 165 · see citing works
Past, present and future role of retinal imaging in neurodegenerative disease
Kashani, A. H., Asanad, S., Chan, J. W., Singer, M., Zhang, J., Sharifi, M., Khansari, M. M., Abdolahi, F., Shi, Y., Biffi, A., et al. (2021) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2020.100938 · Cited by 164 · see citing works
Genetics of age-related macular degeneration (AMD)
DeAngelis, M. M., Owen, L. A., Morrison, M. A., Morgan, D. J., Li, M., Shakoor, A., Vitale, A. T., Iyengar, S. K., Stambolian, D., Kim, I. K., et al. (2017) · Human Molecular Genetics · doi:10.1093/hmg/ddx228 · Cited by 165 · see citing works
Retinal Degeneration and Alzheimer’s Disease: An Evolving Link
Ashok, A., Singh, N., Chaudhary, S., Bellamkonda, V., Kritikos, A. E., Wise, A. S., Rana, N. A., McDonald, D., & Ayyagari, R. V. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21197290 · Cited by 164 · see citing works
Metabolomics in the study of retinal health and disease
Laíns, I., Gantner, M., Murinello, S., Lasky-Su, J. A., Miller, J. W., Friedlander, M., & Husain, D. (2018) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2018.11.002 · Cited by 150 · see citing works
Dementia of the eye: the role of amyloid beta in retinal degeneration
Ratnayaka, J. A., Serpell, L. C., & Lotery, A. J. (2015) · Eye · doi:10.1038/eye.2015.100 · Cited by 153 · see citing works
Common micro RNAs (miRNAs) target complement factor H (CFH) regulation in Alzheimer's disease (AD) and in age-related macular degeneration (AMD).
(2012) · PubMed Central · Cited by 150 · see citing works
A2E Induces IL-1ß Production in Retinal Pigment Epithelial Cells via the NLRP3 Inflammasome
Anderson, O. A., Finkelstein, A., & Shima, D. T. (2013) · PLoS ONE · doi:10.1371/journal.pone.0067263 · Cited by 149 · see citing works
Retinal changes in Alzheimer's disease— integrated prospects of imaging, functional and molecular advances
Gupta, V. B., Chitranshi, N., den Haan, J., Mirzaei, M., You, Y., Lim, J. K. H., Basavarajappa, D. K., Godinez, A., Angelantonio, S. D., Sachdev, P. S., et al. (2020) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2020.100899 · Cited by 143 · see citing works
A fast growing spectrum of biological functions of γ-secretase in development and disease
Jurisch‐Yaksi, N., Sannerud, R., & Annaert, W. G. (2013) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2013.04.016 · Cited by 140 · see citing works
Rational Engineering of a Minimized Immune Inhibitor with Unique Triple-Targeting Properties
Schmidt, C. Q., Bai, H., Lin, Z., Risitano, A. M., Barlow, P. N., Ricklin, D., & Lambris, J. D. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1203548 · Cited by 131 · see citing works
Deletion of autophagy inducer RB1CC1 results in degeneration of the retinal pigment epithelium
Yao, J., Jia, L., Khan, N., Lin, C., Mitter, S. K., Boulton, M. E., Dunaief, J. L., Klionsky, D. J., Guan, J.-L., Thompson, D. A., et al. (2015) · Autophagy · doi:10.1080/15548627.2015.1041699 · Cited by 130 · see citing works
Neprilysin Inhibitors in Heart Failure
Bozkurt, B., Nair, A. P., Misra, A., Scott, C. Z., Mahar, J. H., & Fedson, S. (2022) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2022.05.010 · Cited by 125 · see citing works
Novel roles for α-crystallins in retinal function and disease
Kannan, R., Sreekumar, P. G., & Hinton, D. R. (2012) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2012.06.001 · Cited by 123 · see citing works
Retinal pathology as biomarker for cognitive impairment and Alzheimer's disease
Ikram, M. K., Cheung, C. Y.-L., Wong, T. Y., & Chen, C. (2012) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2011-301628 · Cited by 119 · see citing works
Amyloid-beta and tau protein beyond Alzheimer’s disease
Abyadeh, M., Gupta, V., Paulo, J. A., Mahmoudabad, A. G., Shadfar, S., Mirshahvaladi, S., Gupta, V. B., Nguyen, C. T. O., Finkelstein, D. I., You, Y., et al. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.386406 · Cited by 121 · see citing works
Is age‐related macular degeneration a manifestation of systemic disease? New prospects for early intervention and treatment
Cheung, C. M. G., & Wong, T. Y. (2014) · Journal of Internal Medicine · doi:10.1111/joim.12227 · Cited by 118 · see citing works
Changes in visual function and retinal structure in the progression of Alzheimer's disease
Salobrar‐García, E., de Hoz, R., Ramirez, A. I., López‐Cuenca, I., Rojas, P., Vazirani, R., Cuadrado, C. A., Yubero, R., Gil, P., Pinazo-Duran, M. D., et al. (2019) · PLoS ONE · doi:10.1371/journal.pone.0220535 · Cited by 116 · see citing works
Nonvascular retinal imaging markers of preclinical Alzheimer's disease
Snyder, P. J., Johnson, L. N., Lim, Y. Y., Santos, C. Y., Alber, J., Maruff, P. T., & Fernandez, B. M. (2016) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1016/j.dadm.2016.09.001 · Cited by 115 · see citing works
Choroidal Neovascularization: Mechanisms of Endothelial Dysfunction
Yeo, N. J. Y., Chan, E. J. J., & Cheung, C. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.01363 · Cited by 117 · see citing works
Retinal neurodegeneration and brain MRI markers: the Rotterdam Study
Mutlu, Ü., Bonnemaijer, P. W. M., Ikram, M. A., Colijn, J. M., Cremers, L. G. M., Buitendijk, G. H. S., Vingerling, J. R., Niessen, W. J., Vernooij, M. W., Klaver, C. C. W., et al. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2017.09.003 · Cited by 111 · see citing works
Associations Between Age-Related Macular Degeneration, Alzheimer Disease, and Dementia
Keenan, T. D. L., Goldacre, R., & Goldacre, M. J. (2013) · JAMA Ophthalmology · doi:10.1001/jamaophthalmol.2013.5696 · Cited by 107 · see citing works
Human Plasma Metabolomics Study across All Stages of Age-Related Macular Degeneration Identifies Potential Lipid Biomarkers
Laíns, I., Kelly, R. S., Miller, J. B., da Silva, R. M., Vavvas, D. G., Kim, I. K., Murta, J., Lasky-Su, J. A., Miller, J. W., & Husain, D. (2017) · Ophthalmology · doi:10.1016/j.ophtha.2017.08.008 · Cited by 109 · see citing works
Vitamin D rejuvenates aging eyes by reducing inflammation, clearing amyloid beta and improving visual function
Lee, V., Rekhi, E., Kam, J. H., & Jeffery, G. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.12.002 · Cited by 104 · see citing works
Retinal ganglion cell dendritic degeneration in a mouse model of Alzheimer's disease
Williams, P. A., Thirgood, R. A., Oliphant, H., Frizzati, A., Littlewood, E., Votruba, M., Good, M. A., Williams, J. H., & Morgan, J. E. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.01.006 · Cited by 104 · see citing works
Macular Pigment, Visual Function, and Macular Disease among Subjects with Alzheimer's Disease: An Exploratory Study
Nolan, J. M., Loskutova, E., Howard, A. N., Moran, R., Mulcahy, R., Stack, J., Bolger, M., Dennison, J. L., Akuffo, K. O., Owens, N., et al. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-140507 · Cited by 102 · see citing works
Sacubitril/valsartan: beyond natriuretic peptides
Singh, J. S., Burrell, L. M., Cherif, M., Squire, I. B., Clark, A. L., & Lang, C. C. (2017) · Heart · doi:10.1136/heartjnl-2017-311295 · Cited by 100 · see citing works
Cell Cycle Deficits in Neurodegenerative Disorders: Uncovering Molecular Mechanisms to Drive Innovative Therapeutic Development
Joseph, C., Mangani, A. S., Gupta, V. B., Chitranshi, N., Shen, T., Dheer, Y., Devaraj, K. B., Mirzaei, M., You, Y., Graham, S. L., et al. (2020) · Aging and Disease · doi:10.14336/ad.2019.0923 · Cited by 97 · see citing works
Senescence-accelerated OXYS rats: A model of age-related cognitive decline with relevance to abnormalities in Alzheimer disease
Stefanova, N. A., Kozhevnikova, O. S., Vitovtov, A. O., Maksimova, K. Y., Logvinov, S. V., Rudnitskaya, E. A., Korbolina, E. E., Muraleva, N. A., & Kolosova, N. G. (2014) · Cell Cycle · doi:10.4161/cc.28255 · Cited by 97 · see citing works
Vision function abnormalities in Alzheimer disease
Tzekov, R., & Mullan, M. (2014) · Survey of Ophthalmology · doi:10.1016/j.survophthal.2013.10.002 · Cited by 94 · see citing works
Peripheral Retinal Imaging Biomarkers for Alzheimer’s Disease: A Pilot Study
Csincsik, L., MacGillivray, T., Flynn, E. F., Pellegrini, E., Papanastasiou, G., Barzegar-Befroei, N., Csutak, A., Bird, A. C., Ritchie, C. W., Pető, T., et al. (2018) · Ophthalmic Research · doi:10.1159/000487053 · Cited by 89 · see citing works
Interplay between aging and other factors of the pathogenesis of age-related macular degeneration
Błasiak, J., Sobczuk, P., Pawłowska, E., & Kaarniranta, K. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101735 · Cited by 83 · see citing works
Using magnetic resonance imaging to assess visual deficits: a review
Brown, H. D. H., Woodall, R., Kitching, R. E., Baseler, H. A., & Morland, A. B. (2016) · Ophthalmic and Physiological Optics · doi:10.1111/opo.12293 · Cited by 80 · see citing works
Morphometric analyses of the visual pathways in macular degeneration
Hernowo, A. T., Prins, D., Baseler, H. A., Plank, T., Gouws, A. D., Hooymans, J. M. M., Morland, A. B., Greenlee, M. W., & Cornelissen, F. W. (2013) · Cortex · doi:10.1016/j.cortex.2013.01.003 · Cited by 79 · see citing works
Neurodegeneration in Alzheimer’s disease and glaucoma: overlaps and missing links
Sen, S., Saxena, R., Tripathi, M., Vibha, D., & Dhiman, R. (2020) · Eye · doi:10.1038/s41433-020-0836-x · Cited by 79 · see citing works
Amyloid-β and Tau Pathology of Alzheimer's Disease Induced by Diabetes in a Rabbit Animal Model
Bitel, C. L., Kasinathan, C., Kaswala, R. H., Klein, W. L., & Frederikse, P. H. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-120571 · Cited by 77 · see citing works
Intracellular amyloid beta alters the tight junction of retinal pigment epithelium in 5XFAD mice
Park, S. W., Kim, J. H., Mook‐Jung, I., Kim, K.-W., Park, W. J., Park, K. H., & Kim, J. H. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.03.008 · Cited by 76 · see citing works
Identification of anti-retinal antibodies in patients with age-related macular degeneration
Morohoshi, K., Ohbayashi, M., Patel, N., Chong, V. N., Bird, A. C., & Ono, S. J. (2012) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2012.03.007 · Cited by 77 · see citing works
Protective Mechanisms of the Mitochondrial‐Derived Peptide Humanin in Oxidative and Endoplasmic Reticulum Stress in RPE Cells
Minasyan, L., Sreekumar, P. G., Hinton, D. R., & Kannan, R. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/1675230 · Cited by 77 · see citing works
Supplemental Retinal Carotenoids Enhance Memory in Healthy Individuals with Low Levels of Macular Pigment in A Randomized, Double-Blind, Placebo-Controlled Clinical Trial
Power, R., Coen, R. F., Beatty, S., Mulcahy, R., Moran, R., Stack, J., Howard, A. N., & Nolan, J. M. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-170713 · Cited by 76 · see citing works
Cholesterol-enriched diet causes age-related macular degeneration-like pathology in rabbit retina
Dasari, B., Prasanthi, J. R. P., Marwarha, G., Singh, B. B., & Ghribi, O. (2011) · BMC Ophthalmology · doi:10.1186/1471-2415-11-22 · Cited by 74 · see citing works
Up-Regulation of miRNA-146a in Progressive, Age-Related Inflammatory Neurodegenerative Disorders of the Human CNS
Alexandrov, P. N., Dua, P., & Lukiw, W. J. (2014) · Frontiers in Neurology · doi:10.3389/fneur.2014.00181 · Cited by 72 · see citing works
Age-Related Macular Degeneration and Risk of Degenerative Dementia among the Elderly in Taiwan
Tsai, D., Chen, S., Huang, C., Yuan, M.-K., & Leu, H. (2015) · Ophthalmology · doi:10.1016/j.ophtha.2015.07.033 · Cited by 69 · see citing works
Quantification of Histone Deacetylase Isoforms in Human Frontal Cortex, Human Retina, and Mouse Brain
Anderson, K. W., Chen, J., Wang, M., Mast, N., Pikuleva, I. A., & Turko, I. V. (2015) · PLoS ONE · doi:10.1371/journal.pone.0126592 · Cited by 69 · see citing works
Age-dependent changes in heparan sulfate in human Bruch’s membrane: Implications for age-related macular degeneration
Keenan, T. D. L., Pickford, C. E., Holley, R. J., Clark, S. J., Lin, W., Dowsey, A. W., Merry, C. L., Day, A. J., & Bishop, P. N. (2014) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.14-14126 · Cited by 65 · see citing works
One protein, multiple pathologies: multifaceted involvement of amyloid β in neurodegenerative disorders of the brain and retina
Gupta, V., Gupta, V. B., Chitranshi, N., Gangoda, S. V. S., Wall, R. V., Abbasi, M., Golzan, M., Dheer, Y., Shah, T. M., Avolio, A. P., et al. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2295-x · Cited by 69 · see citing works
Recent developments in the management of dry age-related macular degeneration
Buschini, E., Zola, M., Fea, A. M., Lavia, C. A., Nassisi, M., Pignata, G., & Grignolo, F. M. (2015) · Clinical ophthalmology · doi:10.2147/opth.s59724 · Cited by 67 · see citing works
microRNAs in Neurodegeneration: Current Findings and Potential Impacts
Sharma, S., & Lu, H. (2018) · Journal of Alzheimer’s Disease & Parkinsonism · doi:10.4172/2161-0460.1000420 · Cited by 66 · see citing works
The Dry Form of Age-Related Macular Degeneration (AMD): The Current Concepts of Pathogenesis and Prospects for Treatment
Zając-Pytrus, H. M., Pilecka, A., Turno‐Kręcicka, A., Adamiec-Mroczek, J., & Misiuk‐Hojło, M. (2015) · Advances in Clinical and Experimental Medicine · doi:10.17219/acem/27093 · Cited by 65 · see citing works
Potential retinal biomarkers for dementia: what is new?
Cheung, C. Y.-L., Chan, V. T. T., Mok, V., Chen, C., & Wong, T. Y. (2018) · Current Opinion in Neurology · doi:10.1097/wco.0000000000000645 · Cited by 64 · see citing works
Beta-Amyloid Precursor Protein (βAPP) Processing in Alzheimer’s Disease (AD) and Age-Related Macular Degeneration (AMD)
Zhao, Y., Bhattacharjee, S., Jones, B. M., Hill, J. M., Clément, C., Sambamurti, K., Dua, P., & Lukiw, W. J. (2014) · Molecular Neurobiology · doi:10.1007/s12035-014-8886-3 · Cited by 63 · see citing works
The role of epigenetics in age-related macular degeneration
Gemenetzi, M. K., & Lotery, A. J. (2014) · Eye · doi:10.1038/eye.2014.225 · Cited by 62 · see citing works
Beta-amyloid sequelae in the eye: a critical review on its diagnostic significance and clinical relevance in Alzheimer’s disease
Shah, T. M., Gupta, S. M., Chatterjee, P., Campbell, M., & Martins, R. N. (2017) · Molecular Psychiatry · doi:10.1038/mp.2016.251 · Cited by 61 · see citing works
Complement dysregulation in AMD: RPE-Bruch’s membrane-choroid
Sparrow, J. R., Ueda, K., & Zhou, J. (2012) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2012.03.007 · Cited by 58 · see citing works
Not All Stressors Are Equal: Mechanism of Stressors on RPE Cell Degeneration
Tong, Y., & Wang, S. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.591067 · Cited by 54 · see citing works
Visual Features in Alzheimer’s Disease: From Basic Mechanisms to Clinical Overview
Cerquera-Jaramillo, M. A., Nava-Mesa, M. O., González-Reyes, R. E., Téllez-Conti, C., & de‐la‐Torre, A. (2018) · Neural Plasticity · doi:10.1155/2018/2941783 · Cited by 54 · see citing works
P2X7-pannexin-1 and amyloid β-induced oxysterol input in human retinal cell: Role in age-related macular degeneration?
Olivier, E., Dutot, M., Regazzetti, A., Léguillier, T., Dargère, D., Auzeil, N., Laprévôte, O., & Rat, P. (2016) · Biochimie · doi:10.1016/j.biochi.2016.04.014 · Cited by 53 · see citing works
Ocular Carotenoid Status in Health and Disease
Sauer, L., Li, B., & Bernstein, P. S. (2019) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-082018-124555 · Cited by 52 · see citing works
Hyperphosphorylation of tau protein by calpain regulation in retina of Alzheimer's disease transgenic mouse
Zhao, H., Chang, R., Che, H., Wang, J., Yang, L., Wei, F., Xia, Y., Li, N., Ma, Q., & Wang, X. (2013) · Neuroscience Letters · doi:10.1016/j.neulet.2013.06.026 · Cited by 52 · see citing works
Whole-exome sequencing implicates UBE3D in age-related macular degeneration in East Asian populations
Huang, L., Li, Y., Xie, X., Zhang, J., Cheng, C., Yamashiro, K., Chen, L., Ma, X., Cheung, C. M. G., Wang, Y.-S., et al. (2015) · Nature Communications · doi:10.1038/ncomms7687 · Cited by 51 · see citing works
Understanding AMD by analogy: systematic review of lipid-related common pathogenic mechanisms in AMD, AD, AS and GN
Xu, Q., Cao, S., Rajapakse, S., & Matsubara, J. A. (2018) · Lipids in Health and Disease · doi:10.1186/s12944-017-0647-7 · Cited by 52 · see citing works
The eye as a model of ageing in translational research – Molecular, epigenetic and clinical aspects
Pathai, S., Shiels, P. G., Lawn, S. D., Cook, C., & Gilbert, C. E. (2012) · Ageing Research Reviews · doi:10.1016/j.arr.2012.11.002 · Cited by 50 · see citing works
Cytoprotective Potential of Fucoxanthin in Oxidative Stress-Induced Age-Related Macular Degeneration and Retinal Pigment Epithelial Cell Senescence In Vivo and In Vitro
Chen, S., Lin, T., Peng, H., Liu, H.-J., Lee, A., Lin, C., & Tseng, K. (2021) · Marine Drugs · doi:10.3390/md19020114 · Cited by 49 · see citing works
Interactions between Apolipoprotein E Metabolism and Retinal Inflammation in Age-Related Macular Degeneration
Hu, M. L., Quinn, J., & Xue, K. (2021) · Life · doi:10.3390/life11070635 · Cited by 50 · see citing works
The Prevalence of Age-Related Macular Degeneration in Alzheimer's Disease
Williams, M. A., Silvestri, V., Craig, D., Passmore, A. P., & Silvestri, G. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-140243 · Cited by 48 · see citing works
Detection of retinal nerve fiber layer degeneration in patients with Alzheimer's disease using optical coherence tomography: searching new biomarkers
BAMBO, M., García‐Martín, E., Pinilla, J., Herrero, R., Satué, M., Otín, S., Fuertes, I., Marques, M. L., & Pablo, L. E. (2014) · Acta Ophthalmologica · doi:10.1111/aos.12374 · Cited by 48 · see citing works
Retinal thickness as a potential biomarker in patients with amyloid‐proven early‐ and late‐onset Alzheimer's disease
den Haan, J., van de Kreeke, J. A., Konijnenberg, E., ten Kate, M., den Braber, A., Barkhof, F., van Berckel, B. N. M., Teunissen, C. E., Scheltens, P., Visser, P. J., et al. (2019) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1016/j.dadm.2019.05.002 · Cited by 48 · see citing works
Determination of Zn, Cu and Fe in human patients' serum using micro-sampling ICP-MS and sample dilution
Abduljabbar, T. N., Sharp, B. L., Reid, H. J., Barzegar-Befroei, N., Pető, T., & Lengyel, I. (2019) · Talanta · doi:10.1016/j.talanta.2019.05.098 · Cited by 47 · see citing works
MicroRNAs in the regulation of autophagy and their possible use in age-related macular degeneration therapy
Hyttinen, J. M. T., Błasiak, J., Felszeghy, S., & Kaarniranta, K. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101260 · Cited by 47 · see citing works
Correlation between visual acuity and cognitive functions
Elyashiv, S. M., Shabtai, E. L., & Belkin, M. (2013) · British Journal of Ophthalmology · doi:10.1136/bjophthalmol-2013-304149 · Cited by 46 · see citing works
Is the Eye an Extension of the Brain in Central Nervous System Disease?
Groef, L. D., & Cordeiro, M. F. (2017) · Journal of Ocular Pharmacology and Therapeutics · doi:10.1089/jop.2016.0180 · Cited by 45 · see citing works
In-silico simulated prototype-patients using TPMS technology to study a potential adverse effect of sacubitril and valsartan
Jorba, G., Aguirre‐Plans, J., Junet, V., Segú-Vergés, C., Ruiz, J. L., Pujol, A., Fernández‐Fuentes, N., Mas, J. M., & Oliva, B. (2020) · PLoS ONE · doi:10.1371/journal.pone.0228926 · Cited by 45 · see citing works
α‐Tocopheryl phosphate—An activated form of vitamin E important for angiogenesis and vasculogenesis?
Zingg, J.-M. A., Meydani, M., & Azzi, A. (2012) · BioFactors · doi:10.1002/biof.198 · Cited by 45 · see citing works
Valsartan/Sacubitril for Heart Failure
Feldman, A. M., Haller, J. A., & DeKosky, S. T. (2015) · JAMA · doi:10.1001/jama.2015.17632 · Cited by 41 · see citing works
Oral administration of ferulic acid or ethyl ferulate attenuates retinal damage in sodium iodate-induced retinal degeneration mice
Kohno, M., Musashi, K., Ikeda, H. O., Horibe, T., Matsumoto, A., & Kawakami, K. (2020) · Scientific Reports · doi:10.1038/s41598-020-65673-y · Cited by 40 · see citing works
1,25-Dihydroxyvitamin D decreases HTRA1 promoter activity in the rhesus monkey – A plausible explanation for the influence of vitamin D on age-related macular degeneration?
Pahl, L., Schubert, S., Skawran, B., Sandbothe, M., Schmidtke, J., & Stuhrmann, M. (2013) · Experimental Eye Research · doi:10.1016/j.exer.2013.09.012 · Cited by 39 · see citing works
Increased Expression of CD200 on Circulating CD11b+ Monocytes in Patients with Neovascular Age-related Macular Degeneration
Singh, A., Falk, M. K., Hviid, T. V. F., & Sørensen, T. L. (2013) · Ophthalmology · doi:10.1016/j.ophtha.2012.11.002 · Cited by 40 · see citing works
The contribution of optical coherence tomography in neurodegenerative diseases
Simão, L. M. (2013) · Current Opinion in Ophthalmology · doi:10.1097/icu.0000000000000000 · Cited by 39 · see citing works
The complexities underlying age-related macular degeneration: could amyloid beta play an important role?
Ratnayaka, J. A., Lynn, S. A., Keeling, E., Munday, R., Gabha, G., Griffiths, H., & Lotery, A. J. (2017) · Neural Regeneration Research · doi:10.4103/1673-5374.205083 · Cited by 39 · see citing works
Iron increases APP translation and amyloid-beta production in the retina
Guo, L. Y., Alekseev, O., Li, Y., Song, Y., & Dunaief, J. L. (2014) · Experimental Eye Research · doi:10.1016/j.exer.2014.10.012 · Cited by 37 · see citing works
Nerve Growth Factor-Based Therapy in Alzheimer’s Disease and Age-Related Macular Degeneration
Amadoro, G., Latina, V., Balzamino, B. O., Squitti, R., Varano, M., Calissano, P., & Micera, A. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.735928 · Cited by 40 · see citing works
Biological basis for amyloidogenesis in Alzheimer’S disease
Андреева, Т. В., Lukiw, W. J., & Rogaev, E. I. (2017) · Biochemistry (Moscow) · doi:10.1134/s0006297917020043 · Cited by 36 · see citing works
Retinal Dysfunction in Alzheimer’s Disease and Implications for Biomarkers
Liao, C., Xu, J., Chen, Y., & Ip, N. Y. (2021) · Biomolecules · doi:10.3390/biom11081215 · Cited by 36 · see citing works
Association of AMD-like retinopathy development with an Alzheimer’s disease metabolic pathway in OXYS rats
Kozhevnikova, O. S., Korbolina, E. E., Stefanova, N. A., Muraleva, N. A., Orlov, Y. L., & Kolosova, N. G. (2013) · Biogerontology · doi:10.1007/s10522-013-9439-2 · Cited by 35 · see citing works

Complement proteins and complement inhibitors in Alzheimer's disease
McGeer, P. L., & McGeer, E. G. (1992) · Research in Immunology · doi:10.1016/0923-2494(92)80045-m · Cited by 57 · see citing works
Associations of Alzheimer rsquo s disease with macular degeneration
Parnetti, L. (2016) · Frontiers in Bioscience-Elite · doi:10.2741/e794 · Cited by 38 · see citing works
Age-Related Macular Degeneration and Its Association With Neurodegenerative Disorders
Mody, S., & Joshi, A. (2023) · Cureus · doi:10.7759/cureus.34920 · Cited by 13 · see citing works
Age‐related macular degeneration; an Alzheimer’s disease in the eye?
Ohno‐Matsui, K. (2009) · Acta Ophthalmologica · doi:10.1111/j.1755-3768.2009.378.x · Cited by 4 · see citing works
Self-citation
Targeting age-related macular degeneration with Alzheimer’s disease based immunotherapies: Anti-amyloid-β antibody attenuates pathologies in an age-related macular degeneration mouse model
Ding, J., Lin, J. C., Mace, B. E., Herrmann, R., Sullivan, P. M., & Rickman, C. B. (2007) · Vision Research · doi:10.1016/j.visres.2007.07.025 · Cited by 97 · see citing works

Authors: Ohno-Matsui, K.
Venue: Progress in Retinal and Eye Research
Publisher: Elsevier BV
Published: 2011-07
Volume: 30
Issue: 4
Pages: 217-238
ISSN: 1350-9462 (ISSN-L)
DOI: 10.1016/j.preteyeres.2011.02.004
OpenAlex: W2025313923
Cited by: 280
References: 198
Citations by year: 2026: 13 · 2025: 14 · 2024: 18 · 2023: 16 · 2022: 18 · 2021: 20 · 2020: 22 · 2019: 14 · 2018: 19 · 2017: 26 · 2016: 17 · 2015: 18 · 2014: 24 · 2013: 26 · 2012: 14
FWCI: 3.54
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Progress in Retinal and Eye Research (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Retinal Imaging and Analysis
Keywords: age-related macular degeneration, Alzheimer's disease, amyloid-beta, drusen, amyloid plaques, retinal pigment epithelium, angiogenesis, neprilysin, shared pathogenesis, age-related diseases
MeSH terms: Alzheimer Disease, Animals, Eye Proteins, Gene Expression Regulation, Humans, Macular Degeneration, Retina, Retinal Drusen, Amyloid beta-Peptides, Amyloid beta-Protein Precursor, Mice, Plaque, Amyloid

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Parallel findings in age-related macular degeneration and Alzheimer’s disease

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks