Sensing DNA Damage Through ATRIP Recognition of RPA-ssDNA Complexes
Zou, Lee, Elledge, Stephen J.·2003·Science
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- G2 checkpoint abrogation and checkpoint kinase-1 targeting in the treatment of cancerN Bucher, Carolyn D. Britten · 2008 · British Journal of Cancer
- Everything You Ever Wanted to Know About Saccharomyces cerevisiae Telomeres: Beginning to EndRaymund J. Wellinger, Virginia A. Zakian · 2012 · Genetics
- RPA and RAD51: fork reversal, fork protection, and genome stabilityKamakoti P. Bhat, David Cortez · 2018 · Nature Structural & Molecular Biology
- Dial 9–1–1 for DNA damage: the Rad9–Hus1–Rad1 (9–1–1) clamp complexParrilla-Castellar, Edgardo R., Arlander, Sonnet J.H., Karnitz, Larry · 2004 · DNA Repair
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- Targeting ATR in cancerEmilio Lecona, Óscar Fernández-Capetillo · 2018 · Nature reviews. Cancer
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- ATR signalling: more than meeting at the forkNam, Edward A., Cortez, David · 2011 · Biochemical Journal
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- Increased mobility of double-strand breaks requires Mec1, Rad9 and the homologous recombination machineryVincent Dion, Véronique Kalck, Chihiro Horigome, Benjamin D. Towbin, Susan M. Gasser · 2012 · Nature Cell Biology
- RNF4, a SUMO-targeted ubiquitin E3 ligase, promotes DNA double-strand break repairGalanty, Yaron, Belotserkovskaya, Rimma, Coates, Julia, Jackson, Stephen P. · 2012 · Genes & Development
- Chromatin remodelling beyond transcription: the INO80 and SWR1 complexesAshby J. Morrison, Xuetong Shen · 2009 · Nature Reviews Molecular Cell Biology
- Break-Induced Replication and Recombinational Telomere Elongation in YeastMichael J. McEachern, James E. Haber · 2006 · Annual Review of Biochemistry
- DNA mismatch repair and the DNA damage responseZhongdao Li, Alexander H. Pearlman, Peggy Hsieh · 2015 · DNA repair
- Chk1 promotes replication fork progression by controlling replication initiationPetermann, Eva, Woodcock, Mick, Helleday, Thomas · 2010 · Proceedings of the National Academy of Sciences
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- A mitosis-specific and R loop–driven ATR pathway promotes faithful chromosome segregationLilian Kabeche, Hai Dang Nguyen, Rémi Buisson, Lee Zou · 2017 · Science
- Replication Protein A phosphorylation and the cellular response to DNA damageBinz, Sara K., Sheehan, Anne M., Wold, Marc S. · 2004 · DNA Repair
- Emerging common themes in regulation of PIKKs and PI3KsHarri Lempiäinen, Thanos D. Halazonetis · 2009 · The EMBO Journal
- Repair of and checkpoint response to topoisomerase I-mediated DNA damageYves G. Pommier, Christophe Redon, V.Ashutosh Rao, Jennifer A Seiler, Olivier Sordet, Haruyuki Takemura, Smitha Antony, LingHua Meng, ZhiYong Liao, Glenda Kohlhagen et al. · 2003 · Mutation research. Fundamental and molecular mechanisms of mutagenesis
- Effects of hyperthermia on DNA repair pathways: one treatment to inhibit them allArlene L. Oei, Lianne E. M. Vriend, Johannes Crezee, Nicolaas A.P. Franken, Przemek M. Krawczyk · 2015 · Radiation Oncology
- Rad51-dependent DNA structures accumulate at damaged replication forks in sgs1 mutants defective in the yeast ortholog of BLM RecQ helicaseGiordano Liberi, Giulio Maffioletti, Chiara Lucca, Irene Chiolo, Anastasia Baryshnikova, Cecilia Cotta‐Ramusino, Massimo Lopes, Achille Pellicioli, James E. Haber, Marco Foiani · 2005 · Genes & Development
- Targeting DNA damage response in cancer therapyNoriko Hosoya, Kiyoshi Miyagawa · 2014 · Cancer Science
- Rapid Activation of ATR by Ionizing Radiation Requires ATM and Mre11Jeremy S. Myers, David Cortez · 2006 · Journal of Biological Chemistry
- RPA-like proteins mediate yeast telomere functionHua Gao, Rachel B. Cervantes, Edward K. Mandell, Joel H. Otero, Victoria Lundblad · 2007 · Nature Structural & Molecular Biology
- ATR: a master conductor of cellular responses to DNA replication stressFlynn, Rachel Litman, Zou, Lee · 2011 · Trends in Biochemical Sciences
- Human USP3 Is a Chromatin Modifier Required for S Phase Progression and Genome StabilityFrancesco Nicassio, Nadia Corrado, Joseph H.A. Vissers, Liliana B. Areces, Steven Bergink, Jurgen A. F. Marteijn, Bart Geverts, Adriaan B. Houtsmuller, Wim Vermeulen, Pier Paolo Di Fiore et al. · 2007 · Current Biology
- The same, only different – DNA damage checkpoints and their reversal throughout the cell cycleIndra A. Shaltiël, Lenno Krenning, Wytse Bruinsma, René H. Medema · 2015 · Journal of Cell Science
- ATR Kinase Activation Mediated by MutSα and MutLα in Response to Cytotoxic O6-Methylguanine AdductsYoshioka, Ken-ichi, Yoshioka, Yoshiko, Hsieh, Peggy · 2006 · Molecular Cell
- Chromatin dynamics and the preservation of genetic informationJessica A. Downs, Michel C. Nussenzweig, André Nussenzweig · 2007 · Nature
- ATR Regulates a G2-Phase Cell-Cycle Checkpoint in Arabidopsis thalianaKevin M. Culligan, Alain F. Tissier, Anne Britt · 2004 · The Plant Cell
- Translesion DNA Synthesis and Mutagenesis in EukaryotesSale, J. E. · 2013 · Cold Spring Harbor Perspectives in Biology
- ATR autophosphorylation as a molecular switch for checkpoint activationLiu, Shizhou, Shiotani, Bunsyo, Lahiri, Mayurika, Maréchal, Alexandre, Tse, Alice, Leung, Charles Chung Yun, Glover, J.N. Mark, Yang, Xiaohong H., Zou, Lee · 2011 · Molecular Cell
- Activation of Ubiquitin-Dependent DNA Damage Bypass Is Mediated by Replication Protein AAdelina A. Davies, Diana Huttner, Yasukazu Daigaku, Shuhua Chen, Helle D. Ulrich · 2008 · Molecular Cell
- The Rad9-Hus1-Rad1 Checkpoint Clamp Regulates Interaction of TopBP1 with ATRJoon Lee, Akiko Kumagai, William G. Dunphy · 2007 · Journal of Biological Chemistry
- The Fanconi anemia pathway is required for the DNA replication stress response and for the regulation of common fragile site stabilityNiall G. Howlett, Toshiyasu Taniguchi, Sandra G. Durkin, Alan D. D’Andrea, Thomas W. Glover · 2005 · Human Molecular Genetics
- Common mechanisms of PIKK regulationLovejoy, Courtney A., Cortez, David · 2009 · DNA Repair
- Functional links between telomeres and proteins of the DNA-damage responsed'Adda di Fagagna, Fabrizio, Teo, Soo-Hwang, Jackson, Stephen P. · 2004 · Genes & Development
- DNA repair mechanisms in plants: crucial sensors and effectors for the maintenance of genome integrityClifford M. Bray, Christopher E. West · 2005 · New Phytologist
- ATM and ATR signaling at a glancePoorwa Awasthi, Marco Foiani, Amit Kumar · 2015 · Journal of Cell Science
- DNA Damage Response Genes and the Development of Cancer MetastasisConstantinos G. Broustas, Howard B. Lieberman · 2014 · Radiation Research
- ATM, ATR and DNA-PK: initiators of the cellular genotoxic stress responsesH. J. Yang · 2003 · Carcinogenesis
- Functions of Replication Protein A as a Sensor of R Loops and a Regulator of RNaseH1Hai Dang Nguyen, Tribhuwan Yadav, Sumanprava Giri, Borja Sáez, Timothy Aaron Graubert, Lee Zou · 2017 · Molecular Cell
- RIF1 Counteracts BRCA1-mediated End Resection during DNA RepairLin Feng, Ka-wing Fong, Jiadong Wang, Wenqi Wang, Junjie Chen · 2013 · Journal of Biological Chemistry
- Molecular Pathways: Targeting ATR in Cancer TherapyLarry M. Karnitz, Lee Zou · 2015 · Clinical Cancer Research
- RPA Coordinates DNA End Resection and Prevents Formation of DNA HairpinsHuan Chen, Michael Lisby, Lorraine S. Symington · 2013 · Molecular Cell
- Loss of Geminin induces rereplication in the presence of functional p53Marina B. Melixetian, Andrea Ballabeni, Laura Masiero, Patrizia Gasparini, Raffaella Zamponi, Jiří Bártek, Jiri Lukas, Kristian Helin · 2004 · The Journal of Cell Biology
- Gross Chromosomal Rearrangements and Elevated Recombination at an Inducible Site-Specific Replication Fork BarrierSarah Lambert, Adam T. Watson, Daniel M. Sheedy, B.R. Martin, Antony M. Carr · 2005 · Cell
- Heterochromatin is refractory to γ-H2AX modification in yeast and mammalsJung‐Ae Kim, Michael J. Kruhlak, Farokh Dotiwala, André Nussenzweig, James E. Haber · 2007 · The Journal of Cell Biology
- Oxidative stress and DNA damage after cerebral ischemia: Potential therapeutic targets to repair the genome and improve stroke recoveryPeiying Li, Ruth Anne Stetler, Rehana K. Leak, Yejie Shi, Yan Li, Weifeng Yu, Michael V. L. Bennett, Jun Chen · 2017 · Neuropharmacology
- Distinct roles for DNA-PK, ATM and ATR in RPA phosphorylation and checkpoint activation in response to replication stressShuli Liu, Stephen O. Opiyo, Karoline C. Manthey, Jason G. Glanzer, Amanda K. Ashley, Courtney L. Amerin, Kyle A. Troksa, Meena Shrivastav, Jac A. Nickoloff, Greg G. Oakley · 2012 · Nucleic Acids Research
- Dysfunctional telomeres activate an ATM‐ATR‐dependent DNA damage response to suppress tumorigenesisGuo, Xiaolan, Deng, Yibin, Lin, Yahong, Cosme‐Blanco, Wilfredo, Chan, Suzanne, He, Hua, Yuan, Guohua, Brown, Eric J, Chang, Sandy · 2007 · The EMBO Journal
- ETAA1 acts at stalled replication forks to maintain genome integrityThomas E. Bass, Jessica W. Luzwick, Gina M. Kavanaugh, Clinton M. Carroll, Huzefa Dungrawala, Gloria G. Glick, Michael D. Feldkamp, Reid Putney, Walter Chazin, David Cortez · 2016 · Nature Cell Biology
- Replication protein A: Single‐stranded DNA's first responderRan Chen, Marc S. Wold · 2014 · BioEssays
- Mechanisms Used by Plants to Cope with DNA DamageZhubing Hu, Toon Cools, Lieven De Veylder · 2015 · Annual Review of Plant Biology
- The ATR pathway: Fine-tuning the forkR PAULSEN, Karlene A. Cimprich · 2007 · DNA repair
- Telomere and its role in the aging pathways: telomere shortening, cell senescence and mitochondria dysfunctionZhu, Yukun, Liu, Xuewen, Ding, Xuelu, Wang, Fei, Geng, Xin · 2019 · Biogerontology
- Activation of the ATR kinase by the RPA-binding protein ETAA1Peter Haahr, Saskia Hoffmann, Maxim A. X. Tollenaere, Teresa Ho, Luis Ignacio Toledo, Matthias Mann, Simon Bekker‐Jensen, Markus Räschle, Niels Mailand · 2016 · Nature Cell Biology
- BRCA1 Accelerates CtIP-Mediated DNA-End ResectionAndrés Cruz-García, Ana López-Saavedra, Pablo Huertas · 2014 · Cell Reports
- Replication stress: getting back on trackMatteo Berti, Alessandro Vindigni · 2016 · Nature Structural & Molecular Biology
- Heterochromatic breaks move to the nuclear periphery to continue recombinational repairTaehyun Ryu, Brett N. Spatola, Lætitia Delabaere, Katherine Bowlin, Hannah Hopp, Ryan C. Kunitake, Gary H. Karpen, Irene Chiolo · 2015 · Nature Cell Biology
- Functional interplay between ATM/ATR-mediated DNA damage response and DNA repair pathways in oxidative stressYan, Shan, Sorrell, Melanie, Berman, Zachary · 2014 · Cellular and Molecular Life Sciences
- Mismatch repair-dependent G<sub>2</sub> checkpoint induced by low doses of S<sub>N</sub>1 type methylating agents requires the ATR kinaseStojic, Lovorka, Mojas, Nina, Cejka, Petr, di Pietro, Massimiliano, Ferrari, Stefano, Marra, Giancarlo, Jiricny, Josef · 2004 · Genes & Development
- Nucleoside analogs: molecular mechanisms signaling cell deathBrett Ewald, Deepa Sampath, William K. Plunkett · 2008 · Oncogene
- PRP19 Transforms into a Sensor of RPA-ssDNA after DNA Damage and Drives ATR Activation via a Ubiquitin-Mediated CircuitryAlexandre Maréchal, Ju-Mei Li, Xiao Ye Ji, Ching-Shyi Peter Wu, Stephanie A. Yazinski, Hai Dang Nguyen, Shizhou Liu, Amanda E. Jiménez, Jianping Jin, Lee Zou · 2013 · Molecular Cell
- Roles of Oxidative Stress and Nrf2 Signaling in Pathogenic and Non-Pathogenic Cells: A Possible General Mechanism of Resistance to TherapyMira Hammad, Mohammad Raftari, Rute Cesário, Rima Salma, Paulo R. D. V. Godoy, Seyedeh Noushin Emami, Siamak Haghdoost · 2023 · Antioxidants
- Advances in Understanding the Complex Mechanisms of DNA Interstrand Cross-Link RepairCheryl L. Clauson, Orlando D. Schärer, Laura J. Niedernhofer · 2013 · Cold Spring Harbor Perspectives in Biology
- Chromatin and the genome integrity networkManolis Papamichos‐Chronakis, Craig L. Peterson · 2012 · Nature Reviews Genetics
- The NuRD chromatin–remodeling complex regulates signaling and repair of DNA damageSmeenk, Godelieve, Wiegant, Wouter W., Vrolijk, Hans, Solari, Aldo P., Pastink, Albert, van Attikum, Haico · 2010 · Journal of Cell Biology
- ATRIP Binding to Replication Protein A-Single-stranded DNA Promotes ATR–ATRIP Localization but Is Dispensable for Chk1 PhosphorylationHeather L. Ball, Jeremy S. Myers, David Cortez · 2005 · Molecular Biology of the Cell
- The orally active and bioavailable ATR kinase inhibitor AZD6738 potentiates the anti-tumor effects of cisplatin to resolve ATM-deficient non-small cell lung cancerin vivoFrank P. Vendetti, Alan Lau, Sandra Schamus, Thomas P. Conrads, Mark J. O’Connor, Christopher J. Bakkenist · 2015 · Oncotarget
- The structural determinants of checkpoint activationMacDougall, Christina A., Byun, Tony S., Van, Christopher, Yee, Muh-ching, Cimprich, Karlene A. · 2007 · Genes & Development
- The DNA damage response during DNA replicationDana Branzei, Marco Foiani · 2005 · Current Opinion in Cell Biology
- Saccharomyces cerevisiae Rad9 acts as a Mec1 adaptor to allow Rad53 activationSweeney, Frédéric D., Yang, Feng, Chi, An, Shabanowitz, Jeffrey, Hunt, Donald F., Durocher, Daniel · 2005 · Current Biology
- DNA damage tumor suppressor genes and genomic instabilityNoboru Motoyama, Kazuhito Naka · 2003 · Current Opinion in Genetics & Development
- How DNA lesions are turned into powerful killing structures: Insights from UV-induced apoptosisBatista, Luís F.Z., Kaina, Bernd, Meneghini, Rogério, Menck, Carlos F.M. · 2009 · Mutation Research/Reviews in Mutation Research
- Break dosage, cell cycle stage and DNA replication influence DNA double strand break responseChristian Zierhut, John F.X. Diffley · 2008 · The EMBO Journal
- ATR Mediates a Checkpoint at the Nuclear Envelope in Response to Mechanical StressAmit Kumar, Michele Mazzanti, Martin Mistrík, Martin Košař, Galina V. Beznoussenko, Alexandre Mironov, Massimiliano Garrè, Dario Parazzoli, G. V. Shivashankar, Giorgio Scita et al. · 2014 · Cell
- Nucleolus as an emerging hub in maintenance of genome stability and cancer pathogenesisMikael S. Lindström, Deana Jurada, Slađana Bursać, Ines Oršolić, Jiří Bártek, Siniša Volarević · 2018 · Oncogene
- Repair and tolerance of oxidative DNA damage in plantsTeresa Roldán‐Arjona, Rafael R. Ariza · 2008 · Mutation Research/Reviews in Mutation Research
- Release of Ku and MRN from DNA Ends by Mre11 Nuclease Activity and Ctp1 Is Required for Homologous Recombination Repair of Double-Strand BreaksPetra Langerak, Eva Mejía-Ramírez, Oliver Limbo, Paul R. Russell · 2011 · PLoS Genetics
- CtIP Links DNA Double-Strand Break Sensing to ResectionYou, Zhongsheng, Shi, Linda Z., Zhu, Quan, Wu, Peng, Zhang, You-Wei, Basilio, Andrew, Tonnu, Nina, Verma, Inder M., Berns, Michael W., Hunter, Tony · 2009 · Molecular Cell
- Telomere Protection by TPP1/POT1 Requires Tethering to TIN2Kaori Takai, Tatsuya Kibe, Jill R. Donigian, David Frescas, Titia de Lange · 2011 · Molecular Cell
- Replication Catastrophe: When a Checkpoint Fails because of ExhaustionLuis Ignacio Toledo, Kai J. Neelsen, Jiri Lukas · 2017 · Molecular Cell
- Cellular Responses to DNA Damage: One Signal, Multiple ChoicesTin Tin Su · 2006 · Annual Review of Genetics
- Ionizing Radiation–dependent γ-H2AX Focus Formation Requires Ataxia Telangiectasia Mutated and Ataxia Telangiectasia Mutated and Rad3-relatedJoanna D. Friesner, Bo Liu, Kevin M. Culligan, Anne Britt · 2005 · Molecular Biology of the Cell
- The telosome/shelterin complex and its functionsHuawei Xin, Dan Liu, Zhou Songyang · 2008 · Genome biology
- FANCI phosphorylation functions as a molecular switch to turn on the Fanconi anemia pathwayMasamichi Ishiai, Hiroyuki Kitao, Agata Smogorzewska, Junya Tomida, Aiko Kinomura, Emi Uchida, Alihossein Saberi, Eiji Kinoshita, Emiko Kinoshita‐Kikuta, Tohru Koike et al. · 2008 · Nature Structural & Molecular Biology
- The DNA crosslink‐induced S‐phase checkpoint depends on ATR–CHK1 and ATR–NBS1–FANCD2 pathwaysPietro Pichierri, Filippo Rosselli · 2004 · The EMBO Journal
- FOXM1: An emerging master regulator of DNA damage response and genotoxic agent resistanceStefania Zona, Laura Bella, Matthew J. Burton, Gabriela Nestal de Moraes, Eric W.‐F. Lam · 2014 · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
- From RPA to BRCA2: lessons from single-stranded DNA binding by the OB-foldAlexey V. Bochkarev, Elena S. Bochkareva · 2004 · Current Opinion in Structural Biology