Autoimmune Disease and Impaired Uptake of Apoptotic Cells in MFG-E8-Deficient Mice

Exposure of phosphatidylserine on the surface of apoptotic lymphocytes triggers specific recognition and removal by macrophages

Fadok, V. A., Voelker, D. R., Campbell, P. A., Cohen, J., Bratton, D. L., & Henson, P. M. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.148.7.2207 · Cited by 3,321

Programmed Cell Death in Animal Development

Jacobson, M. D., Weil, M., & RAFF, M. C. (1997) · Cell · doi:10.1016/s0092-8674(00)81873-5 · Cited by 2,685

A blast from the past: clearance of apoptotic cells regulates immune responses

Savill, J., Dransfield, I., Gregory, C. D., & Haslett, C. (2002) · Nature reviews. Immunology · doi:10.1038/nri957 · Cited by 1,574

Corpse clearance defines the meaning of cell death

Savill, J., & Fadok, V. A. (2000) · Nature · doi:10.1038/35037722 · Cited by 1,572

Identification of a factor that links apoptotic cells to phagocytes

Hanayama, R., Tanaka, M., Miwa, K., Shinohara, A., Iwamatsu, A., & Nagata, S. (2002) · Nature · doi:10.1038/417182a · Cited by 1,401

Phagocytosis and clearance of apoptotic cells is mediated by MER

Scott, R. S., McMahon, E. J., Pop, S. M., Reap, E. A., Caricchio, R., Cohen, P. L., Earp, H. S., & Matsushima, G. K. (2001) · Nature · doi:10.1038/35075603 · Cited by 1,215

T-cell apoptosis detected in situ during positive and negative selection in the thymus

Surh, C. D., & Sprent, J. (1994) · Nature · doi:10.1038/372100a0 · Cited by 1,082

Systemic Exposure to Irradiated Apoptotic Cells Induces Autoantibody Production

Mevorach, D., Zhou, J. L., Song, X., & Elkon, K. B. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.2.387 · Cited by 567

Phosphatidylserine (PS) induces PS receptor–mediated macropinocytosis and promotes clearance of apoptotic cells

Hoffmann, P. R., deCathelineau, A. M., Ogden, C. A., Leverrier, Y., Bratton, D. L., Daleke, D. L., Ridley, A. J., Fadok, V. A., & Henson, P. M. (2001) · The Journal of Cell Biology · doi:10.1083/jcb.200108080 · Cited by 541

cDNA cloning of a mouse mammary epithelial cell surface protein reveals the existence of epidermal growth factor-like domains linked to factor VIII-like sequences.

Stubbs, J. D., Lekutis, C., Singer, K. L., Bui, A., Yuzuki, D., Srinivasan, U., & Parry, G. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.21.8417 · Cited by 313

Antigen Is Required for Maturation and Activation of Pathogenic Anti-DNA Antibodies and Systemic Inflammation

Jeganathan, V., Yoshifuji, H., Kawabata, D., Chinnasamy, P., Stanevsky, A., Grimaldi, C. M., Cohen-Solal, J. F. G., & Diamond, B. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1000224 · Cited by 20

Discovering Molecules That Regulate Efferocytosis Using Primary Human Macrophages and High Content Imaging

Santulli-Marotto, S., Gervais, A., Fisher, J., Strake, B., Ogden, C. A., Riveley, C., & Giles-Komar, J. M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0145078 · Cited by 20

Milk fat globule epidermal growth factor-8 limits tissue damage through inflammasome modulation during renal injury

Brissette, M.-J., Laplante, P., Qi, S., Latour, M., & Cailhier, J. (2016) · Journal of Leukocyte Biology · doi:10.1189/jlb.3a0515-213rr · Cited by 20

Cell death recognition model for the immune system

Sun, E. (2007) · Medical Hypotheses · doi:10.1016/j.mehy.2007.05.049 · Cited by 20

Fat(al) attraction: Oxidized lipids act as “eat‐me” signals

Fadeel, B., Quinn, P., Xue, D., & Kagan, V. (2007) · HFSP Journal · doi:10.2976/1.2800110 · Cited by 21

Inflammatory bone loss associated with MFG‐E8 deficiency is rescued by teriparatide

Michalski, M. N., Seydel, A. L., Siismets, E. M., Zweifler, L. E., Koh, A. J., Sinder, B. P., Aguirre, J. I., Atabai, K., Roca, H., & McCauley, L. K. (2018) · The FASEB Journal · doi:10.1096/fj.201701238r · Cited by 20

Single‐dose therapy for lupus nephritis: C‐reactive protein, nature's own dual scavenger and immunosuppressant

Ogden, C. A., & Elkon, K. B. (2005) · Arthritis & Rheumatism · doi:10.1002/art.20847 · Cited by 20

Tempering Allorecognition to Induce Transplant Tolerance With Chemically Modified Apoptotic Donor Cells

McCarthy, D. P., Bryant, J., Galvin, J. P., Miller, S. D., & Luo, X. (2015) · American Journal of Transplantation · doi:10.1111/ajt.13237 · Cited by 19

Defective Efferocytosis in a Murine Model of Sjögren’s Syndrome Is Mediated by Dysfunctional Mer Tyrosine Kinase Receptor

Witas, R., Rasmussen, A., Scofield, R. H., Radfar, L., Stone, D. U., Grundahl, K. M., Lewis, D., Sivils, K. L. M., Lessard, C. J., Farris, A. D., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22189711 · Cited by 19

STATs signaling pathways in dendritic cells: As potential therapeutic targets?

Sohrabi, S., Masoumi, J., Naseri, B., Ghorbaninezhad, F., Alipour, S., Kazemi, T., Heris, J. A., Maleki, L. A., Basirjafar, P., Zandvakili, R., et al. (2023) · International Reviews of Immunology · doi:10.1080/08830185.2023.2274576 · Cited by 21

MFG-E8, a clearance glycoprotein of apoptotic cells, as a new marker of disease severity in chronic obstructive pulmonary disease

Zhang, S., Xie, J., Su, B., Li, J. L., Hu, N., Chen, J., Luo, G., & Cui, T. (2015) · Brazilian Journal of Medical and Biological Research · doi:10.1590/1414-431x20154730 · Cited by 19

Compartments and Connections Within the Germinal Center

Kennedy, D. E., & Clark, M. R. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.659151 · Cited by 20

Harnessing programmed cell death as a therapeutic strategy in rheumatic diseases

Ramaswamy, M., Deng, M., & Siegel, R. M. (2011) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2010.225 · Cited by 21

Experimental Stroke Differentially Affects Discrete Subpopulations of Splenic Macrophages

McCulloch, L. J., Alfieri, A., & McColl, B. W. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01108 · Cited by 19

Apoptosis and autoimmune diseases

Nagata, S. (2006) · IUBMB Life · doi:10.1080/15216540600746401 · Cited by 19

Environmental adjuvants, apoptosis and the censorship over autoimmunity

Rovere, P. Q., Manfredi, A. A., & Sabbadini, M. G. (2005) · Autoimmunity Reviews · doi:10.1016/j.autrev.2005.04.013 · Cited by 19

AIF and Scythe (Bat3) Regulate Phosphatidylserine Exposure and Macrophage Clearance of Cells Undergoing Fas (APO-1)-Mediated Apoptosis

Preta, G., & Fadeel, B. (2012) · PLoS ONE · doi:10.1371/journal.pone.0047328 · Cited by 18

Characterization of the impairment of the uptake of apoptotic polymorphonuclear cells by monocyte subpopulations in systemic lupus erythematosus

Mikolajczyk, T. P., Skiba, D. S., Batko, B. P., Krezelok, M., Wilk, G., Osmenda, G., Pryjma, J. R., & Guzik, T. J. (2014) · Lupus · doi:10.1177/0961203314541316 · Cited by 18

B Cell αv Integrins Regulate TLR-Driven Autoimmunity

Acharya, M., Raso, F., Sagadiev, S., Gilbertson, E., Kadavy, L., Li, Q. Z., Yan, M., Stuart, L. M., Hamerman, J. A., & Lacy‐Hulbert, A. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.1901056 · Cited by 17

Detection of Macrophages Via Paramagnetic Vesicles Incorporating Oxidatively Tailored Cholesterol Ester: An Approach for Atherosclerosis Imaging

Maiseyeu, A., Mihai, G., Roy, S., Kherada, N. I., Simonetti, O. P., Sen, C. K., Sun, Q., Parthasarathy, S., & Rajagopalan, S. (2010) · Nanomedicine · doi:10.2217/nnm.10.87 · Cited by 18

Milk fat globule epidermal growth factor-factor 8 mitigates inflammation and tissue injury after hemorrhagic shock in experimental animals

Zhang, F., Shah, K. G., Lei, Q., Wu, R., Barrera, R., Nicastro, J. M., Coppa, G. F., & Wang, P. (2012) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/ta.0b013e318249a97c · Cited by 18

Immunoregulatory influence of abundant MFG ‐E8 expression by esophageal cancer treated with chemotherapy

Kanemura, T., Miyata, H., Makino, T., Tanaka, K., Sugimura, K., Hamada‐Uematsu, M., Mizote, Y., Uchida, H., Miyazaki, Y., Takahashi, T., et al. (2018) · Cancer Science · doi:10.1111/cas.13785 · Cited by 18

Migratory cues controlling B‐lymphocyte trafficking in human lymph nodes

Park, S. M., Brooks, A. E. S., Chen, C. J., Sheppard, H. M., Loef, E. J., McIntosh, J. D., Angel, C. E., Mansell, C. J., Bartlett, A. S., Cebon, J. S., et al. (2020) · Immunology and Cell Biology · doi:10.1111/imcb.12386 · Cited by 18

Autoregulation of insulin receptor signaling through MFGE8 and the αvβ5 integrin

Datta, R., Lizama, C. O., Soltani, A. K., McKleroy, W., Podolsky, M. J., Yang, C. D., Huynh, T. L., Cautivo, K. M., Wang, B., Koliwad, S. K., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2102171118 · Cited by 18

Autoantibodies: Focus on anti-DNA antibodies

Almqvist, N., Winkler, T., & Mårtensson, I. (2011) · Self/Nonself · doi:10.4161/self.2.1.15087 · Cited by 19

PS externalization: from corpse clearance to drug delivery

Fadeel, B., & Xue, D. (2005) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401836 · Cited by 18

Lupus Nephritis

Agrawal, N., Chiang, L.-K., & Rifkin, I. R. (2006) · Seminars in Nephrology · doi:10.1016/j.semnephrol.2005.09.002 · Cited by 18

Biological Function and Immunotherapy Utilizing Phosphatidylserine-based Nanoparticles

Glassman, F. Y., Dingman, R. K., Yau, H. C., & Balu‐Iyer, S. V. (2020) · Immunological Investigations · doi:10.1080/08820139.2020.1738456 · Cited by 17

Physiological Roles of Apoptotic Cell Clearance: Beyond Immune Functions

Han, M., Ryu, G., Shin, S.-A., An, J., Kim, H., Park, D., Lee, D.-H., & Lee, C. S. (2021) · Life · doi:10.3390/life11111141 · Cited by 18

Inframe insertion and splice site variants in MFGE8 associate with protection against coronary atherosclerosis

Ruotsalainen, S., Surakka, I. L., Mars, N., Karjalainen, J. M., Kurki, M., Kanai, M., Krebs, K., Graham, S. E., Mishra, P. P., Mishra, B. H., et al. (2022) · Communications Biology · doi:10.1038/s42003-022-03552-0 · Cited by 21

Intrarectal administration of milk fat globule epidermal growth factor-8 protein ameliorates murine experimental colitis

Ishihara, S. (2011) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2011.866 · Cited by 17

Comparison of the Kinetics of Maturation of Phagosomes Containing Apoptotic Cells and IgG-Opsonized Particles

Viegas, M. S., Estronca, L. M. B. B., & Vieira, O. V. (2012) · PLoS ONE · doi:10.1371/journal.pone.0048391 · Cited by 18

From T Cell Apoptosis to Chronic Immune Activation in Inflammatory Diseases

Citro, A., Barnaba, V., & Martini, H. (2014) · International Archives of Allergy and Immunology · doi:10.1159/000363385 · Cited by 18

Increased MFG‐E8 at neuromuscular junctions is an exacerbating factor for sarcopenia‐associated denervation

Ikemoto‐Uezumi, M., Zhou, H., Kurosawa, T., Yoshimoto, Y., Toyoda, M., Kanazawa, N., Nakazawa, T., Morita, M., Tsuchida, K., & Uezumi, A. (2021) · Aging Cell · doi:10.1111/acel.13536 · Cited by 16

Negative regulation of human mononuclear phagocyte function

Hedl, M., & Abraham, C. (2013) · Mucosal Immunology · doi:10.1038/mi.2012.139 · Cited by 17

Pharmacokinetics of the phosphatidylserine tracers 99mTc-lactadherin and 99mTc-annexin V in pigs

Poulsen, R. H., Rasmussen, J. T., Ejlersen, J. A., Flø, C., Falborg, L., Heegaard, C. W., & Rehling, M. (2013) · EJNMMI Research · doi:10.1186/2191-219x-3-15 · Cited by 17

Expression and characterization of recombinant human milk fat globule-EGF factor VIII

Wang, P. (2011) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2011.782 · Cited by 17

Autoantigen-specific immune tolerance in pathological and physiological cell death: Nanotechnology comes into view

Tajbakhsh, A., Farahani, N., Gheibihayat, S. M., Mirkhabbaz, A. M., Savardashtaki, A., Hamblin, M. R., & Mirzaei, H. (2020) · International Immunopharmacology · doi:10.1016/j.intimp.2020.107177 · Cited by 17

Single nucleotide polymorphisms as a prerequisite for autoantigens

Stadler, M. B., Arnold, D., Frieden, S., Luginbühl, S., & Stadler, M. B. (2005) · European Journal of Immunology · doi:10.1002/eji.200425481 · Cited by 17

p63(TP63) elicits strong trans-activation of the MFG-E8/lactadherin/BA46 gene through interactions between the TA and ΔN isoforms

Okuyama, T., Kurata, S., Tomimori, Y., Fukunishi, N., Sato, S., Osada, M., Tsukinoki, K., Jin, H.-F., Yamashita, A., Ito, M., et al. (2007) · Oncogene · doi:10.1038/sj.onc.1210646 · Cited by 17

Defective apoptotic cell contractility provokes sterile inflammation, leading to liver damage and tumour suppression

Julian, L., Naylor, G. D., Wickman, G., Rath, N., Castino, G. F., Stevenson, D., Bryson, S., Munro, J., McGarry, L., Mullin, M., et al. (2021) · eLife · doi:10.7554/elife.61983 · Cited by 16

CX3CL1(+) Microparticles-Induced MFG-E8 Enhances Apoptotic Cell Clearance by Alveolar Macrophages

Tsai, W.-H., Chang, S.-C., Lin, Y.-C., & Hsu, H.-C. (2021) · Cells · doi:10.3390/cells10102583 · Cited by 16

Rubicon promotes rather than restricts murine lupus and is not required for LC3-associated phagocytosis

Gordon, R. A., Giannouli, C. C., Raparia, C., Bastacky, S., Marinov, A. D., Hawse, W. F., Cattley, R. T., Tilstra, J. S., Campbell, A. M., Nickerson, K. M., et al. (2022) · JCI Insight · doi:10.1172/jci.insight.155537 · Cited by 15

Efferocytosis: Current status and future prospects in the treatment of autoimmune diseases

Li, Q., Liu, H., Yin, G., & Xie, Q. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e28399 · Cited by 17

The Fetal–Maternal Immune Interface in Uterus Transplantation

Iske, J., Elkhal, A., & Tullius, S. G. (2020) · Trends in Immunology · doi:10.1016/j.it.2020.01.006 · Cited by 17

Distribution of prosaposin in rat lymphatic tissues

Shimokawa, T., Nabeka, H., Yamamiya, K., Wakisaka, H., Takeuchi, T., Kobayashi, N., & Matsuda, S. (2013) · Cell and Tissue Research · doi:10.1007/s00441-013-1575-0 · Cited by 16

Ferritin Expression in Rat Hepatocytes and Kupffer Cells after Lead Nitrate Treatment

Yang, F., Yamada, T., Shimizu, T., Nanashima, N., Akita, M., Suto, K., & Tsuchida, S. (2009) · Toxicologic Pathology · doi:10.1177/0192623308328544 · Cited by 16

Tickling Macrophages, a Serious Business

Züllig, S., & Hengartner, M. O. (2004) · Science · doi:10.1126/science.1099161 · Cited by 16

Transmembrane voltage regulates binding of annexin V and lactadherin to cells with exposed phosphatidylserine

Smith, C., Gibson, D. F., & Tait, J. F. (2009) · BMC Biochemistry · doi:10.1186/1471-2091-10-5 · Cited by 16

Macrophages in intestinal fibrosis and regression

Yao, H., & Tang, G. (2022) · Cellular Immunology · doi:10.1016/j.cellimm.2022.104614 · Cited by 18

A novel opsonic eCIRP inhibitor for lethal sepsis

Nofi, C. P., Tan, C., Ma, G., Kobritz, M., Prince, J. M., Wang, H., Aziz, M., & Wang, P. (2023) · Journal of Leukocyte Biology · doi:10.1093/jleuko/qiad119 · Cited by 15

Immune regulation by apoptotic cell clearance

Tanaka, M., Asano, K., & Qiu, C. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05746.x · Cited by 15

Absence of the MFG‐E8 gene prevents hypoxia‐induced pulmonary hypertension in mice

Wang, J., Wu, J., Zhu, X., Chen, J., Zhao, J., Xu, Y., & Xie, J. (2020) · Journal of Cellular Physiology · doi:10.1002/jcp.29885 · Cited by 15

Myeloid ABCG1 Deficiency Enhances Apoptosis and Initiates Efferocytosis in Bronchoalveolar Lavage Cells of Murine Multi-Walled Carbon Nanotube-Induced Granuloma Model

Soliman, E., Bhalla, S., Elhassanny, A. E. M., Malur, A., Ogburn, D., Leffler, N. R., Malur, A. G., & Thomassen, M. J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms23010047 · Cited by 15

99th Dahlem Conference on Infection, Inflammation and Chronic Inflammatory Disorders: Microbes, apoptosis and TIM-1 in the development of asthma

Umetsu, D. T., & DeKruyff, R. H. (2010) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2010.04136.x · Cited by 15

Vitamin K-dependent proteins: Functions in blood coagulation and beyond

Benzakour, O. (2008) · Thrombosis and Haemostasis · doi:10.1160/th08-07-0497 · Cited by 15

Efficient Amyloid A Clearance in the Absence of Immunoglobulins and Complement Factors

Sponarova, J., Nuvolone, M., Whicher, C., Frei, N., Kana, V., Schwarz, P., Westermark, G. T., & Aguzzi, A. (2013) · American Journal Of Pathology · doi:10.1016/j.ajpath.2012.12.035 · Cited by 14

O death where is thy sting? Immunologic tolerance to apoptotic self

Ravishankar, B., & McGaha, T. L. (2013) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-013-1261-0 · Cited by 16

Elimination of the unnecessary: Intra- and extracellular signaling by anionic phospholipids

Kagan, V. E., Bayır, H., Tyurina, Y. Y., Bolevich, S., Maguire, J. J., Fadeel, B., & Balasubramanian, K. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.11.005 · Cited by 14

Induction of Live Cell Phagocytosis by a Specific Combination of Inflammatory Stimuli

Ishidome, T., Yoshida, T., & Hanayama, R. (2017) · EBioMedicine · doi:10.1016/j.ebiom.2017.07.011 · Cited by 15

Cutting Edge: Identification of Marginal Reticular Cells as Phagocytes of Apoptotic B Cells in Germinal Centers

Satoh, K., Honda, S.-I., Shibuya, A., & Shibuya, K. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1701293 · Cited by 15

Burning controversies in NETs and autoimmunity: The mysteries of cell death and autoimmune disease

Dwivedi, N., & Radic, M. Z. (2018) · Autoimmunity · doi:10.1080/08916934.2018.1523395 · Cited by 18

Molecular Mechanisms Underlying the Regulation of the MFG‐E8 Gene Promoter Activity in Physiological and Inflammatory Conditions

Wang, X., Bu, H., Liu, S. X., Plaen, I. G. D., & Tan, X. (2015) · Journal of Cellular Biochemistry · doi:10.1002/jcb.25142 · Cited by 14

MFG-E8: Origin, Structure, Expression, Functions and Regulation

Oshima, K., Yasueda, T., Nishio, S., & Matsuda, T. (2014) · Springer eBooks · doi:10.1007/978-94-017-8765-9_1 · Cited by 14

Milk fat globule-epidermal growth factor-factor VIII attenuates sepsis-induced acute kidney injury

Cen, C., Aziz, M., Yang, W.-L., Zhou, M., Nicastro, J. M., Coppa, G. F., & Wang, P. (2017) · Journal of Surgical Research · doi:10.1016/j.jss.2017.02.024 · Cited by 13

Polygenic autoimmune disease risk alleles impacting B cell tolerance act in concert across shared molecular networks in mouse and in humans

Harley, I. T. W., Allison, K., & Scofield, R. H. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.953439 · Cited by 15

Neuroprotective and Antiapoptotic Activity of Lineage-Negative Bone Marrow Cells after Intravitreal Injection in a Mouse Model of Acute Retinal Injury

Machalińska, A., Rogińska, D., Pius‐Sadowska, E., Kawa, M. P., Paczkowska, E., Rudnicki, M., Lejkowska, R., Baumert, B., Wiszniewska, B., & Machaliński, B. (2015) · Stem Cells International · doi:10.1155/2015/620364 · Cited by 14

The Healing Effect of Human Milk Fat Globule-EGF Factor 8 Protein (MFG-E8) in A Rat Model of Parkinson’s Disease

Nakashima, Y., Miyagi‐Shiohira, C., Noguchi, H., & Ōmasa, T. (2018) · Brain Sciences · doi:10.3390/brainsci8090167 · Cited by 14

The Evidence of HeLa Cell Apoptosis Induced with Tetraethylammonium Using Proteomics and Various Analytical Methods*

Huang, L., Huang, Q.-Y., & Huang, H.-Q. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.515932 · Cited by 13

Endometriosis associated with defective handling of apoptotic cells in the female genital tract is a major cause of autoimmune disease in women

Seery, J. P. (2006) · Medical Hypotheses · doi:10.1016/j.mehy.2005.11.032 · Cited by 14

Bridging molecules are secreted from the skeletal muscle and potentially regulate muscle differentiation

Chikazawa, M., Shimizu, M., Yamauchi, Y., & Sato, R. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.11.010 · Cited by 13

Mini-review of conventional and hypofractionated radiation therapy combined with immunotherapy for non-small cell lung cancer

Campbell, A. M., & Decker, R. H. (2007) · Translational Lung Cancer Research · doi:10.21037/tlcr.2017.03.02 · Cited by 13

Breaking self-tolerance during autoimmunity and cancer immunity: Myeloid cells and type I IFN response regulation

Tarbell, K. V., & Egen, J. G. (2018) · Journal of Leukocyte Biology · doi:10.1002/jlb.3mir1017-400r · Cited by 15

Serum developmental endothelial locus-1 is associated with severity of sepsis in animals and humans

Kim, W., Lee, S., Kim, D., Ryu, H. J., Chon, G. R., Park, Y. Y., Fu, Y., Huh, J. W., Lim, C., Koh, Y., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-49564-5 · Cited by 13

Retinol Saturase Knock-Out Mice are Characterized by Impaired Clearance of Apoptotic Cells and Develop Mild Autoimmunity

Sarang, Z., Sághy, T., Budai, Z., Ujlaky‐Nagy, L., Bedekovics, J., Beke, L., Méhes, G., Nagy, G., Rühl, R., Moise, A. R., et al. (2019) · Biomolecules · doi:10.3390/biom9110737 · Cited by 14

Understand SLE heterogeneity in the era of omics, big data, and artificial intelligence

Puri, P., Jiang, S., Yang, Y., Mackay, F., & Yu, D. (2021) · Rheumatology & autoimmunity · doi:10.1002/rai2.12010 · Cited by 13

Targeting Bcl6 in the TREX1 D18N murine model ameliorates autoimmunity by modulating T‐follicular helper cells and germinal center B cells

Venkatadri, R., Sabapathy, V., Doğan, M., Mohammad, S., Harvey, S. E., Simpson, S. R., Grayson, J. M., Yan, N., Perrino, F. W., & Sharma, R. (2022) · European Journal of Immunology · doi:10.1002/eji.202149324 · Cited by 13

The phagocytic role of macrophage following myocardial infarction

Li, J., Chen, Q., Zhang, R., Liu, Z., & Cheng, Y. (2023) · Heart Failure Reviews · doi:10.1007/s10741-023-10314-5 · Cited by 13

Toll-like receptor 7 (TLR7) modulates anti-nucleosomal autoantibody isotype and renal complement deposition in mice exposed to syngeneic late apoptotic cells

Pan, Z. J., Maier, S. M., Davis-Schwarz, K., Workman-Azbill, J., Akira, S., Uematsu, S., & Farris, A. D. (2009) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2009.108282 · Cited by 13

Staphylococcal superantigen‐like protein 10 binds to phosphatidylserine and apoptotic cells

Itoh, S., Yokoyama, R., Murase, C., Takii, T., Tsuji, T., & Onozaki, K. (2012) · Microbiology and Immunology · doi:10.1111/j.1348-0421.2012.00452.x · Cited by 13

Phosphatidylserine‐ and integrin‐mediated phagocytosis of apoptotic luteal cells by macrophages of the rat

Kato, S., Shiratsuchi, A., Nagaosa, K., & Nakanishi, Y. (2005) · Development Growth & Differentiation · doi:10.1111/j.1440-169x.2005.00791.x · Cited by 13

Central Nervous System Diseases and Inflammation

Tenner, A. J., & Pisalyaput, K. (2007) · Springer eBooks · doi:10.1007/978-0-387-73894-9_8 · Cited by 14

An astrocyte-microglia MFG-E8 axis promotes synapse engulfment in early amyloid pathology

Sokolova, D., Puletti, F., Ghansah, S. A., Georgiades, T., Zheng, Y., Wu, L., Schepper, S. D., Lange, J., Ferreira, L. S. S., Sierksma, A., et al. (2026) · Neuron · doi:10.1101/2024.08.31.606944 · Cited by 15

Role of transcription factors in apoptotic cells clearance

Gao, Y.-Q., Jiao, Y., Gong, X., Liu, J., Xiao, H., & Zheng, Q. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1110225 · Cited by 12

MFG-E8 induces epithelial-mesenchymal transition and anoikis resistance to promote the metastasis of pancreatic cancer cells

Liu, W., Ren, Y., Wang, T., Wang, M., Xu, Y., Zhang, J., Bi, J., Wu, Z., Lv, Y., & Wu, R. (2024) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2024.176462 · Cited by 12

Genetic polymorphism of the growth arrest-specific 6 gene is associated with cutaneous vasculitis in Taiwanese patients with systemic lupus erythematosus

Wu, C., Hu, C., Chan, C.-J., Chang, S., & Hsu, P. (2012) · Clinical Rheumatology · doi:10.1007/s10067-012-2027-z · Cited by 12

Cell free DNA biology and its involvement in breast carcinogenesis.

Delmonico, L., Alves, G., & Bines, J. (2020) · Advances in Clinical Chemistry · doi:10.1016/bs.acc.2019.12.006 · Cited by 12

Cellular Nrf2 Levels Determine Cell Fate during Chemical Carcinogenesis in Esophageal Epithelium

Horiuchi, M., Taguchi, K., Hirose, W., Tsuchida, K., Suzuki, M., Taniyama, Y., Kamei, T., & Yamamoto, M. P. (2020) · Molecular and Cellular Biology · doi:10.1128/mcb.00536-20 · Cited by 12

Transcriptional Repression of MFG-E8 Causes Disturbance in the Homeostasis of Cell Cycle Through DOCK/ZP4/STAT Signaling in Buffalo Mammary Epithelial Cells

Verma, A. K., Ali, S. A., Singh, P., Kumar, S., & Mohanty, A. K. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.568660 · Cited by 12

Do follicular dendritic cells regulate lupus-specific B cells?

Heesters, B. A., Das, A., Chatterjee, P., & Carroll, M. C. (2014) · Molecular Immunology · doi:10.1016/j.molimm.2014.02.010 · Cited by 12

An Apoptosis-Associated Mammary Protein Deficiency Leads to Enhanced Production of IgM Antibodies against Multiple Damage-Associated Molecules

Chikazawa, M., Otaki, N., Shibata, T., Yasueda, T., Matsuda, T., & Uchida, K. (2013) · PLoS ONE · doi:10.1371/journal.pone.0068468 · Cited by 12

B Cell Tolerance and Positive Selection in Lupus

Eilat, D., & Wabl, M. R. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1200848 · Cited by 12

MicroRNA‐100‐5p indirectly modulates the expression of Il6, Ptgs1/2 and Tlr4 mRNA in the mouse follicular dendritic cell‐like cell line, FL‐Y

Aungier, S. R., Ohmori, H., Clinton, M., & Mabbott, N. A. (2014) · Immunology · doi:10.1111/imm.12342 · Cited by 13

Anti-fumarase antibody promotes the dropout of photoreceptor inner and outer segments in diabetic macular oedema

Yoshitake, S., Murakami, T., Suzuma, K., Yoshitake, T., Uji, A., Morooka, S., Dodo, Y., Fujimoto, M., Shan, Y., Fort, P. E., et al. (2018) · Diabetologia · doi:10.1007/s00125-018-4773-1 · Cited by 12

A rare missense variant in the milk fat globule-EGF factor 8 (MFGE8) increases T2DM susceptibility and cardiovascular disease risk with population-specific effects

Sapkota, B. R., & Sanghera, D. K. (2020) · Acta Diabetologica · doi:10.1007/s00592-019-01463-x · Cited by 12

Fate Determination of Mature Autoreactive B Cells

Zou, Y.-R., & Diamond, B. (2013) · Advances in immunology · doi:10.1016/b978-0-12-407708-9.00001-7 · Cited by 12

Expression, purification and characterization of C2 domain of milk fat globule-EGF-factor 8-L

Nanga, R. P. R., Vivekanandan, S., & Yoon, H. S. (2006) · Protein Expression and Purification · doi:10.1016/j.pep.2006.08.018 · Cited by 11

Checkpoints controlling the induction of B cell mediated autoimmunity in human autoimmune diseases

Reijm, S., Kissel, T., & Toes, R. E. M. (2020) · European Journal of Immunology · doi:10.1002/eji.202048820 · Cited by 11

MFG‐E8 Regulates Vascular Smooth Muscle Cell Migration Through Dose‐Dependent Mediation of Actin Polymerization

Chiang, H., Chu, P., Chen, S., & Lee, T. (2021) · Journal of the American Heart Association · doi:10.1161/jaha.121.020870 · Cited by 11

Meta-Analysis and Systematic Review of the Association between a Hypoactive NCF1 Variant and Various Autoimmune Diseases

Zhang, L., Wax, J., Huang, R., Petersen, F., & Yu, X. (2022) · Antioxidants · doi:10.3390/antiox11081589 · Cited by 11

MFG-E8-Dependent Clearance of Apoptotic Cells, and Autoimmunity Caused by Its Failure

Hanayama, R., Miyasaka, K., Nakaya, M., & Nagata, S. (2005) · KARGER eBooks · doi:10.1159/000090780 · Cited by 69

Cell Death and Autoimmune Disease

(2004) · Science s STKE · doi:10.1126/stke.2342004tw188

Autoimmune Diseases and the Role of MFG-E8

Hanayama, R. (2014) · Springer eBooks · doi:10.1007/978-94-017-8765-9_6 · Cited by 2

Apoptotic cell clearance by phagocytes

Tanaka, M. (2005) · International Congress Series · doi:10.1016/j.ics.2005.07.080 · Cited by 4

Autoimmunity in MFG-E8-deficient mice is associated with altered trafficking and enhanced cross-presentation of apoptotic cell antigens.

Peng, Y.-F., & Elkon, K. (2011) · Journal of Clinical Investigation · doi:10.1172/jci43254 · Cited by 96