Cited by 992Phagocytosis and Immune RegulationSystemic Lupus Erythematosus ResearchLiver Diseases and Immunity

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Autoimmune Disease and Impaired Uptake of Apoptotic Cells in MFG-E8-Deficient Mice

Hanayama, Rikinari, Tanaka, Masato, Miyasaka, Kay, Aozasa, Katsuyuki, Koike, Masato, Uchiyama, Yasuo, Nagata, Shigekazu·2004·Science

DOI 10.1126/science.1094359

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Abstract

Apoptotic cells expose phosphatidylserine and are swiftly engulfed by macrophages. Milk fat globule epidermal growth factor (EGF) factor 8 (MFG-E8) is a protein that binds to apoptotic cells by recognizing phosphatidylserine and that enhances the engulfment of apoptotic cells by macrophages. We report that tingible body macrophages in the germinal centers of the spleen and lymph nodes strongly express MFG-E8. Many apoptotic lymphocytes were found on the MFG-E8 –/– tingible body macrophages, but they were not efficiently engulfed. The MFG-E8 –/– mice developed splenomegaly, with the formation of numerous germinal centers, and suffered from glomerulonephritis as a result of autoantibody production. These data demonstrate that MFG-E8 has a critical role in removing apoptotic B cells in the germinal centers and that its failure can lead to autoimmune diseases.

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Authors: Hanayama, R., Tanaka, M., Miyasaka, K., Aozasa, K., Koike, M., Uchiyama, Y., & Nagata, S.
Affiliations: RIKEN (JP)
Corresponding author: Nagata, Shigekazu
ORCID: Hanayama, Rikinari
Tanaka, Masato
Koike, Masato
Uchiyama, Yasuo
Nagata, Shigekazu
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2004-05-21
Volume: 304
Issue: 5674
Pages: 1147-1150
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.1094359
OpenAlex: W2037393136
Cited by: 992
References: 24
Citations by year: 2026: 10 · 2025: 22 · 2024: 32 · 2023: 37 · 2022: 34 · 2021: 48 · 2020: 36 · 2019: 36 · 2018: 41 · 2017: 46 · 2016: 32 · 2015: 42 · 2014: 51 · 2013: 64 · 2012: 59
FWCI: 21.82
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
Health Sciences › Medicine › Hepatology › Liver Diseases and Immunity
Keywords: MFG-E8, efferocytosis, phosphatidylserine, macrophages, tingible body macrophages, germinal center, splenomegaly, glomerulonephritis, autoantibodies, autoimmune disease, B cell apoptosis
MeSH terms: CD68 Molecule, Animals, Antigens, Surface, Antibodies, Antinuclear, Autoantibodies, Autoimmune Diseases, B-Lymphocytes, Female, Glomerulonephritis, Macrophage Activation, Macrophages, Membrane Glycoproteins, Milk Proteins, Phagocytosis, Phosphatidylserines, Protein Binding, Spleen, Splenomegaly, T-Lymphocytes, Blotting, Northern, Antigens, Differentiation, Myelomonocytic, Antigens, CD, Apoptosis, Macrophages, Peritoneal, Gene Targeting, Germinal Center, In Situ Nick-End Labeling, Mice

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Autoimmune Disease and Impaired Uptake of Apoptotic Cells in MFG-E8-Deficient Mice

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