The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Illumination of the Melanopsin Signaling Pathway
Abstract
In mammals, a small population of intrinsically photosensitive retinal ganglion cells (ipRGCs) plays a key role in the regulation of nonvisual photic responses, such as behavioral responses to light, pineal melatonin synthesis, pupillary light reflex, and sleep latency. These ipRGCs also express melanopsin (Opn4), a putative opsin-family photopigment that has been shown to play a role in mediating these nonvisual photic responses. Melanopsin is required for the function of this inner retinal pathway, but its precise role in generating photic responses has not yet been determined. We found that expression of melanopsin in Xenopus oocytes results in light-dependent activation of membrane currents through the Gα q /Gα 11 G protein pathway, with an action spectrum closely matching that of melanopsin-expressing ipRGCs and of behavioral responses to light in mice lacking rods and cones. When coexpressed with arrestins, melanopsin could use all- trans -retinaldehyde as a chromophore, which suggests that it may function as a bireactive opsin. We also found that melanopsin could activate the cation channel TRPC3, a mammalian homolog of the Drosophila phototransduction channels TRP and TRPL. Melanopsin therefore signals more like an invertebrate opsin than like a classical vertebrate rod-and-cone opsin.
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Citations
Cites
Phototransduction by retinal ganglion cells that set the circadian clock
Berson, D. M., Dunn, F. A., & Takao, M. (2002) · Science · doi:10.1126/science.1067262 · Cited by 3,629
Hattar, S., Liao, H.-W., Takao, M., Berson, D. M., & Yau, K.-W. (2002) · Science · doi:10.1126/science.1069609 · Cited by 2,734
Channelrhodopsin-2, a directly light-gated cation-selective membrane channel
Nagel, G., Szellas, T., Huhn, W., Kateriya, S., Adeishvili, N., Berthold, P., Ollig, D., Hegemann, P., & Bamberg, E. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1936192100 · Cited by 2,663
Hattar, S., Lucas, R. J., Mrosovsky, N., Thompson, S., Douglas, R. H., Hankins, M. W., Lem, J., Biel, M., Hofmann, F., Foster, R. G., et al. (2003) · Nature · doi:10.1038/nature01761 · Cited by 1,245
Channelrhodopsin-1: A Light-Gated Proton Channel in Green Algae
Nagel, G., Ollig, D., Fuhrmann, M., Kateriya, S., Musti, A. M., Bamberg, E., & Hegemann, P. (2002) · Science · doi:10.1126/science.1072068 · Cited by 1,159
Montell, C., & Rubin, G. M. (1989) · Neuron · doi:10.1016/0896-6273(89)90069-x · Cited by 1,135
Melanopsin: An opsin in melanophores, brain, and eye
Provencio, I., Jiang, G., De Grip, W. J., Hayes, W. P., & Rollag, M. D. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.1.340 · Cited by 975
Melanopsin ( Opn4 ) Requirement for Normal Light-Induced Circadian Phase Shifting
Panda, S., Sato, T. K., Castrucci, A. M., Rollag, M. D., DeGrip, W. J., Hogenesch, J. B., Provencio, I., & Kay, S. A. (2002) · Science · doi:10.1126/science.1076848 · Cited by 861
Self-citationDiminished Pupillary Light Reflex at High Irradiances in Melanopsin-Knockout Mice
Lucas, R. J., Hattar, S., Takao, M., Berson, D. M., Foster, R. G., & Yau, K.-W. (2003) · Science · doi:10.1126/science.1077293 · Cited by 832
Melanopsin is required for non-image-forming photic responses in blind mice
Panda, S., Provencio, I., Tu, D. C., Pires, S. S., Rollag, M. D., Castrucci, A. M., Pletcher, M. T., Sato, T. K., Wiltshire, T., Andahazy, M., et al. (2003) · Science · doi:10.1126/science.1086179 · Cited by 711
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Cited by
Venkatachalam, K., & Montell, C. (2007) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.75.103004.142819 · Cited by 1,909
Measuring and using light in the melanopsin age
Lucas, R. J., Peirson, S. N., Berson, D. M., Brown, T. M., Cooper, H. M., Czeisler, C. A., Figueiro, M. G., Gamlin, P. D., Lockley, S. W., O’Hagan, J. B., et al. (2014) · Trends in Neurosciences · doi:10.1016/j.tins.2013.10.004 · Cited by 1,278
Central projections of melanopsin‐expressing retinal ganglion cells in the mouse
Hattar, S., Kumar, M., Park, A., Tong, P., Tung, J., Yau, K., & Berson, D. M. (2006) · Journal of Comparative Neurology · doi:10.1002/cne.20970 · Cited by 996
The circadian visual system, 2005
Morin, L. P., & Allen, C. N. (2006) · Brain Research Reviews · doi:10.1016/j.brainresrev.2005.08.003 · Cited by 784
Bi, A., Cui, J., Ma, Y.-P., Olshevskaya, E., Pu, M., Dizhoor, A. M., & Pan, Z.-H. (2006) · Neuron · doi:10.1016/j.neuron.2006.02.026 · Cited by 771
Metadata
- Authors
- Panda, S., Nayak, S. K., Campo, B., Walker, J. R., Hogenesch, J. B., & Jegla, T.
- Venue
- Science
- Published
- 2005-01-28
- Volume
- 307
- Issue
- 5709
- Pages
- 600-604
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1984116068
- Cited by
- 481
- References
- 25
- FWCI
- 15.38
- Type
- journal article
- Language
- en
- Open access
- closed
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