Phosphorylation and Regulation of Akt/PKB by the Rictor-mTOR Complex

mTOR Interacts with Raptor to Form a Nutrient-Sensitive Complex that Signals to the Cell Growth Machinery

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Mechanism of activation of protein kinase B by insulin and IGF‐1.

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Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα

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Rictor, a Novel Binding Partner of mTOR, Defines a Rapamycin-Insensitive and Raptor-Independent Pathway that Regulates the Cytoskeleton

Sarbassov, D. D., Ali, S. M., Kim, D.-H., Guertin, D. A., Latek, R. R., Erdjument-Bromage, H., Tempst, P., & Sabatini, D. M. (2004) · Current Biology · doi:10.1016/j.cub.2004.06.054 · Cited by 2,665

Two TOR Complexes, Only One of which Is Rapamycin Sensitive, Have Distinct Roles in Cell Growth Control

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Insulin Resistance and a Diabetes Mellitus-Like Syndrome in Mice Lacking the Protein Kinase Akt2 (PKBβ)

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Raptor, a Binding Partner of Target of Rapamycin (TOR), Mediates TOR Action

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RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1

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The TSC1-2 tumor suppressor controls insulin–PI3K signaling via regulation of IRS proteins

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Protein Kinase B Kinases That Mediate Phosphatidylinositol 3,4,5-Trisphosphate-Dependent Activation of Protein Kinase B

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Regulation of Autophagy by Sphingosine Kinase 1 and Its Role in Cell Survival during Nutrient Starvation

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Metformin induces autophagy and G0/G1 phase cell cycle arrest in myeloma by targeting the AMPK/mTORC1 and mTORC2 pathways

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mTOR signaling in skeletal development and disease

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Emerging role of autophagy in kidney function, diseases and aging

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mTORC2 Activity Is Elevated in Gliomas and Promotes Growth and Cell Motility via Overexpression of Rictor

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A Role of DNA-PK for the Metabolic Gene Regulation in Response to Insulin

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Role of a Novel PH-Kinase Domain Interface in PKB/Akt Regulation: Structural Mechanism for Allosteric Inhibition

Calleja, V., Laguerre, M. S., Parker, P. J., & Larijani, B. (2009) · PLoS Biology · doi:10.1371/journal.pbio.1000017 · Cited by 252

Scaffolding function of PAK in the PDK1–Akt pathway

Higuchi, M., Onishi, K., Kikuchi, C., & Gotoh, Y. (2008) · Nature Cell Biology · doi:10.1038/ncb1795 · Cited by 247

Fat Cell–Specific Ablation of Rictor in Mice Impairs Insulin-Regulated Fat Cell and Whole-Body Glucose and Lipid Metabolism

Kumar, A. T., Lawrence, J. C., Jung, D. Y., Ko, H. J., Keller, S. R., Kim, J. K., Magnuson, M. A., & Harris, T. E. (2010) · Diabetes · doi:10.2337/db09-1061 · Cited by 259

Multifactorial Mechanism of Sarcopenia and Sarcopenic Obesity. Role of Physical Exercise, Microbiota and Myokines

Bilski, J., Pierzchalski, P., Szczepanik, M., Bonior, J., & Zoladz, J. A. (2022) · Cells · doi:10.3390/cells11010160 · Cited by 271

The phosphatidylinositol 3-kinase/Akt/mTOR signaling network as a therapeutic target in acute myelogenous leukemia patients

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The cytotoxic T cell proteome and its shaping by the kinase mTOR

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Redox regulation of the nutrient-sensitive raptor-mTOR pathway and complex

Sarbassov, D. D., & Sabatini, D. M. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m506096200 · Cited by 248

Coordinate regulation of ribosome biogenesis and function by the ribosomal protein S6 kinase, a key mediator of mTOR function

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Protein Kinase B (PKB/Akt), a Key Mediator of the PI3K Signaling Pathway

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mTOR Drives Its Own Activation via SCFβTrCP-Dependent Degradation of the mTOR Inhibitor DEPTOR

Gao, D., Inuzuka, H., Tan, M.-K. M., Fukushima, H., Locasale, J. W., Liu, P., Wan, L., Zhai, B., Chin, Y. R., Shaik, S., et al. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.08.030 · Cited by 248

Cardiac regulation by phosphoinositide 3-kinases and PTEN

Oudit, G. Y., & Penninger, J. M. (2008) · Cardiovascular Research · doi:10.1093/cvr/cvp014 · Cited by 243

Alterations of insulin signaling in type 2 diabetes: A review of the current evidence from humans

Fröjdö, S., Vidal, H., & Pirola, L. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2008.10.019 · Cited by 247

Current understanding of CTLA-4: from mechanism to autoimmune diseases

Hossen, M. M., Ma, Y., Yin, Z., Xia, Y., Du, J., Huang, J. Y., Huang, J. J., Zou, L., Ye, Z., & Huang, Z. W. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1198365 · Cited by 268

Role of mTOR in anticancer drug resistance: Perspectives for improved drug treatment

Jiang, B., & Liu, L.-Z. (2008) · Drug Resistance Updates · doi:10.1016/j.drup.2008.03.001 · Cited by 249

The Mammalian Target of Rapamycin Signaling Pathway: Twists and Turns in the Road to Cancer Therapy

Abraham, R. T., & Gibbons, J. J. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-2798 · Cited by 244

Selective Targeting of TNF Receptors as a Novel Therapeutic Approach

Fischer, R., Kontermann, R. E., & Pfizenmaier, K. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00401 · Cited by 255

Brain Cancer Stem Cells Display Preferential Sensitivity to Akt Inhibition

Eyler, C. E., Foo, W., LaFiura, K. M., McLendon, R. E., Hjelmeland, A. B., & Rich, J. N. (2008) · Stem Cells · doi:10.1634/stemcells.2007-1073 · Cited by 242

Wnt and PI3K/Akt/mTOR Survival Pathways as Therapeutic Targets in Glioblastoma

Behrooz, A. B., Talaie, Z., Jusheghani, F., Łoś, M., Klonisch, T. C., & Ghavami, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031353 · Cited by 253

Reelin signals through phosphatidylinositol 3-kinase and Akt to control cortical development and through mTor to regulate dendritic growth

Jossin, Y., & Goffinet, A. M. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00928-07 · Cited by 235

Protein kinase signaling networks in cancer

Brognard, J., & Hunter, T. R. (2010) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2010.10.012 · Cited by 246

A comprehensive map of the mTOR signaling network

Caron, É., Ghosh, S., Matsuoka, Y., Ashton‐Beaucage, D., Therrien, M., Lemieux, S., Perreault, C., Roux, P. P., & Kitano, H. (2010) · Molecular Systems Biology · doi:10.1038/msb.2010.108 · Cited by 248

Selective pharmacogenetic inhibition of mammalian target of Rapamycin complex I (mTORC1) blocks long-term synaptic plasticity and memory storage

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PRAS40 Is a Target for Mammalian Target of Rapamycin Complex 1 and Is Required for Signaling Downstream of This Complex

Fonseca, B. D., Smith, E. M., Lee, V. H.-Y., MacKintosh, C., & Proud, C. G. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m704406200 · Cited by 240

Signal Transduction Pathways in Breast Cancer: The Important Role of PI3K/Akt/mTOR

Ortega, M. A., Fraile‐Μartinez, O., Asúnsolo, Á., Buján, J., García‐Honduvilla, N., & Coca, S. (2020) · Journal of Oncology · doi:10.1155/2020/9258396 · Cited by 253

Neuroprotective actions of sex steroids in Parkinson’s disease

Bourque, M., Dluzen, D. E., & Paolo, T. D. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2009.04.014 · Cited by 239

Cardiac Raptor Ablation Impairs Adaptive Hypertrophy, Alters Metabolic Gene Expression, and Causes Heart Failure in Mice

Shende, P., Plaisance, I., Morandi, C., Pellieux, C., Berthonneche, C., Zorzato, F., Krishnan, J., Lerch, R. A., Hall, M. N., Rüegg, M. A., et al. (2011) · Circulation · doi:10.1161/circulationaha.110.977066 · Cited by 239

New insights on PI3K/AKT pathway alterations and clinical outcomes in breast cancer

Yang, S. X., Polley, E. C., & Lipkowitz, S. (2016) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2016.03.004 · Cited by 240

A GSK-3/TSC2/mTOR pathway regulates glucose uptake and GLUT1 glucose transporter expression

Buller, C. L., Loberg, R. D., Fan, M., Zhu, Q., Park, J. L., Vesely, E. D., Inoki, K., Guan, K., & Brosius, F. C. (2008) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00554.2007 · Cited by 238

PTEN and PI3K/AKT in Non-Small-Cell Lung Cancer

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TGR5, Not Only a Metabolic Regulator

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Polycomb Cbx family members mediate the balance between haematopoietic stem cell self-renewal and differentiation

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Regulation of Imaginal Disc Growth by Tumor-Suppressor Genes in Drosophila

Hariharan, I. K., & Bilder, D. H. (2006) · Annual Review of Genetics · doi:10.1146/annurev.genet.39.073003.100738 · Cited by 237

p53 Regulation of the IGF-1/AKT/mTOR Pathways and the Endosomal CompartmentPreprint

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Hydrogen peroxide inhibits mTOR signaling by activation of AMPKα leading to apoptosis of neuronal cells

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The hallmark of AGC kinase functional divergence is its C-terminal tail, a cis-acting regulatory module

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Discovery of 4-Amino- N -[(1 S )-1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7 H -pyrrolo[2,3- d ]pyrimidin-4-yl)piperidine-4-carboxamide (AZD5363), an Orally Bioavailable, Potent Inhibitor of Akt Kinases

Addie, M., Ballard, P. G., Buttar, D., Crafter, C., Currie, G. S., Davies, B. R., Debreczeni, J. E., Dry, H., Dudley, P., Greenwood, R. D. R., et al. (2013) · Journal of Medicinal Chemistry · doi:10.1021/jm301762v · Cited by 245

Amino Acid Signaling in TOR Activation

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Rb suppresses human cone-precursor-derived retinoblastoma tumours

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Doxorubicin downregulates cell surface B7-H1 expression and upregulates its nuclear expression in breast cancer cells: role of B7-H1 as an anti-apoptotic molecule

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Altered activation of AKT is required for the suppressive function of human CD4+CD25+ T regulatory cells

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Akt deficiency impairs normal cell proliferation and suppresses oncogenesis in a p53-independent and mTORC1-dependent manner

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RTP801 Is Induced in Parkinson's Disease and Mediates Neuron Death by Inhibiting Akt Phosphorylation/Activation

Malagelada, C., Jin, Z. H., & Greene, L. A. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.3928-08.2008 · Cited by 228

Staying alive

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Mitochondria in the signaling pathways that control longevity and health span

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Systems-level interactions between insulin–EGF networks amplify mitogenic signaling

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Parkin promotes the ubiquitination and degradation of the mitochondrial fusion factor mitofusin 1

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Activation of canonical WNT/β-catenin signaling enhances in vitro motility of glioblastoma cells by activation of ZEB1 and other activators of epithelial-to-mesenchymal transition

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Novel Small Molecule Inhibitors of 3-Phosphoinositide-dependent Kinase-1*

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Irs1 and Irs2 signaling is essential for hepatic glucose homeostasis and systemic growth

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PI3K-AKT-mTOR inhibitors in breast cancers: From tumor cell signaling to clinical trials

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Myocardial AKT: The Omnipresent Nexus

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TBK1 Directly Engages Akt/PKB Survival Signaling to Support Oncogenic Transformation

Ou, Y.-H., Torres, M. J., Ram, R. R., Formstecher, É., Roland, C. L., Cheng, T., Brekken, R. A., Wurz, R. P., Tasker, A. S., Polverino, T., et al. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.01.019 · Cited by 224

The TORrid affairs of viruses: effects of mammalian DNA viruses on the PI3K–Akt–mTOR signalling pathway

Buchkovich, N. J., Yu, Y., Zampieri, C. A., & Alwine, J. C. (2008) · Nature Reviews Microbiology · doi:10.1038/nrmicro1855 · Cited by 238

PI3K‐independent AKT activation in cancers: A treasure trove for novel therapeutics

Mahajan, K. N., & Mahajan, N. P. (2012) · Journal of Cellular Physiology · doi:10.1002/jcp.24065 · Cited by 229

Cancer Metabolism: Current Understanding and Therapies

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Insulin Resistance and Diabetes Mellitus in Alzheimer’s Disease

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The PI3K/Akt signaling axis in Alzheimer’s disease: a valuable target to stimulate or suppress?

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Reduced AKT/mTOR signaling and protein synthesis dysregulation in a Rett syndrome animal model

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mTOR Ser-2481 Autophosphorylation Monitors mTORC-specific Catalytic Activity and Clarifies Rapamycin Mechanism of Action

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Reduced resting skeletal muscle protein synthesis is rescued by resistance exercise and protein ingestion following short-term energy deficit

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Targeting the PI3-Kinase/Akt/mTOR Signaling Pathway

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Electrical stimulation increases hypertrophy and metabolic flux in tissue-engineered human skeletal muscle

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Autophagy and aging: Maintaining the proteome through exercise and caloric restriction

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The role of the inositol polyphosphate 5-phosphatases in cellular function and human disease

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Chemoresistance and targeted therapies in ovarian and endometrial cancers

Brasseur, K., Gévry, N. Y., & Asselin, É. (2016) · Oncotarget · doi:10.18632/oncotarget.14021 · Cited by 230

Targeting lysosomes in human disease: from basic research to clinical applications

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Metabolism, migration and memory in cytotoxic T cells

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Maximising the potential of AKT inhibitors as anti-cancer treatments

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Abnormal mTOR Activation in Autism

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Rictor and Integrin-Linked Kinase Interact and Regulate Akt Phosphorylation and Cancer Cell Survival

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PDK1-SGK1 Signaling Sustains AKT-Independent mTORC1 Activation and Confers Resistance to PI3Kα Inhibition

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