Phosphorylation and Regulation of Akt/PKB by the Rictor-mTOR Complex

mTOR Interacts with Raptor to Form a Nutrient-Sensitive Complex that Signals to the Cell Growth Machinery

Kim, D., Sarbassov, D. D., Ali, S. M., King, J. E., Latek, R. R., Erdjument‐Bromage, H., Tempst, P., & Sabatini, D. M. (2002) · Cell · doi:10.1016/s0092-8674(02)00808-5 · Cited by 3,051

Mechanism of activation of protein kinase B by insulin and IGF‐1.

Alessi, D. R., Andjelković, M., Caudwell, B., Cron, P. D., MORRICE, N. A., Cohen, P., & Hemmings, B. A. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb01045.x · Cited by 3,014

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα

Alessi, D. R., James, S. R., Downes, C. P., Holmes, A. B., Gaffney, P. R. J., Reese, C. B., & Cohen, P. (1997) · Current Biology · doi:10.1016/s0960-9822(06)00122-9 · Cited by 2,874

Rictor, a Novel Binding Partner of mTOR, Defines a Rapamycin-Insensitive and Raptor-Independent Pathway that Regulates the Cytoskeleton

Sarbassov, D. D., Ali, S. M., Kim, D.-H., Guertin, D. A., Latek, R. R., Erdjument-Bromage, H., Tempst, P., & Sabatini, D. M. (2004) · Current Biology · doi:10.1016/j.cub.2004.06.054 · Cited by 2,665

Two TOR Complexes, Only One of which Is Rapamycin Sensitive, Have Distinct Roles in Cell Growth Control

Loewith, R., Jacinto, E., Wullschleger, S., Lorberg, A., Crespo, J. L., Bonenfant, D., Oppliger, W., Jenoe, P., & Hall, M. N. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00636-6 · Cited by 1,886

Insulin Resistance and a Diabetes Mellitus-Like Syndrome in Mice Lacking the Protein Kinase Akt2 (PKBβ)

Cho, H., Mu, J., Kim, J. K., Thorvaldsen, J. L., Chu, Q., Crenshaw, E. B., Kaestner, K. H., Bartolomei, M. S., Shulman, G. I., & Birnbaum, M. J. (2001) · Science · doi:10.1126/science.292.5522.1728 · Cited by 1,860

Raptor, a Binding Partner of Target of Rapamycin (TOR), Mediates TOR Action

Hara, K., Maruki, Y., Long, X., Yoshino, K.-I., Oshiro, N., Sujuti, H., Tokunaga, C., Avruch, J., & Yonezawa, K. (2002) · Cell · doi:10.1016/s0092-8674(02)00833-4 · Cited by 1,810

RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1

Burnett, P. E., Barrow, R. K., Cohen, N. A., Snyder, S. H., & Sabatini, D. M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.4.1432 · Cited by 1,130

The TSC1-2 tumor suppressor controls insulin–PI3K signaling via regulation of IRS proteins

Harrington, L. S., Findlay, G. M., Gray, A., Толкачева, Т. А., Wigfield, S., Rebholz, H., Barnett, J., Leslie, N. R., Cheng, S., Shepherd, P. R., et al. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200403069 · Cited by 1,123

Protein Kinase B Kinases That Mediate Phosphatidylinositol 3,4,5-Trisphosphate-Dependent Activation of Protein Kinase B

Stephens, L., Anderson, K. E., Stokoe, D., Erdjument‐Bromage, H., Painter, G. F., Holmes, A. B., Gaffney, P. R. J., Reese, C. B., McCormick, F. P., Tempst, P., et al. (1998) · Science · doi:10.1126/science.279.5351.710 · Cited by 1,061

The PI3K/Akt/mTOR pathway in innate immune cells: emerging therapeutic applications

Weichhart, T., & Säemann, M. D. (2008) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2008.098459 · Cited by 332

Coordination and communication between the p53 and IGF-1–AKT–TOR signal transduction pathways

Levine, A. J., Feng, Z., Mak, T. W., You, H., & Jin, S. (2006) · Genes & Development · doi:10.1101/gad.1363206 · Cited by 321

Portrait of the PI3K/AKT pathway in colorectal cancer

Danielsen, S. A., Eide, P. W., Nesbakken, A., Guren, T. K., Leithe, E., & Lothe, R. A. (2014) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2014.09.008 · Cited by 336

Lipotoxic Hepatocyte‐Derived Exosomal MicroRNA 192‐5p Activates Macrophages Through Rictor/Akt/Forkhead Box Transcription Factor O1 Signaling in Nonalcoholic Fatty Liver Disease

Liu, X., Pan, Q., Cao, H., Xin, F., Zhao, Z., Yang, R., Zeng, J., Zhou, H., & Fan, J. (2019) · Hepatology · doi:10.1002/hep.31050 · Cited by 320

Mechanisms that Regulate Stem Cell Aging and Life Span

Signer, R. A. J., & Morrison, S. J. (2013) · Cell Stem Cell · doi:10.1016/j.stem.2013.01.001 · Cited by 320

A phase II clinical and pharmacodynamic study of temsirolimus in advanced neuroendocrine carcinomas

Durán, I., Kortmansky, J. S., Singh, D., Hirte, H. W., Kocha, W., Goss, G. D., Le, L., Oza, A. M., Nicklee, T., Ho, J., et al. (2006) · British Journal of Cancer · doi:10.1038/sj.bjc.6603419 · Cited by 318

Signaling Pathways in Cancer: Therapeutic Targets, Combinatorial Treatments, and New Developments

Yip, H. Y. K., & Papa, A. (2021) · Cells · doi:10.3390/cells10030659 · Cited by 341

Commentary: IL-4 and IL-13 receptors and signaling

McCormick, S. M., & Heller, N. M. (2015) · Cytokine · doi:10.1016/j.cyto.2015.05.023 · Cited by 329

Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase

Bago, R., Malik, N., Munson, M. J., Prescott, A. R., Davies, P., Sommer, E., Shpiro, N., Ward, R., Cross, D., Ganley, I. G., et al. (2014) · Biochemical Journal · doi:10.1042/bj20140889 · Cited by 308

Raft nanodomains contribute to Akt/PKB plasma membrane recruitment and activation

Lasserre, R., Guo, X., Conchonaud, F., Hamon, Y., Hawchar, O., Bernard, A., Soudja, S. M., Lenne, P., Rigneault, H., Olive, D., et al. (2008) · Nature Chemical Biology · doi:10.1038/nchembio.103 · Cited by 316

Hepatic Sirt1 deficiency in mice impairs mTorc2/Akt signaling and results in hyperglycemia, oxidative damage, and insulin resistance

Wang, R.-H., Kim, H., Xiao, C., Xu, X., Gavrilova, O., & Deng, C. (2011) · Journal of Clinical Investigation · doi:10.1172/jci46243 · Cited by 315

mTOR signaling in aging and neurodegeneration: at the crossroad between metabolism dysfunction and impairment of autophagy

Perluigi, M., Di Domenico, F., & Butterfield, D. A. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2015.03.014 · Cited by 339

PTEN/PTENP1: ‘Regulating the regulator of RTK-dependent PI3K/Akt signalling’, new targets for cancer therapy

Haddadi, N., Lin, Y., Travis, G., Simpson, A. M., Nassif, N. T., & McGowan, E. M. (2018) · Molecular Cancer · doi:10.1186/s12943-018-0803-3 · Cited by 321

The phosphatidyl inositol 3-kinase signaling network: implications for human breast cancer

Dillon, R. L., White, D. E., & Muller, W. J. (2007) · Oncogene · doi:10.1038/sj.onc.1210202 · Cited by 315

Targeting the PI3K/Akt/mTOR pathway in castration-resistant prostate cancer

Bitting, R. L., & Armstrong, A. J. (2013) · Endocrine Related Cancer · doi:10.1530/erc-12-0394 · Cited by 316

TGF-β-induced activation of mTOR complex 2 drives epithelial–mesenchymal transition and cell invasion

Lamouille, S., Connolly, E. C., Smyth, J. W., Akhurst, R. J., & Derynck, R. (2012) · Journal of Cell Science · doi:10.1242/jcs.095299 · Cited by 310

S6K1 Regulates GSK3 under Conditions of mTOR-Dependent Feedback Inhibition of Akt

Zhang, H. H., Lipovsky, A. I., Dibble, C. C., Şahin, M., & Manning, B. D. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.09.019 · Cited by 309

Mammalian/mechanistic target of rapamycin (mTOR) complexes in neurodegeneration

Querfurth, H., & Lee, H.-K. (2021) · Molecular Neurodegeneration · doi:10.1186/s13024-021-00428-5 · Cited by 288

mTOR and the control of whole body metabolism

Polak, P., & Hall, M. N. (2009) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2009.01.024 · Cited by 310

Akt: A Double-Edged Sword in Cell Proliferation and Genome Stability

Xu, N., Lao, Y., Zhang, Y., & Gillespie, D. A. (2012) · Journal of Oncology · doi:10.1155/2012/951724 · Cited by 307

Role of the PI3K/AKT and mTOR signaling pathways in acute myeloid leukemia

Park, S., Chapuis, N., Tamburini, J., Bardet, V., Cornillet‐Lefèbvre, P., Willems, L., Green, A. S., Mayeux, P., Lacombe, C., & Bouscary, D. (2009) · Haematologica · doi:10.3324/haematol.2009.013797 · Cited by 315

mTORC2 controls actin polymerization required for consolidation of long-term memory

Huang, W., Zhu, P. J., Zhang, S., Zhou, H., Stoica, L., Galiano, M., Krnjević, K., Roman, G., & Costa-Mattioli, M. (2013) · Nature Neuroscience · doi:10.1038/nn.3351 · Cited by 307

The Therapeutic Potential of Metformin in Neurodegenerative Diseases

Rotermund, C., Machetanz, G., & Fitzgerald, J. C. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00400 · Cited by 316

Growing knowledge of the mTOR signaling network

Huang, K., & Fingar, D. C. (2014) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2014.09.011 · Cited by 310

Microglial metabolic flexibility supports immune surveillance of the brain parenchyma

Bernier, L., York, E. M., Kamyabi, A., Choi, H. B., Weilinger, N. L., & MacVicar, B. A. (2020) · Nature Communications · doi:10.1038/s41467-020-15267-z · Cited by 316

Intramolecular and Intermolecular Interactions of Protein Kinase B Define Its Activation In Vivo

Calleja, V., Alcor, D., Laguerre, M. S., Park, J., Vojnovic, B., Hemmings, B. A., Downward, J., Parker, P. J., & Larijani, B. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050095 · Cited by 303

Differential Dependence of Hypoxia-inducible Factors 1α and 2α on mTORC1 and mTORC2

Toschi, A., Lee, E., Gadir, N., Ohh, M., & Foster, D. A. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.c800170200 · Cited by 313

Amino acid-dependent control of mTORC1 signaling: a variety of regulatory modes

Takahara, T., Amemiya, Y., Sugiyama, R., Maki, M., & Shibata, H. (2020) · Journal of Biomedical Science · doi:10.1186/s12929-020-00679-2 · Cited by 300

Structural Basis for Activation and Inhibition of Class I Phosphoinositide 3-Kinases

Vadas, O., Burke, J. E., Zhang, X., Berndt, A., & Williams, R. L. (2011) · Science Signaling · doi:10.1126/scisignal.2002165 · Cited by 299

Targeting mTOR: prospects for mTOR complex 2 inhibitors in cancer therapy

Sparks, C. A., & Guertin, D. A. (2010) · Oncogene · doi:10.1038/onc.2010.139 · Cited by 299

Regulation of DNA repair pathway choice in S and G2 phases by the NHEJ inhibitor CYREN

Arnoult, N., Correia, A., Ma, J., Merlo, A., Garcia-Gomez, S., Maric, M., Tognetti, M., Benner, C. W., Boulton, S. J., Saghatelian, A., et al. (2017) · Nature · doi:10.1038/nature24023 · Cited by 299

Targeting Nuclear Factor-Kappa B to Overcome Resistance to Chemotherapy

Godwin, P., Baird, A., Heavey, S., Barr, M. P., O'Byrne, K. J., & Gately, K. A. (2013) · Frontiers in Oncology · doi:10.3389/fonc.2013.00120 · Cited by 312

Akt and foxo Dysregulation Contribute to Infection-Induced Wasting in Drosophila

Dionne, M., Pham, L. N., Shirasu‐Hiza, M., & Schneider, D. S. (2006) · Current Biology · doi:10.1016/j.cub.2006.08.052 · Cited by 302

A Positive Feedback Loop between Akt and mTORC2 via SIN1 Phosphorylation

Yang, G., Murashige, D., Humphrey, S. J., & James, D. E. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.07.016 · Cited by 297

PRAS40 and PRR5-Like Protein Are New mTOR Interactors that Regulate Apoptosis

Thedieck, K., Polak, P., Kim, M. L., Molle, K. D., Cohen, A., Jenö, P., Arrieumerlou, C., & Hall, M. N. (2007) · PLoS ONE · doi:10.1371/journal.pone.0001217 · Cited by 300

The TOR Pathway Couples Nutrition and Developmental Timing in Drosophila

Layalle, S., Arquier, N., & Léopold, P. (2008) · Developmental Cell · doi:10.1016/j.devcel.2008.08.003 · Cited by 295

AMPK and Exercise: Glucose Uptake and Insulin Sensitivity

O'Neill, H. M. (2013) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2013.37.1.1 · Cited by 295

Inflammasome-independent role of AIM2 in suppressing colon tumorigenesis via DNA-PK and Akt

Wilson, J. E., Petrucelli, A., Chen, L., Koblansky, A. A., Truax, A. D., Oyama, Y., Rogers, A. B., Brickey, W. J., Wang, Y., Schneider, M., et al. (2015) · Nature Medicine · doi:10.1038/nm.3908 · Cited by 303

Signalling mechanisms mediated by the phosphoinositide 3‐kinase/Akt cascade in synaptic plasticity and memory in the rat

Horwood, J., Dufour, F., Laroche, S., & Davis, S. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04859.x · Cited by 290

Inhibitor hijacking of Akt activation

Okuzumi, T., Fiedler, D., Zhang, C., Gray, D. C., Aizenstein, B., Hoffman, R., & Shokat, K. M. (2009) · Nature Chemical Biology · doi:10.1038/nchembio.183 · Cited by 302

Targeting AKT for cancer therapy

Shariati, M., & Meric‐Bernstam, F. (2019) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2019.1676726 · Cited by 295

Single-Cell Analysis of Human Retina Identifies Evolutionarily Conserved and Species-Specific Mechanisms Controlling Development

Lu, Y., Shiau, F., Yi, W., Lü, S., Wu, Q., Pearson, J. D., Kallman, A., Zhong, S., Hoang, T. V., Zuo, Z., et al. (2019) · Developmental Cell · doi:10.1016/j.devcel.2020.04.009 · Cited by 285

mTOR inhibitors in cancer therapy

Zaytseva, Y. Y., Valentino, J. D., Gulhati, P., & Evers, B. M. (2012) · Cancer Letters · doi:10.1016/j.canlet.2012.01.005 · Cited by 298

Mitochondrial Stasis Reveals p62-Mediated Ubiquitination in Parkin-Independent Mitophagy and Mitigates Nonalcoholic Fatty Liver Disease

Yamada, T., Murata, D., Adachi, Y., Itoh, K., Kameoka, S., Igarashi, A., Kato, T., Araki, Y., Huganir, R. L., Dawson, T. M., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.06.014 · Cited by 292

Role of the brain‐derived neurotrophic factor at glutamatergic synapses

Carvalho, A. L., Caldeira, M. V., Santos, S. D., & Duarte, C. B. (2008) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707509 · Cited by 290

The AKT-mTOR pathway plays a critical role in the development of leiomyosarcomas

Hernando, E., Charytonowicz, E., Dudas, M. E., Menéndez, S., Matushansky, I., Mills, J. E., Socci, N. D., Behrendt, N., Ma, L., Maki, R. G., et al. (2007) · Nature Medicine · doi:10.1038/nm1560 · Cited by 296

mTORC1 promotes survival through translational control of Mcl-1

Mills, J. R., Hippo, Y., Robert, F., Chen, S. M. H., Malina, A., Lin, C.-J., Trojahn, U., Wendel, H.-G., Charest, A., Bronson, R. T., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804821105 · Cited by 285

Oxidative damage in neurodegeneration: roles in the pathogenesis and progression of Alzheimer disease

Marzia Perluigi, A., Domenico, F. D., & Butterfield, D. A. (2023) · Physiological Reviews · doi:10.1152/physrev.00030.2022 · Cited by 322

TSC1 controls macrophage polarization to prevent inflammatory disease

Zhu, L., Yang, T., Li, L., Sun, L., Hou, Y., Hu, X., Zhang, L., Tian, H., Zhao, Q., Peng, J., et al. (2014) · Nature Communications · doi:10.1038/ncomms5696 · Cited by 287

Hexokinase 2-Mediated Warburg Effect Is Required for PTEN- and p53-Deficiency-Driven Prostate Cancer Growth

Wang, L., Xiong, H., Wu, F., Zhang, Y., Wang, J., Zhao, L., Guo, X., Chang, L.-J., Zhang, Y., You, M. J., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.07.053 · Cited by 299

Roles of the Akt/GSK-3 and Wnt Signaling Pathways in Schizophrenia and Antipsychotic Drug Action

Freyberg, Z., Ferrando, S. J., & Javitch, J. A. (2009) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2009.08121873 · Cited by 288

The PI3K/AKT signaling pathway in regulatory T-cell development, stability, and function

Pompura, S. L., & Dominguez‐Villar, M. (2018) · Journal of Leukocyte Biology · doi:10.1002/jlb.2mir0817-349r · Cited by 291

The multifaceted role of mTORC1 in the control of lipid metabolism

Ricoult, S. J. H., & Manning, B. D. (2013) · EMBO Reports · doi:10.1038/embor.2013.5 · Cited by 291

Akt Signaling in Macrophage Polarization, Survival, and Atherosclerosis

Linton, M. F., Moslehi, J. J., & Babaev, V. R. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20112703 · Cited by 291

Protein Kinases and Phosphatases in the Control of Cell Fate

Bononi, A., Agnoletto, C., Marchi, E. D., Marchi, S., Patergnani, S., Bonora, M., Giorgi, C., Missiroli, S., Poletti, F., Rimessi, A., et al. (2011) · Enzyme Research · doi:10.4061/2011/329098 · Cited by 294

Phase I/II Study of the Mammalian Target of Rapamycin Inhibitor Everolimus (RAD001) in Patients with Relapsed or Refractory Hematologic Malignancies

Yee, K. W. L., Zeng, Z., Konopleva, M. Y., Verstovšek, S., Ravandi, F., Ferrajoli, A., Thomas, D. A., Wierda, W. G., Apostolidou, E., Albitar, M. X., et al. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-0764 · Cited by 283

Targeted Therapy for Advanced Prostate Cancer: Inhibition of the PI3K/Akt/mTOR Pathway

Morgan, T. M., Koreckij, T. D., & Corey, E. (2009) · Current Cancer Drug Targets · doi:10.2174/156800909787580999 · Cited by 288

Signaling pathways in cancer‐associated fibroblasts: recent advances and future perspectives

Fang, Z., Meng, Q., Xu, J., Wang, W., Zhang, B., Liu, J., Liang, C., Hua, J., Zhao, Y., Yu, X., et al. (2022) · 癌症：英文版 · doi:10.1002/cac2.12392 · Cited by 304

Energy metabolism in adult neural stem cell fate

Rafalski, V. A., & Brunet, A. (2010) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2010.10.007 · Cited by 294

The Upstream Pathway of mTOR-Mediated Autophagy in Liver Diseases

Wang, H., Liu, Y., Wang, D., Xu, Y., Dong, R., Yang, Y., Lv, Q., Chen, X., & Zhang, Z. (2019) · Cells · doi:10.3390/cells8121597 · Cited by 286

Notch signals positively regulate activity of the mTOR pathway in T-cell acute lymphoblastic leukemia

Chan, S. M., Weng, A. P., Tibshirani, R. J., Aster, J. C., & Utz, P. J. (2007) · Blood · doi:10.1182/blood-2006-08-039883 · Cited by 282

Lysosomal mTORC2/PHLPP1/Akt Regulate Chaperone-Mediated Autophagy

Arias, E., Koga, H., Díaz, A., Mocholí, E., Patel, B., & Cuervo, A. M. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.05.030 · Cited by 291

The Role of the Mammalian Target Of Rapamycin (mTOR) in Renal Disease

Lieberthal, W., & Levine, J. S. (2009) · Journal of the American Society of Nephrology · doi:10.1681/asn.2008111186 · Cited by 281

FoxO transcription factors activate Akt and attenuate insulin signaling in heart by inhibiting protein phosphatases

Ni, Y. G., Wang, N., Cao, D. J., Sachan, N., Morris, D. J., Gerard, R. D., Kuro‐o, M., Rothermel, B. A., & Hill, J. A. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610290104 · Cited by 278

Receptor-Interacting Protein Homotypic Interaction Motif-Dependent Control of NF-κB Activation via the DNA-Dependent Activator of IFN Regulatory Factors

Kaiser, W. J., Upton, J. W., & Mocarski, E. S. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.9.6427 · Cited by 277

The Interferon Response Inhibits HIV Particle Production by Induction of TRIM22

Barr, S. D., Smiley, J. R., & Bushman, F. D. (2008) · PLoS Pathogens · doi:10.1371/journal.ppat.1000007 · Cited by 275

PTEN function in normal and neoplastic growth

Chow, L. M. L., & Baker, S. J. (2006) · Cancer Letters · doi:10.1016/j.canlet.2005.11.042 · Cited by 277

Reactive oxygen species-dependent signaling regulates cancer

Weinberg, F. D., & Chandel, N. S. (2009) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-009-0099-y · Cited by 279

Rac1 Regulates the Activity of mTORC1 and mTORC2 and Controls Cellular Size

Saci, A., Cantley, L. C., & Carpenter, C. L. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.03.017 · Cited by 275

PI3K-AKT-mTOR signaling in prostate cancer progression and androgen deprivation therapy resistance

Hsieh, A., & Edlind, M. P. (2014) · Asian Journal of Andrology · doi:10.4103/1008-682x.122876 · Cited by 285

Oncogenic EGFR Signaling Activates an mTORC2–NF-κB Pathway That Promotes Chemotherapy Resistance

Tanaka, K., Babić, I., Nathanson, D. A., Akhavan, D., Guo, D., Gini, B., Dang, J. H. T., Zhu, S., Yang, H., Jesus, J. D., et al. (2011) · Cancer Discovery · doi:10.1158/2159-8290.cd-11-0124 · Cited by 279

Mutations in the Phosphatidylinositol-3-Kinase Pathway Predict for Antitumor Activity of the Inhibitor PX-866 whereas Oncogenic Ras Is a Dominant Predictor for Resistance

Ihle, N. T., Lemos, R., Wipf, P., Yacoub, A., Mitchell, C., Siwak, D. R., Mills, G. B., Dent, P., Kirkpatrick, D. L., & Powis, G. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-6656 · Cited by 275

L-type amino acid transport and cancer: targeting the mTORC1 pathway to inhibit neoplasia.

Wang, Q., & Holst, J. (2015) · Europe PMC (PubMed Central) · Cited by 273

AKT in cancer: new molecular insights and advances in drug development

Mundi, P. S., Sachdev, J., McCourt, C., & Kalinsky, K. (2016) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.13021 · Cited by 272

Molecular Mechanisms of Autophagy in the Cardiovascular System

Gatica, D., Chiong, M., Lavandero, S., & Klionsky, D. J. (2015) · Circulation Research · doi:10.1161/circresaha.114.303788 · Cited by 272

PI3K and AKT: Unfaithful Partners in Cancer

Faes, S., & Dormond, O. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms160921138 · Cited by 279

The molecular basis of nutrient sensing and signalling by mTORC1 in metabolism regulation and disease

Goul, C., Peruzzo, R., & Zoncu, R. (2023) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-023-00641-8 · Cited by 280

Role of mTOR Signaling in Tumor Cell Motility, Invasion and Metastasis

Huang, S., & Zhou, H. (2011) · Current Protein and Peptide Science · doi:10.2174/138920311795659407 · Cited by 270

Activation of the Mammalian Target of Rapamycin (mTOR) Is Essential for Oligodendrocyte Differentiation

Tyler, W. A., Gangoli, N., Gokina, P., Kim, H. A., Covey, M., Levison, S. W., & Wood, T. L. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.0234-09.2009 · Cited by 263

Bnip3 Mediates the Hypoxia-induced Inhibition on Mammalian Target of Rapamycin by Interacting with Rheb

Li, Y., Wang, Y., Kim, E., Beemiller, P., Wang, C. Y., Swanson, J. A., You, M., & Guan, K. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m705231200 · Cited by 269

The Phosphoinositide 3-Kinase Pathway in Human Cancer: Genetic Alterations and Therapeutic Implications

Arcaro, A., & Stücklin, A. G. (2007) · Current Genomics · doi:10.2174/138920207782446160 · Cited by 274

The RNA-binding Protein Fused in Sarcoma (FUS) Functions Downstream of Poly(ADP-ribose) Polymerase (PARP) in Response to DNA Damage

Mastrocola, A. S., Kim, S. H., Trinh, A. T., Rodenkirch, L. A., & Tibbetts, R. S. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.497974 · Cited by 280

Mechanisms maintaining the dormancy and survival of mammalian primordial follicles

Reddy, P., Zheng, W., & Liu, K. (2009) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2009.10.001 · Cited by 276

The Role of mTOR Signaling as a Therapeutic Target in Cancer

Popova, N. V., & Jücker, M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041743 · Cited by 273

Diverse signaling mechanisms of mTOR complexes: mTORC1 and mTORC2 in forming a formidable relationship

Jhanwar-Uniyal, M., Wainwright, J. V., Mohan, A. L., Tobias, M. E., Murali, R., Gandhi, C. D., & Schmidt, M. H. (2019) · Advances in Biological Regulation · doi:10.1016/j.jbior.2019.03.003 · Cited by 268

MTOR inhibitors in cancer therapy

Xie, J., Wang, X., & Proud, C. G. (2016) · F1000Research · doi:10.12688/f1000research.9207.1 · Cited by 266

TOR complex 2: a signaling pathway of its own

Cybulski, N., & Hall, M. N. (2009) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2009.09.004 · Cited by 264

Balancing mTOR Signaling and Autophagy in the Treatment of Parkinson’s Disease

Zhu, Z., Yang, C., Iyaswamy, A., Krishnamoorthi, S., Sreenivasmurthy, S. G., Liu, J., Wang, Z., Tong, B. C., Song, J., Lu, J., et al. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20030728 · Cited by 268

Cardioprotection by resveratrol: a novel mechanism via autophagy involving the mTORC2 pathway

Gurusamy, N., Lekli, I., Mukherjee, S., Ray, D., Ahsan, M. K., Gherghiceanu, M., Popescu, L. M., & Das, D. K. (2009) · Cardiovascular Research · doi:10.1093/cvr/cvp384 · Cited by 267

Mechanisms through which sulfur amino acids control protein metabolism and oxidative status

Métayer, S., Seiliez, I., Collin, A., Duchêne, S., Mercier, Y., Geraert, P., & Tesseraud, S. (2007) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2007.05.006 · Cited by 260

Rapamycin Ameliorates PKD Resulting from Conditional Inactivation of Pkd1

Shillingford, J. M., Piontek, K. B., Germino, G. G., & Weimbs, T. (2010) · Journal of the American Society of Nephrology · doi:10.1681/asn.2009040421 · Cited by 262

Regulation of Akt Signaling by Sirtuins

Pillai, V. B., Sundaresan, N. R., & Gupta, M. P. (2014) · Circulation Research · doi:10.1161/circresaha.113.300536 · Cited by 262

Coupling of the NMDA receptor to neuroprotective and neurodestructive events

Hardingham, G. E. (2009) · Biochemical Society Transactions · doi:10.1042/bst0371147 · Cited by 268

mTOR-Raptor Binds and Activates SGK1 to Regulate p27 Phosphorylation

Hong, F., Larrea, M. D., Doughty, C. A., Kwiatkowski, D. J., Squillace, R. M., & Slingerland, J. M. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.04.027 · Cited by 259

The multiple facets of mTOR in immunity

Weichhart, T., & Säemann, M. D. (2009) · Trends in Immunology · doi:10.1016/j.it.2009.02.002 · Cited by 263

Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis

Liu, P., Gan, W., Inuzuka, H., Lazorchak, A. S., Gao, D., Arojo, O., Liu, D., Wan, L., Zhai, B., Yu, Y., et al. (2013) · Nature Cell Biology · doi:10.1038/ncb2860 · Cited by 264

Mammalian target of rapamycin complex 1: Signalling inputs, substrates and feedback mechanisms

Dunlop, E. A., & Tee, A. R. (2009) · Cellular Signalling · doi:10.1016/j.cellsig.2009.01.012 · Cited by 263

Regulation of autophagy by polyphenolic compounds as a potential therapeutic strategy for cancer

Hasima, N., & Özpolat, B. (2014) · Cell Death and Disease · doi:10.1038/cddis.2014.467 · Cited by 259

Function of Akt/PKB signaling to cell motility, invasion and the tumor stroma in cancer

Chin, Y. R., & Toker, A. (2008) · Cellular Signalling · doi:10.1016/j.cellsig.2008.11.015 · Cited by 262

Curcumin inhibits the mammalian target of rapamycin‐mediated signaling pathways in cancer cells

Beevers, C. S., Li, F., Liu, L., & Huang, S. (2006) · International Journal of Cancer · doi:10.1002/ijc.21932 · Cited by 256

Getting In on the Akt

(2005) · Science s STKE · doi:10.1126/stke.2722005tw74

Receptor-Specific Mechanisms Regulate Phosphorylation of AKT at Ser473: Role of RICTOR in b1 Integrin-Mediated Cell

Riaz, A., Zeller, K. S., & Johansson, S. (2012)

Rictor Phosphorylation on the Thr-1135 Site Does Not Require Mammalian Target of Rapamycin Complex 2

Boulbés, D. R., Chen, C.-H., Shaiken, T. E., Agarwal, N., Peterson, T. R., Addona, T. A., Keshishian, H., Carr, S. A., Magnuson, M. A., Sabatini, D. M., et al. (2010) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-09-0409 · Cited by 67

Receptor-Specific Mechanisms Regulate Phosphorylation of AKT at Ser473: Role of RICTOR in β1 Integrin-Mediated Cell Survival

Riaz, A., Zeller, K. S., & Johansson, S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0032081 · Cited by 46

Regulation and functions of protein kinase B in DNA damage signaling

Bozulic, L. (2009) · edoc (University of Basel) · doi:10.5451/unibas-005031495