Phosphorylation and Regulation of Akt/PKB by the Rictor-mTOR Complex

mTOR Interacts with Raptor to Form a Nutrient-Sensitive Complex that Signals to the Cell Growth Machinery

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Mechanism of activation of protein kinase B by insulin and IGF‐1.

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Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα

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Rictor, a Novel Binding Partner of mTOR, Defines a Rapamycin-Insensitive and Raptor-Independent Pathway that Regulates the Cytoskeleton

Sarbassov, D. D., Ali, S. M., Kim, D.-H., Guertin, D. A., Latek, R. R., Erdjument-Bromage, H., Tempst, P., & Sabatini, D. M. (2004) · Current Biology · doi:10.1016/j.cub.2004.06.054 · Cited by 2,665

Two TOR Complexes, Only One of which Is Rapamycin Sensitive, Have Distinct Roles in Cell Growth Control

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Insulin Resistance and a Diabetes Mellitus-Like Syndrome in Mice Lacking the Protein Kinase Akt2 (PKBβ)

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Raptor, a Binding Partner of Target of Rapamycin (TOR), Mediates TOR Action

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RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1

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The TSC1-2 tumor suppressor controls insulin–PI3K signaling via regulation of IRS proteins

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Protein Kinase B Kinases That Mediate Phosphatidylinositol 3,4,5-Trisphosphate-Dependent Activation of Protein Kinase B

Stephens, L., Anderson, K. E., Stokoe, D., Erdjument‐Bromage, H., Painter, G. F., Holmes, A. B., Gaffney, P. R. J., Reese, C. B., McCormick, F. P., Tempst, P., et al. (1998) · Science · doi:10.1126/science.279.5351.710 · Cited by 1,061

Fisetin induces autophagic cell death through suppression of mTOR signaling pathway in prostate cancer cells

Suh, Y., Afaq, F., Khan, N., Johnson, J. J., Khusro, F. H., & Mukhtar, H. (2010) · Carcinogenesis · doi:10.1093/carcin/bgq115 · Cited by 196

Redox toxicology of environmental chemicals causing oxidative stress

Zheng, F., Gonçalves, F. M., Abiko, Y., Li, H., Kumagai, Y., & Aschner, M. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101475 · Cited by 198

Rapamycin inhibits cell motility by suppression of mTOR-mediated S6K1 and 4E-BP1 pathways

Liu, L., Li, F., Cardelli, J. A., Martin, K. A., Blenis, J., & Huang, S. (2006) · Oncogene · doi:10.1038/sj.onc.1209691 · Cited by 187

The PI3K-Akt-mTOR pathway in initiation and progression of thyroid tumors

Saji, M., & Ringel, M. D. (2009) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2009.10.016 · Cited by 193

Curcumin inhibits Akt/mammalian target of rapamycin signaling through protein phosphatase-dependent mechanism

Yu, S., Shen, G., Khor, T. O., Kim, J. H., & Kong, A. T. (2008) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-07-2400 · Cited by 192

Radiation-induced Akt activation modulates radioresistance in human glioblastoma cells

Li, H., Kim, J.-S., & Waldman, T. A. (2009) · Radiation Oncology · doi:10.1186/1748-717x-4-43 · Cited by 198

mTOR Signaling in Protein Translation Regulation: Implications in Cancer Genesis and Therapeutic Interventions

Showkat, M., Beigh, M. A., & Andrabi, K. I. (2014) · Molecular Biology International · doi:10.1155/2014/686984 · Cited by 196

Signaling specificity in the Akt pathway in biology and disease

Toker, A., & Marmiroli, S. (2014) · Advances in Biological Regulation · doi:10.1016/j.jbior.2014.04.001 · Cited by 188

New Insights into mTOR Signaling: mTORC2 and Beyond

Alessi, D. R., Pearce, L. R., & García‐Martínez, J. M. (2009) · Science Signaling · doi:10.1126/scisignal.267pe27 · Cited by 193

TORC2 Plasma Membrane Localization Is Essential for Cell Viability and Restricted to a Distinct Domain

Berchtold, D., & Walther, T. C. (2009) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-10-1001 · Cited by 190

Dynamic culture yields engineered myocardium with near-adult functional output

Jackman, C. P., Carlson, A. L., & Bursac, N. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.09.024 · Cited by 193

Molecular targets of isothiocyanates in cancer: Recent advances

Gupta, P., Kim, B., Kim, S., & Srivastava, S. (2014) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201300684 · Cited by 191

Hypoxia-induced MIR155 is a potent autophagy inducer by targeting multiple players in the MTOR pathway

Wan, G., Xie, W., Liu, Z., Xu, W., Lao, Y., Huang, N., Cui, K., Liao, M., He, J., Jiang, Y., et al. (2013) · Autophagy · doi:10.4161/auto.26534 · Cited by 190

mTOR signaling at the crossroads of environmental signals and T‐cell fate decisions

Huang, H., Long, L., Zhou, P., Chapman, N. M., & Chi, H. (2020) · Immunological Reviews · doi:10.1111/imr.12845 · Cited by 193

New insights into Notch1 regulation of the PI3K–AKT–mTOR1 signaling axis: Targeted therapy of γ-secretase inhibitor resistant T-cell acute lymphoblastic leukemia

Hales, E. C., Taub, J. W., & Matherly, L. H. (2013) · Cellular Signalling · doi:10.1016/j.cellsig.2013.09.021 · Cited by 187

The Skp2 Pathway: A Critical Target for Cancer Therapy

Cai, Z., Moten, A., Peng, D., Hsu, C.-C., Pan, B., Manne, R., Li, H., & Lin, H. (2020) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2020.01.013 · Cited by 186

The role of mTOR in depression and antidepressant responses

Abelaira, H. M., Réus, G. Z., Neotti, M. V., & Quevedo, J. (2014) · Life Sciences · doi:10.1016/j.lfs.2014.02.014 · Cited by 185

Rapamycin suppresses seizures and neuronal hypertrophy in a mouse model of cortical dysplasia

Ljungberg, M. C., Sunnen, C. N., Lugo, J. N., Anderson, A. E., & D’Arcangelo, G. (2009) · Disease Models & Mechanisms · doi:10.1242/dmm.002386 · Cited by 186

The role of PI3K/AKT signaling pathway in myocardial ischemia-reperfusion injury

Deng, R.-M., & Zhou, J. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110714 · Cited by 194

Novel roles of Akt and mTOR in suppressing TGF‐β/ALK5‐mediated Smad3 activation

Song, K. W., Wang, H., Krebs, T. L., & Danielpour, D. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600917 · Cited by 185

Silibinin inhibits hypoxia-inducible factor-1α and mTOR/p70S6K/4E-BP1 signalling pathway in human cervical and hepatoma cancer cells: implications for anticancer therapy

García-Maceira, P., & Mateo, J. (2008) · Oncogene · doi:10.1038/onc.2008.398 · Cited by 185

Re-evaluating the role of FOXOs in cancer

Hornsveld, M., Dansen, T. B., Derksen, P. W. B., & Burgering, B. M. T. (2017) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2017.11.017 · Cited by 184

TSC1/TSC2 and Rheb have different effects on TORC1 and TORC2 activity

Yang, Q., Inoki, K., Kim, E., & Guan, K. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0602282103 · Cited by 183

Curcumin: A Potential Candidate in Prevention of Cancer via Modulation of Molecular Pathways

Rahmani, A. H., Zohairy, M. A. A., Aly, S. M., & Khan, M. A. (2014) · BioMed Research International · doi:10.1155/2014/761608 · Cited by 187

Regulation of Akt/PKB Ser473 Phosphorylation

Bayascas, J. R., & Alessi, D. R. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.03.020 · Cited by 184

EGFR–PI3K–AKT–mTOR signaling in head and neck squamous cell carcinomas: attractive targets for molecular-oriented therapy

Freudlsperger, C., Burnett, J. R., Friedman, J., Kannabiran, V. R., Chen, Z., & Waes, C. V. (2010) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2011.541440 · Cited by 183

PHLiPPing the switch on Akt and protein kinase C signaling

Brognard, J., & Newton, A. C. (2008) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2008.04.001 · Cited by 186

Lysyl hydroxylase 2 induces a collagen cross-link switch in tumor stroma

Chen, Y., Terajima, M., Yang, Y., Sun, L., Ahn, Y., Paňková, D., Puperi, D. S., Watanabe, T., Kim, M. P., Blackmon, S. H., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci74725 · Cited by 186

Pharmacodynamics and pharmacokinetics of inositol(s) in health and disease

Bizzarri, M., Fuso, A., Dinicola, S., Cucina, A., & Bevilacqua, A. (2016) · Expert Opinion on Drug Metabolism & Toxicology · doi:10.1080/17425255.2016.1206887 · Cited by 185

The Role of the Mammalian Target of Rapamycin (mTOR) in Pulmonary Fibrosis

Lawrence, J., & Nho, R. S. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19030778 · Cited by 183

Lysosome: The metabolic signaling hub

Lamming, D. W., & Bar‐Peled, L. (2019) · Traffic · doi:10.1111/tra.12617 · Cited by 173

mTOR pathway in colorectal cancer: an update

Francipane, M. G., & Lagasse, E. (2013) · Oncotarget · doi:10.18632/oncotarget.1548 · Cited by 186

Role of PI3K/Akt signaling in memory CD8 T cell differentiation

Kim, E. H., & Suresh, M. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00020 · Cited by 185

Training for Endurance and Strength

Baar, K. (2006) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000233799.62153.19 · Cited by 183

β-hydroxy-β-methylbutyrate (HMB) stimulates myogenic cell proliferation, differentiation and survival via the MAPK/ERK and PI3K/Akt pathways

Kornasio, R., Riederer, I., Butler-Browne, G. S., Mouly, V., Uni, Z., & Halevy, O. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2008.12.017 · Cited by 184

mTORC1/2 inhibition preserves ovarian function and fertility during genotoxic chemotherapy

Goldman, K. N., Chenette, D. M., Arju, R., Duncan, F. E., Keefe, D. L., GRIFO, J. A., & Schneider, R. J. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1617233114 · Cited by 182

mTOR pathway as a target in tissue hypertrophy

Lee, C.-H., Inoki, K., & Guan, K.-L. (2007) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.47.120505.105359 · Cited by 179

Regulation of Autophagy by Kinases

Sridharan, S., Jain, K., & Basu, A. (2011) · Cancers · doi:10.3390/cancers3022630 · Cited by 189

Targeting the PI3K/Akt signaling pathway in gastric carcinoma: A reality for personalized medicine?

Singh, S. S. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i43.12261 · Cited by 183

Handicapping the Race to Develop Inhibitors of the Phosphoinositide 3-Kinase/Akt/Mammalian Target of Rapamycin Pathway

Granville, C. A., Memmott, R. M., Gills, J. J., & Dennis, P. A. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-1654 · Cited by 181

African Swine Fever Virus Uses Macropinocytosis to Enter Host Cells

Sánchez, E. G., Quintas, A., Pérez-Núñez, D., Nogal, M., Barroso, S., Carrascosa, Á. L., & Revilla, Y. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1002754 · Cited by 180

PIP3-Independent Activation of TorC2 and PKB at the Cell's Leading Edge Mediates Chemotaxis

Kamimura, Y., Xiong, Y., Iglesias, P. A., Hoeller, O., Bolourani, P., & Devreotes, P. N. (2008) · Current Biology · doi:10.1016/j.cub.2008.06.068 · Cited by 176

Behavioral phenotypes of genetic mouse models of autism

Kazdoba, T. M., Leach, P. T., & Crawley, J. N. (2015) · Genes Brain & Behavior · doi:10.1111/gbb.12256 · Cited by 187

Integrating Body and Organ Size in Drosophila: Recent Advances and Outstanding Problems

Mirth, C. K., & Shingleton, A. W. (2012) · Frontiers in Endocrinology · doi:10.3389/fendo.2012.00049 · Cited by 180

The Biology Behind mTOR Inhibition in Sarcoma

Wan, X., & Helman, L. J. (2007) · The Oncologist · doi:10.1634/theoncologist.12-8-1007 · Cited by 181

Hepatic stellate cell senescence in liver fibrosis: Characteristics, mechanisms and perspectives

Zhang, M., Salas, S. S., Damba, T., Borghesan, M., Demaria, M., & Moshage, H. J. (2021) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2021.111572 · Cited by 192

Protor-1 is required for efficient mTORC2-mediated activation of SGK1 in the kidney

Pearce, L. R., Sommer, E. M., Sakamoto, K., Wullschleger, S., & Alessi, D. R. (2011) · Biochemical Journal · doi:10.1042/bj20102103 · Cited by 189

Ack1 Mediated AKT/PKB Tyrosine 176 Phosphorylation Regulates Its Activation

Mahajan, K. N., Coppola, D., Challa, S., Fang, B., Chen, Y. A., Zhu, W., Lopez, A. S., Koomen, J. M., Engelman, R. W., Rivera, C., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009646 · Cited by 179

The insulin receptor substrate (IRS) proteins

Shaw, L. M. (2011) · Cell Cycle · doi:10.4161/cc.10.11.15824 · Cited by 186

Akt/PKB: one kinase, many modifications

Risso, G., Blaustein, M., Pozzi, B., Mammi, P., & Srebrow, A. (2015) · Biochemical Journal · doi:10.1042/bj20150041 · Cited by 191

Signaling pathways in schizophrenia: emerging targets and therapeutic strategies

Karam, C. S., Ballon, J. S., Bivens, N. M., Freyberg, Z., Girgis, R. R., Lizardi-Ortiz, J. E., Markx, S., Lieberman, J. A., & Javitch, J. A. (2010) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2010.05.004 · Cited by 180

Accumulation of autophagosomes confers cytotoxicity

Button, R. W., Roberts, S. L., Willis, T. L., Hanemann, C. O., & Luo, S. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.782276 · Cited by 186

Identification of PHLPP1 as a Tumor Suppressor Reveals the Role of Feedback Activation in PTEN-Mutant Prostate Cancer Progression

Chen, M., Pratt, C. P., Zeeman, M. E., Schultz, N. D., Taylor, B. S., O’Neill, A., Castillo-Martín, M., Nowak, D. G., Naguib, A., Grace, D., et al. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.07.013 · Cited by 178

Epigallocatechin gallate (EGCG), a major component of green tea, is a dual phosphoinositide-3-kinase/mTOR inhibitor

Aller, G. S. V., Carson, J. D., Tang, W. D., Peng, H., Zhao, L., Copeland, R. A., Tummino, P. J., & Luo, L. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.02.010 · Cited by 178

The role of mTOR in memory CD8+ T‐cell differentiation

Araki, K., Youngblood, B., & Ahmed, R. (2010) · Immunological Reviews · doi:10.1111/j.0105-2896.2010.00898.x · Cited by 179

Targeting the Phosphatidylinositol 3-Kinase Signaling Pathway in Breast Cancer

Hernandez-Aya, L. F., & Gonzalez-Angulo, A. M. (2011) · The Oncologist · doi:10.1634/theoncologist.2010-0402 · Cited by 178

mTORC2: The other mTOR in autophagy regulation

Ballesteros‐Álvarez, J., & Andersen, J. K. (2021) · Aging Cell · doi:10.1111/acel.13431 · Cited by 187

Obesity Increases Vascular Senescence and Susceptibility to Ischemic Injury Through Chronic Activation of Akt and mTOR

Wang, C.-Y., Kim, H.-H., Hiroi, Y., Sawada, N., Salomone, S., Benjamin, L. E., Walsh, K., Moskowitz, M. A., & Liao, J. K. (2009) · Science Signaling · doi:10.1126/scisignal.2000143 · Cited by 177

Serum and glucocorticoid‐regulated protein kinases: Variations on a theme

Tessier, M., & Woodgett, J. R. (2006) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20894 · Cited by 176

Role of PRAS40 in Akt and mTOR signaling in health and disease

Wiza, C., Nascimento, E. B. M., & Ouwens, D. M. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00660.2011 · Cited by 188

Targeted Inhibition of Mammalian Target of Rapamycin Signaling Inhibits Tumorigenesis of Colorectal Cancer

Gulhati, P., Cai, Q., Li, J., Liu, J., Rychahou, P. G., Qiu, S., Lee, E. Y., Silva, S. R., Bowen, K. A., Gao, T., et al. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-1249 · Cited by 183

Exosome Release Is Regulated by mTORC1

Zou, W., Lai, M., Zhang, Y., Zheng, L., Xing, Z., Li, T., Zou, Z., Song, Q., Zhao, X., Xia, L., et al. (2018) · Advanced Science · doi:10.1002/advs.201801313 · Cited by 174

Longevity, aging and rapamycin

Ehninger, D., Neff, F., & Xie, K. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1677-1 · Cited by 183

Inhibition of Mechanistic Target of Rapamycin Promotes Dendritic Cell Activation and Enhances Therapeutic Autologous Vaccination in Mice

Amiel, E., Everts, B., Freitas, T. C., King, I. L., Curtis, J. D., Pearce, E. L., & Pearce, E. J. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1103741 · Cited by 178

The Dichotomy of NMDA Receptor Signaling

Papadia, S., & Hardingham, G. E. (2007) · The Neuroscientist · doi:10.1177/10738584070130060401 · Cited by 180

The Regulation of Multiple p53 Stress Responses is Mediated through MDM2

Hu, W., Feng, Z., & Levine, A. J. (2012) · Genes & Cancer · doi:10.1177/1947601912454734 · Cited by 183

Activated FOXO-mediated insulin resistance is blocked by reduction of TOR activity

Luong, N., Davies, C. R., Wessells, R. J., Graham, S. M., King, M. T., Veech, R. L., Bodmer, R., & Oldham, S. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.05.013 · Cited by 173

mTOR complex 2 in adipose tissue negatively controls whole-body growth

Cybulski, N., Polak, P., Auwerx, J. H., Rüegg, M. A., & Hall, M. N. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0811321106 · Cited by 175

A phase II trial of everolimus, temozolomide, and radiotherapy in patients with newly diagnosed glioblastoma: NCCTG N057K

Ma, D. J., Galanis, E., Anderson, S. K., Schiff, D., Kaufmann, T. J., Peller, P. J., Giannini, C., Brown, P. D., Uhm, J. H., McGraw, S. C., et al. (2014) · Neuro-Oncology · doi:10.1093/neuonc/nou328 · Cited by 173

An ATP-Site On-Off Switch That Restricts Phosphatase Accessibility of Akt

Lin, K., Lin, J. M., Wu, W., Ballard, J. A., Lee, B. B., Gloor, S. L., Vigers, G. P. A., Morales, T. H., Friedman, L. S., Skelton, N. J., et al. (2012) · Science Signaling · doi:10.1126/scisignal.2002618 · Cited by 174

Functional distinctions of protein kinase B/Akt isoforms defined by their influence on cell migration

Stambolic, V., & Woodgett, J. R. (2006) · Trends in Cell Biology · doi:10.1016/j.tcb.2006.07.001 · Cited by 176

Insulin receptor signals regulating GLUT4 translocation and actin dynamics.

Kanzaki, M. (2006) · Endocrine journal · doi:10.1507/endocrj.kr-65 · Cited by 181

HLA Class I Antibody-Mediated Endothelial Cell Proliferation via the mTOR Pathway

Jindra, P., Jin, Y., Rozengurt, E., & Reed, E. F. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.4.2357 · Cited by 173

PRMT5-Dependent Methylation of the TIP60 Coactivator RUVBL1 Is a Key Regulator of Homologous Recombination

Clarke, T. L., Sánchez-Bailón, M. P., Chiang, K., Reynolds, J. J., Herrero‐Ruiz, J., Bandeiras, T. M., Matias, P. M., Maslen, S., Skehel, M. J., Stewart, G. S., et al. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.01.019 · Cited by 178

Brain Development and Akt Signaling: the Crossroads of Signaling Pathway and Neurodevelopmental Diseases

Wang, L., Zhou, K., Fu, Z., Yu, D., Huang, H., Zang, X., & Mo, X. (2017) · Journal of Molecular Neuroscience · doi:10.1007/s12031-016-0872-y · Cited by 172

Getting ready for building: signaling and autophagosome biogenesis

Abada, A., & Elazar, Z. (2014) · EMBO Reports · doi:10.15252/embr.201439076 · Cited by 178

Calcium-Activated Chloride Channels (CaCCs) Regulate Action Potential and Synaptic Response in Hippocampal Neurons

Huang, W. C., Xiao, S., Huang, F., Harfe, B. D., Jan, Y. N., & Jan, L. Y. (2012) · Neuron · doi:10.1016/j.neuron.2012.01.033 · Cited by 177

Molecular targeting of hypoxia in radiotherapy

Rey, S., Schito, L., Koritzinsky, M., & Wouters, B. G. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2016.10.002 · Cited by 178

Activation of AMPK and inactivation of Akt result in suppression of mTOR-mediated S6K1 and 4E-BP1 pathways leading to neuronal cell death in in vitro models of Parkinson's disease

Xu, Y., Liu, C., Chen, S., Ye, Y., Guo, M., Ren, Q., Liu, L., Zhang, H., Xu, C., Zhou, Q., et al. (2014) · Cellular Signalling · doi:10.1016/j.cellsig.2014.04.009 · Cited by 170

Rapamycin is efficacious against primary effusion lymphoma (PEL) cell lines in vivo by inhibiting autocrine signaling

Sin, S., Roy, D., Wang, L., Staudt, M. R., Fakhari, F. D., Patel, D. D., Henry, D. H., Harrington, W. J., Damania, B., & Dittmer, D. P. (2006) · Blood · doi:10.1182/blood-2006-06-028092 · Cited by 171

Phosphatidylserine is a critical modulator for Akt activation

Huang, B. X., Akbar, M. D., Kevala, K., & Kim, H. (2011) · The Journal of Cell Biology · doi:10.1083/jcb.201005100 · Cited by 171

Phase I/II study of erlotinib and temsirolimus for patients with recurrent malignant gliomas: North American Brain Tumor Consortium trial 04-02

Wen, P. Y., Chang, S., Lamborn, K. R., Kuhn, J. G., Norden, A. D., Cloughesy, T. F., Robins, H. I., Lieberman, F. S., Gilbert, M. R., Mehta, M. P., et al. (2014) · Neuro-Oncology · doi:10.1093/neuonc/not247 · Cited by 174

Adipose tissue mTORC2 regulates ChREBP-driven de novo lipogenesis and hepatic glucose metabolism

Tang, Y., Wallace, M., Sánchez-Gurmaches, J., Hsiao, W., Li, H., Lee, P. L., Vernia, S., Metallo, C. M., & Guertin, D. A. (2016) · Nature Communications · doi:10.1038/ncomms11365 · Cited by 188

Regulation of FOXO Factors in Mammalian Cells

Brown, A. K., & Webb, A. E. (2017) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2017.10.006 · Cited by 177

PI3K-AKT-mTOR and NFκB Pathways in Ovarian Cancer: Implications for Targeted Therapeutics

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Nonalcoholic fatty liver disease: cause or consequence of type 2 diabetes?

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