Phosphorylation and Regulation of Akt/PKB by the Rictor-mTOR Complex

mTOR Interacts with Raptor to Form a Nutrient-Sensitive Complex that Signals to the Cell Growth Machinery

Kim, D., Sarbassov, D. D., Ali, S. M., King, J. E., Latek, R. R., Erdjument‐Bromage, H., Tempst, P., & Sabatini, D. M. (2002) · Cell · doi:10.1016/s0092-8674(02)00808-5 · Cited by 3,051

Mechanism of activation of protein kinase B by insulin and IGF‐1.

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Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα

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Rictor, a Novel Binding Partner of mTOR, Defines a Rapamycin-Insensitive and Raptor-Independent Pathway that Regulates the Cytoskeleton

Sarbassov, D. D., Ali, S. M., Kim, D.-H., Guertin, D. A., Latek, R. R., Erdjument-Bromage, H., Tempst, P., & Sabatini, D. M. (2004) · Current Biology · doi:10.1016/j.cub.2004.06.054 · Cited by 2,665

Two TOR Complexes, Only One of which Is Rapamycin Sensitive, Have Distinct Roles in Cell Growth Control

Loewith, R., Jacinto, E., Wullschleger, S., Lorberg, A., Crespo, J. L., Bonenfant, D., Oppliger, W., Jenoe, P., & Hall, M. N. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00636-6 · Cited by 1,886

Insulin Resistance and a Diabetes Mellitus-Like Syndrome in Mice Lacking the Protein Kinase Akt2 (PKBβ)

Cho, H., Mu, J., Kim, J. K., Thorvaldsen, J. L., Chu, Q., Crenshaw, E. B., Kaestner, K. H., Bartolomei, M. S., Shulman, G. I., & Birnbaum, M. J. (2001) · Science · doi:10.1126/science.292.5522.1728 · Cited by 1,860

Raptor, a Binding Partner of Target of Rapamycin (TOR), Mediates TOR Action

Hara, K., Maruki, Y., Long, X., Yoshino, K.-I., Oshiro, N., Sujuti, H., Tokunaga, C., Avruch, J., & Yonezawa, K. (2002) · Cell · doi:10.1016/s0092-8674(02)00833-4 · Cited by 1,810

RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1

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The TSC1-2 tumor suppressor controls insulin–PI3K signaling via regulation of IRS proteins

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Protein Kinase B Kinases That Mediate Phosphatidylinositol 3,4,5-Trisphosphate-Dependent Activation of Protein Kinase B

Stephens, L., Anderson, K. E., Stokoe, D., Erdjument‐Bromage, H., Painter, G. F., Holmes, A. B., Gaffney, P. R. J., Reese, C. B., McCormick, F. P., Tempst, P., et al. (1998) · Science · doi:10.1126/science.279.5351.710 · Cited by 1,061

G×G×E for Lifespan in Drosophila: Mitochondrial, Nuclear, and Dietary Interactions that Modify Longevity

Zhu, C.-T., Ingelmo, P., & Rand, D. M. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004354 · Cited by 153

Mammalian Target of Rapamycin Complex 2 (mTORC2) Negatively Regulates Toll-like Receptor 4-mediated Inflammatory Response via FoxO1

Brown, J. R., Wang, H., Suttles, J., Graves, D. T., & Martin, M. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.258053 · Cited by 154

Class 1 PI3K Clinical Candidates and Recent Inhibitor Design Strategies: A Medicinal Chemistry Perspective

Garces, A. E., & Stocks, M. J. (2018) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.8b01492 · Cited by 152

The immunobiology of mTOR in autoimmunity

Suto, T., & Karonitsch, T. (2020) · Journal of Autoimmunity · doi:10.1016/j.jaut.2019.102373 · Cited by 149

PDK1 Signaling Toward PLK1–MYC Activation Confers Oncogenic Transformation, Tumor-Initiating Cell Activation, and Resistance to mTOR-Targeted Therapy

Tan, J. Y., Li, Z., Lee, P. L., Guan, P., Aau, M. Y., Lee, S. T., Feng, M., Lim, C. Z., Lee, E. Y. J., Wee, Z. N., et al. (2013) · Cancer Discovery · doi:10.1158/2159-8290.cd-12-0595 · Cited by 150

Discovery of Novel AKT Inhibitors with Enhanced Anti-Tumor Effects in Combination with the MEK Inhibitor

Dumble, M. L., Crouthamel, M., Zhang, S., Schaber, M. D., Levy, D. S., Robell, K. A., Liu, Q., Figueroa, D. J., Minthorn, E. A., Seefeld, M. A., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0100880 · Cited by 150

Mammalian Target of Rapamycin Contributes to the Acquired Apoptotic Resistance of Human Mesothelioma Multicellular Spheroids

Barbone, D., Yang, T., Morgan, J. R., Gaudino, G., & Broaddus, V. C. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m709698200 · Cited by 149

The Paradox of Akt-mTOR Interactions

Vadlakonda, L., Dash, A., Pasupuleti, M., Kumar, K. A., & Reddanna, P. (2013) · Frontiers in Oncology · doi:10.3389/fonc.2013.00165 · Cited by 156

Autophagy: a multifaceted player in the fate of sperm

Wang, M., Zeng, L., Su, P., Ma, L., Zhang, M., & Zhang, Y. (2021) · Human Reproduction Update · doi:10.1093/humupd/dmab043 · Cited by 155

Cancer signaling, cell/gene therapy, diagnosis and role of nanobiomaterials

Rosic, G. L. (2024) · Advances in Biology & Earth Sciences · doi:10.62476/abes9s11 · Cited by 153

Elevated phosphorylation and activation of PDK-1/AKT pathway in human breast cancer

Lin, H.-J., Hsieh, F.-C., Song, H., & Lin, J. (2005) · British Journal of Cancer · doi:10.1038/sj.bjc.6602862 · Cited by 153

mTOR regulates phagosome and entotic vacuole fission

Krajcovic, M., Krishna, S., Akkari, L., Joyce, J. A., & Overholtzer, M. (2013) · Molecular Biology of the Cell · doi:10.1091/mbc.e13-07-0408 · Cited by 149

Regulation of mTORC1 by the Rab and Arf GTPases

Li, L., Kim, E., Yuan, H., Inoki, K., Goraksha-Hicks, P., Schiesher, R. L., Neufeld, T. P., & Guan, K. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.c110.102483 · Cited by 153

Mammalian Target of Rapamycin: Hitting the Bull′s‐Eye for Neurological Disorders

Chong, Z. Z., Shang, Y., Zhang, L., Wang, S., & Maiese, K. (2010) · Oxidative Medicine and Cellular Longevity · doi:10.4161/oxim.3.6.14787 · Cited by 149

Mammalian Target of Rapamycin Complex 1 (mTORC1) and 2 (mTORC2) Control the Dendritic Arbor Morphology of Hippocampal Neurons

Urbańska, M., Góźdź, A., Swiech, L. J., & Jaworski, J. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.374405 · Cited by 149

mTORC2 Regulates Mechanically Induced Cytoskeletal Reorganization and Lineage Selection in Marrow-Derived Mesenchymal Stem Cells

Sen, B., Xie, Z., Case, N. D., Thompson, W. R., Uzer, G., Styner, M., & Rubin, J. E. (2013) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2031 · Cited by 149

Inhibition of Mammalian Target of Rapamycin Induces Phosphatidylinositol 3-Kinase-Dependent and Mnk-Mediated Eukaryotic Translation Initiation Factor 4E Phosphorylation

Wang, X., Yue, P., Chan, C. B., Ye, K., Ueda, T., Watanabe‐Fukunaga, R., Fukunaga, R., Fu, H., Khuri, F. R., & Sun, S. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00760-07 · Cited by 149

PDK2: the missing piece in the receptor tyrosine kinase signaling pathway puzzle

Dong, L., & Liu, F. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00011.2005 · Cited by 149

MFN2 suppresses cancer progression through inhibition of mTORC2/Akt signaling

Xu, K., Chen, G., Li, X., Wu, X., Chang, Z., Xu, J., Zhu, Y. T., Yin, P., Liang, X., & Dong, L. (2017) · Scientific Reports · doi:10.1038/srep41718 · Cited by 152

The Redox Regulation of PI 3-Kinase–Dependent Signaling

Leslie, N. R. (2006) · Antioxidants and Redox Signaling · doi:10.1089/ars.2006.8.1765 · Cited by 151

Glutaminolysis and autophagy in cancer

Villar, V. H., Merhi, F., Djavaheri-Mergny, M., & Durán, R. V. (2015) · Autophagy · doi:10.1080/15548627.2015.1053680 · Cited by 143

Zebrafish screen identifies novel compound with selective toxicity against leukemia

Ridges, S., Heaton, W. L., Joshi, D., Choi, H., Eiring, A. M., Batchelor, L. A., Choudhry, P., Manos, E. J., Sofla, H., Sanati, A., et al. (2012) · Blood · doi:10.1182/blood-2011-12-398818 · Cited by 148

Proline dehydrogenase is essential for proline protection against hydrogen peroxide-induced cell death

Natarajan, S. K., Zhu, W., Liang, X., Zhang, L., Demers, A., Zimmerman, M. C., Simpson, M. A., & Becker, D. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.07.002 · Cited by 148

Inhibition of Ras Signaling by Blocking Ras–Effector Interactions with Cyclic Peptides

Upadhyaya, P., Qian, Z., Selner, N. G., Clippinger, S. R., Wu, Z., Briesewitz, R., & Pei, D. (2015) · Angewandte Chemie International Edition · doi:10.1002/anie.201502763 · Cited by 149

Obesity and cancer, a case for insulin signaling

Poloz, Y., & Stambolic, V. (2015) · Cell Death and Disease · doi:10.1038/cddis.2015.381 · Cited by 154

Recent advancement of piperidine moiety in treatment of cancer- A review

Goel, P., Alam, O., Naim, M. J., Nawaz, F., Iqbal, M., & Alam, I. (2018) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2018.08.017 · Cited by 150

RAS mutations in human cancers: Roles in precision medicine

Murugan, A. K., Grieco, M., & Tsuchida, N. (2019) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2019.06.007 · Cited by 146

Re-evaluating the Roles of Proposed Modulators of Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling

Wang, X., Fonseca, B. D., Tang, H., Liu, R., Elia, A., Clemens, M. J., Bommer, U., & Proud, C. G. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m803348200 · Cited by 147

SGK3 Mediates INPP4B-Dependent PI3K Signaling in Breast Cancer

Gasser, J. A., Inuzuka, H., Lau, A. W., Wei, W., Beroukhim, R., & Toker, A. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.09.023 · Cited by 148

mTOR kinase inhibitors as potential cancer therapeutic drugs

Sun, S. (2013) · Cancer Letters · doi:10.1016/j.canlet.2013.06.017 · Cited by 152

miR-7 and miR-153 protect neurons against MPP+-induced cell death via upregulation of mTOR pathway

Fragkouli, A., & Doxakis, E. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00182 · Cited by 151

Testosterone Signals through mTOR and Androgen Receptor to Induce Muscle Hypertrophy

Basualto-Alarcón, C., Jorquera, G., Altamirano, F. J., Jaimovich, E., & Estrada, M. (2013) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e31828cf5f3 · Cited by 158

Berberine as a potential autophagy modulator

Mohammadinejad, R., Ahmadi, Z., Tavakol, S., & Ashrafizadeh, M. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28325 · Cited by 132

mTOR signaling regulates the morphology and migration of outer radial glia in developing human cortex

Andrews, M. G., Subramanian, L., & Kriegstein, A. R. (2020) · eLife · doi:10.7554/elife.58737 · Cited by 148

β-Catenin Levels Influence Rapid Mechanical Responses in Osteoblasts

Case, N. D., Ma, M., Sen, B., Xie, Z., Gross, T. S., & Rubin, J. E. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m801907200 · Cited by 148

Statin-induced Ras Activation Integrates the Phosphatidylinositol 3-Kinase Signal to Akt and MAPK for Bone Morphogenetic Protein-2 Expression in Osteoblast Differentiation

Ghosh‐Choudhury, N., Mandal, C. C., & Choudhury, G. G. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m606706200 · Cited by 149

Rapamycin Promotes Vascular Smooth Muscle Cell Differentiation through Insulin Receptor Substrate-1/Phosphatidylinositol 3-Kinase/Akt2 Feedback Signaling

Martin, K. A., Merenick, B. L., Ding, M., Fetalvero, K. M., Rzucidlo, E. M., Kozul, C. D., Brown, D. J., Chiu, H. Y., Shyu, M., Drapeau, B. L., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m703914200 · Cited by 149

Dual inhibition of PI3K and mTOR inhibits autocrine and paracrine proliferative loops in PI3K/Akt/mTOR-addicted lymphomas

Bhatt, A. P., Bhende, P. M., Sin, S., Roy, D., Dittmer, D. P., & Damania, B. (2010) · Blood · doi:10.1182/blood-2009-10-251082 · Cited by 147

Nesfatin-1 Action in the Brain Increases Insulin Sensitivity Through Akt/AMPK/TORC2 Pathway in Diet-Induced Insulin Resistance

Yang, M., Zhang, Z., Wang, C., Li, K., Li, S., Boden, G. H., Li, L., & Yang, G. (2012) · Diabetes · doi:10.2337/db11-1755 · Cited by 149

Key signaling pathways in thyroid cancer

Zaballos, M. A., & Santisteban, P. (2017) · Journal of Endocrinology · doi:10.1530/joe-17-0266 · Cited by 153

Overview of Research into mTOR Inhibitors

Mao, B., Zhang, Q., Ma, L., Zhao, D., Zhao, P., & Yan, P. (2022) · Molecules · doi:10.3390/molecules27165295 · Cited by 155

Functional reprogramming of regulatory T cells in the absence of Foxp3

Charbonnier, L.-M., Cui, Y., Stephen-Victor, E., Harb, H., Lopez, D., Bleesing, J. J., Garcia-Lloret, M. I., Chen, K., Ozen, A., Carmeliet, P., et al. (2019) · Nature Immunology · doi:10.1038/s41590-019-0442-x · Cited by 145

Inactivation of mTORC1 in the Developing Brain Causes Microcephaly and Affects Gliogenesis

Cloëtta, D., Thomanetz, V., Baranek, C., Lustenberger, R. M., Lin, S., Oliveri, F., Atanasoski, S., & Rüegg, M. A. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.3294-12.2013 · Cited by 145

Phosphatidylinositol 3-kinase-AKT-mammalian target of rapamycin (PI3K-Akt-mTOR) signaling pathway in non-small cell lung cancer.

Yip, P. Y. (2015) · PubMed Central · doi:10.3978/j.issn.2218-6751.2015.01.04 · Cited by 144

Ablation of PI3K blocks BCR-ABL leukemogenesis in mice, and a dual PI3K/mTOR inhibitor prevents expansion of human BCR-ABL+ leukemia cells

Kharas, M. G., Janes, M. R., Scarfone, V. M., Lilly, M. B., Knight, Z. A., Shokat, K. M., & Fruman, D. A. (2008) · Journal of Clinical Investigation · doi:10.1172/jci33337 · Cited by 146

PI3K/AKT/mTOR Signaling Regulates the Virus/Host Cell Crosstalk in HPV-Positive Cervical Cancer Cells

Bossler, F., Hoppe‐Seyler, K., & Hoppe‐Seyler, F. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20092188 · Cited by 149

Heterobifunctional Molecules Induce Dephosphorylation of Kinases–A Proof of Concept Study

Yamazoe, S., Tom, J., Fu, Y., Wu, W., Zeng, L., Sun, C., Liu, Q., Lin, J. M., Lin, K., Fairbrother, W. J., et al. (2019) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.9b01167 · Cited by 147

Regulation of the Akt kinase by interacting proteins

Du, K., & Tsichlis, P. N. (2005) · Oncogene · doi:10.1038/sj.onc.1209099 · Cited by 143

MAPK/ERK Signaling Regulates Insulin Sensitivity to Control Glucose Metabolism in Drosophila

Zhang, W., Thompson, B. J., Hietakangas, V., & Cohen, S. M. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002429 · Cited by 151

Autophagy is essential to support skeletal muscle plasticity in response to endurance exercise

Sanchez, A. M. J., Bernardi, H., Py, G., & Candau, R. B. (2014) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00187.2014 · Cited by 125

Arrest of Myelination and Reduced Axon Growth When Schwann Cells Lack mTOR

Sherman, D. L., Krols, M., Wu, L.-M. N., Grove, M., Nave, K., Gangloff, Y., & Brophy, P. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.4814-11.2012 · Cited by 151

mTORC1 signaling: what we still don't know

Wang, X., & Proud, C. G. (2010) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjq038 · Cited by 150

IL-15–PI3K–AKT–mTOR: A Critical Pathway in the Life Journey of Natural Killer Cells

Ali, A. K., Nandagopal, N., & Lee, S. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00355 · Cited by 152

Role for mTOR Signaling and Neuronal Activity in Morphine-Induced Adaptations in Ventral Tegmental Area Dopamine Neurons

Mazei‐Robison, M. S., Koo, J. W., Friedman, A. K., Lansink, C. S., Robison, A. J., Vinish, M., Krishnan, V., Kim, S., Siuta, M., Galli, A., et al. (2011) · Neuron · doi:10.1016/j.neuron.2011.10.012 · Cited by 148

EYA1 and SIX1 drive the neuronal developmental program in cooperation with the SWI/SNF chromatin-remodeling complex and SOX2 in the mammalian inner ear

Ahmed, M. U., Xu, J., & Xu, P. (2012) · Development · doi:10.1242/dev.071670 · Cited by 145

A Dynamic Network Model of mTOR Signaling Reveals TSC-Independent mTORC2 Regulation

Pezze, P. D., Sonntag, A., Thien, A., Prentzell, M. T., Gödel, M., Fischer, S., Neumann‐Haefelin, E., Huber, T. B., Baumeister, R., Shanley, D. P., et al. (2012) · Science Signaling · doi:10.1126/scisignal.2002469 · Cited by 148

Rapamycin Inhibits Cytoskeleton Reorganization and Cell Motility by Suppressing RhoA Expression and Activity

Liu, L., Luo, Y., Chen, L., Shen, T., Xu, B., Chen, W., Zhou, H., Han, X., & Huang, S. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.141168 · Cited by 144

mTOR Cross-Talk in Cancer and Potential for Combination Therapy

Conciatori, F., Ciuffreda, L., Bazzichetto, C., Falcone, I., Pilotto, S., Bria, E., Cognetti, F., & Milella, M. (2018) · Cancers · doi:10.3390/cancers10010023 · Cited by 145

Modulation of the PI3K/Akt/mTOR signaling pathway by probiotics as a fruitful target for orchestrating the immune response

Mohseni, A. H., Casolaro, V., Bermúdez‐Humarán, L. G., Keyvani, H., & Taghinezhad‐S, S. (2021) · Gut Microbes · doi:10.1080/19490976.2021.1886844 · Cited by 143

Dual Phosphoinositide 3-Kinase/Mammalian Target of Rapamycin Blockade Is an Effective Radiosensitizing Strategy for the Treatment of Non–Small Cell Lung Cancer Harboring K-RAS Mutations

Konstantinidou, G., Bey, E. A., Rabellino, A., Schuster, K., Maira, M. S., Gazdar, A. F., Amici, A., Boothman, D. A., & Scaglioni, P. P. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-0823 · Cited by 142

Pushing the Envelope in the mTOR Pathway: The Second Generation of Inhibitors

Vilar, E., Pérez-García, J. M., & Tabernero, J. M. (2011) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-10-0905 · Cited by 149

A New Cytosolic Pathway from a Parkinson Disease-associated Kinase, BRPK/PINK1

Murata, H., Sakaguchi, M., Yu, J. Z., Sakaguchi, Y. M., Futami, J., Yamada, H., Kataoka, K., & Huh, N.-H. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.179390 · Cited by 142

Mechanisms regulating nutrition-dependent developmental plasticity through organ-specific effects in insects

Koyama, T., Mendes, C. C., & Mirth, C. K. (2013) · Frontiers in Physiology · doi:10.3389/fphys.2013.00263 · Cited by 144

Targeting the PI3K/AKT/mTOR pathway: potential for lung cancer treatment

Cheng, H., Shcherba, M., Pendurti, G., Liang, Y., Piperdi, B., & Perez-Soler, R. (2014) · Lung Cancer Management · doi:10.2217/lmt.13.72 · Cited by 145

mTORC2 promotes type I insulin-like growth factor receptor and insulin receptor activation through the tyrosine kinase activity of mTOR

Yin, Y., Hua, H. M., Li, M., Liu, S., Kong, Q., Shao, T., Wang, J., Luo, Y., Wang, Q., Luo, T. L., et al. (2015) · Cell Research · doi:10.1038/cr.2015.133 · Cited by 147

PI3K/Akt/mTOR inhibitors in breast cancer.

Lee, J. J. X., Loh, K. W.-J., & Yap, Y. S. (2015) · Europe PMC (PubMed Central) · doi:10.7497/j.issn.2095-3941.2015.0089 · Cited by 230

Point mutations in TOR confer Rheb-independent growth in fission yeast and nutrient-independent mammalian TOR signaling in mammalian cells

Urano, J., Sato, T., Matsuo, T., Otsubo, Y., Yamamoto, M. P., & Tamanoi, F. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0608510104 · Cited by 140

Large FK506-binding proteins shape the pharmacology of rapamycin

März, A. M., Fabian, A.-K., Kozany, C., Bracher, A., & Hausch, F. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.00678-12 · Cited by 141

The Effects of mTOR-Akt Interactions on Anti-apoptotic Signaling in Vascular Endothelial Cells

Dormond, O., Madsen, J. C., & Briscoe, D. M. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m700563200 · Cited by 144

Modulation of SIRT1-Foxo1 Signaling axis by Resveratrol: Implications in Skeletal Muscle Aging and Insulin Resistance

Sin, T. K., Yung, B. Y., & Siu, P. M. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000369718 · Cited by 144

Suppression of RIP3-dependent Necroptosis by Human Cytomegalovirus

Omoto, S., Guo, H., Talekar, G. R., Roback, L., Kaiser, W. J., & Mocarski, E. S. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.646042 · Cited by 145

Phosphorylation of AKT: a Mutational Analysis

Hart, J. R., & Vogt, P. K. (2011) · Oncotarget · doi:10.18632/oncotarget.293 · Cited by 143

Mammalian Target of Rapamycin Regulates Nox4-Mediated Podocyte Depletion in Diabetic Renal Injury

Eid, A. A., Ford, B. M., Bhandari, B. K., Cavaglieri, R. D. C., Block, K. L., Barnes, J. L., Gorin, Y. C., Choudhury, G. G., & Abboud, H. E. (2013) · Diabetes · doi:10.2337/db12-1504 · Cited by 141

A novel polypeptide encoded by the circular RNA ZKSCAN1 suppresses HCC via degradation of mTOR

Song, R., Ma, S., Xu, J., Ren, X., Guo, P., Liu, H., Li, P., Yin, F., Liu, M., Wang, Q., et al. (2023) · Molecular Cancer · doi:10.1186/s12943-023-01719-9 · Cited by 141

AKTivation of PI3K/AKT/mTOR signaling pathway by KSHV

Bhatt, A. P., & Damania, B. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2012.00401 · Cited by 144

Cadherin-17 interacts with α2β1 integrin to regulate cell proliferation and adhesion in colorectal cancer cells causing liver metastasis

Bartolomé, R. A., Barderas, R., Torres, S., Fernández‐Aceñero, M. J., Mendes, M. L., García‐Foncillas, J., López-Lucendo, M. F., & Casal, J. I. (2013) · Oncogene · doi:10.1038/onc.2013.117 · Cited by 140

Role of AKT signaling in DNA repair and clinical response to cancer therapy

Liu, Q., Turner, K. M., Yung, W. K. A., Chen, K., & Zhang, W. (2014) · Neuro-Oncology · doi:10.1093/neuonc/nou058 · Cited by 144

Extensive Crosstalk between O-GlcNAcylation and Phosphorylation Regulates Akt Signaling

Wang, S., Huang, X., Sun, D., Xin, X., Pan, Q., Peng, S., Liang, Z. T., Luo, C., Yang, Y., Jiang, H., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0037427 · Cited by 145

Posttranslational regulation of Akt in human cancer

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mTOR signaling for biological control and cancer

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ER Stress Inhibits mTORC2 and Akt Signaling Through GSK-3β–Mediated Phosphorylation of Rictor

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The Circadian Protein Period2 Suppresses mTORC1 Activity via Recruiting Tsc1 to mTORC1 Complex

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Structure of S6 Kinase 1 Determines whether Raptor-mTOR or Rictor-mTOR Phosphorylates Its Hydrophobic Motif Site

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DNA-PK Mediates AKT Activation and Apoptosis Inhibition in Clinically Acquired Platinum Resistance

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Inactivation of Rheb by PRAK-mediated phosphorylation is essential for energy-depletion-induced suppression of mTORC1

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Akt signaling in platelets and thrombosis

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Metabolic pathway analyses identify proline biosynthesis pathway as a promoter of liver tumorigenesis

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Molecular characterizations of glioblastoma, targeted therapy, and clinical results to date

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Protein kinase Cε makes the life and death decision

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Evolution of the TOR Pathway

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Hypoxia-Induced Endothelial Proliferation Requires Both mTORC1 and mTORC2

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HIPPO–Integrin-linked Kinase Cross-Talk Controls Self-Sustaining Proliferation and Survival in Pulmonary Hypertension

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mTOR: A Cellular Regulator Interface in Health and Disease

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Akt-ing Up Just About Everywhere: Compartment-Specific Akt Activation and Function in Receptor Tyrosine Kinase Signaling

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The Role of mTORC1 in Regulating Protein Synthesis and Skeletal Muscle Mass in Response to Various Mechanical Stimuli

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Modulation of the PI 3-kinase–Akt signalling pathway by IGF-I and PTEN regulates the differentiation of neural stem/precursor cells

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mTORC2 in the center of cancer metabolic reprogramming

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Activation of the PI3K/Akt Pathway Early during Vaccinia and Cowpox Virus Infections Is Required for both Host Survival and Viral Replication

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Getting In on the Akt

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Receptor-Specific Mechanisms Regulate Phosphorylation of AKT at Ser473: Role of RICTOR in b1 Integrin-Mediated Cell

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Rictor Phosphorylation on the Thr-1135 Site Does Not Require Mammalian Target of Rapamycin Complex 2

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Receptor-Specific Mechanisms Regulate Phosphorylation of AKT at Ser473: Role of RICTOR in β1 Integrin-Mediated Cell Survival

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Regulation and functions of protein kinase B in DNA damage signaling

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