Phosphorylation and Regulation of Akt/PKB by the Rictor-mTOR Complex

mTOR Interacts with Raptor to Form a Nutrient-Sensitive Complex that Signals to the Cell Growth Machinery

Kim, D., Sarbassov, D. D., Ali, S. M., King, J. E., Latek, R. R., Erdjument‐Bromage, H., Tempst, P., & Sabatini, D. M. (2002) · Cell · doi:10.1016/s0092-8674(02)00808-5 · Cited by 3,051

Mechanism of activation of protein kinase B by insulin and IGF‐1.

Alessi, D. R., Andjelković, M., Caudwell, B., Cron, P. D., MORRICE, N. A., Cohen, P., & Hemmings, B. A. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb01045.x · Cited by 3,014

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα

Alessi, D. R., James, S. R., Downes, C. P., Holmes, A. B., Gaffney, P. R. J., Reese, C. B., & Cohen, P. (1997) · Current Biology · doi:10.1016/s0960-9822(06)00122-9 · Cited by 2,874

Rictor, a Novel Binding Partner of mTOR, Defines a Rapamycin-Insensitive and Raptor-Independent Pathway that Regulates the Cytoskeleton

Sarbassov, D. D., Ali, S. M., Kim, D.-H., Guertin, D. A., Latek, R. R., Erdjument-Bromage, H., Tempst, P., & Sabatini, D. M. (2004) · Current Biology · doi:10.1016/j.cub.2004.06.054 · Cited by 2,665

Two TOR Complexes, Only One of which Is Rapamycin Sensitive, Have Distinct Roles in Cell Growth Control

Loewith, R., Jacinto, E., Wullschleger, S., Lorberg, A., Crespo, J. L., Bonenfant, D., Oppliger, W., Jenoe, P., & Hall, M. N. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00636-6 · Cited by 1,886

Insulin Resistance and a Diabetes Mellitus-Like Syndrome in Mice Lacking the Protein Kinase Akt2 (PKBβ)

Cho, H., Mu, J., Kim, J. K., Thorvaldsen, J. L., Chu, Q., Crenshaw, E. B., Kaestner, K. H., Bartolomei, M. S., Shulman, G. I., & Birnbaum, M. J. (2001) · Science · doi:10.1126/science.292.5522.1728 · Cited by 1,860

Raptor, a Binding Partner of Target of Rapamycin (TOR), Mediates TOR Action

Hara, K., Maruki, Y., Long, X., Yoshino, K.-I., Oshiro, N., Sujuti, H., Tokunaga, C., Avruch, J., & Yonezawa, K. (2002) · Cell · doi:10.1016/s0092-8674(02)00833-4 · Cited by 1,810

RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1

Burnett, P. E., Barrow, R. K., Cohen, N. A., Snyder, S. H., & Sabatini, D. M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.4.1432 · Cited by 1,130

The TSC1-2 tumor suppressor controls insulin–PI3K signaling via regulation of IRS proteins

Harrington, L. S., Findlay, G. M., Gray, A., Толкачева, Т. А., Wigfield, S., Rebholz, H., Barnett, J., Leslie, N. R., Cheng, S., Shepherd, P. R., et al. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200403069 · Cited by 1,123

Protein Kinase B Kinases That Mediate Phosphatidylinositol 3,4,5-Trisphosphate-Dependent Activation of Protein Kinase B

Stephens, L., Anderson, K. E., Stokoe, D., Erdjument‐Bromage, H., Painter, G. F., Holmes, A. B., Gaffney, P. R. J., Reese, C. B., McCormick, F. P., Tempst, P., et al. (1998) · Science · doi:10.1126/science.279.5351.710 · Cited by 1,061

A chemical-genetic screen reveals a mechanism of resistance to PI3K inhibitors in cancer

Muellner, M. K., Uras, I. Z., Gapp, B. V., Kerzendorfer, C., Šmída, M., Lechtermann, H., Craig-Mueller, N., Colinge, J., Duernberger, G., & Nijman, S. M. B. (2011) · Nature Chemical Biology · doi:10.1038/nchembio.695 · Cited by 165

Hepatitis C Virus Core Protein Upregulates Serine Phosphorylation of Insulin Receptor Substrate-1 and Impairs the Downstream Akt/Protein Kinase B Signaling Pathway for Insulin Resistance

Banerjee, S., Saito, K., Ait‐Goughoulte, M., Meyer, K., Ray, R. B., & Ray, R. (2007) · Journal of Virology · doi:10.1128/jvi.01672-07 · Cited by 170

Myocardial Loss of IRS1 and IRS2 Causes Heart Failure and Is Controlled by p38α MAPK During Insulin Resistance

Qi, Y., Xu, Z., Zhu, Q., Thomas, C., Kumar, R., Feng, H., Dostal, D. E., White, M. F., Baker, K. M., & Guo, S. (2013) · Diabetes · doi:10.2337/db13-0095 · Cited by 167

Inhibition of lung cancer growth: ATP citrate lyase knockdown and statin treatment leads to dual blockade of mitogen‐activated protein Kinase (MAPK) and Phosphatidylinositol‐3‐kinase (PI3K)/AKT pathways

Hanai, J., Doro, N. C., Sasaki, A. T., Kobayashi, S. S., Cantley, L. C., Seth, P., & Sukhatme, V. P. (2011) · Journal of Cellular Physiology · doi:10.1002/jcp.22895 · Cited by 170

A telomere-dependent DNA damage checkpoint induced by prolonged mitotic arrest

Hayashi, M., Cesare, A. J., Fitzpatrick, J. A. J., Denchi, E. L., & Karlseder, J. (2012) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2245 · Cited by 173

Hyperactivation of the Insulin-like Growth Factor Receptor I Signaling Pathway Is an Essential Event for Cisplatin Resistance of Ovarian Cancer Cells

Eckstein, N., Servan, K., Hildebrandt, B., Pölitz, A., von Jonquières, G., Wolf-Kümmeth, S., Napierski, I., Hamacher, A., Kassack, M. U., Budczies, J., et al. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-3153 · Cited by 166

mTOR kinase leads to PTEN-loss-induced cellular senescence by phosphorylating p53

Jung, S. H., Hwang, H. J., Kang, D., Park, H. A., Lee, H. C., Jeong, D., Lee, K., Park, H. J., Ko, Y.-G., & Lee, J.-S. (2019) · Oncogene · doi:10.1038/s41388-018-0521-8 · Cited by 166

Overview of the relevance of PI3K pathway in HR-positive breast cancer

Vasan, N., Toska, E., & Scaltriti, M. (2019) · Annals of Oncology · doi:10.1093/annonc/mdz281 · Cited by 170

Phosphatidylinositol 3-kinase/Akt signaling as a key mediator of tumor cell responsiveness to radiation

Toulany, M., & Rodemann, H. P. (2015) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2015.07.003 · Cited by 174

Insulin signaling and glucose transport in insulin resistant human skeletal muscle

Karlsson, H. K. R., & Zierath, J. R. (2007) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-007-0030-9 · Cited by 159

mTOR signaling in tumorigenesis

Xu, K. L., Liu, P., & Wei, W. (2014) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2014.10.007 · Cited by 167

PF-04691502, a Potent and Selective Oral Inhibitor of PI3K and mTOR Kinases with Antitumor Activity

Yuan, J., Mehta, P. P., Yin, M.-J., Sun, S., Zou, A., Chen, J. W., Rafidi, K., Feng, Z., Nickel, J., Engebretsen, J., et al. (2011) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-11-0185 · Cited by 168

Role of mTOR Complexes in Neurogenesis

Licausi, F., & Hartman, N. W. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19051544 · Cited by 172

Role of mTOR Signaling in Female Reproduction

Guo, Z., & Yu, Q. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00692 · Cited by 172

Spatiotemporal Analysis of Differential Akt Regulation in Plasma Membrane Microdomains

Gao, X., & Zhang, J. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-05-0449 · Cited by 173

CCL2 Protects Prostate Cancer PC3 Cells from Autophagic Death via Phosphatidylinositol 3-Kinase/AKT-dependent Survivin Up-regulation

Roca, H., Varsos, Z. S., & Pienta, K. J. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m801073200 · Cited by 168

Mapping Insulin/GLUT4 Circuitry

Rowland, A. F., Fazakerley, D. J., & James, D. E. (2011) · Traffic · doi:10.1111/j.1600-0854.2011.01178.x · Cited by 168

Insulin signaling to hepatic lipid metabolism in health and disease

Leavens, K. F., & Birnbaum, M. J. (2011) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238.2011.562481 · Cited by 169

Multiple antiapoptotic targets of the PI3K/Akt survival pathway are activated by epoxyeicosatrienoic acids to protect cardiomyocytes from hypoxia/anoxia

Dhanasekaran, A., Gruenloh, S. K., Buonaccorsi, J. N., Zhang, R., Gross, G. J., Falck, J. R., Patel, P. K., Jacobs, E. R., & Medhora, M. M. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00979.2007 · Cited by 168

TORC2 Structure and Function

Gaubitz, C., Prouteau, M., Kuśmider, B., & Loewith, R. (2016) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2016.04.001 · Cited by 163

High-fat Diet-Induced Deregulation of Hippocampal Insulin Signaling and Mitochondrial Homeostasis Deficiences Contribute to Alzheimer Disease Pathology in Rodents

Petrov, D., Pedrós, I., Artiach, G., Sureda, F. X., Barroso, E., Pallàs, M., Casadesús, G., Beas-Zarate, C., Carro, E., Ferrer, I., et al. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.05.004 · Cited by 163

PRR5L degradation promotes mTORC2-mediated PKC-δ phosphorylation and cell migration downstream of Gα12

Gan, X., Wang, J., Wang, C., Sommer, E. M., Kozasa, T., Srinivasula, S. M., Alessi, D. R., Offermanns, S., Simon, M. I., & Wu, D. (2012) · Nature Cell Biology · doi:10.1038/ncb2507 · Cited by 172

DNA-PKcs plays a dominant role in the regulation of H2AX phosphorylation in response to DNA damage and cell cycle progression

An, J., Huang, Y.-C., Xu, Q.-Z., Zhou, L.-J., Shang, Z., Huang, B., Wang, Y., Liu, X.-D., Wu, D.-C., & Zhou, P. (2010) · BMC Molecular Biology · doi:10.1186/1471-2199-11-18 · Cited by 177

ERK and AKT signaling cooperate to translationally regulate survivin expression for metastatic progression of colorectal cancer

Ye, Q., Cai, W., Zheng, Y., Evers, B. M., & She, Q. (2013) · Oncogene · doi:10.1038/onc.2013.122 · Cited by 168

Inhibition of histone deacetylase overcomes rapamycin-mediated resistance in diffuse large B-cell lymphoma by inhibiting Akt signaling through mTORC2

Gupta, M., Ansell, S. M., Novak, A. J., Kumar, S. K., Kaufmann, S. H., & Witzig, T. E. (2009) · Blood · doi:10.1182/blood-2009-05-220889 · Cited by 163

Autophagy is a protective response to ethanol neurotoxicity

Chen, G., Ke, Z., Xu, M., Liao, M., Wang, X., Qi, Y., Zhang, T., Frank, J. A., Bower, K. A., Shi, X., et al. (2012) · Autophagy · doi:10.4161/auto.21376 · Cited by 164

Integrin-Linked Kinase at the Heart of Cardiac Contractility, Repair, and Disease

Hannigan, G. E., Coles, J. G., & Dedhar, S. (2007) · Circulation Research · doi:10.1161/01.res.0000265233.40455.62 · Cited by 163

High Expression of IL-13 Receptor α2 in Colorectal Cancer Is Associated with Invasion, Liver Metastasis, and Poor Prognosis

Barderas, R., Bartolomé, R. A., Fernández‐Aceñero, M. J., Torres, S., & Casal, J. I. (2012) · Cancer Research · doi:10.1158/0008-5472.can-11-4090 · Cited by 166

Partial Inhibition of mTORC1 in Aged Rats Counteracts the Decline in Muscle Mass and Reverses Molecular Signaling Associated with Sarcopenia

Joseph, G. A., Wang, S. X., Jacobs, C. E., Zhou, W., Kimble, G. C., Tse, H. W., Eash, J. K., Shavlakadze, T., & Glass, D. J. (2019) · Molecular and Cellular Biology · doi:10.1128/mcb.00141-19 · Cited by 158

Mechanisms of mTOR inhibitor resistance in cancer therapy

Carew, J. S., Kelly, K. R., & Nawrocki, S. T. (2011) · Targeted Oncology · doi:10.1007/s11523-011-0167-8 · Cited by 164

PTEN, NHERF1 and PHLPP form a tumor suppressor network that is disabled in glioblastoma

Molina, J. R., Agarwal, N. K., Morales, F. C., Hayashi, Y., Aldape, K., Cote, G., & Georgescu, M.-M. (2011) · Oncogene · doi:10.1038/onc.2011.324 · Cited by 162

mTOR phosphorylated at S2448 binds to raptor and rictor

Rosner, M., Siegel, N., Valli, A., Fuchs, C., & Hengstschläger, M. (2009) · Amino Acids · doi:10.1007/s00726-008-0230-7 · Cited by 162

Constitutive mTOR activation in TSC mutants sensitizes cells to energy starvation and genomic damage via p53

Lee, C., Inoki, K., Karbowniczek, M., Petroulakis, E., Sonenberg, N., Henske, E. P., & Guan, K. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601900 · Cited by 160

Akt-dependent Activation of mTORC1 Complex Involves Phosphorylation of mTOR (Mammalian Target of Rapamycin) by IκB Kinase α (IKKα)

Dan, H. C., Ebbs, A., Pasparakis, M., Dyke, T. V., Bassères, D. S. D. S., & Baldwin, A. S. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.554881 · Cited by 172

Oncogenic regulation of tumor metabolic reprogramming

Tarrado‐Castellarnau, M., de Atauri, P., & Cascante, M. (2016) · Oncotarget · doi:10.18632/oncotarget.10911 · Cited by 165

Judicious Toggling of mTOR Activity to Combat Insulin Resistance and Cancer: Current Evidence and Perspectives

Ong, P. S., Wang, L. Z., Dai, X., Tseng, S. H., Loo, S. J., & Sethi, G. (2016) · Frontiers in Pharmacology · doi:10.3389/fphar.2016.00395 · Cited by 162

Distinct Akt phosphorylation states are required for insulin regulated Glut4 and Glut1-mediated glucose uptake

Beg, M., Abdullah, N., Thowfeik, F. S., Altorki, N. K., & McGraw, T. E. (2017) · eLife · doi:10.7554/elife.26896 · Cited by 162

Metabolism and growth adaptation to environmental conditions in Drosophila

Koyama, T., Texada, M. J., Halberg, K. A., & Rewitz, K. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03547-2 · Cited by 152

Integrin signaling: linking mechanical stimulation to skeletal muscle hypertrophy

Boppart, M. D., & Mahmassani, Z. S. (2019) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00009.2019 · Cited by 157

P-Rex1 Links Mammalian Target of Rapamycin Signaling to Rac Activation and Cell Migration

Hernández-Negrete, I., Carretero-Ortega, J., Rosenfeldt, H. M., Hernández-García, R., Calderón-Salinas, J. V., Reyes‐Cruz, G., Gutkind, J. S., & Vázquez‐Prado, J. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m703771200 · Cited by 161

Inhibition of the mTORC1 pathway suppresses intestinal polyp formation and reduces mortality in Apc Δ716 mice

Fujishita, T., Aoki, K., Lane, H. A., Aoki, M., & Taketo, M. M. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0800041105 · Cited by 167

Class III PI-3-kinase activates phospholipase D in an amino acid–sensing mTORC1 pathway

Yoon, M., Du, G., Backer, J., Frohman, M. A., & Chen, J. (2011) · The Journal of Cell Biology · doi:10.1083/jcb.201107033 · Cited by 166

The molecular basis of insulin-stimulated glucose uptake: signalling, trafficking and potential drug targets

Leney, S. E., & Tavaré, J. M. (2009) · Journal of Endocrinology · doi:10.1677/joe-09-0037 · Cited by 163

The Role of AKT/mTOR Pathway in Stress Response to UV-Irradiation: Implication in Skin Carcinogenesis by Regulation of Apoptosis, Autophagy and Senescence

Strozyk, E. A., & Kulms, D. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms140815260 · Cited by 162

Phase I Study of Everolimus in Pediatric Patients With Refractory Solid Tumors

Fouladi, M., Laningham, F. H., Wu, J., O'Shaughnessy, M. A., Molina, K., Broniscer, A., Spunt, S. L., Luckett, I., Stewart, C. F., Houghton, P. J., et al. (2007) · Journal of Clinical Oncology · doi:10.1200/jco.2007.11.4017 · Cited by 159

Role of PI3K-AKT-mTOR and Wnt Signaling Pathways in Transition of G1-S Phase of Cell Cycle in Cancer Cells

Vadlakonda, L., Pasupuleti, M., & Reddanna, P. (2013) · Frontiers in Oncology · doi:10.3389/fonc.2013.00085 · Cited by 162

The role of mTOR in the management of solid tumors: An overview

Strimpakos, A. S., Karapanagiotou, E. M., Saif, M. W., & Syrigos, K. (2008) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2008.09.006 · Cited by 163

mTOR's role in ageing: protein synthesis or autophagy?

Hands, S. L., Proud, C. G., & Wyttenbach, A. (2009) · Aging · doi:10.18632/aging.100070 · Cited by 162

The ubiquitin ligase CHIP regulates c-Myc stability and transcriptional activity

Paul, I., Ahmed, S. F., Bhowmik, A., Deb, S., & Ghosh, M. K. (2012) · Oncogene · doi:10.1038/onc.2012.144 · Cited by 160

Second AKT: The rise of SGK in cancer signalling

Bruhn, M. A., Pearson, R. B., Hannan, R. D., & Sheppard, K. E. (2010) · Growth Factors · doi:10.3109/08977194.2010.518616 · Cited by 162

The dual mTORC1 and mTORC2 inhibitor AZD8055 has anti-tumor activity in acute myeloid leukemia

Willems, L., Chapuis, N., Puissant, A., Maciel, T. T., Green, A. S., Jacque, N., Vignon, C., Park, S., Guichard, S. M., Hérault, O., et al. (2011) · Leukemia · doi:10.1038/leu.2011.339 · Cited by 172

Structure-Activity Analysis of Niclosamide Reveals Potential Role for Cytoplasmic pH in Control of Mammalian Target of Rapamycin Complex 1 (mTORC1) Signaling

Fonseca, B. D., Diering, G. H., Bidinosti, M., Dalal, K., Alain, T., Balgi, A. D., Forestieri, R., Nodwell, M., Rajadurai, C. V., Gunaratnam, C., et al. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.359638 · Cited by 160

Chemotaxis: finding the way forward with Dictyostelium

King, J., & Insall, R. H. (2009) · Trends in Cell Biology · doi:10.1016/j.tcb.2009.07.004 · Cited by 161

Status of PI3K inhibition and biomarker development in cancer therapeutics

Markman, B., Atzori, F., Pérez-García, J. M., Tabernero, J. M., & Baselga, J. M. (2009) · Annals of Oncology · doi:10.1093/annonc/mdp347 · Cited by 160

Hypoxia Leads to Na,K-ATPase Downregulation via Ca 2+ Release-Activated Ca 2+ Channels and AMPK Activation

Gusarova, G. A., Bittar, H. E. T., Dada, L. A., Briva, A., Welch, L. C., Hamanaka, R. B., Mutlu, G. M., Chandel, N. S., Prakriya, M., & Sznajder, J. I. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.05114-11 · Cited by 162

Convergent Akt activation drives acquired EGFR inhibitor resistance in lung cancer

Jacobsen, K., Bertrán-Alamillo, J., Molina‐Vila, M. Á., Teixidó, C., Karachaliou, N., Pedersen, M. H., Castellví, J., Garzón, M., Codony, C., Codony‐Servat, J., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-00450-6 · Cited by 162

Microbial Imidazole Propionate Affects Responses to Metformin through p38γ-Dependent Inhibitory AMPK Phosphorylation

Koh, A., Mannerås-Holm, L., Yunn, N.-O., Nilsson, P. M., Ryu, S. H., Molinaro, A., Perkins, R., Smith, J. G., & Bäckhed, F. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.07.012 · Cited by 165

REDD1 enhances protein phosphatase 2A-mediated dephosphorylation of Akt to repress mTORC1 signaling

Dennis, M. D., Coleman, C. S., Berg, A., Jefferson, L. S., & Kimball, S. R. (2014) · Science Signaling · doi:10.1126/scisignal.2005103 · Cited by 159

Regulation of AKT Phosphorylation at Ser473 and Thr308 by Endoplasmic Reticulum Stress Modulates Substrate Specificity in a Severity Dependent Manner

Yung, H. W., Charnock-Jones, D. S., & Burton, G. J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017894 · Cited by 158

Roles of mTOR Signaling in Brain Development

Lee, D. Y. (2015) · Experimental Neurobiology · doi:10.5607/en.2015.24.3.177 · Cited by 172

Elevated SGK1 predicts resistance of breast cancer cells to Akt inhibitors

Sommer, E. M., Dry, H., Cross, D. A. E., Guichard, S. M., Davies, B. R., & Alessi, D. R. (2013) · Biochemical Journal · doi:10.1042/bj20130342 · Cited by 166

The PI 3 K / A kt/m TOR axis in head and neck cancer: functions, aberrations, cross‐talk, and therapies

Broek, R. V., Mohan, S., Eytan, D. F., Chen, Z., & Waes, C. V. (2013) · Oral Diseases · doi:10.1111/odi.12206 · Cited by 159

BRCA2 suppresses replication stress-induced mitotic and G1 abnormalities through homologous recombination

Feng, W., & Jasin, M. (2017) · Nature Communications · doi:10.1038/s41467-017-00634-0 · Cited by 161

Crosstalk between phosphorylation and O‐Glc NA cylation: friend or foe

van der Laarse, S. A. M., Leney, A. C., & Heck, A. J. R. (2018) · FEBS Journal · doi:10.1111/febs.14491 · Cited by 165

NRF2 activation induces NADH-reductive stress, providing a metabolic vulnerability in lung cancer

Weiss‐Sadan, T., Ge, M., Hayashi, M., Gohar, M., Yao, C.-H., de Groot, A., Harry, S. A., Carlin, A. D., Fischer, H., Shi, L., et al. (2023) · Cell Metabolism · doi:10.1016/j.cmet.2023.01.012 · Cited by 159

Functional Genomics Identifies TOR-Regulated Genes that Control Growth and Division

Guertin, D. A., Guntur, K., Bell, G. W., Thoreen, C. C., & Sabatini, D. M. (2006) · Current Biology · doi:10.1016/j.cub.2006.03.084 · Cited by 156

Molecular Mechanisms of SH2- and PTB-Domain-Containing Proteins in Receptor Tyrosine Kinase SignalingPreprint

Wagner, M. J., Stacey, M. M., Liu, B. A., & Pawson, T. J. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a008987 · Cited by 162

Induction of therapeutic senescence in vemurafenib-resistant melanoma by extended inhibition of CDK4/6

Yoshida, A., Lee, E. K., & Diehl, J. A. (2016) · Cancer Research · doi:10.1158/0008-5472.can-15-2931 · Cited by 153

Enhancing Mammalian Target of Rapamycin (mTOR)–Targeted Cancer Therapy by Preventing mTOR/Raptor Inhibition-Initiated, mTOR/Rictor-Independent Akt Activation

Wang, X., Yue, P., Kim, Y. A., Fu, H., Khuri, F. R., & Sun, S. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-1522 · Cited by 156

The evolution of the TOR pathway and its role in cancer

Beauchamp, E. M., & Platanias, L. C. (2012) · Oncogene · doi:10.1038/onc.2012.567 · Cited by 158

Fungal Engagement of the C-Type Lectin Mincle Suppresses Dectin-1-Induced Antifungal Immunity

Wevers, B. A., Kaptein, T. M., Willems, E., Theelen, B., Boekhout, T., Geijtenbeek, T. B. H., & Gringhuis, S. I. (2014) · Cell Host & Microbe · doi:10.1016/j.chom.2014.03.008 · Cited by 159

Diet, Autophagy, and Cancer: A Review

Singletary, K. W., & Milner, J. (2008) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-07-2917 · Cited by 160

Mitochondrial ROS-derived PTEN oxidation activates PI3K pathway for mTOR-induced myogenic autophagy

Kim, J. H., Choi, T. G., Park, S., Yun, H. R., Nguyen, N. N. Y., Jo, Y. H., Jang, M., Kim, J., Kim, J., Kang, I., et al. (2018) · Cell Death and Differentiation · doi:10.1038/s41418-018-0165-9 · Cited by 158

The role of PI3K/AKT/FOXO signaling in psoriasis

Zhang, M., & Zhang, X. (2018) · Archives of Dermatological Research · doi:10.1007/s00403-018-1879-8 · Cited by 159

Regulation of Interleukin-6-induced Hepatic Insulin Resistance by Mammalian Target of Rapamycin through the STAT3-SOCS3 Pathway

Kim, J.-H., Kim, J. E., Liu, H.-Y., Cao, W., & Chen, J. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m708568200 · Cited by 154

Rictor is a novel target of p70 S6 kinase-1

Treins, C., Warne, P. H., Magnuson, M. A., Pende, M., & Downward, J. (2009) · Oncogene · doi:10.1038/onc.2009.401 · Cited by 161

Activation of mammalian target of rapamycin in cytomegalic neurons of human cortical dysplasia

Ljungberg, M. C., Bhattacharjee, M. B., Lu, Y., Armstrong, D. L., Yoshor, D., Swann, J. W., Sheldon, M., & D’Arcangelo, G. (2006) · Annals of Neurology · doi:10.1002/ana.20949 · Cited by 155

The Rheb–mTOR Pathway Is Upregulated in Reactive Astrocytes of the Injured Spinal Cord

Codeluppi, S., Svensson, C. I., Hefferan, M. P., Valencia, F., Silldorff, M. D., Oshiro, M., Maršala, M., & Pasquale, E. B. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.4103-08.2009 · Cited by 159

Platelet-Derived Growth Factor-D Overexpression Contributes to Epithelial-Mesenchymal Transition of PC3 Prostate Cancer Cells

Kong, D., Wang, Z., Sarkar, S. H., Li, Y., Banerjee, S., Saliganan, A. D., Kim, H.-R. C., Cher, M. L., & Sarkar, F. H. (2008) · Stem Cells · doi:10.1634/stemcells.2007-1076 · Cited by 160

A Compendium of Signals and Responses Triggered by Prodeath and Prosurvival Cytokines

Gaudet, S., Janes, K. A., Albeck, J. G., Pace, E. A., Lauffenburger, D. A., & Sorger, P. K. (2005) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m500158-mcp200 · Cited by 151

Dual Inhibition of PI3K and mTORC1/2 Signaling by NVP-BEZ235 as a New Therapeutic Strategy for Acute Myeloid Leukemia

Chapuis, N., Tamburini, J., Green, A. S., Vignon, C., Bardet, V., Neyret, A., Pannetier, M., Willems, L., Park, S., Macone, A., et al. (2010) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-10-1102 · Cited by 163

Akt Kinase Activation Mechanisms Revealed Using Protein Semisynthesis

Chu, N. K., Salguero, A. L., Liu, A. Z., Chen, Z., Dempsey, D. R., Ficarro, S. B., Alexander, W. M., Marto, J. A., Li, Y., Amzel, L. M., et al. (2018) · Cell · doi:10.1016/j.cell.2018.07.003 · Cited by 155

mTORC2-AKT signaling to ATP-citrate lyase drives brown adipogenesis and de novo lipogenesis

Calejman, C. M., Trefely, S., Entwisle, S. W., Luciano, A. K., Jung, S., Hsiao, W., Torres, A., Hung, C. M., Li, H., Snyder, N. W., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-14430-w · Cited by 161

Genetic wiring maps of single-cell protein states reveal an off-switch for GPCR signalling

Brockmann, M., Blomen, V. A., Nieuwenhuis, J., Stickel, E., Raaben, M., Bleijerveld, O. B., Altelaar, A. F. M., Jae, L. T., & Brummelkamp, T. R. (2017) · Nature · doi:10.1038/nature22376 · Cited by 140

The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2

Kovalski, J. R., Bhaduri, A., Zehnder, A. M., Neela, P. H., Che, Y., Wozniak, G. G., & Khavari, P. A. (2019) · Molecular Cell · doi:10.1016/j.molcel.2018.12.001 · Cited by 154

Identification of Akt-independent Regulation of Hepatic Lipogenesis by Mammalian Target of Rapamycin (mTOR) Complex 2

Yuan, M., Pino, E. C., Wu, L., Kacergis, M. C., & Soukas, A. A. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.386854 · Cited by 163

mTORC1 pathway in DNA damage response

Ma, Y., Vassetzky, Y. S., & Dokudovskaya, S. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2018.06.011 · Cited by 157

Cannabinoid type 1 receptors in human skeletal muscle cells participate in the negative crosstalk between fat and muscle

Eckardt, K., Sell, H., Taube, A., Koenen, M., Platzbecker, B., Cramer, A., Horrighs, A., Lehtonen, M., Tennagels, N., & Eckel, J. (2008) · Diabetologia · doi:10.1007/s00125-008-1240-4 · Cited by 153

Mammalian Target of Rapamycin (mTOR) Inhibition with Rapamycin Improves Cardiac Function in Type 2 Diabetic Mice

Das, A., Durrant, D., Koka, S., Salloum, F. N., Xi, L., & Kukreja, R. C. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.521062 · Cited by 154

Rapamycin inhibits F-actin reorganization and phosphorylation of focal adhesion proteins

Liu, L., Chen, L., Chung, J., & Huang, S. (2008) · Oncogene · doi:10.1038/onc.2008.137 · Cited by 153

Proline-rich Akt substrate of 40 kDa (PRAS40): A novel downstream target of PI3k/Akt signaling pathway

Wang, H., Zhang, Q., Wen, Q. J., Zheng, Y., Lazarovici, P., Jiang, H., Lin, J., & Zheng, W. (2011) · Cellular Signalling · doi:10.1016/j.cellsig.2011.08.010 · Cited by 156

TOR coordinates bulk and targeted endocytosis in the Drosophila melanogaster fat body to regulate cell growth

Hennig, K. M., Colombani, J., & Neufeld, T. P. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200511140 · Cited by 153

TOR Signaling in Caenorhabditis elegans Development, Metabolism, and Aging

Blackwell, T. K., Sewell, A. K., Wu, Z., & Han, M. (2019) · Genetics · doi:10.1534/genetics.119.302504 · Cited by 148

Perifosine Inhibits Mammalian Target of Rapamycin Signaling through Facilitating Degradation of Major Components in the mTOR Axis and Induces Autophagy

Fu, L., Kim, Y.-A., Wang, X., Wu, X., Yue, P., Lonial, S., Khuri, F. R., & Sun, S. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-2190 · Cited by 153

mTOR function and therapeutic targeting in breast cancer.

Hare, S. H., & Harvey, A. (2017) · PubMed Central · Cited by 150

A Genome-Wide Screen for Regulators of TORC1 in Response to Amino Acid Starvation Reveals a Conserved Npr2/3 Complex

Neklesa, T. K., & Davis, R. W. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000515 · Cited by 151

Genetic Etiologies, Diagnosis, and Treatment of Tuberous Sclerosis Complex

Salussolia, C. L., Klonowska, K., Kwiatkowski, D. J., & Sahin, M. (2019) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev-genom-083118-015354 · Cited by 163

FoxO Transcription Factors Promote AKT Ser473 Phosphorylation and Renal Tumor Growth in Response to Pharmacologic Inhibition of the PI3K–AKT Pathway

Lin, A., Piao, H.-L., Li, Z., Sarbassov, D. D., Ma, L., & Gan, B. (2014) · Cancer Research · doi:10.1158/0008-5472.can-13-1729 · Cited by 152

PI3Kδ inhibitor, GS-1101 (CAL-101), attenuates pathway signaling, induces apoptosis, and overcomes signals from the microenvironment in cellular models of Hodgkin lymphoma

Meadows, S. A., Vega, F., Kashishian, A., Johnson, D., Diehl, V., Miller, L. L., Younes, A., & Lannutti, B. J. (2011) · Blood · doi:10.1182/blood-2011-10-386763 · Cited by 152

Rapamycin Reverses Pulmonary Artery Smooth Muscle Cell Proliferation in Pulmonary Hypertension

Houssaini, A., Abid, S., Mouraret, N., Wan, F., Rideau, D., Saker, M., Marcos, É., Tissot, C.-M., Dubois‐Randé, J., Amsellem, V., et al. (2013) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2012-0429oc · Cited by 151

Getting In on the Akt

(2005) · Science s STKE · doi:10.1126/stke.2722005tw74

Receptor-Specific Mechanisms Regulate Phosphorylation of AKT at Ser473: Role of RICTOR in b1 Integrin-Mediated Cell

Riaz, A., Zeller, K. S., & Johansson, S. (2012)

Rictor Phosphorylation on the Thr-1135 Site Does Not Require Mammalian Target of Rapamycin Complex 2

Boulbés, D. R., Chen, C.-H., Shaiken, T. E., Agarwal, N., Peterson, T. R., Addona, T. A., Keshishian, H., Carr, S. A., Magnuson, M. A., Sabatini, D. M., et al. (2010) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-09-0409 · Cited by 67

Receptor-Specific Mechanisms Regulate Phosphorylation of AKT at Ser473: Role of RICTOR in β1 Integrin-Mediated Cell Survival

Riaz, A., Zeller, K. S., & Johansson, S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0032081 · Cited by 46

Regulation and functions of protein kinase B in DNA damage signaling

Bozulic, L. (2009) · edoc (University of Basel) · doi:10.5451/unibas-005031495