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mTOR Interacts with Raptor to Form a Nutrient-Sensitive Complex that Signals to the Cell Growth Machinery

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Mechanism of activation of protein kinase B by insulin and IGF‐1.

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Rictor, a Novel Binding Partner of mTOR, Defines a Rapamycin-Insensitive and Raptor-Independent Pathway that Regulates the Cytoskeleton

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Two TOR Complexes, Only One of which Is Rapamycin Sensitive, Have Distinct Roles in Cell Growth Control

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Insulin Resistance and a Diabetes Mellitus-Like Syndrome in Mice Lacking the Protein Kinase Akt2 (PKBβ)

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Raptor, a Binding Partner of Target of Rapamycin (TOR), Mediates TOR Action

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RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1

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The TSC1-2 tumor suppressor controls insulin–PI3K signaling via regulation of IRS proteins

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Protein Kinase B Kinases That Mediate Phosphatidylinositol 3,4,5-Trisphosphate-Dependent Activation of Protein Kinase B

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Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase

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Rapamycin induces feedback activation of Akt signaling through an IGF-1R-dependent mechanism

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Sch9 Is a Major Target of TORC1 in Saccharomyces cerevisiae

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Role of the PI3K/AKT/mTOR signaling pathway in ovarian cancer: Biological and therapeutic significance

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Biochemical and cellular properties of insulin receptor signalling

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Ca2+ signalling checkpoints in cancer: remodelling Ca2+ for cancer cell proliferation and survival

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Pivotal Role of mTOR Signaling in Hepatocellular Carcinoma

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A complex interplay between Akt, TSC2 and the two mTOR complexes

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FKBP51 Affects Cancer Cell Response to Chemotherapy by Negatively Regulating Akt

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The Targets of Curcumin

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Defective Mitophagy in XPA via PARP-1 Hyperactivation and NAD+/SIRT1 Reduction

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FROM MICE TO MEN: Insights into the Insulin Resistance Syndromes

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PI3K/Akt: getting it right matters

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mSin1 Is Necessary for Akt/PKB Phosphorylation, and Its Isoforms Define Three Distinct mTORC2s

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Nutrient overload, insulin resistance, and ribosomal protein S6 kinase 1, S6K1

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Lysosomal metabolomics reveals V-ATPase- and mTOR-dependent regulation of amino acid efflux from lysosomes

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The PI3K/AKT/mTOR interactive pathway

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ILK, PINCH and parvin: the tIPP of integrin signalling

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Reactive oxygen species (ROS) scavenging biomaterials for anti-inflammatory diseases: from mechanism to therapy

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Dominant-activating germline mutations in the gene encoding the PI(3)K catalytic subunit p110δ result in T cell senescence and human immunodeficiency

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The regulation and function of Class III PI3Ks: novel roles for Vps34

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Activation of mTORC2 by Association with the Ribosome

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Skeletal Muscle-Specific Ablation of raptor, but Not of rictor, Causes Metabolic Changes and Results in Muscle Dystrophy

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Mitochondria-Ros Crosstalk in the Control of Cell Death and Aging

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Akt-dependent regulation of NF-κB is controlled by mTOR and Raptor in association with IKKPreprint

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The Regulation of AMPK β1, TSC2, and PTEN Expression by p53: Stress, Cell and Tissue Specificity, and the Role of These Gene Products in Modulating the IGF-1-AKT-mTOR Pathways

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mTOR·RICTOR Is the Ser473 Kinase for Akt/Protein Kinase B in 3T3-L1 Adipocytes

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Macrophage binding to receptor VCAM-1 transmits survival signals in breast cancer cells that invade the lungs

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The PI3K-AKT-mTOR Pathway and Prostate Cancer: At the Crossroads of AR, MAPK, and WNT Signaling

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Insulin signaling, resistance, and metabolic syndrome: insights from mouse models into disease mechanisms

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Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling

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The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR

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Class I PI3K in oncogenic cellular transformation

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Regulation of Dendritic Morphogenesis by Ras–PI3K–Akt–mTOR and Ras–MAPK Signaling Pathways

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Frailty and sarcopenia: The potential role of an aged immune system

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Sphingolipids, Insulin Resistance, and Metabolic Disease: New Insights from in Vivo Manipulation of Sphingolipid Metabolism

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PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms

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Chapter 2 PI3K/PTEN Signaling in Angiogenesis and Tumorigenesis

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The Folliculin Tumor Suppressor Is a GAP for the RagC/D GTPases That Signal Amino Acid Levels to mTORC1

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Signaling pathways controlling skeletal muscle mass

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Uses for JNK: the Many and Varied Substrates of the c-Jun N-Terminal Kinases

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Dysregulation of mTOR signaling in fragile X syndrome

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Virus Inhibition of RIP3-Dependent Necrosis

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The Pharmacology of mTOR Inhibition

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Resistance to targeted therapy in renal-cell carcinoma

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Emerging insights into the molecular and cellular basis of glioblastomaPreprint

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Protein Phosphorylation: A Major Switch Mechanism for Metabolic Regulation

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mTOR complex 2 signaling and functions

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Hepatic mTORC2 Activates Glycolysis and Lipogenesis through Akt, Glucokinase, and SREBP1c

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SIGNALING AND FUNCTION OF INSULIN-LIKE PEPTIDES IN INSECTS

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Cancer Metabolism: Phenotype, Signaling and Therapeutic Targets

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Role of mTOR in podocyte function and diabetic nephropathy in humans and mice

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The mechanistic target of rapamycin: the grand conducTOR of metabolism and aging

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Insulin/insulin-like growth factor signaling in C. elegans

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PI3K/Akt/mTOR signaling pathway and targeted therapy for glioblastoma

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Positive and Negative Regulation of Insulin Signaling by Reactive Oxygen and Nitrogen Species

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Expanding mTOR signaling

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mTOR complex 2-Akt signaling at mitochondria-associated endoplasmic reticulum membranes (MAM) regulates mitochondrial physiology

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Mammalian Target of Rapamycin (mTOR): Conducting the Cellular Signaling Symphony

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Targeting the PI3K/Akt/mTOR pathway in non‐small cell lung cancer (NSCLC)

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A Method for the Acute and Rapid Degradation of Endogenous Proteins

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Fighting neurodegeneration with rapamycin: mechanistic insights

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An expanding role for mTOR in cancer

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AKT-Independent Signaling Downstream of Oncogenic PIK3CA Mutations in Human Cancer

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Signalling to translation: How signal transduction pathways control the protein synthetic machinery

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Regulation of macroautophagy by mTOR and Beclin 1 complexes

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Insulin Signaling and the Regulation of Glucose Transport

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Glioblastoma: From Molecular Pathology to Targeted Treatment

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Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activityPreprint

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The TSC1-TSC2 Complex Is Required for Proper Activation of mTOR Complex 2

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The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C

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The Akt/PKB pathway: molecular target for cancer drug discovery

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Regulation of neuronal morphology and function by the tumor suppressors Tsc1 and Tsc2

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New Insights Into the Role of mTOR Signaling in the Cardiovascular System

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PRAS40 Regulates mTORC1 Kinase Activity by Functioning as a Direct Inhibitor of Substrate Binding

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Emerging role for AS160/TBC1D4 and TBC1D1 in the regulation of GLUT4 traffic

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mTOR: Role in cancer, metastasis and drug resistance

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mTOR Complex1–S6K1 signaling: at the crossroads of obesity, diabetes and cancer

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Cross-talk between mitogenic Ras/MAPK and survival PI3K/Akt pathways: a fine balance

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Drug discovery approaches targeting the PI3K/Akt pathway in cancer

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Identification of Protor as a novel Rictor-binding component of mTOR complex-2

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PTEN: Multiple Functions in Human Malignant Tumors

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Mammalian Target of Rapamycin Protein Complex 2 Regulates Differentiation of Th1 and Th2 Cell Subsets via Distinct Signaling Pathways

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A keratin cytoskeletal protein regulates protein synthesis and epithelial cell growth

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