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mTOR Interacts with Raptor to Form a Nutrient-Sensitive Complex that Signals to the Cell Growth Machinery

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Mechanism of activation of protein kinase B by insulin and IGF‐1.

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Rictor, a Novel Binding Partner of mTOR, Defines a Rapamycin-Insensitive and Raptor-Independent Pathway that Regulates the Cytoskeleton

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Two TOR Complexes, Only One of which Is Rapamycin Sensitive, Have Distinct Roles in Cell Growth Control

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Insulin Resistance and a Diabetes Mellitus-Like Syndrome in Mice Lacking the Protein Kinase Akt2 (PKBβ)

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Raptor, a Binding Partner of Target of Rapamycin (TOR), Mediates TOR Action

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RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1

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The TSC1-2 tumor suppressor controls insulin–PI3K signaling via regulation of IRS proteins

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Protein Kinase B Kinases That Mediate Phosphatidylinositol 3,4,5-Trisphosphate-Dependent Activation of Protein Kinase B

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Autophagic cell death restricts chromosomal instability during replicative crisis

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How flies get their size: genetics meets physiology

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A systems study reveals concurrent activation of AMPK and mTOR by amino acids

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Pathological angiogenesis is induced by sustained Akt signaling and inhibited by rapamycin

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mTOR substrate phosphorylation in growth control

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Loss of the Tuberous Sclerosis Complex Tumor Suppressors Triggers the Unfolded Protein Response to Regulate Insulin Signaling and Apoptosis

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Mitochondrial Regulation of Cell Cycle and Proliferation

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mTORC1-Activated S6K1 Phosphorylates Rictor on Threonine 1135 and Regulates mTORC2 Signaling

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Oxygen availability and metabolic adaptations

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mTOR and cancer: many loops in one pathway

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Akt-dependent transformation: there is more to growth than just surviving

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Next-generation mTOR inhibitors in clinical oncology: how pathway complexity informs therapeutic strategy

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Role of Autophagy and Apoptosis in Non-Small-Cell Lung Cancer

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The Concise Guide to PHARMACOLOGY 2013/14: Enzymes

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Mechanisms Regulating Neuromuscular Junction Development and Function and Causes of Muscle Wasting

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Characterization of Rictor Phosphorylation Sites Reveals Direct Regulation of mTOR Complex 2 by S6K1

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TORC-Specific Phosphorylation of Mammalian Target of Rapamycin (mTOR): Phospho-Ser2481 Is a Marker for Intact mTOR Signaling Complex 2

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Rictor/TORC2 regulates fat metabolism, feeding, growth, and life span in Caenorhabditis elegans

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The Role of Skeletal Muscle Glycogen Breakdown for Regulation of Insulin Sensitivity by Exercise

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Structure of the Human mTOR Complex I and Its Implications for Rapamycin Inhibition

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mTORC1 and mTORC2 selectively regulate CD8+ T cell differentiation

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Free Radicals in Cross Talk Between Autophagy and Apoptosis

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Dynamic Adipocyte Phosphoproteome Reveals that Akt Directly Regulates mTORC2

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The role of insulin receptors and IGF-I receptors in cancer and other diseases

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The tuberous sclerosis complex

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The survival kinases Akt and Pim as potential pharmacological targets.

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Smooth muscle cell-driven vascular diseases and molecular mechanisms of VSMC plasticity

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The importance of the endothelium in atherothrombosis and coronary stenting

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4E-BP1 Is a Key Effector of the Oncogenic Activation of the AKT and ERK Signaling Pathways that Integrates Their Function in Tumors

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Angiocrine factors from Akt-activated endothelial cells balance self-renewal and differentiation of haematopoietic stem cells

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mTOR Complex 2 Is Required for the Development of Prostate Cancer Induced by Pten Loss in Mice

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Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation

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Insulin Stimulates Adipogenesis through the Akt-TSC2-mTORC1 Pathway

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Identification of a tumour suppressor network opposing nuclear Akt function

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Tuberous sclerosis: a GAP at the crossroads of multiple signaling pathways

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Tumor-Intrinsic PD-L1 Signals Regulate Cell Growth, Pathogenesis, and Autophagy in Ovarian Cancer and Melanoma

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The life of a cell: apoptosis regulation by the PI3K/PKB pathway

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Multiallelic Disruption of the rictor Gene in Mice Reveals that mTOR Complex 2 Is Essential for Fetal Growth and Viability

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Upstream of the mammalian target of rapamycin: do all roads pass through mTOR?

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Dysregulated molecular networks in head and neck carcinogenesis

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Germline mutations in TMEM127 confer susceptibility to pheochromocytoma

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PKBα/Akt1 Acts Downstream of DNA-PK in the DNA Double-Strand Break Response and Promotes Survival

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Akt-dependent and -independent mechanisms of mTOR regulation in cancer

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Amino acid regulation of TOR complex 1

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Targeting RTK Signaling Pathways in Cancer

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A Membraneless Organelle Associated with the Endoplasmic Reticulum Enables 3′UTR-Mediated Protein-Protein Interactions

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mTOR Inhibition by Rapamycin Prevents β-Cell Adaptation to Hyperglycemia and Exacerbates the Metabolic State in Type 2 Diabetes

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Discovery of GSK2126458, a Highly Potent Inhibitor of PI3K and the Mammalian Target of Rapamycin

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PI3K-AKT-mTOR inhibition in cancer immunotherapy, redux

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Polyglutamine tracts regulate beclin 1-dependent autophagy

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The PI3K/AKT Pathway and Renal Cell Carcinoma

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Apoptosis Deregulation and the Development of Cancer Multi-Drug Resistance

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Tsc/mTORC1 signaling in oocytes governs the quiescence and activation of primordial follicles

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FoxOs Inhibit mTORC1 and Activate Akt by Inducing the Expression of Sestrin3 and Rictor

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Regulation of Phosphorylation of Thr-308 of Akt, Cell Proliferation, and Survival by the B55α Regulatory Subunit Targeting of the Protein Phosphatase 2A Holoenzyme to Akt

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WNT-LRP5 Signaling Induces Warburg Effect through mTORC2 Activation during Osteoblast Differentiation

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Inositol Pyrophosphates Inhibit Akt Signaling, Thereby Regulating Insulin Sensitivity and Weight Gain

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Oncogenic EGFR Signaling Networks in Glioma

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mTOR Regulates Lysosomal ATP-Sensitive Two-Pore Na+ Channels to Adapt to Metabolic State

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Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus

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The Akt–SREBP nexus: cell signaling meets lipid metabolism

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The regulation of energy metabolism and the IGF-1/mTOR pathways by the p53 protein

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The role of PTEN signaling perturbations in cancer and in targeted therapy

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Regulation of cardiac growth and coronary angiogenesis by the Akt/PKB signaling pathwayPreprint

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Targeting the PI3K/Akt/mTOR Pathway - Beyond Rapalogs

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A novel tumor suppressor protein encoded by circular AKT3 RNA inhibits glioblastoma tumorigenicity by competing with active phosphoinositide-dependent Kinase-1

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GOLPH3 modulates mTOR signalling and rapamycin sensitivity in cancer

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The Deacetylase SIRT1 Promotes Membrane Localization and Activation of Akt and PDK1 During Tumorigenesis and Cardiac Hypertrophy

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Metabolic Reprogramming in Glioma

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LTB4 Is a Signal-Relay Molecule during Neutrophil Chemotaxis

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PI3K/PTEN signaling in tumorigenesis and angiogenesis

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Phosphoinositide 3-kinase/Akt signaling pathway and its therapeutical implications for human acute myeloid leukemia

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Integrin-linked kinase – essential roles in physiology and cancer biology

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Screen for Chemical Modulators of Autophagy Reveals Novel Therapeutic Inhibitors of mTORC1 Signaling

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Rapamycin derivatives reduce mTORC2 signaling and inhibit AKT activation in AML

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Stress and mTORture signaling

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Nuclear sensing of breaks in mitochondrial DNA enhances immune surveillance

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Role of mTOR in physiology and pathology of the nervous system

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MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice

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ETV1 is a lineage survival factor that cooperates with KIT in gastrointestinal stromal tumours

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