The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Obestatin, a Peptide Encoded by the Ghrelin Gene, Opposes Ghrelin's Effects on Food Intake
Abstract
Ghrelin, a circulating appetite-inducing hormone, is derived from a prohormone by posttranslational processing. On the basis of the bioinformatic prediction that another peptide also derived from proghrelin exists, we isolated a hormone from rat stomach and named it obestatin—a contraction of obese, from the Latin “obedere,” meaning to devour, and “statin,” denoting suppression. Contrary to the appetite-stimulating effects of ghrelin, treatment of rats with obestatin suppressed food intake, inhibited jejunal contraction, and decreased body-weight gain. Obestatin bound to the orphan G protein–coupled receptor GPR39. Thus, two peptide hormones with opposing action in weight regulation are derived from the same ghrelin gene. After differential modification, these hormones activate distinct receptors.
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Cited by
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Metadata
- Authors
- Zhang, J. V., Ren, P.-G., Avsian-Kretchmer, O., Luo, C.-W., Rauch, R., Klein, C., & Hsueh, A. J. W.
- Venue
- Science
- Published
- 2005-11-11
- Volume
- 310
- Issue
- 5750
- Pages
- 996-999
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2037328290
- Cited by
- 1,165
- References
- 7
- FWCI
- 33.25
- Type
- journal article
- Language
- en
- Open access
- closed
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- Zhang, J. V., Ren, P.-G., Avsian-Kretchmer, O., Luo, C.-W., Rauch, R., Klein, C., & Hsueh, A. J. W. (2005). Obestatin, a Peptide Encoded by the Ghrelin Gene, Opposes Ghrelin's Effects on Food Intake. Science. https://doi.org/10.1126/science.1117255
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