The Kinase LKB1 Mediates Glucose Homeostasis in Liver and Therapeutic Effects of Metformin

Shaw, Reuben J., Lamia, Katja A., Vasquez, Debbie, Koo, Seung-Hoi, Bardeesy, Nabeel, DePinho, Ronald A., Montminy, Marc, Cantley, Lewis C.·2005·Science
DOI 10.1126/science.1120781

Cited by (138)

Items 101–138 of 138

  1. Energy sensing by the AMP-activated protein kinase and its effects on muscle metabolism
    Hardie, D. Grahame · 2011 · Proceedings of the Nutrition Society
  2. Metformin for Weight Loss and Metabolic Control in Overweight Outpatients With Schizophrenia and Schizoaffective Disorder
    Jarskog, L. Fredrik, Hamer, Robert M., Catellier, Diane J., Stewart, Dawn D., LaVange, Lisa, Ray, Neepa, Golden, Lauren H., Lieberman, Jeffrey A., Stroup, T. Scott, for the METS Investigators · 2013 · American Journal of Psychiatry
  3. Metformin Activates AMP-Activated Protein Kinase by Promoting Formation of the αβγ Heterotrimeric Complex
    Meng, Shumei, Cao, Jia, He, Qiyi, Xiong, Lishou, Chang, Evan, Radovick, Sally, Wondisford, Fredric E., He, Ling · 2015 · Journal of Biological Chemistry
  4. Diabetes and Pancreatic Cancer: Chicken or Egg?
    Magruder, J. Trent, Elahi, Dariush, Andersen, Dana K. · 2011 · Pancreas
  5. Serine deprivation enhances antineoplastic activity of biguanides
    Gravel, Simon-Pierre, Hulea, Laura, Toban, Nader, Birman, Elena, Blouin, Marie-José, Zakikhani, Mahvash, Zhao, Yunhua, Topisirovic, Ivan, St-Pierre, Julie, Pollak, Michael · 2014 · Cancer Research
  6. AMP-activated protein kinase phosphorylates and inactivates liver glycogen synthase
    Bultot, Laurent, Guigas, Bruno, Von Wilamowitz-Moellendorff, Alexander, Maisin, Liliane, Vertommen, Didier, Hussain, Nusrat, Beullens, Monique, Guinovart, Joan J., Foretz, Marc, Viollet, Benoît et al. · 2012 · Biochemical Journal
  7. Mechanism of Metformin-dependent Inhibition of Mammalian Target of Rapamycin (mTOR) and Ras Activity in Pancreatic Cancer
    Nair, Vijayalekshmi, Sreevalsan, Sandeep, Basha, Riyaz, Abdelrahim, Maen, Abudayyeh, Ala, Rodrigues Hoffman, Aline, Safe, Stephen · 2014 · Journal of Biological Chemistry
  8. Signalling mechanisms linking hepatic glucose and lipid metabolism
    Weickert, M. O., Pfeiffer, A. F. H. · 2006 · Diabetologia
  9. LKB1 and AMPK regulate synaptic remodeling in old age
    Samuel, Melanie A, Voinescu, P Emanuela, Lilley, Brendan N, de Cabo, Rafa, Foretz, Marc, Viollet, Benoit, Pawlyk, Basil, Sandberg, Michael A, Vavvas, Demetrios G, Sanes, Joshua R · 2014 · Nature Neuroscience
  10. Changes in Insulin Receptor Signaling Underlie Neoadjuvant Metformin Administration in Breast Cancer: A Prospective Window of Opportunity Neoadjuvant Study
    Dowling, Ryan JO, Niraula, Saroj, Chang, Martin C, Done, Susan J, Ennis, Marguerite, McCready, David R, Leong, Wey L, Escallon, Jaime M, Reedijk, Michael, Goodwin, Pamela J et al. · 2015 · Breast Cancer Research
  11. Phenformin as prophylaxis and therapy in breast cancer xenografts
    Appleyard, M V C L, Murray, K E, Coates, P J, Wullschleger, S, Bray, S E, Kernohan, N M, Fleming, S, Alessi, D R, Thompson, A M · 2012 · British Journal of Cancer
  12. Metformin inhibits human androgen production by regulating steroidogenic enzymes HSD3B2 and CYP17A1 and complex I activity of the respiratory chain
    Hirsch, Andrea, Hahn, Dagmar, Kempná, Petra, Hofer, Gaby, Nuoffer, Jean-Marc, Mullis, Primus E., Flück, Christa E. · 2012 · Endocrinology
  13. Metformin selectively attenuates mitochondrial H2O2 emission without affecting respiratory capacity in skeletal muscle of obese rats
    Kane, Daniel A., Anderson, Ethan J., Price, Jesse W., Woodlief, Tracey L., Lin, Chien-Te, Bikman, Benjamin T., Cortright, Ronald N., Neufer, P. Darrell · 2010 · Free Radical Biology and Medicine
  14. The Anti-Proliferative Effect of Metformin in Triple-Negative MDA-MB-231 Breast Cancer Cells Is Highly Dependent on Glucose Concentration: Implications for Cancer Therapy and Prevention
    Zordoky, Beshay N.M., Bark, Diana, Soltys, Carrie L., Sung, Miranda M., Dyck, Jason R.B. · 2014 · Biochimica et Biophysica Acta (BBA) - General Subjects
  15. Bile acids: From digestion to cancers
    Baptissart, Marine, Vega, Aurelie, Maqdasy, Salwan, Caira, Françoise, Baron, Silvère, Lobaccaro, Jean-Marc A., Volle, David H. · 2013 · Biochimie
  16. Sucrose nonfermenting AMPK-related kinase (SNARK) mediates contraction-stimulated glucose transport in mouse skeletal muscle
    Koh, Ho-Jin, Toyoda, Taro, Fujii, Nobuharu, Jung, Michelle M., Rathod, Amee, Middelbeek, R. Jan-Willem, Lessard, Sarah J., Treebak, Jonas T., Tsuchihara, Katsuya, Esumi, Hiroyasu et al. · 2010 · Proceedings of the National Academy of Sciences
  17. LKB1 is essential for the proliferation of T‐cell progenitors and mature peripheral T cells
    Tamás, Peter, Macintyre, Andrew, Finlay, David, Clarke, Rosemary, Feijoo‐Carnero, Carmen, Ashworth, Alan, Cantrell, Doreen · 2010 · European Journal of Immunology
  18. Metformin exerts glucose-lowering action in high-fat fed mice via attenuating endotoxemia and enhancing insulin signaling
    Zhou, Zi-yu, Ren, Li-wei, Zhan, Ping, Yang, Han-yan, Chai, Dan-dan, Yu, Zhi-wen · 2016 · Acta Pharmacologica Sinica
  19. Inhibition of lung tumorigenesis by metformin is associated with decreased plasma IGF-I and diminished receptor tyrosine kinase signaling
    Quinn, Brendan J., Dallos, Matthew, Kitagawa, Hiroshi, Kunnumakkara, Ajaikumar B., Memmott, Regan M., Hollander, M. Christine, Gills, Joell J., Dennis, Phillip A. · 2013 · Cancer Prevention Research
  20. Metformin induces <scp>PGC</scp>‐1α expression and selectively affects hepatic <scp>PGC</scp>‐1α functions
    Aatsinki, Sanna‐Mari, Buler, Marcin, Salomäki, Henriikka, Koulu, Markku, Pavek, Petr, Hakkola, Jukka · 2014 · British Journal of Pharmacology
  21. LKB1 and AMPK and the regulation of skeletal muscle metabolism
    Koh, Ho-Jin, Brandauer, Josef, Goodyear, Laurie J · 2008 · Current Opinion in Clinical Nutrition and Metabolic Care
  22. Intestinal AMPK modulation of microbiota mediates crosstalk with brown fat to control thermogenesis
    Zhang, Eryun, Jin, Lihua, Wang, Yangmeng, Tu, Jui, Zheng, Ruirong, Ding, Lili, Fang, Zhipeng, Fan, Mingjie, Al-Abdullah, Ismail, Natarajan, Rama et al. · 2022 · Nature Communications
  23. Orosomucoid 2 maintains hepatic lipid homeostasis through suppression of de novo lipogenesis
    Zhou, Bing, Luo, Yunchen, Ji, Nana, Hu, Cheng, Lu, Yan · 2022 · Nature Metabolism
  24. LKB1 regulates polarity remodeling and adherens junction formation in the <i>Drosophila</i> eye
    Amin, Nancy, Khan, Afifa, St. Johnston, Daniel, Tomlinson, Ian, Martin, Sophie, Brenman, Jay, McNeill, Helen · 2009 · Proceedings of the National Academy of Sciences
  25. New Insights Into the Anti-Diabetic Actions of Metformin: From the Liver to the Gut
    Wu, Tongzhi, Horowitz, Michael, Rayner, Christopher K. · 2017 · Expert Review of Gastroenterology &amp; Hepatology
  26. Sympathetic inputs regulate adaptive thermogenesis in brown adipose tissue through cAMP-Salt inducible kinase axis
    Paulo, Esther, Wu, Dongmei, Wang, Yangmeng, Zhang, Yun, Wu, Yixuan, Swaney, Danielle L., Soucheray, Margaret, Jimenez-Morales, David, Chawla, Ajay, Krogan, Nevan J. et al. · 2018 · Scientific Reports
  27. Cyanidin-3-O-β-glucoside and protocatechuic acid activate AMPK/mTOR/S6K pathway and improve glucose homeostasis in mice
    Talagavadi, Veena, Rapisarda, Paolo, Galvano, Fabio, Pelicci, Piergiuseppe, Giorgio, Marco · 2016 · Journal of Functional Foods
  28. Activation of Autophagy Flux by Metformin Downregulates Cellular FLICE-Like Inhibitory Protein and Enhances TRAIL- Induced Apoptosis
    Nazim, Uddin MD., Moon, Ji-Hong, Lee, Ju-Hee, Lee, You-Jin, Seol, Jae-Won, Eo, Seong-Kug, Lee, John-Hwa, Park, Sang-Youel · 2016 · Oncotarget
  29. Genome protective effect of metformin as revealed by reduced level of constitutive DNA damage signaling
    Halicka, H. Dorota, Zhao, Hong, Li, Jiangwei, Traganos, Frank, Zhang, Sufang, Lee, Marietta, Darzynkiewicz, Zbigniew · 2011 · Aging
  30. Tetrahydrobiopterin has a glucose-lowering effect by suppressing hepatic gluconeogenesis in an endothelial nitric oxide synthase-dependent manner in diabetic mice
    Abudukadier, Abulizi, Fujita, Yoshihito, Obara, Akio, Ohashi, Akiko, Fukushima, Toru, Sato, Yuichi, Ogura, Masahito, Nakamura, Yasuhiko, Fujimoto, Shimpei, Hosokawa, Masaya et al. · 2013 · Diabetes
  31. Metformin and Cancer Stem Cells: Old Drug, New Targets
    Bednar, Filip, Simeone, Diane M. · 2012 · Cancer Prevention Research
  32. Why the endothelium? The endothelium as a target to reduce diabetes-associated vascular disease
    Triggle, Chris R., Ding, Hong, Marei, Isra, Anderson, Todd J., Hollenberg, Morley D. · 2020 · Canadian Journal of Physiology and Pharmacology
  33. Potential effects of metformin in DNA BER system based on oxidative status in type 2 diabetes
    Dogan Turacli, Irem, Candar, Tuba, Yuksel, Emine Berrin, Kalay, Sebnem, Oguz, Ali Kemal, Demirtas, Selda · 2018 · Biochimie
  34. Cation-selective transporters are critical to the AMPK-mediated antiproliferative effects of metformin in human breast cancer cells: Transporters in metformin effect against breast cancer cells
    Cai, Hao, Zhang, Yunhui, Han, Tianxiang Kevin, Everett, Ruth S., Thakker, Dhiren R. · 2016 · International Journal of Cancer
  35. IL11 stimulates ERK/P90RSK to inhibit LKB1/AMPK and activate mTOR initiating a mesenchymal program in stromal, epithelial, and cancer cells
    Widjaja, Anissa A., Viswanathan, Sivakumar, Wei Ting, Joyce Goh, Tan, Jessie, Shekeran, Shamini G., Carling, David, Lim, Wei-Wen, Cook, Stuart A. · 2022 · iScience
  36. Impact of diabetes on promoting the growth of breast cancer
    Chou, Ping‐Chieh, Choi, Hyun Ho, Huang, Yizhi, Fuentes‐Mattei, Enrique, Velazquez‐Torres, Guermarie, Zhang, Fanmao, Phan, Liem, Lee, Jaehyuk, Shi, Yanxia, Bankson, James A. et al. · 2021 · Cancer Communications
  37. Pharmacogenetics: potential role in the treatment of diabetes and obesity
    Vella, Adrian, Camilleri, Michael · 2008 · Expert Opinion on Pharmacotherapy
  38. Therapeutic Manipulation of Ageing: Repurposing Old Dogs and Discovering New Tricks
    Mallikarjun, Venkatesh, Swift, Joe · 2016 · EBioMedicine