The DOI matches its Crossref record.
Gene Regulatory Networks in the Evolution and Development of the Heart
Open accessAbstract
The heart, an ancient organ and the first to form and function during embryogenesis, evolved by the addition of new structures and functions to a primitive pump. Heart development is controlled by an evolutionarily conserved network of transcription factors that connect signaling pathways with genes for muscle growth, patterning, and contractility. During evolution, this ancestral gene network was expanded through gene duplication and co-option of additional networks. Mutations in components of the cardiac gene network cause congenital heart disease, the most common human birth defect. The consequences of such mutations reveal the logic of organogenesis and the evolutionary origins of morphological complexity.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Clapham, D. E. (2007) · Cell · doi:10.1016/j.cell.2007.11.028 · Cited by 4,175
Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors
Ieda, M., Fu, J.-D., Delgado-Olguin, P., Vedantham, V., Hayashi, Y., Bruneau, B. G., & Srivastava, D. (2010) · Cell · doi:10.1016/j.cell.2010.07.002 · Cited by 2,454
Evo-Devo and an Expanding Evolutionary Synthesis: A Genetic Theory of Morphological Evolution
Carroll, S. B. (2008) · Cell · doi:10.1016/j.cell.2008.06.030 · Cited by 2,067
FoxA1 Translates Epigenetic Signatures into Enhancer-Driven Lineage-Specific Transcription
Lupien, M., Eeckhoute, J., Meyer, C. A., Wang, Q., Zhang, Y., Li, W., Carroll, J. S., Liu, X. S., & Brown, M. (2008) · Cell · doi:10.1016/j.cell.2008.01.018 · Cited by 983
Pierpont, M. E., Brueckner, M., Chung, W. K., Garg, V., Lacro, R. V., McGuire, A. L., Mital, S., Priest, J. R., Pu, W. T., Roberts, A., et al. (2018) · Circulation · doi:10.1161/cir.0000000000000606 · Cited by 654
Mending broken hearts: cardiac development as a basis for adult heart regeneration and repair
Xin, M., Olson, E. N., & Bassel-Duby, R. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3619 · Cited by 514
Self-citationA postnatal switch of CELF and MBNL proteins reprograms alternative splicing in the developing heart
Kalsotra, A., Xiao, X., Ward, A. J., Castle, J. C., Johnson, J. M., Burge, C. B., & Cooper, T. A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0809045105 · Cited by 508
Karakikes, I., Ameen, M., Termglinchan, V., & Wu, J. C. (2015) · Circulation Research · doi:10.1161/circresaha.117.305365 · Cited by 478
Rapid and Pervasive Changes in Genome-wide Enhancer Usage during Mammalian Development
Nord, A. S., Blow, M. J., Attanasio, C., Akiyama, J. A., Holt, A., Hosseini, R., Phouanenavong, S., Plajzer-Frick, I., Shoukry, M., Afzal, V., et al. (2013) · Cell · doi:10.1016/j.cell.2013.11.033 · Cited by 375
Direct lineage conversions: unnatural but useful?
Vierbuchen, T., & Wernig, M. (2011) · Nature Biotechnology · doi:10.1038/nbt.1946 · Cited by 259
A Transcription Factor Collective Defines Cardiac Cell Fate and Reflects Lineage History
Junion, G., Spivakov, M., Girardot, C., Braun, M., Gustafson, E. H., Birney, E., & Furlong, E. E. M. (2012) · Cell · doi:10.1016/j.cell.2012.01.030 · Cited by 257
Li, Z., Yu, T., Morishima, M., Pao, A., LaDuca, J., Conroy, J., Nowak, N., Matsui, S.-I., Shiraishi, I., & Yu, Y. E. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm086 · Cited by 218
Analysis of Transcriptome Complexity Through RNA Sequencing in Normal and Failing Murine Hearts
Lee, J.-H., Gao, C., Peng, G., Greer, C., Ren, S., Wang, Y., & Xiao, X. (2011) · Circulation Research · doi:10.1161/circresaha.111.249433 · Cited by 209
Gene regulatory programmes of tissue regeneration
Goldman, J. A., & Poss, K. D. (2020) · Nature Reviews Genetics · doi:10.1038/s41576-020-0239-7 · Cited by 200
Reptilian heart development and the molecular basis of cardiac chamber evolution
Koshiba-Takeuchi, K., Mori, A. D., Kaynak, B. L., Cebra-Thomas, J., Sukonnik, T., Georges, R. O., Latham, S., Beck, L., Henkelman, R. M., Black, B. L., et al. (2009) · Nature · doi:10.1038/nature08324 · Cited by 182
Self-citationMicroRNAs and cardiovascular diseases
Ono, K., Kuwabara, Y., & Han, J. (2011) · The FEBS Journal · doi:10.1111/j.1742-4658.2011.08090.x · Cited by 169
Rittschof, C. C., Bukhari, S. A., Sloofman, L. G., Troy, J. M., Caetano-Anollés, D., Cash-Ahmed, A., Kent, M., Lu, X., Sanogo, Y. O., Weisner, P. A., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1420369111 · Cited by 163
MicroRNAs coordinate an alternative splicing network during mouse postnatal heart development
Kalsotra, A., Wang, K., Li, P.-F., & Cooper, T. A. (2010) · Genes & Development · doi:10.1101/gad.1894310 · Cited by 129
p53 ancestry: gazing through an evolutionary lens
Lu, W.-J., Amatruda, J. F., & Abrams, J. M. (2009) · Nature reviews. Cancer · doi:10.1038/nrc2732 · Cited by 112
Genetic and epigenetic regulation of cardiomyocytes in development, regeneration and disease
Cui, M., Wang, Z., Bassel-Duby, R., & Olson, E. N. (2018) · Development · doi:10.1242/dev.171983 · Cited by 92
Self-citationMcCauley, B. S., Weideman, E. P., & Hinman, V. F. (2010) · Developmental Biology · doi:10.1016/j.ydbio.2009.11.020 · Cited by 79
Calcium-mediated histone modifications regulate alternative splicing in cardiomyocytes
Sharma, A., Nguyen, H., Geng, C., Hinman, M. N., Luo, G., & Lou, H. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1408964111 · Cited by 59
Genetic Networks Governing Heart Development
Waardenberg, A. J., Ramialison, M., Bouveret, R., & Harvey, R. P. (2014) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a013839 · Cited by 59
Lemons, D., Fritzenwanker, J. H., Gerhart, J., Lowe, C. J., & McGinnis, W. (2010) · Developmental Biology · doi:10.1016/j.ydbio.2010.04.022 · Cited by 45
Li, A., Ponten, F., & dos Remedios, C. G. (2012) · PROTEOMICS · doi:10.1002/pmic.201100492 · Cited by 47
Cardiac splicing as a diagnostic and therapeutic target
Gotthardt, M., Badillo-Lisakowski, V., Parikh, V. N., Ashley, E., Furtado, M., Carmo-Fonseca, M., Schudy, S., Meder, B., Grosch, M., Steinmetz, L., et al. (2023) · Nature Reviews Cardiology · doi:10.1038/s41569-022-00828-0 · Cited by 46
Hinman, V. F., Yankura, K. A., & McCauley, B. S. (2009) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2009.01.004 · Cited by 32
Nim, H. T., Dang, L., Thiyagarajah, H., Bakopoulos, D., See, M., Charitakis, N., Sibbritt, T., Eichenlaub, M. P., Archer, S. K., Fossat, N., et al. (2021) · Genome Biology · doi:10.1186/s13059-021-02539-0 · Cited by 11
Zinati, Y., Takiddeen, A., & Emad, A. (2023) · doi:10.1101/2023.07.25.550225 · Cited by 36
Metadata
- Authors
- Olson, E. N.
- Venue
- Science
- Published
- 2006-09-29
- Volume
- 313
- Issue
- 5795
- Pages
- 1922-1927
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2143837955
- Cited by
- 1,015
- References
- 0
- FWCI
- 18.42
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
