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Requirement of bic/microRNA-155 for Normal Immune Function
Open accessAbstract
MicroRNAs are a class of small RNAs that are increasingly being recognized as important regulators of gene expression. Although hundreds of microRNAs are present in the mammalian genome, genetic studies addressing their physiological roles are at an early stage. We have shown that mice deficient for bic/microRNA-155 are immunodeficient and display increased lung airway remodeling. We demonstrate a requirement of bic/microRNA-155 for the function of B and T lymphocytes and dendritic cells. Transcriptome analysis of bic/microRNA-155 –deficient CD4 + T cells identified a wide spectrum of microRNA-155–regulated genes, including cytokines, chemokines, and transcription factors. Our work suggests that bic/microRNA-155 plays a key role in the homeostasis and function of the immune system.
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“Expression of miR-155 is, therefore, required for normal immune function [24].”
From Microglia specific deletion of miR-155 in Alzheimer’s disease mouse models reduces amyloid-β pathology but causes hyperexcitability and seizures (2023) · cites this paper as [24]
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Metadata
- Authors
- Rodriguez, A., Vigorito, E., Clare, S., Warren, M. V., Couttet, P., Soond, D. R., van Dongen, S., Grocock, R. J., Das, P. P., Miska, E. A., Vetrie, D., Okkenhaug, K., Enright, A. J., Dougan, G., Turner, M., & Bradley, A.
- Affiliations
- Babraham Institute (GB)
- The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
- Corresponding author
- Rodriguez, Antony
- Vigorito, Elena
- Turner, Martin
- Bradley, Allan
- ORCID
- Venue
- Science
- Published
- 2007-04-27
- Volume
- 316
- Issue
- 5824
- Pages
- 608-611
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC2610435
- OpenAlex
- W2014869583
- Cited by
- 1,833
- References
- 29
- Citations by year
- 2026: 16 · 2025: 31 · 2024: 53 · 2023: 38 · 2022: 57 · 2021: 80 · 2020: 82 · 2019: 76 · 2018: 89 · 2017: 106 · 2016: 114 · 2015: 114 · 2014: 140 · 2013: 171 · 2012: 121
- FWCI
- 46.59
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Wellcome Trust (077187, 79643)
- Biotechnology and Biological Sciences Research Council (BBS/E/B/0000M206)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- miR-155, immunodeficiency, B cells, T cells, dendritic cells, CD4+ T cells, cytokines, chemokines, transcription factors, immune homeostasis
- MeSH terms
- Animals, B-Lymphocytes, Dendritic Cells, Gene Expression Regulation, Homeostasis, Immunoglobulin G, Immune System, Lung, Lung Diseases, Lymphocyte Activation, Salmonella Infections, Animal, T-Lymphocytes, Vaccination, Cytokines, Gene Targeting, Th1 Cells, Th2 Cells, Oligonucleotide Array Sequence Analysis, 3' Untranslated Regions, MicroRNAs, Proto-Oncogene Proteins c-maf, Mice
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