Cited by 1,096Chromosomal and Genetic VariationsRNA Interference and Gene DeliveryPlant Molecular Biology Research

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The Piwi-piRNA Pathway Provides an Adaptive Defense in the Transposon Arms Race

Aravin, Alexei A., Hannon, Gregory J., Brennecke, Julius·2007·Science

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Abstract

Increasingly complex networks of small RNAs act through RNA-interference (RNAi) pathways to regulate gene expression, to mediate antiviral responses, to organize chromosomal domains, and to restrain the spread of selfish genetic elements. Historically, RNAi has been defined as a response to double-stranded RNA. However, some small RNA species may not arise from double-stranded RNA precursors. Yet, like microRNAs and small interfering RNAs, such species guide Argonaute proteins to silencing targets through complementary base-pairing. Silencing can be achieved by corecruitment of accessory factors or through the activity of Argonaute itself, which often has endonucleolytic activity. As a specific and adaptive regulatory system, RNAi is used throughout eukarya, which indicates a long evolutionary history. A likely function of RNAi throughout that history is to protect the genome from both pathogenic and parasitic invaders.

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Authors: Aravin, A. A., Hannon, G. J., & Brennecke, J.
Affiliations: Howard Hughes Medical Institute (US)
Corresponding author: Aravin, Alexei A.
Hannon, Gregory J.
Brennecke, Julius
ORCID: Aravin, Alexei A.
Hannon, Gregory J.
Brennecke, Julius
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2007-11-02
Volume: 318
Issue: 5851
Pages: 761-764
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.1146484
OpenAlex: W2046318418
Cited by: 1,096
References: 38
Citations by year: 2026: 28 · 2025: 43 · 2024: 37 · 2023: 32 · 2022: 41 · 2021: 45 · 2020: 42 · 2019: 56 · 2018: 62 · 2017: 46 · 2016: 53 · 2015: 78 · 2014: 76 · 2013: 68 · 2012: 74
FWCI: 6.79
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory) (acceptedVersion)
CaltechAUTHORS (California Institute of Technology) (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Chromosomal and Genetic Variations
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
Keywords: RNA interference, transposable elements, small RNA, Argonaute proteins, genome defense, selfish genetic elements, gene silencing
MeSH terms: Adaptation, Biological, Animals, Base Sequence, DNA Transposable Elements, Molecular Sequence Data, Proteins, RNA-Binding Proteins, Evolution, Molecular, Gene Silencing, Drosophila Proteins, RNA, Small Interfering, RNA-Induced Silencing Complex, Argonaute Proteins

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The Piwi-piRNA Pathway Provides an Adaptive Defense in the Transposon Arms Race

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