Cited by 1,096Chromosomal and Genetic VariationsRNA Interference and Gene DeliveryPlant Molecular Biology Research

The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.

The Piwi-piRNA Pathway Provides an Adaptive Defense in the Transposon Arms Race

Aravin, Alexei A., Hannon, Gregory J., Brennecke, Julius·2007·Science

Open this paper in CoChat — free account

Abstract

Increasingly complex networks of small RNAs act through RNA-interference (RNAi) pathways to regulate gene expression, to mediate antiviral responses, to organize chromosomal domains, and to restrain the spread of selfish genetic elements. Historically, RNAi has been defined as a response to double-stranded RNA. However, some small RNA species may not arise from double-stranded RNA precursors. Yet, like microRNAs and small interfering RNAs, such species guide Argonaute proteins to silencing targets through complementary base-pairing. Silencing can be achieved by corecruitment of accessory factors or through the activity of Argonaute itself, which often has endonucleolytic activity. As a specific and adaptive regulatory system, RNAi is used throughout eukarya, which indicates a long evolutionary history. A likely function of RNAi throughout that history is to protect the genome from both pathogenic and parasitic invaders.

Integrity signals

Registry

Crossref · 10.1126/science.1146484

Cites

38 of 38 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Untitled work
Bartel (2004) · doi:10.1016/s0092-8674(04)00045-5 · Cited by 34,714
Discrete Small RNA-Generating Loci as Master Regulators of Transposon Activity in Drosophila
Brennecke, J., Aravin, A. A., Stark, A., Dus, M., Kellis, M., Sachidanandam, R., & Hannon, G. J. (2007) · Cell · doi:10.1016/j.cell.2007.01.043 · Cited by 2,524
Self-citation
Transposable elements and the epigenetic regulation of the genome
Slotkin, R. K., & Martienssen, R. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2072 · Cited by 2,044
A germline-specific class of small RNAs binds mammalian Piwi proteins
Girard, A., Sachidanandam, R., Hannon, G. J., & Carmell, M. A. (2006) · Nature · doi:10.1038/nature04917 · Cited by 1,762
Self-citation
A novel class of small RNAs bind to MILI protein in mouse testes
Aravin, A., Gaidatzis, D., Pfeffer, S., Lagos-Quintana, M., Landgraf, P., Iovino, N., Morris, P., Brownstein, M. J., Kuramochi-Miyagawa, S., Nakano, T., et al. (2006) · Nature · doi:10.1038/nature04916 · Cited by 1,516
Self-citation
A Distinct Small RNA Pathway Silences Selfish Genetic Elements in the Germline
Vagin, V. V., Sigova, A. A., Li, C., Seitz, H., Gvozdev, V. A., & Zamore, P. D. (2006) · Science · doi:10.1126/science.1129333 · Cited by 1,385
Meiotic catastrophe and retrotransposon reactivation in male germ cells lacking Dnmt3L
Bourc’his, D., & Bestor, T. H. (2004) · Nature · doi:10.1038/nature02886 · Cited by 1,279
A Slicer-Mediated Mechanism for Repeat-Associated siRNA 5' End Formation in Drosophila
Gunawardane, L. S., Saito, K., Nishida, K. M., Miyoshi, K., Kawamura, Y., Nagami, T., Siomi, H., & Siomi, M. C. (2007) · Science · doi:10.1126/science.1140494 · Cited by 1,173
MIWI2 Is Essential for Spermatogenesis and Repression of Transposons in the Mouse Male Germline
Carmell, M. A., Girard, A., van de Kant, H. J. G., Bourc’his, D., Bestor, T. H., de Rooij, D. G., & Hannon, G. J. (2007) · Developmental Cell · doi:10.1016/j.devcel.2007.03.001 · Cited by 1,170
Self-citation
A Role for Piwi and piRNAs in Germ Cell Maintenance and Transposon Silencing in Zebrafish
Houwing, S., Kamminga, L. M., Berezikov, E., Cronembold, D., Girard, A., van den Elst, H., Filippov, D. V., Blaser, H., Raz, E., Moens, C. B., et al. (2007) · Cell · doi:10.1016/j.cell.2007.03.026 · Cited by 1,132
Self-citation

Flagged first, then by citations

Show all 38 references

Sorted by citations

Items 101–200 of 999

Gene family innovation, conservation and loss on the animal stem lineage
(2018) · doi:10.7554/elife.34226 · Cited by 226
MicroRNAs as Effectors of Brain Function with Roles in Ischemia and Injury, Neuroprotection, and Neurodegeneration
Saugstad, J. A. (2010) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2010.101 · Cited by 229
Bridging the transgenerational gap with epigenetic memory
Lim, J. P., & Brunet, A. (2013) · Trends in Genetics · doi:10.1016/j.tig.2012.12.008 · Cited by 228
Mouse MOV10L1 associates with Piwi proteins and is an essential component of the Piwi-interacting RNA (piRNA) pathway
Zheng, K., Xiol, J., Reuter, M., Eckardt, S., Leu, N. A., McLaughlin, K. J., Stark, A., Sachidanandam, R., Pillai, R. S., & Wang, P. J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1003953107 · Cited by 227
Argonautes ALG-3 and ALG-4 are required for spermatogenesis-specific 26G-RNAs and thermotolerant sperm in Caenorhabditis elegans
Conine, C. C., Batista, P. J., Gu, W., Claycomb, J. M., Chaves, D. A., Shirayama, M., & Mello, C. C. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911685107 · Cited by 215
MicroRNAs: Biogenesis and Molecular Functions
Liu, X., Fortin, K., & Mourelatos, Z. (2008) · Brain Pathology · doi:10.1111/j.1750-3639.2007.00121.x · Cited by 218
Genome sequence of an Australian kangaroo, Macropus eugenii, provides insight into the evolution of mammalian reproduction and development
Renfree, M. B., Papenfuss, A. T., Deakin, J. E., Lindsay, J., Heider, T. N., Belov, K., Rens, W., Waters, P. D., Pharo, E. A., Shaw, G., et al. (2011) · Genome biology · doi:10.1186/gb-2011-12-8-r81 · Cited by 207
Sex differences in DNA methylation assessed by 450 K BeadChip in newborns
Yousefi, P., Huen, K., Davé, V., Barcellos, L., Eskenazi, B., & Holland, N. (2015) · BMC Genomics · doi:10.1186/s12864-015-2034-y · Cited by 205
The Role of Transposable Elements in Speciation
Serrato-Capuchina, A., & Matute, D. R. (2018) · Genes · doi:10.3390/genes9050254 · Cited by 210
Evolution of Eukaryotic DNA Methylation and the Pursuit of Safer Sex
Zemach, A., & Zilberman, D. (2010) · Current Biology · doi:10.1016/j.cub.2010.07.007 · Cited by 206
REVIEW ARTICLE: Epigenetics in the Placenta
Maccani, M. A., & Marsit, C. J. (2009) · American Journal of Reproductive Immunology · doi:10.1111/j.1600-0897.2009.00716.x · Cited by 215
p53 genes function to restrain mobile elementsPreprint
Wylie, A., Jones, A. E., D’Brot, A., Lu, W.-J., Kurtz, P., Moran, J. V., Rakheja, D., Chen, K. S.-M., Hammer, R. E., Comerford, S. A., et al. (2015) · Genes & Development · doi:10.1101/gad.266098.115 · Cited by 204
Functional involvement of Tudor and dPRMT5 in the piRNA processing pathway in Drosophila germlines
Nishida, K. M., Okada, T. N., Kawamura, T., Mituyama, T., Kawamura, Y., Inagaki, S., Huang, H., Chen, D., Kodama, T., Siomi, H., et al. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.365 · Cited by 197
Transposable Elements in Human Cancer: Causes and Consequences of Deregulation
Anwar, S. L., Wulaningsih, W., & Lehmann, U. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18050974 · Cited by 209
How does the Royal Family of Tudor rule the PIWI-interacting RNA pathway?Preprint
Siomi, M. C., Mannen, T., & Siomi, H. (2010) · Genes & Development · doi:10.1101/gad.1899210 · Cited by 203
26G endo-siRNAs regulate spermatogenic and zygotic gene expression in Caenorhabditis elegans
Han, T., Manoharan, A. P., Harkins, T. T., Bouffard, P., Fitzpatrick, C., Chu, D. S., Thierry‐Mieg, D., Thierry‐Mieg, J., & Kim, J. K. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0906378106 · Cited by 186
Characterization and comparative profiling of the small RNA transcriptomes in two phases of locust
Wei, Y., Chen, S., Yang, P., Ma, Z., & Kang, L. (2009) · Genome biology · doi:10.1186/gb-2009-10-1-r6 · Cited by 184
Transposable elements in the mammalian germline: a comfortable niche or a deadly trap?
Zamudio, N., & Bourc’his, D. (2010) · Heredity · doi:10.1038/hdy.2010.53 · Cited by 191
piRNA Biogenesis in Drosophila melanogaster
Huang, X., Tóth, K. F., & Aravin, A. A. (2017) · Trends in Genetics · doi:10.1016/j.tig.2017.09.002 · Cited by 185
Self-citation
Importance of potassium ions for ribosome structure and function revealed by long-wavelength X-ray diffraction
Rozov, A., Khusainov, I., El Omari, K., Duman, R., Mykhaylyk, V., Yusupov, M., Westhof, E., Wagner, A., & Yusupova, G. (2019) · Nature Communications · doi:10.1038/s41467-019-10409-4 · Cited by 179
Roles of small regulatory RNAs in determining neuronal identity
Li, X., & Jin, P. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2739 · Cited by 151
Hen1 is required for oocyte development and piRNA stability in zebrafish
Kamminga, L. M., Luteijn, M. J., den Broeder, M. J., Redl, S., Kaaij, L. J. T., Roovers, E. F., Ladurner, P., Berezikov, E., & Ketting, R. F. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.233 · Cited by 184
A Decade of Exploring the Mammalian Sperm Epigenome: Paternal Epigenetic and Transgenerational Inheritance
Champroux, A., Cocquet, J., Henry-Berger, J., Drevet, J. R., & Kocer, A. (2018) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2018.00050 · Cited by 191
Dicer-Independent Primal RNAs Trigger RNAi and Heterochromatin Formation
Halić, M., & Moazed, D. (2010) · Cell · doi:10.1016/j.cell.2010.01.019 · Cited by 175
Endogenous retroviruses
Maksakova, I. A., Mager, D. L., & Reiss, D. (2008) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-008-8494-3 · Cited by 177
Small RNA-Mediated Quiescence of Transposable Elements in Animals
Saito, K., & Siomi, M. C. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.10.011 · Cited by 188
Long Noncoding RNAs : Insights from Biological Features and Functions to Diseases
Li, X., Wu, Z., Fu, X., & Han, W. (2012) · Medicinal Research Reviews · doi:10.1002/med.21254 · Cited by 172
Unique somatic and malignant expression patterns implicate PIWI-interacting RNAs in cancer-type specific biology
Martínez, V. D., Vucic, E. A., Thu, K. L., Hubaux, R., Enfield, K. S. S., Pikor, L. A., Becker‐Santos, D. D., Brown, C. J., Lam, S. C., & Lam, W. L. (2015) · Scientific Reports · doi:10.1038/srep10423 · Cited by 174
Mobile Genetic Elements and Evolution of CRISPR-Cas Systems: All the Way There and Back
Koonin, E. V., & Makarova, K. S. (2017) · Genome Biology and Evolution · doi:10.1093/gbe/evx192 · Cited by 172
Arabidopsis ARGONAUTE 1 Binds Chromatin to Promote Gene Transcription in Response to Hormones and Stresses
Liu, C., Xin, Y., Xu, L., Cai, Z., Xue, Y., Liu, Y., Xie, D., Liu, Y., & Qi, Y. (2017) · Developmental Cell · doi:10.1016/j.devcel.2017.12.002 · Cited by 168
Chromatoid body and small RNAs in male germ cells
Meikar, O., Ros, M. D., Korhonen, H., & Kotaja, N. (2011) · Reproduction · doi:10.1530/rep-11-0057 · Cited by 174
Dogma Derailed: The Many Influences of RNA on the Genome
Sabin, L. R., Delàs, M. J., & Hannon, G. J. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.02.010 · Cited by 172
Self-citation
Small RNA guides for de novo DNA methylation in mammalian germ cells: Figure 1.Preprint
Aravin, A. A., & Bourc’his, D. (2008) · Genes & Development · doi:10.1101/gad.1669408 · Cited by 178
Self-citation
MALAT1 promotes cell proliferation in gastric cancer by recruiting SF2/ASF
Wang, J., Su, L., Chen, X., Li, P., Cai, Q., Yu, B., Liu, B., Wu, W., & Zhu, Z. (2014) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2014.04.007 · Cited by 164
Non-LTR retrotransposons encode noncanonical RRM domains in their first open reading frame
Khazina, E., & Weichenrieder, O. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0809964106 · Cited by 160
deepBase: a database for deeply annotating and mining deep sequencing data
Yang, J., Shao, P., Zhou, H., Chen, Y., & Qu, L. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp943 · Cited by 163
Stable RNA interference rules for silencing
Fellmann, C., & Lowe, S. W. (2013) · Nature Cell Biology · doi:10.1038/ncb2895 · Cited by 170
Planarian stem cells: a simple paradigm for regeneration
Aboobaker, A. A. (2011) · Trends in Cell Biology · doi:10.1016/j.tcb.2011.01.005 · Cited by 159
Dicer Is Required for Haploid Male Germ Cell Differentiation in Mice
Korhonen, H. M., Meikar, O., Yadav, R. P., Papaioannou, M. D., Romero, Y., Ros, M. D., Herrera, P. L., Toppari, J., Nef, S., & Kotaja, N. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024821 · Cited by 161
Maternal overnutrition programs hedonic and metabolic phenotypes across generations through sperm tsRNAs
Sarker, G., Sun, W., Rosenkranz, D., Pelczar, P., Opitz, L., Efthymiou, V., Wolfrum, C., & Peleg‐Raibstein, D. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1820810116 · Cited by 163
Widespread evidence for horizontal transfer of transposable elements across Drosophilagenomes
Bartolomé, C., Bello, X., & Maside, X. (2009) · Genome biology · doi:10.1186/gb-2009-10-2-r22 · Cited by 155
Promoter DNA methylation couples genome-defence mechanisms to epigenetic reprogramming in the mouse germline
Hackett, J. A., Reddington, J. P., Nestor, C. E., Dunican, D. S., Branco, M. R., Reichmann, J., Reik, W., Surani, M. A., Adams, I. R., & Meehan, R. R. (2012) · Development · doi:10.1242/dev.081661 · Cited by 157
PIWI-interacting RNA 021285 is involved in breast tumorigenesis possibly by remodeling the cancer epigenome
Fu, A., Jacobs, D., Hoffman, A. E., Zheng, T., & Zhu, Y. L. (2015) · Carcinogenesis · doi:10.1093/carcin/bgv105 · Cited by 156
High‐throughput deep sequencing shows that micro RNA s play important roles in switchgrass responses to drought and salinity stress
Xie, F., Stewart, C. N., Taki, F., He, Q., Liu, H., & Zhang, B. (2013) · Plant Biotechnology Journal · doi:10.1111/pbi.12142 · Cited by 151
Cutoff Suppresses RNA Polymerase II Termination to Ensure Expression of piRNA Precursors
Chen, Y.-C. A., Stuwe, E., Luo, Y., Ninova, M., Thomas, A. L., Rozhavskaya, E., Li, S., Vempati, S., Laver, J. D., Patel, D. J., et al. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.05.010 · Cited by 146
Self-citation
Enhancement of the Seed-Target Recognition Step in RNA Silencing by a PIWI/MID Domain Protein
Parker, J. S., Parizotto, E. A., Wang, M., Roe, S. M., & Barford, D. (2009) · Molecular Cell · doi:10.1016/j.molcel.2008.12.012 · Cited by 157
Taming transposable elements in vertebrates: from epigenetic silencing to domestication
Almeida, M. V., Vernaz, G., Putman, A. L. K., & Miska, E. A. (2022) · Trends in Genetics · doi:10.1016/j.tig.2022.02.009 · Cited by 150
Somatic stem cells express Piwi and Vasa genes in an adult ctenophore: Ancient association of “germline genes” with stemness
Alié, A., Leclère, L., Jager, M., Dayraud, C., Chang, P., Guyader, H. L., Quéinnec, É., & Manuel, M. (2010) · Developmental Biology · doi:10.1016/j.ydbio.2010.10.019 · Cited by 147
Beyond transposons: the epigenetic and somatic functions of the Piwi-piRNA mechanism
Peng, J. C., & Lin, H. (2013) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2013.01.010 · Cited by 146
Genetic conflict and sex chromosome evolution
Meiklejohn, C. D., & Tao, Y. (2009) · Trends in Ecology & Evolution · doi:10.1016/j.tree.2009.10.005 · Cited by 147
Eukaryotic Protein Domains as Functional Units of Cellular Evolution
Jin, J., Xie, X., Chen, C., Park, J. G., Stark, C., James, D. A., Olhovsky, M., Linding, R., Mao, Y., & Pawson, T. J. (2009) · Science Signaling · doi:10.1126/scisignal.2000546 · Cited by 144
mrhl RNA, a Long Noncoding RNA, Negatively Regulates Wnt Signaling through Its Protein Partner Ddx5/p68 in Mouse Spermatogonial Cells
Arun, G., Akhade, V. S., Donakonda, S., & Rao, M. R. S. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.00006-12 · Cited by 145
Probing the initiation and effector phases of the somatic piRNA pathway inDrosophilaPreprint
Haase, A. D., Fenoglio, S., Muerdter, F., Guzzardo, P. M., Czech, B., Pappin, D., Chen, C., Gordon, A., & Hannon, G. J. (2010) · Genes & Development · doi:10.1101/gad.1968110 · Cited by 156
Self-citation
The Yb Body, a Major Site for Piwi-associated RNA Biogenesis and a Gateway for Piwi Expression and Transport to the Nucleus in Somatic Cells
Qi, H., Watanabe, T., Ku, H.-Y., Liu, N., Zhong, M., & Lin, H. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.193888 · Cited by 142
Multiple Roles for Heterochromatin Protein 1 Genes in Drosophila
Vermaak, D., & Malik, H. S. (2009) · Annual Review of Genetics · doi:10.1146/annurev-genet-102108-134802 · Cited by 150
Transposable element origins of epigenetic gene regulation
Lisch, D. R., & Bennetzen, J. L. (2011) · Current Opinion in Plant Biology · doi:10.1016/j.pbi.2011.01.003 · Cited by 142
DNA Elimination in Ciliates: Transposon Domestication and Genome Surveillance
Chalker, D. L., & Yao, M.-C. (2011) · Annual Review of Genetics · doi:10.1146/annurev-genet-110410-132432 · Cited by 136
Our Conflict with Transposable Elements and Its Implications for Human Disease
Burns, K. H. (2020) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathmechdis-012419-032633 · Cited by 137
Ancient and Novel Small RNA Pathways Compensate for the Loss of piRNAs in Multiple Independent Nematode Lineages
Sarkies, P., Selkirk, M. E., Jones, J. T., Blok, V. C., Boothby, T., Goldstein, B., Hanelt, B., Ardila‐Garcia, A. M., Fast, N. M., Schiffer, P. M., et al. (2015) · PLoS Biology · doi:10.1371/journal.pbio.1002061 · Cited by 141
A new approach to gene therapy using Sleeping Beauty to genetically modify clinical‐grade T cells to target CD 19
Singh, H., Huls, H. M., Kebriaei, P., & Cooper, L. J. N. (2013) · Immunological Reviews · doi:10.1111/imr.12137 · Cited by 139
MicroRNA: basic mechanisms and transcriptional regulatory networks for cell fate determination
Fazi, F., & Nervi, C. (2008) · Cardiovascular Research · doi:10.1093/cvr/cvn151 · Cited by 139
Germ Cells Are Forever
Cinalli, R. M., Rangan, P., & Lehmann, R. (2008) · Cell · doi:10.1016/j.cell.2008.02.003 · Cited by 132
Dynamic expression of small non-coding RNAs, including novel microRNAs and piRNAs/21U-RNAs, during Caenorhabditis elegansdevelopment
Kato, M., de Lencastre, A., Pincus, Z., & Slack, F. J. (2009) · Genome biology · doi:10.1186/gb-2009-10-5-r54 · Cited by 138
piRNAs and their involvement in male germline development in mice
Pillai, R. S., & Chuma, S. (2012) · Development Growth & Differentiation · doi:10.1111/j.1440-169x.2011.01320.x · Cited by 143
High-resolution profiling and discovery of planarian small RNAs
Friedländer, M. R., Adamidi, C., Han, T., Lebedeva, S., Isenbarger, T. A., Hirst, M., Marra, M. A., Nusbaum, C., Lee, W. L., Jenkin, J. C., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0905222106 · Cited by 137
A Role for Fkbp6 and the Chaperone Machinery in piRNA Amplification and Transposon Silencing
Xiol, J., Cora, E., Koglgruber, R., Chuma, S., Subramanian, S. L., Hosokawa, M., Reuter, M., Yang, Z., Berninger, P., Palencia, A., et al. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.07.019 · Cited by 140
A small RNA response at DNA ends in Drosophila
Michalik, K., Böttcher, R., & Förstemann, K. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks711 · Cited by 134
Piwi-interacting RNAs (piRNAs) and cancer: Emerging biological concepts and potential clinical implications
Weng, W., Li, H., & Goel, A. (2018) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2018.12.005 · Cited by 137
HENMT1 and piRNA Stability Are Required for Adult Male Germ Cell Transposon Repression and to Define the Spermatogenic Program in the Mouse
Lim, S. L., Qu, Z., Kortschak, R. D., Lawrence, D., Geoghegan, J. M., Hempfling, A.-L., Bergmann, M., Goodnow, C. C., Ormandy, C. J., Wong, L. H., et al. (2015) · PLoS Genetics · doi:10.1371/journal.pgen.1005620 · Cited by 140
Hypomethylation of Repeated Dna Sequences in Cancer
Ross, J. P., Rand, K. N., & Molloy, P. L. (2010) · Epigenomics · doi:10.2217/epi.10.2 · Cited by 136
A comprehensive analysis of piRNAs from adult human testis and their relationship with genes and mobile elements
Ha, H., Song, J., Wang, S., Kapusta, A., Feschotte, C., Chen, K. C., & Xing, J. (2014) · BMC Genomics · doi:10.1186/1471-2164-15-545 · Cited by 136
TEMP: a computational method for analyzing transposable element polymorphism in populations
Zhuang, J., Wang, J., Theurkauf, W. E., & Weng, Z. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku323 · Cited by 130
An Inside Job for siRNAs
Golden, D. E., Gerbasi, V. R., & Sontheimer, E. J. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.07.008 · Cited by 129
The stem cell-associated Hiwi gene in human adenocarcinoma of the pancreas: expression and risk of tumour-related death
Grochola, L. F., Greither, T., Taubert, H. W., Mӧller, P., Knippschild, U., Udelnow, A., Henne‐Bruns, D., & Würl, P. (2008) · British Journal of Cancer · doi:10.1038/sj.bjc.6604653 · Cited by 130
Tertiary siRNAs Mediate Paramutation in C. elegans
Sapetschnig, A., Sarkies, P., Lehrbach, N. J., & Miska, E. A. (2015) · PLoS Genetics · doi:10.1371/journal.pgen.1005078 · Cited by 125
Aub and Ago3 Are Recruited to Nuage through Two Mechanisms to Form a Ping-Pong Complex Assembled by Krimper
Webster, A., Li, S., Hur, J. K., Wachsmuth, M., Bois, J. S., Perkins, E. M., Patel, D. J., & Aravin, A. A. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.07.017 · Cited by 130
Self-citation
Aedes aegypti Piwi4 Is a Noncanonical PIWI Protein Involved in Antiviral Responses
Varjak, M., Maringer, K., Watson, M., Sreenu, V. B., Fredericks, A. C., Pondeville, E., Donald, C. L., Sterk, J., Kean, J., Vazeille, M., et al. (2017) · mSphere · doi:10.1128/msphere.00144-17 · Cited by 123
SAMHD1 Inhibits LINE-1 Retrotransposition by Promoting Stress Granule Formation
Hu, S., Li, J., Xu, F., Mei, S., Le Duff, Y., Yin, L., Pang, X., Cen, S., Jin, Q., Liang, C., et al. (2015) · PLOS Genetics · doi:10.1371/journal.pgen.1005367 · Cited by 121
Microarray Profiling and Co-Expression Network Analysis of Circulating lncRNAs and mRNAs Associated with Major Depressive Disorder
Liu, Z., Li, X., Sun, N., Xu, Y. J., Meng, Y.-Q., Yang, C., Wang, Y., & Zhang, K. (2014) · PLoS ONE · doi:10.1371/journal.pone.0093388 · Cited by 123
MicroRNAs in platelet production and activation
Edelstein, L. C., & Bray, P. F. (2011) · Blood · doi:10.1182/blood-2011-01-292011 · Cited by 120
An Abundant Class of Non-coding DNA Can Prevent Stochastic Gene Silencing in the C. elegans Germline
Frøkjær‐Jensen, C., Jain, N., Hansen, L. L., Davis, M. W., Li, Y., Zhao, D., Rébora, K., Millet, J. R., Liu, X., Kim, S. K., et al. (2016) · Cell · doi:10.1016/j.cell.2016.05.072 · Cited by 121
Long noncoding RNAs in mammalian cells: what, where, and why?
Chen, L., & Carmichael, G. (2010) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.5 · Cited by 118
The recent invasion of natural Drosophila simulans populations by the P-element
Kofler, R., Hill, T., Nolte, V., Betancourt, A. J., & Schlötterer, C. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1500758112 · Cited by 118
piRNA and spermatogenesis in mice
Chuma, S., & Nakano, T. (2012) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2011.0338 · Cited by 125
Germ granules in Drosophila
Trcek, T., & Lehmann, R. (2019) · Traffic · doi:10.1111/tra.12674 · Cited by 119
Influence of Na+ and Mg2+ ions on RNA structures studied with molecular dynamics simulations
Fischer, N. M., Polêto, M. D., Steuer, J., & van der Spoel, D. (2018) · Nucleic Acids Research · doi:10.1093/nar/gky221 · Cited by 117
Recognition of 2′-O-Methylated 3′-End of piRNA by the PAZ Domain of a Piwi Protein
Simon, B., Kirkpatrick, J., Eckhardt, S., Reuter, M., Rocha, E. A., Andrade-Navarro, M. A., Sehr, P. A., Pillai, R. S., & Carlomagno, T. (2011) · Structure · doi:10.1016/j.str.2010.11.015 · Cited by 119
piRNA profiling during specific stages of mouse spermatogenesis
Gan, H., Lin, X., Zhang, Z., Zhang, W., Liao, S., Wang, L., & Han, C. (2011) · RNA · doi:10.1261/rna.2648411 · Cited by 120
Small RNA Silencing Pathways in Germ and Stem CellsPreprint
Aravin, A. A., & Hannon, G. J. (2008) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2008.73.058 · Cited by 120
Self-citation
Comparative Principles of DNA Methylation Reprogramming during Human and Mouse In Vitro Primordial Germ Cell Specification
von Meyenn, F., Berrens, R. V., Andrews, S., Santos, F., Collier, A. J., Krueger, F., Osorno, R., Dean, W., Rugg‐Gunn, P. J., & Reik, W. (2016) · Developmental Cell · doi:10.1016/j.devcel.2016.09.015 · Cited by 115
Genomic Features of Parthenogenetic Animals
Jaroň, K. S., Bast, J., Nowell, R. W., Ranallo-Benavidez, T. R., Robinson‐Rechavi, M., & Schwander, T. (2020) · Journal of Heredity · doi:10.1093/jhered/esaa031 · Cited by 111
Closing the circle of germline and stem cells: the Primordial Stem Cell hypothesis
Solana, J. (2013) · EvoDevo · doi:10.1186/2041-9139-4-2 · Cited by 114
Biogenesis pathways of piRNAs loaded onto AGO3 in the Drosophila testis
Nagao, A., Mitsuyama, T., Huang, H., Chen, D., Siomi, M. C., & Siomi, H. (2010) · RNA · doi:10.1261/rna.2270710 · Cited by 114
Untangling the web: The diverse functions of the PIWI/piRNA pathway
Mani, S. R., & Juliano, C. E. (2013) · Molecular Reproduction and Development · doi:10.1002/mrd.22195 · Cited by 118
Cnidarian microRNAs frequently regulate targets by cleavagePreprint
Moran, Y., Fredman, D., Praher, D., Li, X. Z., Wee, L. M., Rentzsch, F., Zamore, P. D., Technau, U., & Seitz, H. (2014) · Genome Research · doi:10.1101/gr.162503.113 · Cited by 113
Production of artificial piRNAs in flies and mice
Muerdter, F., Olovnikov, I. A., Molaro, A., Rozhkov, N. V., Czech, B., Gordon, A., Hannon, G. J., & Aravin, A. A. (2011) · RNA · doi:10.1261/rna.029769.111 · Cited by 114
Self-citation
Processing of Drosophila endo-siRNAs depends on a specific Loquacious isoform
Zhou, R., Czech, B., Brennecke, J., Sachidanandam, R., Wohlschlegel, J. A., Perrimon, N., & Hannon, G. J. (2009) · RNA · doi:10.1261/rna.1611309 · Cited by 114
Self-citation
Evolutionary dynamics of transposable elements in a small RNA world
Blumenstiel, J. P. (2010) · Trends in Genetics · doi:10.1016/j.tig.2010.10.003 · Cited by 113
The MOV10 Helicase Inhibits LINE-1 Mobility
Li, X., Zhang, J., Jia, R., Cheng, V., Xu, X., Qiao, W., Guo, F., Liang, C., & Cen, S. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.465856 · Cited by 121
Interspecies regulation of microRNAs and their targets
Ha, M., Pang, M., Agarwal, V., & Chen, Z. J. (2008) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2008.03.004 · Cited by 112

Authors: Aravin, A. A., Hannon, G. J., & Brennecke, J.
Affiliations: Howard Hughes Medical Institute (US)
Corresponding author: Aravin, Alexei A.
Hannon, Gregory J.
Brennecke, Julius
ORCID: Aravin, Alexei A.
Hannon, Gregory J.
Brennecke, Julius
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2007-11-02
Volume: 318
Issue: 5851
Pages: 761-764
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.1146484
OpenAlex: W2046318418
Cited by: 1,096
References: 38
Citations by year: 2026: 28 · 2025: 43 · 2024: 37 · 2023: 32 · 2022: 41 · 2021: 45 · 2020: 42 · 2019: 56 · 2018: 62 · 2017: 46 · 2016: 53 · 2015: 78 · 2014: 76 · 2013: 68 · 2012: 74
FWCI: 6.79
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory) (acceptedVersion)
CaltechAUTHORS (California Institute of Technology) (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Chromosomal and Genetic Variations
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
Keywords: RNA interference, transposable elements, small RNA, Argonaute proteins, genome defense, selfish genetic elements, gene silencing
MeSH terms: Adaptation, Biological, Animals, Base Sequence, DNA Transposable Elements, Molecular Sequence Data, Proteins, RNA-Binding Proteins, Evolution, Molecular, Gene Silencing, Drosophila Proteins, RNA, Small Interfering, RNA-Induced Silencing Complex, Argonaute Proteins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The Piwi-piRNA Pathway Provides an Adaptive Defense in the Transposon Arms Race

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks