Cited by 1,096Chromosomal and Genetic VariationsRNA Interference and Gene DeliveryPlant Molecular Biology Research

The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.

The Piwi-piRNA Pathway Provides an Adaptive Defense in the Transposon Arms Race

Aravin, Alexei A., Hannon, Gregory J., Brennecke, Julius·2007·Science

Open this paper in CoChat — free account

Abstract

Increasingly complex networks of small RNAs act through RNA-interference (RNAi) pathways to regulate gene expression, to mediate antiviral responses, to organize chromosomal domains, and to restrain the spread of selfish genetic elements. Historically, RNAi has been defined as a response to double-stranded RNA. However, some small RNA species may not arise from double-stranded RNA precursors. Yet, like microRNAs and small interfering RNAs, such species guide Argonaute proteins to silencing targets through complementary base-pairing. Silencing can be achieved by corecruitment of accessory factors or through the activity of Argonaute itself, which often has endonucleolytic activity. As a specific and adaptive regulatory system, RNAi is used throughout eukarya, which indicates a long evolutionary history. A likely function of RNAi throughout that history is to protect the genome from both pathogenic and parasitic invaders.

Integrity signals

Registry

Crossref · 10.1126/science.1146484

Cites

38 of 38 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Untitled work
Bartel (2004) · doi:10.1016/s0092-8674(04)00045-5 · Cited by 34,714
Discrete Small RNA-Generating Loci as Master Regulators of Transposon Activity in Drosophila
Brennecke, J., Aravin, A. A., Stark, A., Dus, M., Kellis, M., Sachidanandam, R., & Hannon, G. J. (2007) · Cell · doi:10.1016/j.cell.2007.01.043 · Cited by 2,524
Self-citation
Transposable elements and the epigenetic regulation of the genome
Slotkin, R. K., & Martienssen, R. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2072 · Cited by 2,044
A germline-specific class of small RNAs binds mammalian Piwi proteins
Girard, A., Sachidanandam, R., Hannon, G. J., & Carmell, M. A. (2006) · Nature · doi:10.1038/nature04917 · Cited by 1,762
Self-citation
A novel class of small RNAs bind to MILI protein in mouse testes
Aravin, A., Gaidatzis, D., Pfeffer, S., Lagos-Quintana, M., Landgraf, P., Iovino, N., Morris, P., Brownstein, M. J., Kuramochi-Miyagawa, S., Nakano, T., et al. (2006) · Nature · doi:10.1038/nature04916 · Cited by 1,516
Self-citation
A Distinct Small RNA Pathway Silences Selfish Genetic Elements in the Germline
Vagin, V. V., Sigova, A. A., Li, C., Seitz, H., Gvozdev, V. A., & Zamore, P. D. (2006) · Science · doi:10.1126/science.1129333 · Cited by 1,385
Meiotic catastrophe and retrotransposon reactivation in male germ cells lacking Dnmt3L
Bourc’his, D., & Bestor, T. H. (2004) · Nature · doi:10.1038/nature02886 · Cited by 1,279
A Slicer-Mediated Mechanism for Repeat-Associated siRNA 5' End Formation in Drosophila
Gunawardane, L. S., Saito, K., Nishida, K. M., Miyoshi, K., Kawamura, Y., Nagami, T., Siomi, H., & Siomi, M. C. (2007) · Science · doi:10.1126/science.1140494 · Cited by 1,173
MIWI2 Is Essential for Spermatogenesis and Repression of Transposons in the Mouse Male Germline
Carmell, M. A., Girard, A., van de Kant, H. J. G., Bourc’his, D., Bestor, T. H., de Rooij, D. G., & Hannon, G. J. (2007) · Developmental Cell · doi:10.1016/j.devcel.2007.03.001 · Cited by 1,170
Self-citation
A Role for Piwi and piRNAs in Germ Cell Maintenance and Transposon Silencing in Zebrafish
Houwing, S., Kamminga, L. M., Berezikov, E., Cronembold, D., Girard, A., van den Elst, H., Filippov, D. V., Blaser, H., Raz, E., Moens, C. B., et al. (2007) · Cell · doi:10.1016/j.cell.2007.03.026 · Cited by 1,132
Self-citation

Show all 38 references

Sorted by citations

Items 701–800 of 999

Divergence of functional effects among bacterial sRNA paralogs
Chen, I. K., Velicer, G. J., & Yu, Y. N. (2017) · BMC Evolutionary Biology · doi:10.1186/s12862-017-1037-5 · Cited by 11
Rapid divergence of the male reproductive proteins in the Drosophila dunni group and implications for postmating incompatibilities between species
Hill, T., Rosales-Stephens, H.-L., & Unckless, R. L. (2021) · G3 Genes Genomes Genetics · doi:10.1093/g3journal/jkab050 · Cited by 11
Patterns of piRNA Regulation in Drosophila Revealed through Transposable Element Clade Inference
Said, I., McGurk, M. P., Clark, A. G., & Barbash, D. A. (2021) · Molecular Biology and Evolution · doi:10.1093/molbev/msab336 · Cited by 10
Retrotransposon-centered analysis of piRNA targeting shows a shift from active to passive retrotransposon transcription in developing mouse testes
Mourier, T. (2011) · BMC Genomics · doi:10.1186/1471-2164-12-440 · Cited by 11
Epigenetics and Ovarian Cancer
Nephew, K. P., Balch, C., Zhang, S., & Huang, T. H. ‐. (2009) · Cancer treatment and research · doi:10.1007/978-0-387-98094-2_6 · Cited by 11
Identification of candidate piRNAs in the gonads of Paralichthys olivaceus (Japanese flounder).
Wang, C., Wang, Z., Wang, J., Li, M., & Chen, X. (2016) · Europe PMC (PubMed Central) · doi:10.13918/j.issn.2095-8137.2016.5.301 · Cited by 11
Fidelity in RNA-based recognition of transposable elements
Ugolini, I., & Halić, M. (2018) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2018.0168 · Cited by 11
Genomic features of parthenogenetic animalsPreprint
Jaroň, K. S., Bast, J., Nowell, R. W., Ranallo-Benavidez, T. R., Robinson‐Rechavi, M., & Schwander, T. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/497495 · Cited by 13
Correction: A Transcriptomic Analysis of Echinococcus granulosus Larval Stages: Implications for Parasite Biology and Host Adaptation
Parkinson, J., Wasmuth, J. D., Salinas, G., Bizarro, C. V., Sanford, C., Berriman, M., Ferreira, H. B., Zaha, A., Blaxter, M., Maizels, R. M., et al. (2012) · PLoS neglected tropical diseases · doi:10.1371/annotation/984cd209-4e98-467c-b462-c11090e43be7 · Cited by 11
miRNAs, piRNAs, and lncRNAs: A triad of non-coding RNAs regulating the neurovascular unit in diabetic retinopathy and their therapeutic potentials
Karpagavalli, M., Sindal, M. D., Arunachalam, J. P., & Chidambaram, S. (2025) · Experimental Eye Research · doi:10.1016/j.exer.2025.110236 · Cited by 10
Epigenetic Aspects of Fertilization and Preimplantation Development in Mammals: Lessons from the Mouse
Rivera, R. M. (2010) · Systems Biology in Reproductive Medicine · doi:10.3109/19396368.2010.482726 · Cited by 11
Infra- and Transspecific Clues to Understanding the Dynamics of Transposable Elements
Vieira, C. P., Fablet, M., & Lerat, E. (2009) · Genome dynamics and stability · doi:10.1007/7050_2009_044 · Cited by 11
Transposon regulation in Drosophila: piRNA-producing P elements facilitate repression of hybrid dysgenesis by a P element that encodes a repressor polypeptide
Simmons, M. J., THORP, M. W., Buschette, J. T., & Becker, J. R. (2014) · Molecular Genetics and Genomics · doi:10.1007/s00438-014-0902-9 · Cited by 10
Maternal enhancement of cytotype regulation inDrosophila melanogasterby genetic interactions between telomericPelements and non-telomeric transgenicPelements
Simmons, M. J., RAGATZ, L. M., SINCLAIR, I. R., THORP, M. W., Buschette, J. T., & Grimes, C. D. (2012) · Genetics Research · doi:10.1017/s0016672312000523 · Cited by 10
Targeted identification of TE insertions in a Drosophila genome through hemi-specific PCR
Zhang, S., & Kelleher, E. S. (2017) · Mobile DNA · doi:10.1186/s13100-017-0092-1 · Cited by 10
sRNA/L1 retrotransposition: using siRNAs and miRNAs to expand the applications of the cell culture-based LINE-1 retrotransposition assay
Tristán-Ramos, P., Morell, S., Sánchez, L., Toledo, B., Garcia-Perez, J. L., & Heras, S. R. (2020) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2019.0346 · Cited by 11
Mammalian Meiosis
Cohen, P. E., & Holloway, J. K. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-397175-3.00001-6 · Cited by 11
Gene Regulation System with an Artificial RNA Switch Operating in Human Cells
Endoh, T., & Sugimoto, N. (2011) · ChemBioChem · doi:10.1002/cbic.201100093 · Cited by 10
CRISPR/Cas and CRISPR/Cmr Immune Systems of Archaea
Shah, S. A., Vestergaard, G., & Garrett, R. A. (2012) · Springer eBooks · doi:10.1007/978-3-7091-0218-3_9 · Cited by 10
Molecular characterization of mitochondrial Zucchini and its relation to nuage-piRNA pathway components in Bombyx mori ovary-derived BmN4 cells
Patil, A. A., Tatsuke, T., Mon, H., Lee, J. M., Morokuma, D., Hino, M., & Kusakabe, T. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.09.107 · Cited by 10
flam piRNA precursors channel from the nucleus to the cytoplasm in a temporally regulated manner along Drosophila oogenesis
Dennis, C., Brasset, É., & Vaury, C. (2019) · Mobile DNA · doi:10.1186/s13100-019-0170-7 · Cited by 9
C. elegans RNA-dependent RNA polymerases rrf-1 and ego-1 silence Drosophila transgenes by differing mechanisms
Duan, G., Saint, R. B., Helliwell, C. A., Behm, C. A., Wang, M. B., Waterhouse, P. M., & Gordon, K. H. J. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1218-8 · Cited by 10
piRNA-like RNAs in the marsupial Monodelphis domestica identify transcription clusters and likely marsupial transposon targets
Devor, E. J., Huang, L., & Samollow, P. B. (2008) · Mammalian Genome · doi:10.1007/s00335-008-9109-x · Cited by 10
P-Element-Induced Wimpy Testis Proteins and P-Element-Induced Wimpy Testis-Interacting RNAs Expression in Ovarian Cancer Stem Cells
Sohn, E. J., & Oh, S. (2023) · Genetic Testing and Molecular Biomarkers · doi:10.1089/gtmb.2022.0113 · Cited by 9
Paternal Epigenetic Inheritance
Rahia Mashoodh, A., & Champagne, F. A. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-405944-3.00017-9 · Cited by 9
Dynamic Interactions Between the Genome and an Endogenous Retrovirus: Tirant in Drosophila simulans Wild-Type Strains
Fablet, M., Jacquet, A., Rebollo, R., Haudry, A., Rey, C., Salces-Ortiz, J., Bajad, P., Burlet, N., Jantsch, M. F., Guerreiro, M. P. G., et al. (2019) · G3 Genes Genomes Genetics · doi:10.1534/g3.118.200789 · Cited by 11
The RNA Helicase BELLE Is Involved in Circadian Rhythmicity and in Transposons Regulation in Drosophila melanogaster
Cusumano, P., Damulewicz, M., Carbognin, E., Caccin, L., Puricella, A., Specchia, V., Bozzetti, M. P., Costa, R., & Mazzotta, G. M. (2019) · Frontiers in Physiology · doi:10.3389/fphys.2019.00133 · Cited by 9
Global Analysis of Small Non-Coding RNA Populations across Tissues in the Malaria Vector, Anopheles gambiae
Bryant, W. B., Ray, S., & Mills, M. K. (2020) · Insects · doi:10.3390/insects11070406 · Cited by 9
Chromatin-bound RNA and the neurobiology of psychiatric disease
Tushir, J. S., & Akbarian, S. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.06.051 · Cited by 10
Insect Transposable Elements
Tu, Z. J. (2011) · Elsevier eBooks · doi:10.1016/b978-0-12-384747-8.10003-0 · Cited by 9
Genome Defense Against Transposable Elements and the Origins of Regulatory RNA
Jordan, I. K., & Miller, W. J. (2008) · Genome dynamics and stability · doi:10.1007/7050_2008_041 · Cited by 9
Abundant piRNA production mediated by the Drosophila GTSF1 homolog Tpp ensures Aubergine localization and germ plasm assembly
Kina, H., Izumi, N., Hanyu‐Nakamura, K., Yoshitani, T., Yamane, M., Niwa, H., Tomari, Y., & Nakamura, A. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2419375122 · Cited by 8
Cloning and expression characterization of the chicken Piwil1 gene
Chen, R., Chang, G., Dai, A., Ma, T., Zhai, F., Xia, M., Liu, L., Li, J., Hua, D., & Chen, G. (2013) · Molecular Biology Reports · doi:10.1007/s11033-013-2831-9 · Cited by 8
Inheritance of Stress Responses via Small Non-Coding RNAs in Invertebrates and Mammals
Ow, M. C., & Hall, S. E. (2023) · Epigenomes · doi:10.3390/epigenomes8010001 · Cited by 8
Zili Antagonizes Bmp Signaling to Regulate Dorsal-Ventral Patterning during Zebrafish Early Embryogenesis
Li, D., Sun, H., Deng, W., Tao, D., Liu, Y., & Ma, Y. (2011) · ZOOLOGICAL SCIENCE · doi:10.2108/zsj.28.397 · Cited by 8
Piwi-interacting RNAs (piRNAs) in animals: The story so far
Wahid, F., Khan, T., Hwang, K.-H., & Kim, Y. Y. (2009) · AFRICAN JOURNAL OF BIOTECHNOLOGY · doi:10.4314/ajb.v8i17.62111 · Cited by 7
Epigenetic regulation of gene and genome expression
Choudhuri, S. (2011) · Elsevier eBooks · doi:10.1016/b978-0-12-382032-7.10060-8 · Cited by 7
Paternal pachytene piRNAs are not required for fertilization, embryonic development and sperm-mediated epigenetic inheritance in mice
Yuan, S., Tang, C., Schuster, A. S., Zhang, Y., Zheng, H., & Yan, W. (2016) · Current Zoology · doi:10.1093/eep/dvw021 · Cited by 8
Structure and Mechanism of Argonaute Proteins
(2012) · The Enzymes · doi:10.1016/b978-0-12-404741-9.00004-0 · Cited by 8
Epigenetics: advances of non-coding RNAs regulation in mammalian cells
Hong, Y. (2009) · Hereditas (Beijing) · doi:10.3724/sp.j.1005.2009.01077 · Cited by 9
The Canonical RNA Interference Pathway in Animals
Nejepinska, J., Flemr, M., & Svoboda, P. (2011) · Springer eBooks · doi:10.1007/978-3-642-22517-8_5 · Cited by 8
Transposable element dynamics are consistent across the Drosophila phylogeny, despite drastically differing contentPreprint
Hill, T. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/651059 · Cited by 8
The origin of genetic and metabolic systems: Evolutionary structuralinsights
Deng, S. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e14466 · Cited by 7
Schlafen-5 inhibits LINE-1 retrotransposition
Ding, J., Wang, S., Liu, Q., Duan, Y., Cheng, T., Ye, Z., Cui, Z., Zhang, A., Liu, Q., Zhang, Z., et al. (2023) · iScience · doi:10.1016/j.isci.2023.107968 · Cited by 8
Pre-piRNA trimming safeguards piRNAs against erroneous targeting by RNA-dependent RNA polymerase
(2024) · doi:10.1016/j.celrep.2024.113692 · Cited by 7
Predicting Human Disease-Associated piRNAs Based on Multi-source Information and Random Forest
Zheng, K., You, Z., Wang, L., Li, H., & Ji, B. (2020) · Lecture notes in computer science · doi:10.1007/978-3-030-60802-6_20 · Cited by 8
Nucleic acids movement and its relation to genome dynamics of repetitive DNA
Kejnovský, E., & Jedlička, P. (2022) · BioEssays · doi:10.1002/bies.202100242 · Cited by 8
piRNA-like small RNAs target transposable elements in a Clade IV parasitic nematode
Suleiman, M., Kounosu, A., Murcott, B., Dayı, M., Pawluk, R., Yoshida, A., Viney, M., Kikuchi, T., & Hunt, V. L. (2022) · Scientific Reports · doi:10.1038/s41598-022-14247-1 · Cited by 7
Omics Tools for the Genome-Wide Analysis of Methylation and Histone Modifications
Jiménez‐Chillarón, J. C., Díaz, R., & Ramon‐Krauel, M. (2014) · Comprehensive analytical chemistry · doi:10.1016/b978-0-444-62651-6.00004-0 · Cited by 7
Genetic Interactions BetweenPElements Involved in piRNA-Mediated Repression of Hybrid Dysgenesis inDrosophila melanogaster
Simmons, M. J., Meeks, M. W., Jessen, E., Becker, J. R., Buschette, J. T., & THORP, M. W. (2014) · G3 Genes Genomes Genetics · doi:10.1534/g3.114.011221 · Cited by 7
Cytotype Regulation Facilitates Repression of Hybrid Dysgenesis by Naturally OccurringKPElements inDrosophila melanogaster
Simmons, M. J., Grimes, C. D., & Czora, C. S. (2016) · G3 Genes Genomes Genetics · doi:10.1534/g3.116.028597 · Cited by 7
Effect of dietary Astragalus Polysaccharide supplements on testicular piRNA expression profiles of breeding cocks
Wu, S., Li, Y., Chen, S., Liang, S., Ren, X., Guo, W., Sun, Q., & Yang, X. (2017) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2017.05.122 · Cited by 7
Translational regulation by non-protein-coding RNAs: Different targets, common themes
Xie, W. Q., Brown, W. T., & Denman, R. B. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.06.075 · Cited by 7
Noncoding RNAs in Chromatin Organization and Transcription Regulation: An Epigenetic View
Dhanasekaran, K., Kumari, S., & Kanduri, C. (2012) · Sub-cellular biochemistry/Subcellular biochemistry · doi:10.1007/978-94-007-4525-4_15 · Cited by 7
Meiotic Sex Chromosome Inactivation
Daish, T., & Grützner, F. (2010) · Wiley eBooks · doi:10.1002/9780470015902.a0022109 · Cited by 7
Transposable elements resistant to epigenetic resetting in the human germline are epigenetic hotspots for development and diseasePreprint
Dietmann, S., Keogh, M. J., Tang, W. W. C., Magnúsdóttir, E., Kobayashi, T., Chinnery, P. F., & Surani, M. A. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.03.19.998930 · Cited by 7
Non‐gonadal expression of piRNAs is widespread across Arthropoda
Yamashita, T., Komenda, K., Miłodrowski, R., Robak, D., Szrajer, S., Gaczorek, T. S., & Ylla, G. (2024) · FEBS Letters · doi:10.1002/1873-3468.15023 · Cited by 6
Environmentally induced variation in sperm sRNAs is linked to gene expression and transposable elements in zebrafish offspring
Godden, A. M., Silva, W. T. A. F., Kiehl, B., Jolly, C., Folkes, L., Alavioon, G., & Immler, S. (2025) · Heredity · doi:10.1038/s41437-025-00752-2 · Cited by 6
The impact of ncRNAs on type 2 diabetes: A comprehensive review covering molecular mechanisms to clinical applications
Ikhanjal, M. A., Hamdi, S., Bakkali, F., Benmoussa, A., & Errafii‬, K. (2025) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2025.102629 · Cited by 10
Quercetin inhibits testicular toxicity induced by the mixture of three commonly used phthalates in rats
Xia, L., Jiang, M., Liu, L., Wu, Y. J., Zhang, Y., Yang, L., Shen, X., Zhang, Q., Lin, M., & Gao, H. (2022) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.12251 · Cited by 6
Direct interaction of Su(var)2‐10 via the SIM‐binding site of the Piwi protein is required for transposon silencing in Drosophila melanogaster
Bence, M., Jankovics, F., Kristó, I., Gyetvai, Á., Vértessy, B. G., & Erdélyi, M. (2024) · FEBS Journal · doi:10.1111/febs.17073 · Cited by 6
Ameliorative effects of zinc and vitamin E against phthalates‐induced reproductive toxicity in male rats
Xia, L., Liu, L., Yue, J., Lu, Z., Deng, R., He, X., Li, C., Hu, B., & Gao, H. (2024) · Environmental Toxicology · doi:10.1002/tox.24191 · Cited by 6
A decision support system based on multi-sources information to predict piRNA–disease associations using stacked autoencoder
Zheng, K., Liang, Y., Liu, Y., Yasir, M., & Wang, P. (2022) · Soft Computing · doi:10.1007/s00500-022-07396-y · Cited by 6
In vivo profiling of the Zucchini proximal proteome in the Drosophila ovary
Nguyen, T. T. M., Munkhzul, C., Kim, J., Kyoung, Y., Vianney, M., Shin, S., Ju, S., Pham-Bui, H.-A., Kim, J., Kim, J., et al. (2023) · Development · doi:10.1242/dev.201220 · Cited by 6
Differential Expression of Non-Coding RNAs and Continuous Evolution of the X Chromosome in Testicular Transcriptome of Two Mouse Species
Homolka, D., Ivánek, R., Forejt, J., & Jansa, P. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017198 · Cited by 6
Analyses of piRNA-Mediated Transcriptional Transposon Silencing in Drosophila: Nuclear Run-On Assay on Ovaries
Shpiz, S., & Kalmykova, A. I. (2013) · Methods in molecular biology · doi:10.1007/978-1-62703-694-8_12 · Cited by 6
Genes underlying the evolution of tetrapod testes size
Baker, J., Meade, A., & Venditti, C. (2021) · BMC Biology · doi:10.1186/s12915-021-01107-z · Cited by 6
The PIWI/piRNA response is relaxed in a rodent that lacks mobilizing transposable elements
Vandewege, M. W., Patt, R. N., Merriman, D. K., Ray, D. A., & Hoffmann, F. G. (2022) · RNA · doi:10.1261/rna.078862.121 · Cited by 8
Small RNAs Present in Semen and Their Role in Reproduction
Jodar, M., & Antón, E. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-812571-7.00008-3 · Cited by 6
Paternal epigenetic inheritance
Rahia Mashoodh, A., & Champagne, F. A. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-816363-4.00006-7 · Cited by 7
Embryonic piRNAs target horizontally transferred vertebrate transposons in assassin bugs
de Brito, T. F., Cardoso, M. A., Atinbayeva, N., Brito, I. A. D. A., da Costa, L. A., Iovino, N., & Pane, A. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1481881 · Cited by 4
Bioinformatic analyses of sense and antisense expression from terminal inverted repeat transposons inDrosophilasomatic cells
Harrington, A. W., & Steiniger, M. (2016) · Fly · doi:10.1080/19336934.2016.1165372 · Cited by 5
Global 3’UTR shortening and down-regulation of repeated element related piRNA play crucial roles in boys with cryptorchidism
Ge, W., Chen, M., Tian, W., Chen, J., Zhao, Y., Xian, H., Chen, J., & Xu, Y. (2021) · Genomics · doi:10.1016/j.ygeno.2021.01.006 · Cited by 5
Co-expression analysis identifies neuro-inflammation as a driver of sensory neuron aging in Aplysia californica
Kron, N. S., & Fieber, L. A. (2021) · PLoS ONE · doi:10.1371/journal.pone.0252647 · Cited by 5
From parasites to partners: exploring the intricacies of host-transposon dynamics and coevolution
Chakrabarty, P., Sen, R., & Sengupta, S. (2023) · Functional & Integrative Genomics · doi:10.1007/s10142-023-01206-w · Cited by 5
Control of Telomere Length in Drosophila
Shpiz, S., & Kalmykov, A. (2012) · InTech eBooks · doi:10.5772/38160 · Cited by 5
Morphologic and molecular manifestations of hybrid dysgenesis in ontogenesis of Drosophila virilis
Sokolova, M. I., Zelentsova, E. S., Rozhkov, N. V., & Evgeniev, M. B. (2010) · Russian Journal of Developmental Biology · doi:10.1134/s1062360410060068 · Cited by 5
Self and Nonself from a Genomic Perspective: Transposable Elements
Fablet, M., Salces-Ortiz, J., Menezes, B. F., Roy, M., & Vieira, C. P. (2017) · Springer eBooks · doi:10.1007/978-3-319-61569-1_6 · Cited by 5
Circulating non-coding RNAs in recurrent and metastatic ovarian cancer
Schwarzenbach, H., & Gahan, P. B. (2019) · Cancer Drug Resistance · doi:10.20517/cdr.2019.51 · Cited by 5
An evolutionarily conserved stop codon enrichment at the 5′ ends of mammalian piRNAs
Bornelöv, S., Czech, B., & Hannon, G. J. (2022) · Nature Communications · doi:10.1038/s41467-022-29787-3 · Cited by 5
Self-citation
Ty3, a Position-specific Retrotransposon in Budding Yeast
Sandmeyer, S. B., Patterson, K., & Bilanchone, V. (2015) · ASM Press eBooks · doi:10.1128/9781555819217.ch42 · Cited by 5
RNA-Based Technologies
Clark, D. P., & Pazdernik, N. J. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-385015-7.00005-3 · Cited by 5
piRNA-mediated transposon regulation and the germ-line mutation rate in Drosophila melanogaster males
Simmons, M. J., Peterson, M. P., THORP, M. W., Buschette, J. T., DiPrima, S., Harter, C. L., & Skolnick, M. J. (2015) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2015.01.011 · Cited by 5
Identification of LncRNAs/mRNAs related to endometrium function regulated by Homeobox A10 in Ishikawa cells
Lin, R., Zhao, C., Jing, L., & Zhao, S. (2015) · Cell Biology International · doi:10.1002/cbin.10458 · Cited by 5
Identification of piRNAs in Hela cells by massive parallel sequencing
Lu, Y., Li, C., Zhang, K., Sun, H., Tao, D., Liu, Y., Zhang, S., & Ma, Y. (2010) · BMB Reports · doi:10.3858/bmbrep.2010.43.9.635 · Cited by 5
Molecular Mechanisms of Transposon Epigenetic Regulation
Martienssen, R. A., & Chandler, V. L. (2013) · Wiley eBooks · doi:10.1002/9781118500156.ch5 · Cited by 6
Decoding the Follicular Fluid Microenvironment: Integrative Biomarkers and Multiomics Signatures to Predict IVF Outcomes
Muraoka, A., & Kajiyama, H. (2026) · Reproductive Medicine and Biology · doi:10.1002/rmb2.70056 · Cited by 4
RNA Interference: A Versatile Tool for Functional Genomics and Unraveling the Genes Required for Viral Disease Resistance in Plants
Ranjan, T., Kumari, N., Sahni, S., & Prasad, B. D. (2019) · Current Journal of Applied Science and Technology · doi:10.9734/cjast/2019/v35i530197 · Cited by 4
Deconfining heterochromatin for expression
Burton, A., & Torres‐Padilla, M. (2021) · Nature Cell Biology · doi:10.1038/s41556-021-00726-6 · Cited by 4
Non-coding RNAs in genome integrity
Kovalchuk, I. (2021) · Elsevier eBooks · doi:10.1016/b978-0-323-85679-9.00024-6 · Cited by 4
LSTM4piRNA: Efficient piRNA Detection in Large-Scale Genome Databases Using a Deep Learning-Based LSTM Network
Chen, C.-C., Chan, Y.-M., & Jeong, H. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242115681 · Cited by 4
sRNAflow: A Tool for the Analysis of Small RNA-Seq Data
Zayakin, P. (2024) · Non-Coding RNA · doi:10.3390/ncrna10010006 · Cited by 5
Transcriptome analysis of testis in response to silencing of Piwi2 sheds light on spermatogenesis in the mud crab Scylla paramamosain
Wang, T., Lu, L., Liu, F., Liu, A., & Ye, H. (2024) · Aquaculture Reports · doi:10.1016/j.aqrep.2024.102550 · Cited by 4
MFF-nDA: A Computational Model for ncRNA–Disease Association Prediction Based on Multimodule Fusion
Guan, Z., Jin, X., & Zhang, X. (2025) · Journal of Chemical Information and Modeling · doi:10.1021/acs.jcim.5c00174 · Cited by 4
Molecular analysis of porcine TDRD10 gene: a novel member of the TDRD family
Cong, P., Li, A., Ji, Q., Chen, Y., & Mo, D. (2014) · Gene · doi:10.1016/j.gene.2014.07.026 · Cited by 4
Elucidating Gene Regulatory Mechanisms for Sperm Function Through the Integration of Classical and Systems Approaches in C. elegans
Wu, T. F., Nera, B., Chu, D. S., & Shakes, D. C. (2010) · Systems Biology in Reproductive Medicine · doi:10.3109/19396361003749986 · Cited by 4
Expression of Caenorhabditis elegans RNA-directed RNA polymerase in transgenic Drosophila melanogaster does not affect morphological development
Duan, G., Saint, R. B., Helliwell, C. A., Behm, C. A., Waterhouse, P. M., & Gordon, K. H. J. (2010) · Transgenic Research · doi:10.1007/s11248-010-9372-y · Cited by 4
Set Phasers to Cleave: PIWI Cleavage Directs All piRNA Biogenesis
Vourekas, A., & Mourelatos, Z. (2018) · Molecular Cell · doi:10.1016/j.molcel.2018.08.035 · Cited by 4
Molecular organization of recombinant human-Arabidopsis chromosomes in hybrid cell lines
Liu, Y., Liaw, Y. M., Teo, C. H., Cápal, P., Wada, N., Fukui, K., Doležel, J., & Ohmido, N. (2021) · Scientific Reports · doi:10.1038/s41598-021-86130-4 · Cited by 3
Association of miRNA-145 Single Nucleotide Polymorphisms in Abdominal Aortic Aneurysms
Hasemaki, N., Andreou, N., Legaki, E., Katsargyris, Α., Gazouli, M., & Klonaris, C. (2022) · In Vivo · doi:10.21873/invivo.12810 · Cited by 4

Authors: Aravin, A. A., Hannon, G. J., & Brennecke, J.
Affiliations: Howard Hughes Medical Institute (US)
Corresponding author: Aravin, Alexei A.
Hannon, Gregory J.
Brennecke, Julius
ORCID: Aravin, Alexei A.
Hannon, Gregory J.
Brennecke, Julius
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2007-11-02
Volume: 318
Issue: 5851
Pages: 761-764
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.1146484
OpenAlex: W2046318418
Cited by: 1,096
References: 38
Citations by year: 2026: 28 · 2025: 43 · 2024: 37 · 2023: 32 · 2022: 41 · 2021: 45 · 2020: 42 · 2019: 56 · 2018: 62 · 2017: 46 · 2016: 53 · 2015: 78 · 2014: 76 · 2013: 68 · 2012: 74
FWCI: 6.79
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory) (acceptedVersion)
CaltechAUTHORS (California Institute of Technology) (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Chromosomal and Genetic Variations
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Interference and Gene Delivery
Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
Keywords: RNA interference, transposable elements, small RNA, Argonaute proteins, genome defense, selfish genetic elements, gene silencing
MeSH terms: Adaptation, Biological, Animals, Base Sequence, DNA Transposable Elements, Molecular Sequence Data, Proteins, RNA-Binding Proteins, Evolution, Molecular, Gene Silencing, Drosophila Proteins, RNA, Small Interfering, RNA-Induced Silencing Complex, Argonaute Proteins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The Piwi-piRNA Pathway Provides an Adaptive Defense in the Transposon Arms Race

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks