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Internally Generated Cell Assembly Sequences in the Rat Hippocampus
Open accessAbstract
A long-standing conjecture in neuroscience is that aspects of cognition depend on the brain's ability to self-generate sequential neuronal activity. We found that reliably and continually changing cell assemblies in the rat hippocampus appeared not only during spatial navigation but also in the absence of changing environmental or body-derived inputs. During the delay period of a memory task, each moment in time was characterized by the activity of a particular assembly of neurons. Identical initial conditions triggered a similar assembly sequence, whereas different conditions gave rise to different sequences, thereby predicting behavioral choices, including errors. Such sequences were not formed in control (nonmemory) tasks. We hypothesize that neuronal representations, evolved for encoding distance in spatial navigation, also support episodic recall and the planning of action sequences.
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“In fact, the sequential activation of place cells is thought to reflect specific episodic-like memories, occurring across similar time scales to the actual experience, all while the rat is concurrently engaged in other activities (and thus is not confusing imagined representations with current reality) [127].”
From Is episodic-like memory like episodic memory? (2024) · cites this paper as [127]
In the citing paper
“evidence suggests that place cell activity in rats can also encode information about the ‘what’ (e.g. odours and their status, i.e. match/non-match [124–126]) and ‘when’ (i.e. elapsed time [127,128]) of events.”
From Is episodic-like memory like episodic memory? (2024) · cites this paper as [127]
In the citing paper
“recent remodelling of sharp-wave-ripple events suggests that this neuronal replay often occurs at ‘real-world’ speeds that reflect actual experience [185], as observed in other studies [127].”
From Is episodic-like memory like episodic memory? (2024) · cites this paper as [127]
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Cites
(1978) · UA Campus Repository (The University of Arizona) · Cited by 8,010
The hippocampus as a spatial map. Preliminary evidence from unit activity in the freely-moving rat
O'Keefe, J., & Dostrovsky, J. (1971) · Brain Research · doi:10.1016/0006-8993(71)90358-1 · Cited by 6,151
(1983) · Medical Entomology and Zoology · Cited by 6,051
Memory and the hippocampus: A synthesis from findings with rats, monkeys, and humans.
Squire, L. R. (1992) · Psychological Review · doi:10.1037/0033-295x.99.2.195 · Cited by 5,376
The Organization of Behavior; A Neuropsychological Theory.
Attneave, F., B., M., & Hebb, D. O. (1950) · The American Journal of Psychology · doi:10.2307/1418888 · Cited by 5,146
Reactivation of hippocampal ensemble memories during sleep
Wilson, M. A., & McNaughton, B. L. (1994) · Science · doi:10.1126/science.8036517 · Cited by 3,118
Phase relationship between hippocampal place units and the EEG theta rhythm
O'Keefe, J. M., & Recce, M. L. (1993) · Hippocampus · doi:10.1002/hipo.450030307 · Cited by 2,643
Path integration and the neural basis of the 'cognitive map'
McNaughton, B. L., Battaglia, F. P., Jensen, O., Moser, E. I., & Moser, M.-B. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1932 · Cited by 2,024
Two-stage model of memory trace formation: A role for “noisy” brain states
Buzsáki, G. (1989) · Neuroscience · doi:10.1016/0306-4522(89)90423-5 · Cited by 1,709
Self-citationAbbott, L. F., & Regehr, W. G. (2004) · Nature · doi:10.1038/nature03010 · Cited by 1,684
Conjunctive Representation of Position, Direction, and Velocity in Entorhinal Cortex
Sargolini, F., Fyhn, M., Hafting, T., McNaughton, B. L., Witter, M. P., Moser, M.-B., & Moser, E. I. (2006) · Science · doi:10.1126/science.1125572 · Cited by 1,485
Abeles, M. (1991) · Cambridge University Press eBooks · doi:10.1017/cbo9780511574566 · Cited by 1,341
Geometric determinants of the place fields of hippocampal neurons
O'Keefe, J., & Burgess, N. (1996) · Nature · doi:10.1038/381425a0 · Cited by 1,166
Temporally structured replay of awake hippocampal ensemble activity during rapid eye movement sleep
Louie, K., & Wilson, M. A. (2001) · Neuron · doi:10.1016/s0896-6273(01)00186-6 · Cited by 1,148
McNaughton, B. L., Barnes, C. A., & O'Keefe, J. (1983) · Experimental Brain Research · doi:10.1007/bf00237147 · Cited by 1,071
The Hippocampus, Memory, and Place Cells
Eichenbaum, H., Dudchenko, P., Wood, E., Shapiro, M., & Tanila, H. (1999) · Neuron · doi:10.1016/s0896-6273(00)80773-4 · Cited by 1,064
Wood, E. R., Dudchenko, P. A., Robitsek, R. J., & Eichenbaum, H. (2000) · Neuron · doi:10.1016/s0896-6273(00)00071-4 · Cited by 992
Deciphering The Hippocampal Polyglot: the Hippocampus as a Path Integration System
McNaughton, B. L., Barnes, C. A., Gerrard, J. L., Gothard, K. M., Jung, M. W., Knierim, J. J., Kudrimoti, H. S., Qin, Y., Skaggs, W. E., Suster, M. S., et al. (1996) · Journal of Experimental Biology · doi:10.1242/jeb.199.1.173 · Cited by 914
Spatial firing patterns of hippocampal complex-spike cells in a fixed environment
Muller, R., Kubie, J., & Ranck, J. B. (1987) · Journal of Neuroscience · doi:10.1523/jneurosci.07-07-01935.1987 · Cited by 898
Trajectory Encoding in the Hippocampus and Entorhinal Cortex
Frank, L. M., Brown, E. N., & Wilson, M. A. (2000) · Neuron · doi:10.1016/s0896-6273(00)00018-0 · Cited by 760
Temporal Encoding of Place Sequences by Hippocampal Cell Assemblies
Dragoi, G., & Buzsáki, G. (2006) · Neuron · doi:10.1016/j.neuron.2006.02.023 · Cited by 756
The hippocampal CA3 network: An in vivo intracellular labeling study
Li, X. ‐., Somogyi, P., Ylinen, A., & Buzsáki, G. (1994) · The Journal of Comparative Neurology · doi:10.1002/cne.903390204 · Cited by 751
Behavior-dependent short-term assembly dynamics in the medial prefrontal cortex
Fujisawa, S., Amarasingham, A., Harrison, M. T., & Buzsáki, G. (2008) · Nature Neuroscience · doi:10.1038/nn.2134 · Cited by 701
Self-citationIndependent rate and temporal coding in hippocampal pyramidal cells
Huxter, J. R., Burgess, N., & O'Keefe, J. M. (2003) · Nature · doi:10.1038/nature02058 · Cited by 610
Relating Hippocampal Circuitry to Function
Lisman, J. E. (1999) · Neuron · doi:10.1016/s0896-6273(00)81085-5 · Cited by 607
Prospective and Retrospective Memory Coding in the Hippocampus
Ferbinteanu, J., & Shapiro, M. L. (2003) · Neuron · doi:10.1016/s0896-6273(03)00752-9 · Cited by 560
Transient Dynamics for Neural Processing
Rabinovich, M., Huerta, R., & Laurent, G. (2008) · Science · doi:10.1126/science.1155564 · Cited by 498
Gothard, K. M., Skaggs, W. E., & McNaughton, B. L. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-24-08027.1996 · Cited by 436
Imagery neurons in the human brain
Kreiman, G., Christof Koch, A., & Fried, I. (2000) · Nature · doi:10.1038/35042575 · Cited by 382
Sustained activation of hippocampal pyramidal cells by ‘space clamping’ in a running wheel
Czurkó, A., Hirase, H., Csicsvari, J., & Buzsáki, G. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00446.x · Cited by 327
Hippocampal place cell assemblies are speed-controlled oscillators
Geisler, C. E., Robbe, D., Zugaro, M., Sirota, A., & Buzsáki, G. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610121104 · Cited by 286
Howard, M. W., Fotedar, M. S., Datey, A. V., & Hasselmo, M. E. (2005) · Psychological Review · doi:10.1037/0033-295x.112.1.75 · Cited by 283
Hippocampal ensemble activity during spatial delayed-nonmatch-to-sample performance in rats
Deadwyler, S., Bunn, T., & Hampson, R. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-01-00354.1996 · Cited by 233
Theta phase–specific codes for two-dimensional position, trajectory and heading in the hippocampus
Huxter, J. R., Senior, T. J., Allen, K. L., & Csicsvari, J. (2008) · Nature Neuroscience · doi:10.1038/nn.2106 · Cited by 206
Exploring the role of context‐dependent hippocampal activity in spatial alternation behavior
Ainge, J. A., van der Meer, M. A. A., Langston, R. F., & Wood, E. R. (2007) · Hippocampus · doi:10.1002/hipo.20301 · Cited by 181
Firing rate and theta‐phase coding by hippocampal pyramidal neurons during ‘space clamping’
Hirase, H., Czurkó, A., Csicsvari, J., & Buzsáki, G. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00853.x · Cited by 148
Maurer, A. P., Cowen, S. L., Burke, S. N., Barnes, C. A., & McNaughton, B. L. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.2882-06.2006 · Cited by 132
Spike phase precession persists after transient intrahippocampal perturbation
Zugaro, M., Monconduit, L., & Buzsáki, G. (2004) · Nature Neuroscience · doi:10.1038/nn1369 · Cited by 125
Interpreting hippocampal function as recoding and forecasting
Levy, W. B., Hocking, A. B., & Wu, X. (2005) · Neural Networks · doi:10.1016/j.neunet.2005.08.005 · Cited by 50
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Research works printed but not linked: 1
- B. L. McNaughton, F. P. Battaglia, O. Jensen, E. I. Moser, M. B. Moser, Nat. Rev. Neurosci.7, 663 (2006).
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Hippocampal sharp wave-ripple: A cognitive biomarker for episodic memory and planning
Buzsáki, G. (2015) · Hippocampus · doi:10.1002/hipo.22488 · Cited by 1,759
Memory, navigation and theta rhythm in the hippocampal-entorhinal system
Buzsáki, G., & Moser, E. I. (2013) · Nature Neuroscience · doi:10.1038/nn.3304 · Cited by 1,847
Functional organization of the hippocampal longitudinal axis
Strange, B. A., Witter, M. P., Lein, E. S., & Moser, E. I. (2014) · Nature reviews. Neuroscience · doi:10.1038/nrn3785 · Cited by 1,738
Lisman, J. E., & Jensen, O. (2013) · Neuron · doi:10.1016/j.neuron.2013.03.007 · Cited by 1,609
Neural syntax: cell assemblies, synapsembles, and readers
Buzsáki, G. (2010) · Neuron · doi:10.1016/j.neuron.2010.09.023 · Cited by 1,289
Metadata
- Authors
- Pastalkova, E., Itskov, V., Amarasingham, A., & Buzsáki, G.
- Affiliations
- Rutgers, The State University of New Jersey (US)
- Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, 197 University Avenue, Newark, NJ 07102, USA.
- Corresponding author
- Itskov, Vladimir
- Venue
- Science
- Published
- 2008-09-05
- Volume
- 321
- Issue
- 5894
- Pages
- 1322-1327
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC2570043
- OpenAlex
- W2172122397
- Cited by
- 1,301
- References
- 40
- Citations by year
- 2026: 63 · 2025: 100 · 2024: 101 · 2023: 84 · 2022: 81 · 2021: 85 · 2020: 83 · 2019: 97 · 2018: 82 · 2017: 94 · 2016: 65 · 2015: 67 · 2014: 69 · 2013: 63 · 2012: 38
- FWCI
- 21.70
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R01MH054671, MH54671)
- National Institute of Neurological Disorders and Stroke (R01NS034994, NS-34994)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- cell assemblies, hippocampus, spontaneous neuronal activity, spatial navigation, episodic memory, action planning, behavior prediction
- MeSH terms
- Action Potentials, Animals, Behavior, Animal, Choice Behavior, Cues, Hippocampus, Interneurons, Male, Memory, Models, Neurological, Motor Activity, Mental Recall, Pyramidal Cells, Maze Learning, Rats, Long-Evans, Rats
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