Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys

In the citing paper

“dietary restriction has been the most effective strategy to demonstrate an increase in lifespan across a whole range of investigated species, including nonhuman primates”

In the citing paper

“dietary restriction (DR) increases lifespan or healthspan in all investigated eukaryote species, including unicellular and multicellular organisms of several distinct phyla, including non-human primates”

In the citing paper

“Such a diet is known to extend the lifespan in a range of animal species including primates 43”

In the citing paper

“Correspondingly, CR was found to prolong the healthy lifespan of rhesus monkeys in 2009.40”

In the citing paper

“Recently, this phenomenon has been extended to primates, in a long-term experiment showing lifespan extension in calorie-restricted rhesus macaques (75).”

In the citing paper

“Caloric restriction has also been widely documented to have beneficial effects on the function of the brain and its vulnerability to age-dependent pathology.”

In the citing paper

“It prevents many age-dependent gene expression changes in the mouse brain (8,43), reduces age-related brain atrophy in rhesus macaques (75) and has significant beneficial effects on the age-dependent impairment of learning and memory in rodents (76,77) and humans (78).”

In the citing paper

“A longitudinal study suggested that long-term calorie restriction of 30% significantly reduces age-related deaths in adult rhesus monkeys and a 50% lower incidence of cancer and cardiovascular disease as compared to control animals (208).”

In the citing paper

“A longitudinal study suggested that long-term calorie restriction of 30% significantly reduces age-related deaths in adult rhesus monkeys and a 50% lower incidence of cancer and cardiovascular disease as compared to control animals (208).”

In the citing paper

“However, both studies point to the fact that CR increases healthspan in monkeys by reducing the risk for diabetes, cardiovascular disease, and cancer.”

In the citing paper

“Two studies have addressed the effects of CR on non-human primates, but with different outcomes. One study observed prolonged life (Colman et al., 2009) while the other did not (Mattison et al., 2012).”

In the citing paper

“It would appear that the high sugar (sucrose) concentration contained in the ad libitum diet (control group) of the UW study (Colman et al., 2009) led to a shortened lifespan within the cohort of control monkeys, thus accounting for the lifespan extension when animals were fed a CR diet.”

In the citing paper

“Caloric restriction (middle) is associated with prolonged life, increased gray matter volume, improved motor function, and reduced chronic pathology (eg, neoplasia) and inflammatory markers (complement proteins, antigen presentation markers, and pro-inflammatory cytokines) in rodents, non-human primates, and humans (Colman et al, 2009;Willette et al, 2012;Witte et al, 2009).”

In the citing paper

“In a 20-year-long longitudinal study on Rhesus monkeys, the survival rates of monkeys under calorierestriction diet (30% of normal diet) and those under normal diet were reported to be 80% and 50%, respectively (Colman et al, 2009).”

In the citing paper

“The benefits of caloric restriction observed in humans have also been reported in other species, such as rats, mice, and monkeys (Colman et al, 2009;Richardson et al, 2015;Youm et al, 2016).”

In the citing paper

“Furthermore, monkeys under the caloric restriction condition had delayed onset of aging-associated pathology, such as, neoplasia, cardiovascular diseases, and glucose-associated impairments, and showed higher gray matter volume in subcortical regions (Colman et al, 2009).”

In the citing paper

“Caloric restriction (middle) is associated with prolonged life, increased gray matter volume, improved motor function, and reduced chronic pathology (eg, neoplasia) and inflammatory markers (complement proteins, antigen presentation markers, and pro-inflammatory cytokines) in rodents, non-human primates, and humans(Colman et al, 2009;Willette et al, 2012;Witte et al, 2009).”

In the citing paper

“Caloric restriction (middle) is associated with prolonged life, increased gray matter volume, improved motor function, and reduced chronic pathology (eg, neoplasia) and inflammatory markers (complement proteins, antigen presentation markers, and pro-inflammatory cytokines) in rodents, non-human primates, and humans(Colman et al, 2009;Willette et al, 2012;Witte et al, 2009).”

In the citing paper

“Caloric restriction (middle) is associated with prolonged life, increased gray matter volume, improved motor function, and reduced chronic pathology (eg, neoplasia) and inflammatory markers (complement proteins, antigen presentation markers, and pro-inflammatory cytokines) in rodents, non-human primates, and humans(Colman et al, 2009;Willette et al, 2012;Witte et al, 2009).”

In the citing paper

“Caloric restriction (middle) is associated with prolonged life, increased gray matter volume, improved motor function, and reduced chronic pathology (eg, neoplasia) and inflammatory markers (complement proteins, antigen presentation markers, and pro-inflammatory cytokines) in rodents, non-human primates, and humans(Colman et al, 2009;Willette et al, 2012;Witte et al, 2009).”

In the citing paper

“Caloric restriction (middle) is associated with prolonged life, increased gray matter volume, improved motor function, and reduced chronic pathology (eg, neoplasia) and inflammatory markers (complement proteins, antigen presentation markers, and pro-inflammatory cytokines) in rodents, non-human primates, and humans(Colman et al, 2009;Willette et al, 2012;Witte et al, 2009).”