The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Cell Signaling in Space and Time: Where Proteins Come Together and When They’re Apart
Open accessAbstract
Signal transduction can be defined as the coordinated relay of messages derived from extracellular cues to intracellular effectors. More simply put, information received on the cell surface is processed across the plasma membrane and transmitted to intracellular targets. This requires that the activators, effectors, enzymes, and substrates that respond to cellular signals come together when they need to.
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Cites
Vogelstein, B., Lane, D., & Levine, A. J. (2000) · Nature · doi:10.1038/35042675 · Cited by 6,607
Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
Cross, D. A. E., Alessi, D. R., Cohen, P., Andjelkovich, M., & Hemmings, B. A. (1995) · Nature · doi:10.1038/378785a0 · Cited by 5,244
Berra, E., Benizri, E., Ginouvès, A., Volmat, V., Roux, D., & Pouysségur, J. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg392 · Cited by 1,348
Hypoxia-Inducible Factors, Stem Cells, and Cancer
Keith, B., & Simon, M. C. (2007) · Cell · doi:10.1016/j.cell.2007.04.019 · Cited by 1,179
A Mammalian Scaffold Complex That Selectively Mediates MAP Kinase Activation
Whitmarsh, A. J., Cavanagh, J., Tournier, C., Yasuda, J., & Davis, R. J. (1998) · Science · doi:10.1126/science.281.5383.1671 · Cited by 652
Rotation of photoreceptor clusters in the developing drosophila eye requires the nemo gene
Choi, K.-W., & Benzer, S. (1994) · Cell · doi:10.1016/0092-8674(94)90579-7 · Cited by 339
Distinct enzyme combinations in AKAP signalling complexes permit functional diversity
Hoshi, N., Langeberg, L. K., & Scott, J. D. (2005) · Nature Cell Biology · doi:10.1038/ncb1315 · Cited by 183
Self-citation
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Coskun, Ü., Grzybek, M., Drechsel, D., & Simons, K. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1105666108 · Cited by 316
Anton, S. E., Kayser, C., Maiellaro, I., Nemec, K., Möller, J., Koschinski, A., Zaccolo, M., Annibale, P., Falcke, M., Lohse, M. J., et al. (2022) · Cell · doi:10.1016/j.cell.2022.02.011 · Cited by 186
Hota, P. K., & Buck, M. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1019-0 · Cited by 170
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Gpr161 anchoring of PKA consolidates GPCR and cAMP signaling
Bachmann, V. A., Mayrhofer, J. E., Ilouz, R., Tschaikner, P., Raffeiner, P., Röck, R., Courcelles, M., Apelt, F., Lu, T.-W., Baillie, G. S., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1608061113 · Cited by 111
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Bunney, T. D., Esposito, D., Mas-Droux, C., Lamber, E., Baxendale, R. W., Martins, M., Cole, A., Svergun, D., Driscoll, P. C., & Katan, M. (2012) · Structure · doi:10.1016/j.str.2012.09.005 · Cited by 88
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Aeluri, M., Chamakuri, S., Dasari, B., Guduru, S. K. R., Jimmidi, R., Jogula, S., & Arya, P. (2014) · Chemical Reviews · doi:10.1021/cr4004049 · Cited by 79
Evolving specificity from variability for protein interaction domains
Kaneko, T., Sidhu, S. S., & Li, S. S. C. (2011) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2010.12.001 · Cited by 45
Koveal, D., Schuh-Nuhfer, N., Ritt, D., Page, R., Morrison, D. K., & Peti, W. (2012) · Science Signaling · doi:10.1126/scisignal.2003289 · Cited by 36
Cancer proteome and metabolite changes linked to SHMT2
Tong, J., Krieger, J. R., Taylor, P., Bagshaw, R., Kang, J., Jeedigunta, S., Wybenga-Groot, L. E., Zhang, W., Badr, H., Mirhadi, S., et al. (2020) · PLoS ONE · doi:10.1371/journal.pone.0237981 · Cited by 24
“Protein-protein interactions are known to occur among enzymes involved in folate-dependent metabolism [41] and represent a basic mechanism of protein regulation [42].”
Courcelles, M., Coulombe-Huntington, J., Cossette, É., Gingras, A.-C., Thibault, P., & Tyers, M. (2017) · Journal of Proteome Research · doi:10.1021/acs.jproteome.7b00205 · Cited by 21
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Bachmann, V. A., Bister, K., & Stefan, E. (2013) · Small GTPases · doi:10.4161/sgtp.27281 · Cited by 14
Proximity-Dependent Labeling of Cysteines
Sen, S., Sultana, N., Shaffer, S. A., & Thompson, P. R. (2021) · Journal of the American Chemical Society · doi:10.1021/jacs.1c07069 · Cited by 11
The fitness cost of spurious phosphorylation
Bradley, D., Hogrebe, A., Dandage, R., Dubé, A. K., Leutert, M., Dionne, U., Chang, A., Villén, J., & Landry, C. R. (2024) · The EMBO Journal · doi:10.1038/s44318-024-00200-7 · Cited by 10
Metadata
- Authors
- Scott, J. D., & Pawson, T.
- Venue
- Science
- Published
- 2009-11-27
- Volume
- 326
- Issue
- 5957
- Pages
- 1220-1224
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2148315081
- Cited by
- 645
- References
- 7
- FWCI
- 19.32
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
