The DOI matches its Crossref record; 30 of the 31 references it cites were found in a registry or an index.
MicroRNA-33 and the SREBP Host Genes Cooperate to Control Cholesterol Homeostasis
Open accessAbstract
miR-33 in Cholesterol Control: With the well-established link between serum cholesterol levels and cardiovascular disease and the availability of effective cholesterol-lowering drugs, cholesterol screening has rapidly become a routine part of health care. Yet, much remains to be learned about how cholesterol levels are regulated at the cellular level (see the Perspective by Brown et al. ). Now, Najafi-Shoushtari et al. (p. 1566 , published online 13 May) and Rayner et al. (p. 1570 , published online 13 May) have discovered a new molecular player in cholesterol control—a small noncoding RNA that, intriguingly, is embedded within the genes coding for sterol regulatory element-binding proteins (SREBPs), transcription factors already known to regulate cholesterol levels. This microRNA, called miR-33, represses expression of the adenosine triphosphate–binding cassette transporter A1, a protein that regulates synthesis of high-density lipoprotein (HDL, or “good” cholesterol) and that helps to remove “bad” cholesterol from the blood. Reducing the levels of miR-33 in mice boosted serum HDL levels, suggesting that manipulation of this regulatory circuit might be therapeutically useful.
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“Pharmacological inhibition of miR-33 increased plasma high-density lipoprotein cholesterol levels in mice (Horie et al., 2010;Najafi-Shoushtari et al., 2010;Rayner et al., 2011a) and primates (Rayner et al., 2011b;Rottiers et al., 2013), leading to a marked reduction of atherosclerosis phenotypes.”
From microRNA-33 Regulates ApoE Lipidation and Amyloid-β Metabolism in the Brain (2015) · cites this paper as Najafi-Shoushtari et al., 2010
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In the citing paper
“in vivo antagonism or genetic deletion of miR-33 enhances hepatic ABCA1 expression and increases circulating HDL-cholesterol (HDL-C) (Marquart et al., 2010; Najafi-Shoushtari et al., 2010; Rayner et al., 2010).”
From Genetic dissection of the impact of miR-33a and miR-33b during the progression of atherosclerosis (2017) · cites this paper as Najafi-Shoushtari et al., 2010
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“These differences in miRNA expression vary between cell types suggesting that the role of miR-33b in the liver, where miR-33 is most highly expressed both in our mouse model and in human tissues (Najafi-Shoushtari et al., 2010), and other tissues may be considerably more important.”
From Genetic dissection of the impact of miR-33a and miR-33b during the progression of atherosclerosis (2017) · cites this paper as Najafi-Shoushtari et al., 2010
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“In miR-33a knockout mice or when miR-33a is suppressed by synthetic nucleic acids such as antagomirs, the expression of ABCA1 in macrophages and the liver is increased 11 - 15) .”
From Critical Role of microRNA-33a/b in Cardiovascular and Metabolic Disease: Molecular Mechanisms and Therapeutic Perspectives (2026) · cites this paper as [11]
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In the citing paper
“MicroRNA (miR)-33 is known to target ABCA1 and ABCG1 in vivo.”
From MicroRNA‐33 Deficiency Reduces the Progression of Atherosclerotic Plaque in ApoE −/− Mice (2012) · cites this paper as [17]
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“Two miR-33 genes are present in humans: miR-33b, which is present in intron 17 of the Srebp-1 gene on chromosome 17, and miR-33a, which is located in intron 16 of the Srebp-2 gene on chromosome 22.”
From miR-33a/b contribute to the regulation of fatty acid metabolism and insulin signaling (2011) · cites this paper as [13]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“We and others have recently established that, during sterol-limited states, miR-33a is coincidentally generated with Srebp-2 transcription and works to increase cellular cholesterol levels by limiting cholesterol export through the down-regulation of ABC transporters, ABCA1 and ABCG1 (12–14).”
From miR-33a/b contribute to the regulation of fatty acid metabolism and insulin signaling (2011) · cites this paper as [13]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“miR-33a and miR-33b are intronic miRNAs encoded within the SREBP-2 and SREBP-1 genes respectively (Marquart et al., 2010; Najafi-Shoushtari et al., 2010; Rayner et al., 2010).”
From Genetic dissection of the impact of miR-33a and miR-33b during the progression of atherosclerosis (2017) · cites this paper as Najafi-Shoushtari et al., 2010
The cited source says what the claim attributes to it.
In the citing paper
“This work led to the demonstration that miR-33a and miR-33b are co-transcribed along with SREBP-2 and SREBP-1, and work in concert with their host genes to help maintain proper lipid levels within the cell (Davalos et al., 2011; Marquart et al., 2010; Najafi-Shoushtari et al., 2010; Rayner et al., 2010).”
From Genetic dissection of the impact of miR-33a and miR-33b during the progression of atherosclerosis (2017) · cites this paper as Najafi-Shoushtari et al., 2010
The cited source says what the claim attributes to it.
In the citing paper
“The most well-known target gene of miR-33a/b is ATP-binding cassette subfamily A member 1 (ABCA1).”
From Critical Role of microRNA-33a/b in Cardiovascular and Metabolic Disease: Molecular Mechanisms and Therapeutic Perspectives (2026) · cites this paper as [11]
The cited source says what the claim attributes to it.
In the citing paper
“Recent reports, including ours, have indicated that miR-33 controls cholesterol homeostasis based on knockdown experiments using antisense technology.16–18”
From MicroRNA‐33 Deficiency Reduces the Progression of Atherosclerotic Plaque in ApoE −/− Mice (2012) · cites this paper as [17]
The cited source says what the claim attributes to it.
In the citing paper
“We and others provided identification of a highly conserved miRNA family, miR-33, within the intronic sequences of the Srebp genes in organisms ranging from Drosophila to humans (11–14).”
From miR-33a/b contribute to the regulation of fatty acid metabolism and insulin signaling (2011) · cites this paper as [13]
The cited source says what the claim attributes to it.
In the citing paper
“In mice, however, there is only one miR-33 gene, which is conserved with human miR-33a and located within intron 15 of the mouse Srebp-2 gene.”
From miR-33a/b contribute to the regulation of fatty acid metabolism and insulin signaling (2011) · cites this paper as [13]
The cited source says what the claim attributes to it.
In the citing paper
“Importantly, these pathways regulate circulating HDL levels through their roles in HDL biogenesis and cellular cholesterol efflux (12–14).”
From miR-33a/b contribute to the regulation of fatty acid metabolism and insulin signaling (2011) · cites this paper as [13]
In the citing paper
“These microRNAs participate in the regulation of cholesterol synthesis, fatty acid metabolism, and insulin signaling.”
From The Vasculature in Prediabetes (2018) · cites this paper as [143]
In the citing paper
“They are co-transcribed and act in conjunction with their host genes, Srebp1 and Srebp2, to regulate cholesterol synthesis.”
From The Vasculature in Prediabetes (2018) · cites this paper as [143]
In the citing paper
“Furthermore, an intronic microRNA located within Srebf2 gene, miR-33, inhibits the expression of Abca1 (Najafi-Shoushtari et al., 2010; Rayner et al., 2010).”
From Inhibition of cholesterol biosynthesis through RNF145-dependent ubiquitination of SCAP (2017) · cites this paper as Najafi-Shoushtari et al., 2010
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Citations
Cites
Bartel (2004) · doi:10.1016/s0092-8674(04)00045-5 · Cited by 34,714
MicroRNAs: Target Recognition and Regulatory Functions
Bartel, D. P. (2009) · Cell · doi:10.1016/j.cell.2009.01.002 · Cited by 20,068
MicroRNAs: small RNAs with a big role in gene regulation
He, L., & Hannon, G. J. (2004) · Nature Reviews Genetics · doi:10.1038/nrg1379 · Cited by 7,118
SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver
Horton, J. D., Goldstein, J. L., & Brown, M. S. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15593 · Cited by 4,794
SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver
Horton, J. D., Goldstein, J. L., & Brown, M. S. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215593 · Cited by 4,092
Silencing of microRNAs in vivo with ‘antagomirs’
Krützfeldt, J., Rajewsky, N., Braich, R., Rajeev, K. G., Tuschl, T., Manoharan, M., & Stoffel, M. (2005) · Nature · doi:10.1038/nature04303 · Cited by 3,949
Brown, M. S., & Goldstein, J. L. (1997) · Cell · doi:10.1016/s0092-8674(00)80213-5 · Cited by 3,834
Identification of Mammalian microRNA Host Genes and Transcription Units
Rodriguez, A., Griffiths-Jones, S., Ashurst, J. L., & Bradley, A. (2004) · Genome Research · doi:10.1101/gr.2722704 · Cited by 2,128
miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting
Esau, C., Davis, S., Murray, S. F., Yu, X. X., Pandey, S. K., Pear, M., Watts, L., Booten, S. L., Graham, M., McKay, R., et al. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.01.005 · Cited by 2,082
LNA-mediated microRNA silencing in non-human primates
Elmén, J., Lindow, M., Schütz, S., Lawrence, M., Petri, A., Obad, S., Lindholm, M., Hedtjärn, M., Hansen, H. F., Berger, U., et al. (2008) · Nature · doi:10.1038/nature06783 · Cited by 1,589
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MicroRNA Regulatory Networks as Biomarkers in Obesity: The Emerging Role
Zhang, L., Miller, D., Yang, Q., & Wu, B. (2017) · Methods in molecular biology · doi:10.1007/978-1-4939-7046-9_18 · Cited by 9
Advanced in Molecular Mechanisms of Atherosclerosis: From Lipids to Inflammation
Meiliana, A., Dewi, N. M., & Wijaya, A. (2018) · The Indonesian Biomedical Journal · doi:10.18585/inabj.v10i2.479 · Cited by 11
MiR-33a is a therapeutic target in SPG4-related hereditary spastic paraplegia human neurons
Nakazeki, F., Tsuge, I., Horie, T., Imamura, K., Tsukita, K., Hotta, A., Baba, O., Kuwabara, Y., Nishino, T., Nakao, T., et al. (2019) · Clinical Science · doi:10.1042/cs20180980 · Cited by 11
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Das, S., Vasanthi, H. R., & Parjapath, R. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-55330-6_23 · Cited by 9
Zhang, Y., Zhan, Y., Liu, D., & Yu, B. (2019) · Drug Delivery · doi:10.1080/10717544.2019.1628117 · Cited by 9
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Vickers, K. C., & Rader, D. J. (2013) · Circulation Research · doi:10.1161/circresaha.113.301422 · Cited by 9
Oladosu, O., Chin, E., Barksdale, C., Powell, R. R., Bruce, T., & Stamatikos, A. D. (2024) · Pathophysiology · doi:10.3390/pathophysiology31010009 · Cited by 8
Liu, X., Wang, W., Li, Q., Niu, H., & Zhang, W. (2024) · International Journal of Smart and Nano Materials · doi:10.1080/19475411.2024.2395270 · Cited by 9
Li, X., Hernandez, R., Zhang, X., Tang, S., Yuan, X., Wu, J., Pham, K., Rawal, H. C., Heinrich, E. C., Zhang, S., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-67387-z · Cited by 10
Non-coding RNAs in lipid metabolism and their roles in atherosclerosis
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Lipid metabolic alterations in cancer: Common pathophysiology with cardiovascular disease
Llena-Meler, M., Canfrán‐Duque, A., Madrigal‐Matute, J., & Rotllán, N. (2026) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2026.01.003 · Cited by 12
Tarlton, J., Patterson, S., & Graham, A. (2021) · Biology · doi:10.3390/biology10060534 · Cited by 8
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Wang, Y., Guo, M. Y., & Tang, C. (2023) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2023.102036 · Cited by 10
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Mačvanin, M., & Isenović, E. R. (2023) · Cardiology Plus · doi:10.1097/cp9.0000000000000062 · Cited by 10
Ohde, D., Brenmoehl, J., Walz, C., Tuchscherer, A., Wirthgen, E., & Hoeflich, A. (2016) · Journal of Comparative Physiology B · doi:10.1007/s00360-016-1006-0 · Cited by 8
chai, J., Chen, L., Luo, Z., Zhang, T., Chen, L., Lou, P., Sun, W., Long, X., Lan, J. Q., Wang, J., et al. (2018) · Bioscience Biotechnology and Biochemistry · doi:10.1080/09168451.2018.1459175 · Cited by 8
Zhu, T., Corraze, G. R., Plagnes‐Juan, E., & Cassy, S. (2018) · PLoS ONE · doi:10.1371/journal.pone.0206727 · Cited by 8
Cetrullo, S., D’Adamo, S., Panichi, V., Borzı̀, R. M., Pignatti, C., & Flamigni, F. (2020) · Cells · doi:10.3390/cells9030537 · Cited by 8
Li, J., Kong, D., Gao, X., Tian, Z., Wang, X., Guo, Q., Wang, Z., & Zhang, Q. (2021) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2021.111280 · Cited by 9
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Gonçalves, B. D. S., Meadows, A., Pereira, D. G., Puri, R., & Pillai, S. S. (2023) · Biomedicines · doi:10.3390/biomedicines11061597 · Cited by 10
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Cho, Y., & Baldán, Á. (2013) · Europe PMC (PubMed Central) · Cited by 8
Regulation of Hepatobiliary Transporters during Liver Injury
Manautou, J. E., Campion, S. N., & Aleksunes, L. M. (2010) · Elsevier eBooks · doi:10.1016/b978-0-08-046884-6.01008-3 · Cited by 8
Cerda, Á., Issa, M. H., Genvigir, F. D. V., et al. (2013) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2013.08.017 · Cited by 8
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Miller, W. L., & Gucev, Z. S. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-416006-4.00011-9 · Cited by 7
MiR‐144 affects fatty acid composition by regulating ELOVL6 expression in duck hepatocytes
He, J., Tian, Y., Zhao, Y., Liu, Y., Tao, Z., Li, G., Niu, D., Lu, L., & Lu, Y. (2017) · Cell Biology International · doi:10.1002/cbin.10753 · Cited by 9
Huesca‐Gómez, C., Torres-Paz, Y. E., Martínez-Alvarado, M. R., Fuentevilla-Álvarez, G., del Valle‐Mondragón, L., Torres‐Tamayo, M., Soto, M. E., & Gamboa, R. (2019) · Molecular Biology Reports · doi:10.1007/s11033-019-05229-0 · Cited by 8
Malinowska, A. L., Łaski, A., & Hall, J. (2021) · Chemistry - A European Journal · doi:10.1002/chem.202101171 · Cited by 7
Pavlík, V., Machalová, V., Čepa, M., Šínová, R., Šafránková, B., Kulhánek, J., Drmota, T., Kubala, L., Huerta‐Ángeles, G., Velebný, V., et al. (2022) · Biomolecules · doi:10.3390/biom12020200 · Cited by 8
Liu, Z., Cheng, S., Zhang, X., Yang, M., Wei, J., Ye, F., Feei, Z., Kang, H., Zhang, Z., Li, H., et al. (2024) · Poultry Science · doi:10.1016/j.psj.2024.104463 · Cited by 9
ATP8B1 regulates PIP2 localization and cleavage of pyroptotic executioner Gasdermin D
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Chen, W., Yin, K., Zhao, G., & Tang, C. (2011) · PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS · doi:10.3724/sp.j.1206.2011.00072 · Cited by 7
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Masoumi-Ardakani, Y., Eghbalian, M., Fallah, H., Jafari, A., & Shahouzehi, B. (2025) · BMC Endocrine Disorders · doi:10.1186/s12902-025-01849-9 · Cited by 7
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Zhang, X., Zhao, H., Sheng, Q., Liu, X., You, W., Lin, H., & Liu, G. (2021) · Archives animal breeding/Archiv für Tierzucht · doi:10.5194/aab-64-103-2021 · Cited by 7
Lu, R., Lin, M., Yang, F., Jia, S., Zhang, Y., Qin, C., Meng, X., & Nie, G.-X. (2021) · Fish Physiology and Biochemistry · doi:10.1007/s10695-021-00956-3 · Cited by 6
Luo, H., Gan, L., Liu, Y.-G., Wei, Y., Chen, J., Gu, X., Tang, J., Zhao, Y., Su, C., Xiao, L., et al. (2022) · Current Issues in Molecular Biology · doi:10.3390/cimb44100328 · Cited by 7
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Stachowiak, G., Zając, A. E., Nowak, M., Stetkiewicz, T., & Wilczyński, J. R. (2015) · Menopause Review/Przegląd Menopauzalny · doi:10.5114/pm.2015.52155 · Cited by 7
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Flowers, E., & Aouizerat, B. E. (2013) · Physiological Genomics · doi:10.1152/physiolgenomics.00106.2013 · Cited by 7
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Li, S., Sun, Y., Zhou, Y.-T., et al. (2016) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2016.3646 · Cited by 7
Caputo, T. M., Cummaro, A., Lettera, V., Mazzarotta, A., Battista, E., Netti, P. A., & Causa, F. (2018) · The Analyst · doi:10.1039/c8an02166j · Cited by 7
Liu, Y., Lei, P., Qiao, H., Sun, K., Lu, X., Bao, F., Yu, R., Lian, C., Li, Y., Chen, W., et al. (2019) · Journal of Cellular Biochemistry · doi:10.1002/jcb.29192 · Cited by 7
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Ahmadi, Y., Ghorbanihaghjo, A., Dastmalchi, S., Nemati, M., & Bargahi, N. (2018) · Gene · doi:10.1016/j.gene.2018.03.092 · Cited by 8
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Sharma, R., Mendez, K. M., Begum, S., Chu, S. H., Prince, N., Hecker, J., Kelly, R. S., Chen, Q., Wheelock, C. E., Celedon, J. C., et al. (2024) · EBioMedicine · doi:10.1016/j.ebiom.2024.105534 · Cited by 7
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Michihara, A., Ide, N., Mizutani, Y., Okamoto, M., Uchida, M., Matsuoka, H., & Akasaki, K. (2015) · Bioscience Biotechnology and Biochemistry · doi:10.1080/09168451.2015.1061417 · Cited by 6
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Ørum, H. (2013) · Wiley eBooks · doi:10.1002/9781118300312.ch40 · Cited by 6
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Rasmi, R. R., Kovatich, R., Farley, A., Sakthivel, K. M., Takiar, V., & Sertorio, M. G. (2025) · Cellular Signalling · doi:10.1016/j.cellsig.2025.112044 · Cited by 10
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Wu, Y., Zhang, W., Wang, Y., Lu, Q., Zhou, J., Chen, Z., Yang, Z., & Loor, J. J. (2022) · Animal Biotechnology · doi:10.1080/10495398.2022.2111308 · Cited by 5
Noncoding RNAs as additional mediators of epigenetic regulation in nonalcoholic fatty liver disease
Zaiou, M. (2022) · World Journal of Gastroenterology · doi:10.3748/wjg.v28.i35.5111 · Cited by 5
Zhao, G., Wang, Y., An, J.-H., Tang, W., Xu, X., & Ren, K. (2024) · Aging · doi:10.18632/aging.205992 · Cited by 6
MiR-33 connects cholesterol to the cell cycle
Inukai, S., & Slack, F. J. (2012) · Cell Cycle · doi:10.4161/cc.11.6.19786 · Cited by 5
MicroRNA modulation of cholesterol
Harrison, C. (2010) · Nature Reviews Drug Discovery · doi:10.1038/nrd3208 · Cited by 5
Lin, H., Chaudhury, M., Sharma, N., et al. (2020) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2020.108397 · Cited by 5
MicroRNAs Linking Cancer and Inflammation: Focus on Liver Cancer
Gougèlet, A., & Colnot, S. (2014) · Springer eBooks · doi:10.1007/978-3-319-03725-7_8 · Cited by 5
miRNA Biology in Pathological Processes
Zhang, X., Dong, H., & Tian, Y. (2015) · Springer briefs in molecular science · doi:10.1007/978-3-662-47293-4_2 · Cited by 5
Nakaya, K., Ayaori, M., & Ikewaki, K. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-812513-7.00006-9 · Cited by 5
miRNAs in the Pathophysiology of Diabetes and Their Value as Biomarkers
Brennan, E. P., McClelland, A., Hagiwara, S., Godson, C., & Kantharidis, P. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-801899-6.00031-0 · Cited by 7
Characterization and biological health implications of microRNAs from human milk and infant formulas
Ali, A. H., Najjar, Z., & Ayyash, M. M. (2025) · npj Science of Food · doi:10.1038/s41538-025-00661-y · Cited by 6
Doxorubicin inhibits cholesterol efflux through the miR-33/ABCA1 pathway
Zhu, F., Chang, G., Tang, X., Gao, L., & Zhang, N. (2023) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2023.01.024 · Cited by 5
Identification of Important Genes Associated with the Development of Atherosclerosis
Kotlyarov, S. N. (2023) · Current Gene Therapy · doi:10.2174/1566523223666230330091241 · Cited by 4
Circulating and Exosomal microRNA-33 in Childhood Obesity
Cabiati, M., Guiducci, L., Randazzo, E., Casieri, V., Federico, G., & Ry, S. D. (2023) · Biomedicines · doi:10.3390/biomedicines11082295 · Cited by 4
Huang, K., Pokhrel, A., Echesabal-Chen, J., Scott, J., Bruce, T., Jo, H., & Stamatikos, A. D. (2025) · Medicina · doi:10.3390/medicina61020329 · Cited by 5
MicroRNA-33 inhibition ameliorates muscular dystrophy by enhancing skeletal muscle regeneration
Sowa, N., Horie, T., Ide, Y., Baba, O., Kora, K., Yoshida, T., Nakamura, Y., Matsumura, S., Matsushita, K., Imanaka, M., et al. (2025) · EMBO Molecular Medicine · doi:10.1038/s44321-025-00273-9 · Cited by 4
Immunometabolic Signaling Pathways Contribute to Macrophage and Dendritic Cell Function
Jennelle, L. T., Dandekar, A. P., Magoro, T., & Hahn, Y. S. (2016) · Critical Reviews in Immunology · doi:10.1615/critrevimmunol.2017018803 · Cited by 4
Effect of diet and genotype on the miRNome of mice with altered lipoprotein metabolism
Busnelli, M., Manzini, S., Colombo, A., Franchi, E., Chiara, M., Zaffaroni, G., Horner, D. S., & Chiesa, G. (2023) · iScience · doi:10.1016/j.isci.2023.107615 · Cited by 4
Scherrer, D. Z., Zago, V. H. D. S., Parra, E. S., Avansini, S. H., Panzoldo, N. B., Alexandre, F., Baracat, J., Nakandakare, E. R., Quintão, E. C. R., & de Faria, E. C. (2015) · Gene · doi:10.1016/j.gene.2015.05.074 · Cited by 4
Spatio-temporal expression patterns of microRNAs in remodelling and repair of the infarcted heart.
Chiarella-Redfern, H., Rayner, K. J., & Suuronen, E. J. (2015) · PubMed · doi:10.14670/hh-30.141 · Cited by 4
Novel non‐coding RNA‐based therapeutic approaches to prevent statin‐induced liver damage
Bang, C., & Thum, T. (2012) · EMBO Molecular Medicine · doi:10.1002/emmm.201201565 · Cited by 4
[Recent advances of miRNAs in adipose tissues].
Guo, Y., Zhang, X., Huang, W., & Miao, X. (2016) · PubMed · Cited by 4
Gao, F., Wang, F., Lyu, R., et al. (2018) · Molecular Medicine Reports · doi:10.3892/mmr.2018.8498 · Cited by 4
Lanktree, M. B., JOY, T. R., & Hegele, R. A. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-382227-7.00083-5 · Cited by 5
MicroRNAs in metabolic syndrome: Mechanisms, diagnosis, and therapy
Rahman, M. A., Islam, M. M., Islam, M. M., Ripon, M. A. R., & Hossain, M. S. (2025) · Advances in clinical chemistry · doi:10.1016/bs.acc.2025.06.003 · Cited by 4
SREBP2 confers ferroptosis resistance by targeting GPX4 in colorectal cancer
Zhong, H., Chen, R., Chen, T., Lin, M., Wen, S., Zhang, M., Liu, D., Yu, J., Chen, J., Yi, B., et al. (2026) · APOPTOSIS · doi:10.1007/s10495-025-02209-7 · Cited by 5
Aliakbari, M., Saghebjoo, M., Sarir, H., & Hedayati, M. (2022) · Journal of Food Biochemistry · doi:10.1111/jfbc.14195 · Cited by 3
Regulation of Hepatobiliary Transporters During Liver Injury
Manautou, J. E., & Ghanem, C. I. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.95661-7 · Cited by 3
Guo, Y., Zhao, H., Zhao, J., Li, S., Meng, L., Li, J., Qian, Y., Li, Y.-L., Cui, B.-Y., Guo, S., et al. (2025) · European Journal of Nutrition · doi:10.1007/s00394-024-03578-6 · Cited by 3
Self-citationMicroRNAs in Lipid Metabolism and Atherosclerosis
Meiliana, A., & Wijaya, A. (2014) · The Indonesian Biomedical Journal · doi:10.18585/inabj.v6i1.39 · Cited by 3
A Novel Role of SMG1 in Cholesterol Homeostasis That Depends Partially on p53 Alternative Splicing
Li, M., Philantrope, F., Diot, A., Bourdon, J., & Thompson, P. A. (2022) · Cancers · doi:10.3390/cancers14133255 · Cited by 3
MicroRNAs and cardiovascular medicine
Kaur, U., Chakrabarti, S., & Pandey, B. (2014) · SAGE Open Medicine · doi:10.1177/2050312114524952 · Cited by 3
Noncoding RNAs in Cardiovascular Disease
Lesizza, P., Paldino, A., Merlo, M., Giacca, M., & Sinagra, G. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-814470-1.00003-4 · Cited by 3
MicroRNAs and Energy Metabolism in Cancer Cells
Sun, L., He, X., Cao, Y., Gao, P., & Zhang, H. (2014) · Springer eBooks · doi:10.1007/978-3-319-03725-7_4 · Cited by 3
Metadata
- Authors
- Najafi-Shoushtari, S. H., Kristo, F., Li, Y., Shioda, T., Cohen, D. E., Gerszten, R. E., & Näär, A. M.
- Affiliations
- Harvard University (US)
- Massachusetts General Hospital (US)
- Brigham and Women's Hospital (US)
- Corresponding author
- Näär, Anders M.
- ORCID
- Venue
- Science
- Published
- 2010-06-18
- Volume
- 328
- Issue
- 5985
- Pages
- 1566-1569
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC3840500
- OpenAlex
- W2102901373
- Semantic Scholar
- 8e1f87e5a8c468d11cb938b52c20c8e6954402ce
- Cited by
- 957
- References
- 31
- Citations by year
- 2026: 20 · 2025: 30 · 2024: 24 · 2023: 47 · 2022: 41 · 2021: 56 · 2020: 50 · 2019: 65 · 2018: 66 · 2017: 59 · 2016: 86 · 2015: 88 · 2014: 85 · 2013: 92 · 2012: 73
- FWCI
- 80.88
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of General Medical Sciences (R01GM071449)
- National Institute of Diabetes and Digestive and Kidney Diseases (R21DK084459, R01 DK48873, P30-DK34854, R01DK056626, R01 DK56626, R37DK048873, P30DK034854, R01DK048873)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
- Keywords
- miR-33, cholesterol homeostasis, ABCA1, reverse cholesterol transport, HDL synthesis, cholesterol efflux, post-transcriptional regulation, antisense oligonucleotides, locked nucleic acid, cholesterol biosynthesis, cardiometabolic disease
- MeSH terms
- Animals, Cell Line, Cholesterol, Diet, Gene Expression Regulation, Homeostasis, Humans, Introns, Cholesterol, HDL, Liver, Macrophages, Mice, Inbred C57BL, Up-Regulation, Oligonucleotides, Antisense, ATP-Binding Cassette Transporters, 3' Untranslated Regions, RNA Interference, MicroRNAs, Mice, Sterol Regulatory Element Binding Proteins, Sterol Regulatory Element Binding Protein 1, Sterol Regulatory Element Binding Protein 2, ATP Binding Cassette Transporter 1
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