The DOI matches its Crossref record; 30 of the 31 references it cites were found in a registry or an index.
MicroRNA-33 and the SREBP Host Genes Cooperate to Control Cholesterol Homeostasis
Open accessAbstract
miR-33 in Cholesterol Control: With the well-established link between serum cholesterol levels and cardiovascular disease and the availability of effective cholesterol-lowering drugs, cholesterol screening has rapidly become a routine part of health care. Yet, much remains to be learned about how cholesterol levels are regulated at the cellular level (see the Perspective by Brown et al. ). Now, Najafi-Shoushtari et al. (p. 1566 , published online 13 May) and Rayner et al. (p. 1570 , published online 13 May) have discovered a new molecular player in cholesterol control—a small noncoding RNA that, intriguingly, is embedded within the genes coding for sterol regulatory element-binding proteins (SREBPs), transcription factors already known to regulate cholesterol levels. This microRNA, called miR-33, represses expression of the adenosine triphosphate–binding cassette transporter A1, a protein that regulates synthesis of high-density lipoprotein (HDL, or “good” cholesterol) and that helps to remove “bad” cholesterol from the blood. Reducing the levels of miR-33 in mice boosted serum HDL levels, suggesting that manipulation of this regulatory circuit might be therapeutically useful.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Pharmacological inhibition of miR-33 increased plasma high-density lipoprotein cholesterol levels in mice (Horie et al., 2010;Najafi-Shoushtari et al., 2010;Rayner et al., 2011a) and primates (Rayner et al., 2011b;Rottiers et al., 2013), leading to a marked reduction of atherosclerosis phenotypes.”
From microRNA-33 Regulates ApoE Lipidation and Amyloid-β Metabolism in the Brain (2015) · cites this paper as Najafi-Shoushtari et al., 2010
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“in vivo antagonism or genetic deletion of miR-33 enhances hepatic ABCA1 expression and increases circulating HDL-cholesterol (HDL-C) (Marquart et al., 2010; Najafi-Shoushtari et al., 2010; Rayner et al., 2010).”
From Genetic dissection of the impact of miR-33a and miR-33b during the progression of atherosclerosis (2017) · cites this paper as Najafi-Shoushtari et al., 2010
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“These differences in miRNA expression vary between cell types suggesting that the role of miR-33b in the liver, where miR-33 is most highly expressed both in our mouse model and in human tissues (Najafi-Shoushtari et al., 2010), and other tissues may be considerably more important.”
From Genetic dissection of the impact of miR-33a and miR-33b during the progression of atherosclerosis (2017) · cites this paper as Najafi-Shoushtari et al., 2010
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“In miR-33a knockout mice or when miR-33a is suppressed by synthetic nucleic acids such as antagomirs, the expression of ABCA1 in macrophages and the liver is increased 11 - 15) .”
From Critical Role of microRNA-33a/b in Cardiovascular and Metabolic Disease: Molecular Mechanisms and Therapeutic Perspectives (2026) · cites this paper as [11]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“MicroRNA (miR)-33 is known to target ABCA1 and ABCG1 in vivo.”
From MicroRNA‐33 Deficiency Reduces the Progression of Atherosclerotic Plaque in ApoE −/− Mice (2012) · cites this paper as [17]
Experimental — accuracy not yet measured
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Two miR-33 genes are present in humans: miR-33b, which is present in intron 17 of the Srebp-1 gene on chromosome 17, and miR-33a, which is located in intron 16 of the Srebp-2 gene on chromosome 22.”
From miR-33a/b contribute to the regulation of fatty acid metabolism and insulin signaling (2011) · cites this paper as [13]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“We and others have recently established that, during sterol-limited states, miR-33a is coincidentally generated with Srebp-2 transcription and works to increase cellular cholesterol levels by limiting cholesterol export through the down-regulation of ABC transporters, ABCA1 and ABCG1 (12–14).”
From miR-33a/b contribute to the regulation of fatty acid metabolism and insulin signaling (2011) · cites this paper as [13]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“miR-33a and miR-33b are intronic miRNAs encoded within the SREBP-2 and SREBP-1 genes respectively (Marquart et al., 2010; Najafi-Shoushtari et al., 2010; Rayner et al., 2010).”
From Genetic dissection of the impact of miR-33a and miR-33b during the progression of atherosclerosis (2017) · cites this paper as Najafi-Shoushtari et al., 2010
The cited source says what the claim attributes to it.
In the citing paper
“This work led to the demonstration that miR-33a and miR-33b are co-transcribed along with SREBP-2 and SREBP-1, and work in concert with their host genes to help maintain proper lipid levels within the cell (Davalos et al., 2011; Marquart et al., 2010; Najafi-Shoushtari et al., 2010; Rayner et al., 2010).”
From Genetic dissection of the impact of miR-33a and miR-33b during the progression of atherosclerosis (2017) · cites this paper as Najafi-Shoushtari et al., 2010
The cited source says what the claim attributes to it.
In the citing paper
“The most well-known target gene of miR-33a/b is ATP-binding cassette subfamily A member 1 (ABCA1).”
From Critical Role of microRNA-33a/b in Cardiovascular and Metabolic Disease: Molecular Mechanisms and Therapeutic Perspectives (2026) · cites this paper as [11]
The cited source says what the claim attributes to it.
In the citing paper
“Recent reports, including ours, have indicated that miR-33 controls cholesterol homeostasis based on knockdown experiments using antisense technology.16–18”
From MicroRNA‐33 Deficiency Reduces the Progression of Atherosclerotic Plaque in ApoE −/− Mice (2012) · cites this paper as [17]
The cited source says what the claim attributes to it.
In the citing paper
“We and others provided identification of a highly conserved miRNA family, miR-33, within the intronic sequences of the Srebp genes in organisms ranging from Drosophila to humans (11–14).”
From miR-33a/b contribute to the regulation of fatty acid metabolism and insulin signaling (2011) · cites this paper as [13]
The cited source says what the claim attributes to it.
In the citing paper
“In mice, however, there is only one miR-33 gene, which is conserved with human miR-33a and located within intron 15 of the mouse Srebp-2 gene.”
From miR-33a/b contribute to the regulation of fatty acid metabolism and insulin signaling (2011) · cites this paper as [13]
The cited source says what the claim attributes to it.
In the citing paper
“Importantly, these pathways regulate circulating HDL levels through their roles in HDL biogenesis and cellular cholesterol efflux (12–14).”
From miR-33a/b contribute to the regulation of fatty acid metabolism and insulin signaling (2011) · cites this paper as [13]
In the citing paper
“These microRNAs participate in the regulation of cholesterol synthesis, fatty acid metabolism, and insulin signaling.”
From The Vasculature in Prediabetes (2018) · cites this paper as [143]
In the citing paper
“They are co-transcribed and act in conjunction with their host genes, Srebp1 and Srebp2, to regulate cholesterol synthesis.”
From The Vasculature in Prediabetes (2018) · cites this paper as [143]
In the citing paper
“Furthermore, an intronic microRNA located within Srebf2 gene, miR-33, inhibits the expression of Abca1 (Najafi-Shoushtari et al., 2010; Rayner et al., 2010).”
From Inhibition of cholesterol biosynthesis through RNF145-dependent ubiquitination of SCAP (2017) · cites this paper as Najafi-Shoushtari et al., 2010
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Bartel (2004) · doi:10.1016/s0092-8674(04)00045-5 · Cited by 34,714
MicroRNAs: Target Recognition and Regulatory Functions
Bartel, D. P. (2009) · Cell · doi:10.1016/j.cell.2009.01.002 · Cited by 20,068
MicroRNAs: small RNAs with a big role in gene regulation
He, L., & Hannon, G. J. (2004) · Nature Reviews Genetics · doi:10.1038/nrg1379 · Cited by 7,118
SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver
Horton, J. D., Goldstein, J. L., & Brown, M. S. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15593 · Cited by 4,794
SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver
Horton, J. D., Goldstein, J. L., & Brown, M. S. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215593 · Cited by 4,092
Silencing of microRNAs in vivo with ‘antagomirs’
Krützfeldt, J., Rajewsky, N., Braich, R., Rajeev, K. G., Tuschl, T., Manoharan, M., & Stoffel, M. (2005) · Nature · doi:10.1038/nature04303 · Cited by 3,949
Brown, M. S., & Goldstein, J. L. (1997) · Cell · doi:10.1016/s0092-8674(00)80213-5 · Cited by 3,834
Identification of Mammalian microRNA Host Genes and Transcription Units
Rodriguez, A., Griffiths-Jones, S., Ashurst, J. L., & Bradley, A. (2004) · Genome Research · doi:10.1101/gr.2722704 · Cited by 2,128
miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting
Esau, C., Davis, S., Murray, S. F., Yu, X. X., Pandey, S. K., Pear, M., Watts, L., Booten, S. L., Graham, M., McKay, R., et al. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.01.005 · Cited by 2,082
LNA-mediated microRNA silencing in non-human primates
Elmén, J., Lindow, M., Schütz, S., Lawrence, M., Petri, A., Obad, S., Lindholm, M., Hedtjärn, M., Hansen, H. F., Berger, U., et al. (2008) · Nature · doi:10.1038/nature06783 · Cited by 1,589
Research works printed but not linked: 1
- 10.1172/jci0215748 · DOI · Paper page
Cited by
Sorted by citations
Items 801–900 of 957
MicroRNA in Breast Cancer — Gene Regulators and Targets for Novel Therapies
Luqmani, Y. A., & Khajah, M. A. (2015) · InTech eBooks · doi:10.5772/59428 · Cited by 3
How Gene Networks Can Uncover Novel CVD Players
Parnell, L. D., Casas‐Agustench, P., Iyer, L. K., & Ordovás, J. M. (2014) · Current Cardiovascular Risk Reports · doi:10.1007/s12170-013-0372-3 · Cited by 3
miR-33a, an important marker and putative therapeutic target in chronic HBV-induced fibrosis
(2015) · RNA & DISEASE · doi:10.14800/rd.416 · Cited by 3
Not Junk After All: Non-Protein-Coding DNA Carries Extensive Biological Information
Wells, J. N. (2013) · doi:10.1142/9789814508728_0009 · Cited by 3
MicroRNA-Linked Heart Disease and Therapeutic Potential
Ono, K. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-800553-8.00010-x · Cited by 3
MiR-33a and statins collaboratively reduce the proliferative capacity of prostate cancer cells
Karataş, Ö. F., & Ittmann, M. (2018) · The European Research Journal · doi:10.18621/eurj.380619 · Cited by 3
Zhang, Y.-F., Li, X., Cao, X., Ji, C., Gao, X.-Y., Gao, D., Han, H., Yu, F., & Zheng, M. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.866020 · Cited by 2
High-Density Lipoprotein Metabolism
Brewer, H. B. (2015) · Elsevier eBooks · doi:10.1016/b978-0-323-28786-9.00004-9 · Cited by 3
Nutritional Regulation of Mammary miRNome: Implications for Human Studies
Leroux, C., Milenković, D., Mobuchon, L., Guillou, S. L., Faulconnier, Y., German, B. J., & Provost, F. L. (2017) · Springer eBooks · doi:10.1007/978-3-319-31143-2_88-1 · Cited by 3
The role of micro-RNA in cerebrovascular disease
Раскуражев, А. А., & Tanashyan, M. M. (2019) · Annals of Clinical and Experimental Neurology · doi:10.25692/acen.2019.3.6 · Cited by 3
Darabi, M., Zakiev, E., & Kontush, A. (2020) · Contemporary cardiology · doi:10.1007/978-3-030-56514-5_18 · Cited by 3
Zambrano, T., & Salazar, L. A. (2018) · Pharmacogenomics · doi:10.2217/pgs-2018-0051 · Cited by 3
MicroRNAs and Cardiovascular Diseases
Ono, K. (2013) · Wiley eBooks · doi:10.1002/9781118300312.ch29 · Cited by 3
Statins Stimulate Hepatic Glucose Production via the miR-183/96/182 ClusterPreprint
Marquart, T. J., Allen, R. M., Chen, M. R., Dorn, G. W., Matkovich, S. J., & Baldán, Á. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/726695 · Cited by 3
Hepatocyte-specific miR-33 deletion attenuates NAFLD-NASH-HCC progressionPreprint
Fernández-Tussy, P., Sun, J., Cardelo, M. P., Price, N., Goedeke, L., Xirouchaki, C. E., Yang, X.-Y., Pastor-Rojo, O., Bennett, A., Tiganis, T., et al. (2023) · bioRxiv · doi:10.1101/2023.01.18.523503 · Cited by 5
Encarnação, M., David, H., Coutinho, M. F., Moreira, L., & Alves, S. (2023) · Biomedicines · doi:10.3390/biomedicines11102615 · Cited by 2
Zhang, Y., Yang, W., Kumagai, Y., Loza, M., Yang, Y., Park, S., & Nakai, K. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms26010111 · Cited by 3
Zhang, Z., Ye, F., Zhang, H., et al. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107827 · Cited by 2
Oxysterol-binding protein ORP6 regulates lipid metabolism and brain Aβ production
Kasongo, A. A., Vijithakumar, V., Abd‐Elrahman, K. S., Prabhune, R., Gharibeh, L., Nadeau, R., Frayne, I. R., Spring, S., Robichaud, S., Asif, S., et al. (2025) · Journal of Lipid Research · doi:10.1016/j.jlr.2025.100868 · Cited by 4
Kochetova, O. V., Korytina, G. F., Timasheva, Y., Gilyazova, I. B., Akhmetshin, A. G., Abdeeva, G., Karunas, A. S., Хуснутдинова, Э. К., & Gusev, O. (2026) · Animals · doi:10.3390/ani16020260 · Cited by 2
Gordeladze, J. O., Stakkestad, Ø., Haugen, S., Reseland, J. E., Syversen, U., Johnsen, G. F., Haugen, H. J., Lyngstadaas, S. P., Møller, M. E., & Valtieri, M. (2014) · InTech eBooks · doi:10.5772/59149 · Cited by 2
Mazza, T., Castellana, S., Andriulli, A., Auffray, C., Vinciguerra, M., & Pazienza, V. (2013) · Biosystems · doi:10.1016/j.biosystems.2013.05.009 · Cited by 2
THE ROLE OF MICRORNA IN CHOLESTEROL METABOLISM REGULATION
Gutsol, L. O., Юрьевна, К. Е., & Nepomnyaschikh, S. F. (2019) · Современные проблемы науки и образования · doi:10.17513/spno.29020 · Cited by 2
Ekici, S., & Özmen, Ö. (2020) · Journal of Equine Veterinary Science · doi:10.1016/j.jevs.2020.103218 · Cited by 2
Regulation of ABCA1 by miR-33 and miR-34a in the Aging Eye
Peters, F., & Grimm, C. (2023) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-27681-1_9 · Cited by 3
Non-coding RNA and Atherosclerosis
Adyan, A., Bezsonov, E. E., Grebenshchikov, E. S., Гринев, А. В., & Bogomolov, D. (2024) · Gene Expression · doi:10.14218/ge.2023.00117 · Cited by 1
Tiny Guides, Big Impact: Focus on the Opportunities and Challenges of miR-Based Treatments for ARDS
Vaswani, C. M., Simone, J., Pavelick, J. L., Wu, X., Tan, G. W., Ektesabi, A. M., Gupta, S., Tsoporis, J. N., & dos Santos, C. C. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25052812 · Cited by 2
Research and Development of Oligonucleotides Targeting MicroRNAs (miRNAs)
Malinowska, A. L., & Hall, J. (2019) · Royal Society of Chemistry eBooks · doi:10.1039/9781788015714-00151 · Cited by 2
Nesan, D., & Ng, D. S. (2014) · Critical Reviews in Clinical Laboratory Sciences · doi:10.3109/10408363.2014.937523 · Cited by 2
Therapeutic modulation of microRNAs
Chau, B. N., Esau, C., MacKenna, D. A., Neben, S., & Gibson, N. W. (2013) · Drug Discovery Today Therapeutic Strategies · doi:10.1016/j.ddstr.2013.12.002 · Cited by 2
Vega‐Badillo, J. (2016) · TIP Revista Especializada en Ciencias Químico-Biológicas · doi:10.1016/j.recqb.2016.11.005 · Cited by 2
MicroRNA Regulation of HDL Homeostasis
Sun, X., & Feinberg, M. W. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-812513-7.00010-0 · Cited by 2
Noncoding RNAs in Cholesterol Metabolism and Atherosclerosis
Price, N. L., & Fernandez-Hernando, C. F. (2017) · Cardiac and vascular biology · doi:10.1007/978-3-319-52945-5_2 · Cited by 2
Characterization of Circulating Exosomal MicroRNAs and Its Role as Biomarkers for Metabolic Syndrome
El-Dawy, K., Ali, H., & Abdo, S. A. (2019) · Zagazig Veterinary Journal/Zagazig Veterinary Journal (Online) · doi:10.21608/zvjz.2019.6293.1016 · Cited by 2
Ayaori, M., & Ikewaki, K. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-407867-3.00005-6 · Cited by 2
MicroRNAs in Cardiometabolic Diseases
Meiliana, A., & Wijaya, A. (2013) · The Indonesian Biomedical Journal · doi:10.18585/inabj.v5i2.55 · Cited by 2
The Multifaceted Roles of CHROMR in Innate Immunity, Cancer, and Cholesterol Homeostasis
Blaustein, E. R., & Solingen, C. V. (2025) · Non-Coding RNA · doi:10.3390/ncrna11030044 · Cited by 1
Profiles of PCSK9, SREBP-2, and histopathology in COVID-19 and non-COVID-19 critical illness
Weber, F., Pavel, V., Müller, M., Boor, P., Läber, L., von Stillfried, S. F., & Buechler, C. (2025) · BMC Infectious Diseases · doi:10.1186/s12879-025-12129-1 · Cited by 1
Rahimi‐vala, M., Alani, B., Arjmand, A., Mazoochi, T., & Ardjmand, A. (2025) · Brain and Behavior · doi:10.1002/brb3.71105 · Cited by 1
Lipid metabolism in cancer is regulated by the integrated natural product–miRNA–target axis
Chuang, Y.-T., Yen, C.-Y., Tsai, Y., Chang, F., Farooqı, A. A., & Chang, H.-W. (2025) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2025.11.024 · Cited by 1
Wu, X., Zhou, S., & Li, Y. (2026) · Nano Biomedicine and Engineering · doi:10.1016/j.nbe.2025.100035 · Cited by 1
Self-citationRNA-Targeted Therapeutics for Lipid Metabolic Disorders: From Bench to Bedside
Ali, I., Qiu, J., Cheang, W. S., Wang, G., & Xu, S. (2026) · Research · doi:10.34133/research.1288 · Cited by 1
Nikpour, P., Mahabadi, H. M., Emadi‐Baygi, M., & Kelishadi, R. (2016) · International Journal of Preventive Medicine · doi:10.4103/2008-7802.177314 · Cited by 1
MicroRNAs in Obesity, Metabolic Syndrome and Diabetes Mellitus
Meiliana, A., & Wijaya, A. (2011) · The Indonesian Biomedical Journal · doi:10.18585/inabj.v3i1.130 · Cited by 1
Targeting Intracellular Cholesterol is a Novel Therapeutic Strategy for Cancer
Mandal, T., & Rahman, M. M. (2014) · Cited by 1
Gene- and Cell-Based Therapy for Cardiovascular Disease
Marín-García, J. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-404599-6.00023-8 · Cited by 1
Politano, G. M. M., Benso, A., Carlo, S. D., et al. (2014) · International Conference on Bioinformatics Models, Methods and Algorithms (BIOINFORMATICS) · doi:10.5220/0004799500490056 · Cited by 1
Fatima, Q., Jeelani, H., Abass, S., Farooq, M., & Rashid, F. (2023) · Springer eBooks · doi:10.1007/978-981-99-2193-5_9 · Cited by 2
He, H., Hao, D., Tian, L., Zhu, C., Guo, L., Zhang, K., & Zhu, S. (2024) · European Journal of Translational Myology · doi:10.4081/ejtm.2024.12678 · Cited by 1
MicroRNAs and Cardiovascular Diseases
Henderson, J. M., Farina, F. M., & Santovito, D. (2024) · Epigenetics and human health · doi:10.1007/978-3-031-64788-8_9 · Cited by 1
Modern Transcriptomics and Small RNA Diversity
Vickers, K. C. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-799961-6.00002-0 · Cited by 1
Martínez‐González, J. (2011) · Clínica e Investigación en Arteriosclerosis · doi:10.1016/j.arteri.2011.06.007 · Cited by 1
MicroRNA-33: natureʼs own RNAi controls cholesterol homeostasis
Gelissen, I. C., & Jessup, W. (2010) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e32833e4eea · Cited by 1
MicroRNAs in the Pathogenesis, Diagnosis, and Treatment of Liver Disease
Madison, B., & Kerr, T. A. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-800553-8.00004-4 · Cited by 1
Therapies Targeting HDLc Levels and HDL Function
Vitali, C., & Cuchel, M. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-812513-7.00012-4 · Cited by 1
Interplay between Cholesterol, Srebps, Microrna-33 in Dyslipidemia
Kandhro, A. H. (2016) · INTERNATIONAL JOURNAL OF ENDORSING HEALTH SCIENCE RESEARCH (IJEHSR) · doi:10.29052/ijehsr.v4.i2.2016.05-10 · Cited by 1
Role of microRNAs in cardiovascular diseases and their therapeutic implications
Kumar, S., & Suryawanshi, H. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-815669-8.00009-9 · Cited by 1
Non-coding RNAs Related to Lipid Metabolism and Non-alcoholic Fatty Liver Disease
Holvoet, P. (2021) · Springer eBooks · doi:10.1007/978-3-030-68844-8_4 · Cited by 1
Yu, C., Chen, J., & Ren, J. (2022) · Molecular Biology Reports · doi:10.1007/s11033-022-07503-0 · Cited by 1
Therapeutic Modulation of MicroRNAs
Aigner, A. M., & Dassow, H. (2013) · Wiley eBooks · doi:10.1002/9781118300312.ch39 · Cited by 1
Regazzi, R. (2013) · Wiley eBooks · doi:10.1002/9781118300312.ch30 · Cited by 1
Examining MicroRNAs as Regulators of Hepatic Lipid Homeostasis and Hepatitis C Virus Replication
Singaravelu, R. (2016) · uO Research (University of Ottawa) · doi:10.20381/ruor-5541 · Cited by 1
Wang, S., & Anderson, C. A. (2015) · Atherosclerosis · doi:10.1002/9781118828533.ch33 · Cited by 1
Yang, L., Yang, J., Li, J., Shen, X., Le, Y., Zhou, C., Wang, S., Zhang, S., Xu, D., & Gong, Z. (2021) · Scientific Reports · doi:10.1038/s41598-021-88178-8 · Cited by 1
RetractedABCA1, Tangier Disease, and Lipid Flopping
Zarubica, A., & Chimini, G. (2011) · Wiley eBooks · doi:10.1002/9781118120118.ch17 · Cited by 1
MicroRNAs as Drugs and Drug Targets in Cancer
Ling, H. Y., & Călin, G. A. (2014) · Wiley eBooks · doi:10.1002/9781118501665.ch6
Melaiu, O., Facioni, M. S., Cabiati, M., et al. (2013) · Peptides · doi:10.1016/j.peptides.2013.03.012
MicroRNA Research Reagent Review
Johnson, M. (2012) · Materials and Methods · doi:10.13070/mm.en.2.129
microRNAs, Plasma Lipids, and Cardiovascular Disease
Dávalos, A., & Fernandez-Hernando, C. F. (2010) · Current Cardiovascular Risk Reports · doi:10.1007/s12170-010-0145-1
Sinovas, C. R. (2011) · Clínica e Investigación en Arteriosclerosis · doi:10.1016/j.arteri.2011.10.003
ABCA1, Apoe and apoA-I As Potential Therapeutic Targets for Treating Alzheimer’s Disease
Namjoshi, D., Stukas, S. K., & Wellington, C. L. (2011) · Neurodegenerative Disease Management · doi:10.2217/nmt.11.23
Physiological effects of Type 2 diabetes on mRNA processing and gene expression
Morrison, F. S., Johnstone, K. A., & Harries, L. W. (2011) · Expert Review of Endocrinology & Metabolism · doi:10.1586/eem.10.76
Evaluation of MicroRNA Mechanisms Involved in Collagen Matrix Therapy for Myocardial Infarction
Chiarella-Redfern, H. (2015) · uO Research (University of Ottawa) · doi:10.20381/ruor-5016
Computational methods for RNA-RNA interaction prediction
Salari, R. (2010) · Summit (Simon Fraser University)
microRNA Regulation of Endotoxin Tolerance
Seeley, J. J. (2014) · doi:10.7916/d8hx19v9
A Computational Pipeline to Identify New Potential Regulatory Motifs in Melanoma Progression
Politano, G. M. M., Benso, A., Carlo, S. D., et al. (2015) · Communications in computer and information science · doi:10.1007/978-3-319-26129-4_12
Teupser, D., & München, Z. (2013)
KLF2 Upregulates miR-483 to Modulate Endothelial Function
Woo, B. J. (2013) · eScholarship (California Digital Library)
In vitro veritas: 90 years of biochemistry at Saint Louis University.
Eissenberg, J. C., & Di Cera, E. (2013) · Europe PMC (PubMed Central)
Role of microRNA-21 in atherogenesis.
Hamed-Berair, R. E. (2016) · ThinkIR: The University of Louisville's Institutional Repository (University of Louisville) · doi:10.18297/etd/2431
Modulation of mir-33 and mir-122 by dietary polyphenols
Baselga‐Escudero, L. (2013) · TDX (Tesis Doctorals en Xarxa)
Role of microRNA-709 in murine liver
Surendran, S. (2014) · IUScholarWorks (Indiana University) · doi:10.7912/c2/1957
The role of O-GlcNAcase during heart failure.
Dassanayaka, S. (2016) · doi:10.18297/etd/2493
Expresión de PPAR-γ y miR-27 en el tejido adiposo de pacientes obesos
Triana, J. L. T. (2015) · doi:10.14201/gredos.127896
MicroRNAs in Diabetes and Its Vascular Complications
Shantikumar, S., Rovira‐Llopis, S., Spinetti, G., & Emanueli, C. (2017) · Cardiac and vascular biology · doi:10.1007/978-3-319-52945-5_3
The) regulation of PCSK9 and cholesterol homeostasis by microRNAs
이찬주 (2015) · YUHSpace (Yonsei University Medical Library)
Karataş, Ö. F., & Ittmann, M. (2017) · The European Research Journal · doi:10.18621/eurj.341363
de Oliveira, G. B. (2017) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.11.2017.tde-26072017-103507
Davis, R. V. N. (2017) · Library, Museums and Press - UDSpace (University of Delaware) · doi:10.58088/wy2h-at19
Martinelli, A. E. M. (2017) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.5.2017.tde-07082017-084252
Mechanisms of Oligonucleotide Actions
Aartsma-Rus, A. M., Jackson, A. L., & Levin, A. A. (2018) · Wiley eBooks · doi:10.1002/9781119070153.ch1
RNAi-based anti-cancer strategies - targeting the proto-oncogene PIM1 and oncogenic miRNAs
Thomas, M. (2013) · open_UMR Marburg DSpace 10.0 (Philipps-Universität Marburg) · doi:10.17192/z2013.0238
Chu, W. H. (2018) · Adelaide Research & Scholarship (AR&S) (University of Adelaide)
Hoogeveen, R. C. (2018) · Elsevier eBooks · doi:10.1016/b978-0-323-54835-9.00001-6
Top Advances in Functional Genomics and Translational Biology for 2010
Johnson, A. D., & Prakash, S. K. (2011) · Circulation Cardiovascular Genetics · doi:10.1161/circgenetics.111.959502
Cellular cholesterol regulation of HIV-1 trafficking during macrophage-mediated trans infection
DeLucia, D. C. (2018) · D-Scholarship@Pitt (University of Pittsburgh)
尾野, 亘. (2015) · Journal of JCS Cardiologists · doi:10.1253/jjcsc.23.2_196
Ma, C., Zhang, J., Yang, S., Hua, Y., Su, J., Shang, Y., Wang, Z., Feng, K., Zhang, J., Zhang, H., et al. (2020) · Research Square · doi:10.21203/rs.3.rs-50056/v1
Metadata
- Authors
- Najafi-Shoushtari, S. H., Kristo, F., Li, Y., Shioda, T., Cohen, D. E., Gerszten, R. E., & Näär, A. M.
- Affiliations
- Harvard University (US)
- Massachusetts General Hospital (US)
- Brigham and Women's Hospital (US)
- Corresponding author
- Näär, Anders M.
- ORCID
- Venue
- Science
- Published
- 2010-06-18
- Volume
- 328
- Issue
- 5985
- Pages
- 1566-1569
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC3840500
- OpenAlex
- W2102901373
- Semantic Scholar
- 8e1f87e5a8c468d11cb938b52c20c8e6954402ce
- Cited by
- 957
- References
- 31
- Citations by year
- 2026: 20 · 2025: 30 · 2024: 24 · 2023: 47 · 2022: 41 · 2021: 56 · 2020: 50 · 2019: 65 · 2018: 66 · 2017: 59 · 2016: 86 · 2015: 88 · 2014: 85 · 2013: 92 · 2012: 73
- FWCI
- 80.88
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of General Medical Sciences (R01GM071449)
- National Institute of Diabetes and Digestive and Kidney Diseases (R21DK084459, R01 DK48873, P30-DK34854, R01DK056626, R01 DK56626, R37DK048873, P30DK034854, R01DK048873)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
- Keywords
- miR-33, cholesterol homeostasis, ABCA1, reverse cholesterol transport, HDL synthesis, cholesterol efflux, post-transcriptional regulation, antisense oligonucleotides, locked nucleic acid, cholesterol biosynthesis, cardiometabolic disease
- MeSH terms
- Animals, Cell Line, Cholesterol, Diet, Gene Expression Regulation, Homeostasis, Humans, Introns, Cholesterol, HDL, Liver, Macrophages, Mice, Inbred C57BL, Up-Regulation, Oligonucleotides, Antisense, ATP-Binding Cassette Transporters, 3' Untranslated Regions, RNA Interference, MicroRNAs, Mice, Sterol Regulatory Element Binding Proteins, Sterol Regulatory Element Binding Protein 1, Sterol Regulatory Element Binding Protein 2, ATP Binding Cassette Transporter 1
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
