The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
A Novel miRNA Processing Pathway Independent of Dicer Requires Argonaute2 Catalytic Activity
Open accessAbstract
No Dicer for Me: MicroRNAs (miRNAs) are small noncoding RNAs found in most eukaryotes. Most are processed from primary transcripts in the nucleus by the microprocessor enzyme complex, which includes the nuclease Drosha, with a small number being generated by the messenger RNA splicing machinery. All pre-miRNAs are then exported into the cytoplasm where they are cleaved further by a second nuclease, Dicer, into the mature, functional miRNA. Cifuentes et al. (p. 1694 , published online 6 May), now show that in a Dicer mutant fish at least one miRNA, miR-451, is still formed from pre-miR-451. The processing of pre-miR-451 requires the slicing activity of another protein in the miRNA pathway, Argonaute2. The unusual secondary structure of the pre-miR-451 determines its noncanonical processing pathway, which suggests that other miRNAs might also be processed in this way.
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Cited by
Regulation of microRNA biogenesis
Ha, M., & Kim, V. N. (2014) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3838 · Cited by 5,462
The widespread regulation of microRNA biogenesis, function and decay
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Bartel, D. P. (2018) · Cell · doi:10.1016/j.cell.2018.03.006 · Cited by 3,751
Regulation of microRNA function in animals
Gebert, L. F. R., & MacRae, I. J. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0045-7 · Cited by 2,284
MicroRNA: Biogenesis, Function and Role in Cancer
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Metadata
- Authors
- Cifuentes, D., Xue, H., Taylor, D. W., Patnode, H., Mishima, Y., Cheloufi, S., Ma, E., Mane, S., Hannon, G. J., Lawson, N. D., Wolfe, S. A., & Giraldez, A. J.
- Venue
- Science
- Published
- 2010-06-25
- Volume
- 328
- Issue
- 5986
- Pages
- 1694-1698
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1989015932
- Cited by
- 836
- References
- 29
- FWCI
- 28.54
- Type
- journal article
- Language
- en
- Open access
- green
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- Cifuentes, D., Xue, H., Taylor, D. W., Patnode, H., Mishima, Y., Cheloufi, S., Ma, E., Mane, S., Hannon, G. J., Lawson, N. D., Wolfe, S. A., & Giraldez, A. J. (2010). A Novel miRNA Processing Pathway Independent of Dicer Requires Argonaute2 Catalytic Activity. Science. https://doi.org/10.1126/science.1190809
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