The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Spatial Coupling of mTOR and Autophagy Augments Secretory Phenotypes
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A cellular compartment allows simultaneous protein synthesis and degradation.
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In the citing paper
“Interestingly, OIS is associated with accumulation of autolysosome compartments, where a Rag GTPase-dependent sequestration of mTOR correlates with enhanced autophagosome formation as well as cytokine production (Narita et al. 2011).”
From Cellular senescence and its effector programs (2014) · cites this paper as Narita et al. 2011
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Accordingly, the ULK activity state may thus reflect its role in these processes [780-786].”
From Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 1 (2021) · cites this paper as [782]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“We recently showed that the subcellular localization of autophagy and mTOR might play a key role for the simultaneous activation of anabolic and catabolic processes during senescence (Narita et al. 2011).”
From Cellular senescence and its effector programs (2014) · cites this paper as Narita et al. 2011
In the citing paper
“macro-autophagy (hereafter referred to as autophagy)—a tightly regulated major lysosomal degradation pathway (27–30)—has been implicated in establishing the SASP through the target of rapamycin (TOR) autophagy spatial coupling compartment (TASCC).”
From The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4. (2015) · cites this paper as [32]
In the citing paper
“Our results indicate that autophagy is both a negative and a positive regulator of senescence, resolving apparently contradictory reports in the literature (31–33, 44).”
From The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4. (2015) · cites this paper as [32]
In the citing paper
“Autophagy is dynamically activated during OIS and facilitates the synthesis of interleukin 6 (IL-6) and IL-8, major components of the SASP 58,59 .”
From Inside and out: the activities of senescence in cancer (2014) · cites this paper as [58]
In the citing paper
“The mTOR–autophagy spatial coupling compartment (TASCC), which is close to the nucleus, is highly enriched in mTOR and keeps mTOR away from the autophagy machinery, located away from the TASCC, to avoid its inactivation.”
From Mechanisms and Regulation of Cellular Senescence (2021) · cites this paper as [246]
In the citing paper
“This paradoxical outcome is possible through the spatiotemporal sub-compartmentalization of mTOR and autophagy that allows their simultaneous activation [246].”
From Mechanisms and Regulation of Cellular Senescence (2021) · cites this paper as [246]
In the citing paper
“These amino acids are then used by mTOR to support the increased biosynthetic demand during the acquisition of the OIS phenotype [246].”
From Mechanisms and Regulation of Cellular Senescence (2021) · cites this paper as [246]
In the citing paper
“Conversely, selective autophagy, for instance of GATA4 that accumulates during senescence induction [160], can prevent senescence [160,246].”
From Mechanisms and Regulation of Cellular Senescence (2021) · cites this paper as [246]
In the citing paper
“In the TASCC, mTOR is closely associated with lysosomes/autolysosomes that generate a high flux of recycled amino acids and other metabolites.”
From Mechanisms and Regulation of Cellular Senescence (2021) · cites this paper as [246]
In the citing paper
“TASCCs provide cells with a mechanism for simultaneous activation of anabolic and catabolic processes, which facilitates mTOR-controlled synthesis of secretory proteins with sources of energy or building blocks provided by constitutive autophagy”
From Autophagy in kidney homeostasis and disease (2020) · cites this paper as [53]
In the citing paper
“podocytes form TOR–autophagy spatial coupling compartments (TASCCs), which are distinct cytoplasmic compartments enriched for mTORC1 that include autolysosomes but largely exclude autophagosomes”
From Autophagy in kidney homeostasis and disease (2020) · cites this paper as [53]
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Cites
Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
Li, Y., Jiang, Q. L., Cao, G.-F., Yao, J., & Yan, B. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000373980 · Cited by 16,351
LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing.
Kabeya, Y., Mizushima, N., Ueno, T., Yamamoto, A., Kirisako, T., Noda, T., Kominami, E., Ohsumi, Y., & Yoshimori, T. (2000) · The EMBO Journal · doi:10.1093/emboj/19.21.5720 · Cited by 6,605
TOR signaling in growth and metabolism
Wullschleger, S., Loewith, R., & Hall, M. N. (2006) · Cell · doi:10.1016/j.cell.2006.01.016 · Cited by 5,787
Cui, C., Cui, J., Jin, F., Cui, Y., Li, R., Jiang, X., Tian, Y., Wang, R. C., Jiang, P., & Gao, J. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000479571 · Cited by 5,214
The senescence-associated secretory phenotype: the dark side of tumor suppression
Coppé, J.-P., Desprez, P.-Y., Krtolica, A., & Campisi, J. (2010) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-121808-102144 · Cited by 5,206
Pankiv, S., Clausen, T. H., Lamark, T., Brech, A., Bruun, J.-A., Outzen, H., Øvervatn, A., Bjørkøy, G., & Johansen, T. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m702824200 · Cited by 4,578
Methods in Mammalian Autophagy Research
Mizushima, N., Yoshimori, T., & Levine, B. (2010) · Cell · doi:10.1016/j.cell.2010.01.028 · Cited by 4,497
Regulation mechanisms and signaling pathways of autophagy
He, C., & Klionsky, D. J. (2009) · Annual Review of Genetics · doi:10.1146/annurev-genet-102808-114910 · Cited by 3,609
The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1
Sancak, Y., Peterson, T. R., Shaul, Y. D., Lindquist, R. A., Thoreen, C. C., Bar-Peled, L., & Sabatini, D. M. (2008) · Science · doi:10.1126/science.1157535 · Cited by 2,773
Molecular mechanisms of mTOR-mediated translational control
Ma, X. M., & Blenis, J. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2672 · Cited by 2,558
Flagged first, then by citations
Cited by
Sorted by citations
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Klionsky, D. J., Abdelmohsen, K., Abe, A., Abedin, M. J., Abeliovich, H., Acevedo Arozena, A., Adachi, H., Adams, C. M., Adams, P. D., Adeli, K., et al. (2016) · Autophagy · doi:10.1080/15548627.2015.1100356 · Cited by 5,894
Ageing as a risk factor for neurodegenerative disease
Hou, Y., Dan, X., Babbar, M., Wei, Y., Hasselbalch, S. G., Croteau, D. L., & Bohr, V. A. (2019) · Nature Reviews Neurology · doi:10.1038/s41582-019-0244-7 · Cited by 3,310
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition) 1
Klionsky, D. J., Abdel-Aziz, A. K., Abdelfatah, S., Abdellatif, M., Abdoli, A., Abel, S., Abeliovich, H., Abildgaard, M. H., Abudu, Y. P., Acevedo-Arozena, A., et al. (2021) · Autophagy · doi:10.1080/15548627.2020.1797280 · Cited by 2,897
Self-citationCellular senescence in ageing: from mechanisms to therapeutic opportunities
Di Micco, R., Krizhanovsky, V., Baker, D., & d’Adda di Fagagna, F. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-00314-w · Cited by 2,277
Autophagy in infection, inflammation and immunity
Deretic, V., Saitoh, T., & Akira, S. (2013) · Nature Reviews Immunology · doi:10.1038/nri3532 · Cited by 1,919
Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype
Kumari, R., & Jat, P. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.645593 · Cited by 1,622
Autophagy in major human diseases
Klionsky, D. J., Petroni, G., Amaravadi, R. K., Baehrecke, E. H., Ballabio, A., Boya, P., Bravo‐San Pedro, J. M., Cadwell, K., Cecconi, F., Choi, A. M. K., et al. (2021) · The EMBO Journal · doi:10.15252/embj.2021108863 · Cited by 1,585
Autophagy and autophagy-related pathways in cancer
Debnath, J., Gammoh, N., & Ryan, K. M. (2023) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-023-00585-z · Cited by 1,506
Autophagy maintains stemness by preventing senescence
García-Prat, L., Martínez-Vicente, M., Perdiguero, E., Ortet, L., Rodríguez-Ubreva, J., Rebollo, E., Ruiz-Bonilla, V., Gutarra, S., Ballestar, E., Serrano, A. L., et al. (2016) · Nature · doi:10.1038/nature16187 · Cited by 1,355
Senescence and aging: Causes, consequences, and therapeutic avenues
McHugh, D., & Gil, J. (2018) · Journal of Cell Biology · doi:10.1083/jcb.201708092 · Cited by 1,233
Mechanisms and functions of cellular senescence
Herranz, N., & Gil, J. (2018) · Journal of Clinical Investigation · doi:10.1172/jci95148 · Cited by 1,232
Emerging regulation and functions of autophagy
Boya, P., Reggiori, F., & Codogno, P. (2013) · Nature Cell Biology · doi:10.1038/ncb2788 · Cited by 1,216
Autophagy: Regulator of cell death
Liu, S., Yao, S., Yang, H., Liu, S., & Wang, Y. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-06154-8 · Cited by 1,293
Senescence and the SASP: many therapeutic avenues
Birch, J., & Gil, J. (2020) · Genes & Development · doi:10.1101/gad.343129.120 · Cited by 1,177
“Sen- escent cells can communicate via direct cell-cell contact (Nelson et al. 2012; Hoare et al. 2016), cell fusion (Chuprin et al. 2013), through the formation of cytoplasmic bridges (Biran et al. 2017), by extracellular vesicle (EV) signaling (Takasugi et al. 2017), and through the SASP.”
BackgroundAutophagy at the crossroads of catabolism and anabolism
Kaur, J., & Debnath, J. (2015) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm4024 · Cited by 1,036
The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4.
Kang, C., Xu, Q., Martin, T. D., Li, M. Z., Demaria, M., Aron, L., Lu, T., Yankner, B. A., Campisi, J., & Elledge, S. J. (2015) · Science · doi:10.1126/science.aaa5612 · Cited by 982
Cellular senescence and its effector programs
Salama, R., Sadaie, M., Hoare, M., & Narita, M. (2014) · Genes & Development · doi:10.1101/gad.235184.113 · Cited by 855
Self-citationRegulation of innate immune cell function by mTOR
Weichhart, T., Hengstschläger, M., & Linke, M. (2015) · Nature reviews. Immunology · doi:10.1038/nri3901 · Cited by 864
Transcriptional control of autophagy-lysosome function drives pancreatic cancer metabolism
Perera, R. M., Stoykova, S., Nicolay, B. N., Ross, K. N., Fitamant, J., Boukhali, M., Lengrand, J., Deshpande, V., Selig, M. K., Ferrone, C. R., et al. (2015) · Nature · doi:10.1038/nature14587 · Cited by 799
mTOR regulates MAPKAPK2 translation to control the senescence-associated secretory phenotype
Herranz, N., Gallage, S., Mellone, M., Wuestefeld, T., Klotz, S., Hanley, C. J., Raguz, S., Acosta, J. C., Innes, A. J., Banito, A., et al. (2015) · Nature Cell Biology · doi:10.1038/ncb3225 · Cited by 788
Salminen, A., Kauppinen, A., & Kaarniranta, K. (2012) · Cellular Signalling · doi:10.1016/j.cellsig.2011.12.006 · Cited by 763
The dynamic nature of senescence in cancer
Lee, S., & Schmitt, C. A. (2019) · Nature Cell Biology · doi:10.1038/s41556-018-0249-2 · Cited by 588
The dynamic nature of autophagy in cancerPreprint
Kimmelman, A. C. (2011) · Genes & Development · doi:10.1101/gad.17558811 · Cited by 599
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Ivanov, A., Pawlikowski, J., Manoharan, I., van Tuyn, J., Nelson, D. M., Rai, T. S., Shah, P. P., Hewitt, G., Korolchuk, V. I., Passos, J. F., et al. (2013) · Journal of Cell Biology · doi:10.1083/jcb.201212110 · Cited by 539
Cell Biology and Pathology of Podocytes
Greka, A., & Mundel, P. H. (2011) · Annual Review of Physiology · doi:10.1146/annurev-physiol-020911-153238 · Cited by 530
Ponpuak, M., Mandell, M. A., Kimura, T., Chauhan, S., Cleyrat, C., & Deretic, V. P. (2015) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2015.04.016 · Cited by 527
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Tang, C., Livingston, M. J., Liu, Z., & Dong, Z. (2020) · Nature Reviews Nephrology · doi:10.1038/s41581-020-0309-2 · Cited by 496
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Xu, C., Wang, L., Fozouni, P., Evjen, G., Chandra, V., Jiang, J., Lu, C., Nicastri, M. C., Bretz, C. L., Winkler, J. D., et al. (2020) · Nature Cell Biology · doi:10.1038/s41556-020-00579-5 · Cited by 478
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Self-citationRegulation of TFEB and V‐ATPases by mTORC1
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A systems study reveals concurrent activation of AMPK and mTOR by amino acids
Dalle Pezze, P., Ruf, S., Sonntag, A. G., Langelaar-Makkinje, M., Hall, P., Heberle, A. M., Razquin Navas, P., van Eunen, K., Tölle, R. C., Schwarz, J. J., et al. (2016) · Nature Communications · doi:10.1038/ncomms13254 · Cited by 148
From Ancient Pathways to Aging Cells—Connecting Metabolism and Cellular Senescence
Wiley, C. D., & Campisi, J. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.05.010 · Cited by 440
Amino acids and mTORC1: from lysosomes to disease
Efeyan, A., Zoncu, R., & Sabatini, D. M. (2012) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2012.05.007 · Cited by 436
mTOR as a central regulator of lifespan and aging
Papadopoli, D. J., Boulay, K., Kazak, L., Pollak, M., Mallette, F. A., Topisirović, I., & Hulea, L. (2019) · F1000Research · doi:10.12688/f1000research.17196.1 · Cited by 447
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Korolchuk, V. I., Miwa, S., Carroll, B., & von Zglinicki, T. (2017) · EBioMedicine · doi:10.1016/j.ebiom.2017.03.020 · Cited by 409
“Knockdown of the essential autophagy genes Atg5 and Atg7 was found to decrease SASP and bypass senescence (Narita et al., 2011; Young et al., 2009).”
BackgroundResultInfluentialMechanisms and Regulation of Cellular Senescence
Roger, L., Tomas, F., & Gire, V. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222313173 · Cited by 395
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Lotz, M., & Loeser, R. F. (2012) · Bone · doi:10.1016/j.bone.2012.03.023 · Cited by 393
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Zhang, J., Rane, G., Dai, X., Shanmugam, M. K., Arfuso, F., Samy, R. P., Lai, M. K. P., Kappei, D., Kumar, A. P., & Sethi, G. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2015.11.006 · Cited by 396
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Aoki, M., & Fujishita, T. (2017) · Current topics in microbiology and immunology · doi:10.1007/82_2017_6 · Cited by 355
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Muñoz‐Espín, D., Rovira, M., Galiana, I., Giménez, C., Lozano‐Torres, B., Paez‐Ribes, M., Llanos, S., Chaib, S., Muñoz‐Martín, M., Ucero, A. C., et al. (2018) · EMBO Molecular Medicine · doi:10.15252/emmm.201809355 · Cited by 339
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Sadaie, M., Salama, R., Carroll, T., Tomimatsu, K., Chandra, T., Young, A. R. J., Narita, M., Pérez-Mancera, P. A., Bennett, D. C., Chong, H., et al. (2013) · Genes & Development · doi:10.1101/gad.217281.113 · Cited by 323
Self-citationWatanabe, S., Kawamoto, S., Ohtani, N., & Hara, E. (2017) · Cancer Science · doi:10.1111/cas.13184 · Cited by 321
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“In turn, mTORC1 (mTOR Complex 1) promotes the utilization of these metabolites for the synthesis of the SASP components (Narita et al., 2011).”
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Livingston, M. J., Shu, S., Fan, Y., Li, Z., Jiao, Q., Yin, X., Venkatachalam, M. A., & Dong, Z. (2022) · Autophagy · doi:10.1080/15548627.2022.2072054 · Cited by 235
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Liu, F., Fang, F., Yuan, H., Yang, D., Chen, Y., Williams, L., Goldstein, S. A., Krebsbach, P. H., & Guan, J. (2013) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.1971 · Cited by 228
Arora, M. (2013) · Materials and Methods · doi:10.13070/mm.en.3.175 · Cited by 247
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Nilsson, P., & Saido, T. C. (2014) · BioEssays · doi:10.1002/bies.201400002 · Cited by 206
New, J., Arnold, L., Ananth, M., Alvi, S. A., Thornton, M. M., Werner, L. R., Tawfik, O. W., Dai, H. D., Shnayder, Y., Kakarala, K., et al. (2017) · Cancer Research · doi:10.1158/0008-5472.can-17-1077 · Cited by 202
Cellular senescence in cancer: from mechanisms to detection
Ou, H., Hoffmann, R. J., González‐López, C., Doherty, G. J., Korkola, J. E., & Muñoz‐Espín, D. (2020) · Molecular Oncology · doi:10.1002/1878-0261.12807 · Cited by 208
Senescence as a therapeutic target in cancer and age-related diseases
McHugh, D., Durán, I., & Gil, J. (2025) · Nature Reviews Drug Discovery · doi:10.1038/s41573-024-01074-4 · Cited by 197
Gut stem cell aging is driven by mTORC1 via a p38 MAPK-p53 pathway
He, D. N., Wu, H., Xiang, J., Ruan, X., Peng, P., Ruan, Y., Chen, Y., Wang, Y., Yu, Q., Zhang, H., et al. (2020) · Nature Communications · doi:10.1038/s41467-019-13911-x · Cited by 198
Cellular Senescence in Postmitotic Cells: Beyond Growth Arrest
Sapieha, P., & Mallette, F. A. (2018) · Trends in Cell Biology · doi:10.1016/j.tcb.2018.03.003 · Cited by 193
Carroll, B., Nelson, G., Rabanal‐Ruiz, Y., Kucheryavenko, O., Dunhill-Turner, N. A., Chesterman, C. C., Zahari, Q., Zhang, T., Conduit, S. E., Mitchell, C. A., et al. (2017) · The Journal of Cell Biology · doi:10.1083/jcb.201610113 · Cited by 188
Ogrodnik, M., Salmonowicz, H., & Gladyshev, V. N. (2019) · Aging Cell · doi:10.1111/acel.12841 · Cited by 184
Endocytosis and autophagy: Shared machinery for degradation
Lamb, C. A., Dooley, H. C., & Tooze, S. A. (2012) · BioEssays · doi:10.1002/bies.201200130 · Cited by 186
C. Elegans Eats Its Own Intestine to Make Yolk: A Cause of Senescent Polymorbidity
Ezcurra, M., Benedetto, A., Sornda, T., Gilliat, A. F., Au, C., Zhang, Q., van Schelt, S., Petrache, A. L., Wang, H., de la Guardia, Y., et al. (2018) · Current Biology · doi:10.1016/j.cub.2018.06.035 · Cited by 185
Bent, E. H., Gilbert, L. A., & Hemann, M. T. (2016) · Genes & Development · doi:10.1101/gad.284851.116 · Cited by 179
Spatial and Temporal Control of Senescence
Ito, Y., Hoare, M., & Narita, M. (2017) · Trends in Cell Biology · doi:10.1016/j.tcb.2017.07.004 · Cited by 178
Self-citationRegulation of Survival Networks in Senescent Cells: From Mechanisms to Interventions
Soto-Gamez, A., Quax, W. J., & Demaria, M. (2019) · Journal of Molecular Biology · doi:10.1016/j.jmb.2019.05.036 · Cited by 175
Senescence in chronic liver disease: Is the future in aging?
Aravinthan, A. D., & Alexander, G. J. M. (2016) · Journal of Hepatology · doi:10.1016/j.jhep.2016.05.030 · Cited by 174
Inhibition of MTOR Disrupts Autophagic Flux in Podocytes
Cinà, D. P., Onay, T., Paltoo, A., Li, C., Maezawa, Y., De Arteaga, J., Jurisicova, A., & Quaggin, S. E. (2012) · Journal of the American Society of Nephrology · doi:10.1681/asn.2011070690 · Cited by 172
Senescence in Post-Mitotic Cells: A Driver of Aging?
von Zglinicki, T., Wan, T., & Miwa, S. (2021) · Antioxidants & Redox Signaling · doi:10.1089/ars.2020.8048 · Cited by 170
“Social Life” of Senescent Cells: What Is SASP and Why Study It?
Borodkina, A. V., Deryabin, P. I., Giukova, А. А., & Nikolsky, N. N. (2018) · Acta Naturae · doi:10.32607/20758251-2018-10-1-4-14 · Cited by 170
DNA Damage Response and Autophagy: A Meaningful Partnership
Eliopoulos, A. G., Havaki, S., & Gorgoulis, V. G. (2016) · Frontiers in Genetics · doi:10.3389/fgene.2016.00204 · Cited by 169
Cellular Senescence: From Mechanisms to Current Biomarkers and Senotherapies
Lucas, V., Cavadas, C., & Aveleira, C. A. (2023) · Pharmacological Reviews · doi:10.1124/pharmrev.122.000622 · Cited by 172
Autophagy and CancerPreprint
Mah, L. Y., & Ryan, K. M. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a008821 · Cited by 169
Translation is actively regulated during the differentiation of CD8+ effector T cells
Araki, K., Morita, M., Bederman, A., Konieczny, B. T., Kissick, H. T., Sonenberg, N., & Ahmed, R. (2017) · Nature Immunology · doi:10.1038/ni.3795 · Cited by 166
Hepatitis C Virus Upregulates Beclin1 for Induction of Autophagy and Activates mTOR Signaling
Shrivastava, S., Bhanja Chowdhury, J., Steele, R., Ray, R., & Ray, R. B. (2012) · Journal of Virology · doi:10.1128/jvi.00616-12 · Cited by 163
Lysosomes in senescence and aging
Tan, J. X., & Finkel, T. (2023) · EMBO Reports · doi:10.15252/embr.202357265 · Cited by 178
Autophagy in bone: Self-eating to stay in balance
Pierrefite‐Carle, V., Santucci‐Darmanin, S., Breuil, V., Camuzard, O., & Carle, G. F. (2015) · Ageing Research Reviews · doi:10.1016/j.arr.2015.08.004 · Cited by 161
Qi, Z., Yang, W., Xue, B., Chen, T., Lu, X., Zhang, R., Li, Z., Zhao, X., Zhang, Y., Han, F., et al. (2024) · Autophagy · doi:10.1080/15548627.2024.2353548 · Cited by 162
Metadata
- Authors
- Narita, M., Young, A. R. J., Arakawa, S., Samarajiwa, S. A., Nakashima, T., Yoshida, S., Hong, S., Berry, L. S., Reichelt, S., Ferreira, M., Tavaré, S., Inoki, K., Shimizu, S., & Narita, M.
- Affiliations
- Cancer Research UK (GB)
- Tokyo Medical and Dental University (JP)
- University of Cambridge (GB)
- University of Michigan (US)
- Corresponding author
- Narita, Masako
- Young, Andrew R. J.
- Narita, Masashi
- ORCID
- Venue
- Science
- Published
- 2011-05-20
- Volume
- 332
- Issue
- 6032
- Pages
- 966-970
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC3426290
- OpenAlex
- W1965493795
- Cited by
- 594
- References
- 26
- Citations by year
- 2026: 30 · 2025: 26 · 2024: 41 · 2023: 40 · 2022: 52 · 2021: 50 · 2020: 39 · 2019: 38 · 2018: 36 · 2017: 28 · 2016: 37 · 2015: 31 · 2014: 36 · 2013: 44 · 2012: 45
- FWCI
- 35.04
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (DK083491)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Keywords
- mTOR, autophagy, spatial coupling, Golgi apparatus, lysosomes, Ras-induced senescence, Rag GTPases, amino acid signaling, protein secretion, interleukin-6, interleukin-8, macrophage differentiation, glomerular podocytes, protein turnover
- MeSH terms
- Amino Acids, Animals, Autophagy, Cell Line, Cytoplasm, Golgi Apparatus, Humans, Lysosomes, Phagosomes, Phenotype, Proteins, Genes, ras, Protein Biosynthesis, Vacuoles, Nocodazole, Interleukin-6, Interleukin-8, Cellular Senescence, Endoplasmic Reticulum, Rough, HL-60 Cells, Monomeric GTP-Binding Proteins, trans-Golgi Network, Cytoplasmic Vesicles, Podocytes, Mice, TOR Serine-Threonine Kinases
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