BRCA1 tumor suppression depends on BRCT phosphoprotein binding, but not its E3 ligase activity
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The properties of breast cancer susceptibility protein required for tumor suppression have been explored.
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Mice carrying a BRCA1 BRCT mutant defective in phosphoprotein recognition are prone to tumors, indicating that BRCT phosphoprotein recognition is required for BRCA1 tumor suppression.
“Mice carrying a BRCT mutant of BRCA1 defective in recognition of phosphorylated proteins are prone to tumor development indicating that BRCT phosphoprotein recognition is required for BRCA1 tumor suppression (Shakya et al., 2011).”
From The BRCA1-Interacting Protein Abraxas Is Required for Genomic Stability and Tumor Suppression (2014) · cites this paper as Shakya et al., 2011
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- Authors
- Shakya, R., Reid, L. J., Reczek, C. R., Cole, F., Egli, D., Lin, C.-S., deRooij, D. G., Hirsch, S., Ravi, K., Hicks, J. B., Szabolcs, M., Jasin, M., Baer, R., & Ludwig, T.
- Affiliations
- Columbia University (US)
- Memorial Sloan Kettering Cancer Center (US)
- New York Stem Cell Foundation (US)
- Amsterdam University Medical Centers (NL)
- Cold Spring Harbor Laboratory (US)
- Herbert Irving Comprehensive Cancer Center (US)
- Corresponding author
- Shakya, Reena
- Reid, Latarsha J.
- Baer, Richard
- Ludwig, Thomas
- ORCID
- Venue
- Science
- Published
- 2011-10-28
- Volume
- 334
- Issue
- 6055
- Pages
- 525-528
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC3904783
- OpenAlex
- W2000636252
- Cited by
- 244
- References
- 28
- Citations by year
- 2026: 7 · 2025: 7 · 2024: 7 · 2023: 10 · 2022: 12 · 2021: 14 · 2020: 19 · 2019: 11 · 2018: 17 · 2017: 15 · 2016: 25 · 2015: 20 · 2014: 20 · 2013: 22 · 2012: 35
- FWCI
- 15.74
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Cold Spring Harbor Laboratory Institutional Repository (Cold Spring Harbor Laboratory) (acceptedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Pure Amsterdam UMC (submittedVersion)
- Funders
- National Cancer Institute (P01CA097403, R01CA137023, T32CA009503, F31CA132626)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (F32HD051392, R01HD040916)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › BRCA gene mutations in cancer
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Keywords
- BRCA1, tumor suppression, BRCT domain, E3 ubiquitin ligase activity, germline mutations, hereditary breast cancer, ovarian cancer, genetically engineered mouse models, ubiquitination
- MeSH terms
- Animals, Cells, Cultured, Disease Models, Animal, Ligands, Mammary Neoplasms, Experimental, Pancreatic Neoplasms, Phosphoproteins, Protein Binding, BRCA1 Protein, Genes, BRCA1, Tumor Suppressor Proteins, Ubiquitin-Protein Ligases, Mutant Proteins, Basic-Leucine Zipper Transcription Factors, Mice, Embryonic Stem Cells, Protein Interaction Domains and Motifs, RING Finger Domains, Protein Multimerization
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