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Ribosome Profiling Shows That miR-430 Reduces Translation Before Causing mRNA Decay in Zebrafish
Open accessAbstract
Translation Block: MicroRNAs (miRNAs) are small, noncoding RNA genes that are found in the genomes of most eukaryotes, where they play an important role in the regulation of gene expression. Although whether gene activity is repressed by blocking translation of messenger RNA (mRNA) targets, or by promoting their deadenylation and then degradation, has been open to debate. Bazzini et al. (p. 233 , published online 15 March) and Djuranovic et al. (p. 237 ) looked at early points in the repression reaction in the zebrafish embryo or in Drosophila tissue culture cells, respectively, and found that translation was blocked before target mRNAs were significantly deadenylated and degraded. Thus, miRNAs appear to interfere with the initiation step of translation.
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“miRNAs are excised from larger stem-loop-containing transcripts and are subsequently incorporated into argonaute (Ago) proteins. This generates functional entities capable of silencing target transcripts via translational repression and mRNA destabilization (Bazzini et al., 2012; Djuranovic et al., 2012).”
From Transcriptome-wide Discovery of microRNA Binding Sites in Human Brain (2014) · cites this paper as Bazzini et al., 2012
Experimental — accuracy not yet measuredIn the citing paper
“Global measurements indicate that miRNA targeting causes mostly mRNA destabilization, with translational repression comprising a detectable but minor component of the overall repression33–36.”
From Poly(A)-tail profiling reveals an embryonic switch in translational control (2014) · cites this paper as [36]
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“The only known exception is the transient translational repression observed in early zebrafish embryos36.”
From Poly(A)-tail profiling reveals an embryonic switch in translational control (2014) · cites this paper as [36]
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“At 4 hpf miR-430 targeting causes mostly translational repression with very little mRNA destabilization, whereas by 6 hpf the outcome shifts to mostly mRNA destabilization36.”
From Poly(A)-tail profiling reveals an embryonic switch in translational control (2014) · cites this paper as [36]
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Michaud, P., Shah, V. N., Adjibade, P., Houle, F., Huberdeau, M. Q., Rioux, R., Lavoie‐Ouellet, C., Gu, W., Mazrouï, R., & Simard, M. J. (2021) · PLoS Genetics · doi:10.1371/journal.pgen.1009511 · Cited by 7
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InfluentialSelf-citationmiRISC Composition Determines Target Fates in Time and Space
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“…of different subgroups: short time courses after miRNA perturbation but before dead-enylation may lead to more observations of the UD group (30, 31, 56, 57), and long time courses after miRNA perturbation, when mRNA deadenylation and decay show strong effects, might lead to more genes…”
BackgroundInfluentialCritical role of Spatio-Temporally Regulated Maternal RNAs in Zebrafish EmbryogenesisPreprint
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“MicroRNA-dependent mechanisms, which often promote deadenylation is common, with the miR-430 destabilizing hundreds of mRNAs in zebrafish (Bazzini et al., 2012), miR427 acting in Xenopus (Lund et al.”
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Role of MicroRNA Molecules in Colon Cancer Etiology
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“Recent work on miR-430 has shown that translational repression is caused by the disruption of translation initiation, independent of mRNA deadenylation [86].”
BackgroundNoncoding RNAs in Platelet Biology
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“…proteins across multiple species [31–34], recognizing target mRNA via sequence and structural elements encoded in their 3’ untranslated regions (3’ UTRs). micro-RNAs have also emerged as maternal clearance regulators in zebrafish (miR-430), Xenopus (miR-427), and Drosophila (miR-309) [35–38].”
Self-citationmiR-31-mediated local translation at the mitotic spindle is important for early development
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Metadata
- Authors
- Bazzini, A. A., Lee, M. T., & Giraldez, A. J.
- Affiliations
- Yale University (US)
- Department of Genetics, Yale University School of Medicine, New Haven, CT 06510, USA.
- Corresponding author
- Bazzini, Ariel A.
- Lee, Miler T.
- Venue
- Science
- Published
- 2012-04-13
- Volume
- 336
- Issue
- 6078
- Pages
- 233-237
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC3547538
- OpenAlex
- W2026570758
- Cited by
- 709
- References
- 30
- Citations by year
- 2026: 11 · 2025: 22 · 2024: 30 · 2023: 19 · 2022: 31 · 2021: 43 · 2020: 33 · 2019: 34 · 2018: 67 · 2017: 70 · 2016: 59 · 2015: 54 · 2014: 81 · 2013: 97 · 2012: 56
- FWCI
- 30.58
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of General Medical Sciences (R01GM081602, R01GM102251)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (F32HD071697)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Keywords
- miR-430, microRNA, protein synthesis inhibition, mRNA degradation, deadenylation, ribosome profiling, ribosome occupancy, translation initiation, Dicer, zebrafish embryos, embryonic development
- MeSH terms
- Animals, Embryo, Nonmammalian, Peptide Chain Initiation, Translational, Poly A, Ribosomes, RNA, Messenger, Protein Biosynthesis, Zebrafish, Gene Expression Regulation, Developmental, 3' Untranslated Regions, RNA Stability, Zebrafish Proteins, MicroRNAs, Ribonuclease III, Embryonic Development
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