The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Ribosome Profiling Shows That miR-430 Reduces Translation Before Causing mRNA Decay in Zebrafish
Open accessAbstract
Translation Block: MicroRNAs (miRNAs) are small, noncoding RNA genes that are found in the genomes of most eukaryotes, where they play an important role in the regulation of gene expression. Although whether gene activity is repressed by blocking translation of messenger RNA (mRNA) targets, or by promoting their deadenylation and then degradation, has been open to debate. Bazzini et al. (p. 233 , published online 15 March) and Djuranovic et al. (p. 237 ) looked at early points in the repression reaction in the zebrafish embryo or in Drosophila tissue culture cells, respectively, and found that translation was blocked before target mRNAs were significantly deadenylated and degraded. Thus, miRNAs appear to interfere with the initiation step of translation.
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“miRNAs are excised from larger stem-loop-containing transcripts and are subsequently incorporated into argonaute (Ago) proteins. This generates functional entities capable of silencing target transcripts via translational repression and mRNA destabilization (Bazzini et al., 2012; Djuranovic et al., 2012).”
From Transcriptome-wide Discovery of microRNA Binding Sites in Human Brain (2014) · cites this paper as Bazzini et al., 2012
Experimental — accuracy not yet measuredIn the citing paper
“Global measurements indicate that miRNA targeting causes mostly mRNA destabilization, with translational repression comprising a detectable but minor component of the overall repression33–36.”
From Poly(A)-tail profiling reveals an embryonic switch in translational control (2014) · cites this paper as [36]
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“The only known exception is the transient translational repression observed in early zebrafish embryos36.”
From Poly(A)-tail profiling reveals an embryonic switch in translational control (2014) · cites this paper as [36]
In the citing paper
“At 4 hpf miR-430 targeting causes mostly translational repression with very little mRNA destabilization, whereas by 6 hpf the outcome shifts to mostly mRNA destabilization36.”
From Poly(A)-tail profiling reveals an embryonic switch in translational control (2014) · cites this paper as [36]
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Citations
Cites
MicroRNAs: Target Recognition and Regulatory Functions
Bartel, D. P. (2009) · Cell · doi:10.1016/j.cell.2009.01.002 · Cited by 20,068
The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
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Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs
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Mammalian microRNAs predominantly act to decrease target mRNA levels
Guo, H., Ingolia, N. T., Weissman, J. S., & Bartel, D. P. (2010) · Nature · doi:10.1038/nature09267 · Cited by 3,886
Genome-Wide Analysis in Vivo of Translation with Nucleotide Resolution Using Ribosome Profiling
Ingolia, N. T., Ghaemmaghami, S., Newman, J. R. S., & Weissman, J. S. (2009) · Science · doi:10.1126/science.1168978 · Cited by 3,853
The impact of microRNAs on protein output
Baek, D., Villén, J., Shin, C., Camargo, F. D., Gygi, S. P., & Bartel, D. P. (2008) · Nature · doi:10.1038/nature07242 · Cited by 3,592
Regulation of mRNA Translation and Stability by microRNAs
Fabian, M. R., Sonenberg, N., & Filipowicz, W. (2010) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060308-103103 · Cited by 3,214
Gene silencing by microRNAs: contributions of translational repression and mRNA decay
Huntzinger, E., & Izaurralde, E. (2011) · Nature Reviews Genetics · doi:10.1038/nrg2936 · Cited by 2,339
Zebrafish MiR-430 Promotes Deadenylation and Clearance of Maternal mRNAs
Giraldez, A. J., Mishima, Y., Rihel, J., Grocock, R. J., Van Dongen, S., Inoue, K., Enright, A. J., & Schier, A. F. (2006) · Science · doi:10.1126/science.1122689 · Cited by 1,647
Inhibition of Translational Initiation by Let-7 MicroRNA in Human Cells
Pillai, R. S., Bhattacharyya, S. N., Artus-Revel, C. G., Zoller, T., Cougot, N., Basyuk, E. I., Bertrand, É., & Filipowicz, W. (2005) · Science · doi:10.1126/science.1115079 · Cited by 1,489
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Mengardi, C. (2016) · theses.fr (ABES) · doi:10.70675/99113a96zb45cz47efzb5f2z52eb15be3fe5
Terenzi, O. (2019) · theses.fr (ABES) · doi:10.70675/d4ee73eaz5530z4c20z93c0zda3e94eda084
Long, F. N. V. (2019) · theses.fr (ABES) · doi:10.70675/12a8367cz6b6bz4592zbd98zf68b8cd5151d
Leclercq, J. (2022) · theses.fr (ABES) · doi:10.70675/0e2196a4z7dfdz42f6za19fz55c161b9874f
Time-Resolved Proteomic Analysis in Zebrafish Using Bioorthogonal Noncanonical Amino Acid Tagging
Miller, S., Wang, T., Quan, B., Cammidge, T., Chou, T., Prober, D. A., & Tirrell, D. A. (2026) · Journal of Proteome Research · doi:10.1021/acs.jproteome.5c00845
Gupta, A., Struba, A. Z., Madhavan, S., Strayer, E. C., & Beaudoin, J.-D. (2026) · Current Protocols · doi:10.1002/cpz1.70417
“To assess 3’-UTR effects on translation, wild-type, or mutated 3 × miRNA-430 sites (Bazzini et al., 2012) were cloned downstream of the 3 × FLAG-GFP open reading frame.”
Spatiotemporal Control of microRNA –Target Interactions
Le, L. T. T. (2026) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.70053
“In zebrafish embryos, miR-430 decreases ribosome density on target mRNAs after ~2 h, whereas detectable mRNA decay occurs later, around ~4 h (Bazzini et al. 2012; Janas and Novina 2012).”
InfluentialPCBP2 facilitates miR-93-5p-mediated repression of GDF11 in HCC cell lines
Kim, J., Kim, S., Yoon, M., Baek, S. J., & Shin, C. (2026) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2026.103066
“65,66 Furthermore, given the pleiotropic nature of miRNAs, individual miRNAs, including miR-93-5p, bind numerous target mRNAs and regulate their expression post-transcriptionally.”
Molecular Analysis of miRNA Stability and Decay Dynamics by Northern Blot
Eun, K.-H., Jeong, H., & Han, J. (2026) · Methods in molecular biology · doi:10.1007/978-1-0716-5352-4_4
The RNA-binding proteins Ddx6 and Ddx61 support development in mRNA-decay deficient pnrc2 mutants
Gallagher, T. L., Blatnik, M. C., Austin, C. C., Thompson, K. G., Pvirre, D. M., Denniston, R., Morgan, A., Kearse, M. G., & Amacher, S. L. (2026) · Development · doi:10.1242/dev.204954
Metadata
- Authors
- Bazzini, A. A., Lee, M. T., & Giraldez, A. J.
- Affiliations
- Yale University (US)
- Department of Genetics, Yale University School of Medicine, New Haven, CT 06510, USA.
- Corresponding author
- Bazzini, Ariel A.
- Lee, Miler T.
- Venue
- Science
- Published
- 2012-04-13
- Volume
- 336
- Issue
- 6078
- Pages
- 233-237
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC3547538
- OpenAlex
- W2026570758
- Cited by
- 709
- References
- 30
- Citations by year
- 2026: 11 · 2025: 22 · 2024: 30 · 2023: 19 · 2022: 31 · 2021: 43 · 2020: 33 · 2019: 34 · 2018: 67 · 2017: 70 · 2016: 59 · 2015: 54 · 2014: 81 · 2013: 97 · 2012: 56
- FWCI
- 30.58
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of General Medical Sciences (R01GM081602, R01GM102251)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (F32HD071697)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Keywords
- miR-430, microRNA, protein synthesis inhibition, mRNA degradation, deadenylation, ribosome profiling, ribosome occupancy, translation initiation, Dicer, zebrafish embryos, embryonic development
- MeSH terms
- Animals, Embryo, Nonmammalian, Peptide Chain Initiation, Translational, Poly A, Ribosomes, RNA, Messenger, Protein Biosynthesis, Zebrafish, Gene Expression Regulation, Developmental, 3' Untranslated Regions, RNA Stability, Zebrafish Proteins, MicroRNAs, Ribonuclease III, Embryonic Development
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