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The Cellular Basis of GABA B -Mediated Interhemispheric Inhibition
Abstract
Interhemispheric inhibition is thought to mediate cortical rivalry between the two hemispheres through callosal input. The long-lasting form of this inhibition is believed to operate via γ-aminobutyric acid type B (GABA(B)) receptors, but the process is poorly understood at the cellular level. We found that the firing of layer 5 pyramidal neurons in rat somatosensory cortex due to contralateral sensory stimulation was inhibited for hundreds of milliseconds when paired with ipsilateral stimulation. The inhibition acted directly on apical dendrites via layer 1 interneurons but was silent in the absence of pyramidal cell firing, relying on metabotropic inhibition of active dendritic currents recruited during neuronal activity. The results not only reveal the microcircuitry underlying interhemispheric inhibition but also demonstrate the importance of active dendritic properties for cortical output.
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“Thus, RCs may provide supplementary inhibitory control required to balance the potentially higher excitability in human dendrites8 and modulate interactions between long range excitatory connections arriving to layer 1 and backpropagating action potentials suggested to participate in interhemispheric modulation45.”
From Transcriptomic and morphophysiological evidence for a specialized human cortical GABAergic cell type (2018) · cites this paper as [45]
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Metadata
- Authors
- Palmer, L. M., Schulz, J. M., Murphy, S. C., Ledergerber, D., Murayama, M., & Larkum, M. E.
- Affiliations
- University of Bern (CH)
- RIKEN Center for Brain Science (JP)
- Corresponding author
- Larkum, Matthew E.
- ORCID
- Venue
- Science
- Published
- 2012-02-24
- Volume
- 335
- Issue
- 6071
- Pages
- 989-993
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2031248308
- Cited by
- 284
- References
- 34
- Citations by year
- 2026: 9 · 2025: 9 · 2024: 11 · 2023: 14 · 2022: 9 · 2021: 26 · 2020: 35 · 2019: 25 · 2018: 26 · 2017: 24 · 2016: 20 · 2015: 15 · 2014: 21 · 2013: 27 · 2012: 13
- FWCI
- 9.98
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Keywords
- interhemispheric inhibition, GABAB receptors, corpus callosum, layer 5 pyramidal neurons, somatosensory cortex, dendritic inhibition, layer 1 interneurons, paired stimulation, cortical microcircuitry, active dendrites
- MeSH terms
- Action Potentials, Animals, Calcium, Corpus Callosum, Dendrites, Electric Stimulation, Hindlimb, Interneurons, Neural Inhibition, Somatosensory Cortex, Rats, Wistar, Pyramidal Cells, Receptors, GABA-B, Patch-Clamp Techniques, Rats, Cerebrum
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