Cited by 284Neuroscience and Neuropharmacology ResearchNeural dynamics and brain functionVisual perception and processing mechanisms

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The Cellular Basis of GABA B -Mediated Interhemispheric Inhibition

Palmer, Lucy M., Schulz, Jan M., Murphy, Sean C., Ledergerber, Debora, Murayama, Masanori, Larkum, Matthew E.·2012·Science

DOI 10.1126/science.1217276

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Abstract

Interhemispheric inhibition is thought to mediate cortical rivalry between the two hemispheres through callosal input. The long-lasting form of this inhibition is believed to operate via γ-aminobutyric acid type B (GABA(B)) receptors, but the process is poorly understood at the cellular level. We found that the firing of layer 5 pyramidal neurons in rat somatosensory cortex due to contralateral sensory stimulation was inhibited for hundreds of milliseconds when paired with ipsilateral stimulation. The inhibition acted directly on apical dendrites via layer 1 interneurons but was silent in the absence of pyramidal cell firing, relying on metabotropic inhibition of active dendritic currents recruited during neuronal activity. The results not only reveal the microcircuitry underlying interhemispheric inhibition but also demonstrate the importance of active dendritic properties for cortical output.

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Authors: Palmer, L. M., Schulz, J. M., Murphy, S. C., Ledergerber, D., Murayama, M., & Larkum, M. E.
Affiliations: University of Bern (CH)
RIKEN Center for Brain Science (JP)
Corresponding author: Larkum, Matthew E.
ORCID: Palmer, Lucy M.
Schulz, Jan M.
Murphy, Sean C.
Ledergerber, Debora
Murayama, Masanori
Larkum, Matthew E.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2012-02-24
Volume: 335
Issue: 6071
Pages: 989-993
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.1217276
OpenAlex: W2031248308
Cited by: 284
References: 34
Citations by year: 2026: 9 · 2025: 9 · 2024: 11 · 2023: 14 · 2022: 9 · 2021: 26 · 2020: 35 · 2019: 25 · 2018: 26 · 2017: 24 · 2016: 20 · 2015: 15 · 2014: 21 · 2013: 27 · 2012: 13
FWCI: 9.98
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
Keywords: interhemispheric inhibition, GABAB receptors, corpus callosum, layer 5 pyramidal neurons, somatosensory cortex, dendritic inhibition, layer 1 interneurons, paired stimulation, cortical microcircuitry, active dendrites
MeSH terms: Action Potentials, Animals, Calcium, Corpus Callosum, Dendrites, Electric Stimulation, Hindlimb, Interneurons, Neural Inhibition, Somatosensory Cortex, Rats, Wistar, Pyramidal Cells, Receptors, GABA-B, Patch-Clamp Techniques, Rats, Cerebrum

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The Cellular Basis of GABA B -Mediated Interhemispheric Inhibition

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