Cited by 1,464Circadian rhythm and melatoninGenomics and Chromatin DynamicsPlant Molecular Biology Research

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Transcriptional Architecture and Chromatin Landscape of the Core Circadian Clock in Mammals

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Koike, Nobuya, Yoo, Seung-Hee, Huang, Hung-Chung, Kumar, Vivek, Lee, Choogon, Kim, Tae-Kyung, Takahashi, Joseph S.·2012·Science

DOI 10.1126/science.1226339PMC PMC3694775

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Abstract

Transcription Around the Clock: The biological clock that controls daily rhythms in mammalian physiology and behavior is thought to be regulated in large part by transcriptional events (see the Perspective by Doherty and Kay ). Koike et al. (p. 349 ; published online 30 August) produced a comprehensive analysis of these transcriptional events across the entire mouse liver genome over a 24-hour period. Only ∼22% of cycling messenger RNA transcripts were driven by de novo transcription, suggesting that posttranscriptional events also play an important regulatory role in the mammalian clock. Biological timing in organisms can also respond to rhythmic cues from the environment. Morf et al. (p. 379 , published online 23 August) explored how one such cue, cycles in ambient temperature, influence circadian timing in mammalian cells. Cold-inducible RNA–binding protein (CIRP) accumulates when body temperature is low. A systematic search for binding partners of CIRP identified RNA encoding core components of the circadian clock. Loss of CIRP decreased the amplitude of circadian gene expression and cells lacking CIRP adapted more quickly to temperature cycles.

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Authors: Koike, N., Yoo, S.-H., Huang, H.-C., Kumar, V., Lee, C., Kim, T.-K., & Takahashi, J. S.
Affiliations: The University of Texas Southwestern Medical Center (US)
Florida State University (US)
Howard Hughes Medical Institute (US)
Corresponding author: Takahashi, Joseph S.
ORCID: Yoo, Seung-Hee
Kumar, Vivek
Lee, Choogon
Kim, Tae-Kyung
Takahashi, Joseph S.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2012-10-19
Volume: 338
Issue: 6105
Pages: 349-354
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.1226339
PMC: PMC3694775
OpenAlex: W2091531174
Cited by: 1,464
References: 80
Citations by year: 2026: 72 · 2025: 99 · 2024: 93 · 2023: 97 · 2022: 121 · 2021: 112 · 2020: 158 · 2019: 105 · 2018: 109 · 2017: 97 · 2016: 111 · 2015: 102 · 2014: 102 · 2013: 72 · 2012: 13
FWCI: 41.23
Type: journal article
Language: en
Open access: green
europepmc.org
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Open Access System for Information Sharing (Pohang University of Science and Technology) (submittedVersion)
Funders: Howard Hughes Medical Institute
National Institute on Drug Abuse (F32DA024556)
National Institute of Neurological Disorders and Stroke (R01NS053616)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
Keywords: circadian clock, transcriptional feedback loop, clocks, Bmal1, period gene, RNA polymerase II recruitment, chromatin remodeling, transcription factor binding, de novo transcription, post-transcriptional regulation, mouse liver, chromatin state
MeSH terms: Animals, Chromatin, Enhancer Elements, Genetic, Histones, Liver, Male, Mice, Inbred C57BL, RNA Polymerase II, RNA, Messenger, Transcription, Genetic, Transcriptional Activation, Gene Expression Profiling, DNA, Intergenic, Chromatin Assembly and Disassembly, Epigenesis, Genetic, Mice, Genetic Loci, CLOCK Proteins, ARNTL Transcription Factors, Cryptochromes, Period Circadian Proteins, Circadian Clocks

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Transcriptional Architecture and Chromatin Landscape of the Core Circadian Clock in Mammals

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