The DOI matches its Crossref record; 80 of the 80 references it cites were found in a registry or an index.
Transcriptional Architecture and Chromatin Landscape of the Core Circadian Clock in Mammals
Open accessAbstract
Transcription Around the Clock: The biological clock that controls daily rhythms in mammalian physiology and behavior is thought to be regulated in large part by transcriptional events (see the Perspective by Doherty and Kay ). Koike et al. (p. 349 ; published online 30 August) produced a comprehensive analysis of these transcriptional events across the entire mouse liver genome over a 24-hour period. Only ∼22% of cycling messenger RNA transcripts were driven by de novo transcription, suggesting that posttranscriptional events also play an important regulatory role in the mammalian clock. Biological timing in organisms can also respond to rhythmic cues from the environment. Morf et al. (p. 379 , published online 23 August) explored how one such cue, cycles in ambient temperature, influence circadian timing in mammalian cells. Cold-inducible RNA–binding protein (CIRP) accumulates when body temperature is low. A systematic search for binding partners of CIRP identified RNA encoding core components of the circadian clock. Loss of CIRP decreased the amplitude of circadian gene expression and cells lacking CIRP adapted more quickly to temperature cycles.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“In the livers of WT mice, BMAL1/CLOCK transcriptional activity is low at ZT2 and 18 but peaks at ZT6 (Koike et al., 2012)”
From Circadian Homeostasis of Liver Metabolism Suppresses Hepatocarcinogenesis (2016) · cites this paper as Koike et al., 2012
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The Sequence Alignment/Map format and SAMtools
Li, H., Handsaker, B., Wysoker, A., Fennell, T., Ruan, J., Homer, N., Marth, G., Abecasis, G., Durbin, R., & 1000 Genome Project Data Processing Subgroup (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp352 · Cited by 62,041
Ultrafast and memory-efficient alignment of short DNA sequences to the human genome.
Langmead, B., Trapnell, C., Pop, M., & Salzberg, S. L. (2009) · Genome Biology · doi:10.1186/gb-2009-10-3-r25 · Cited by 21,849
Model-based Analysis of ChIP-Seq (MACS)
Zhang, Y., Liu, T., Meyer, C. A., Eeckhoute, J., Johnson, D. S., Bernstein, B. E., Nusbaum, C., Myers, R. M., Brown, M., Li, W., et al. (2008) · Genome Biology · doi:10.1186/gb-2008-9-9-r137 · Cited by 18,386
Heinz, S., Benner, C., Spann, N., Bertolino, E., Lin, Y. C., Laslo, P., Cheng, J. X., Murre, C., Singh, H., & Glass, C. K. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.05.004 · Cited by 13,382
TopHat: discovering splice junctions with RNA-Seq
Trapnell, C., Pachter, L. S., & Salzberg, S. L. (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp120 · Cited by 11,682
The Human Genome Browser at UCSC
Kent, W. J., Sugnet, C. W., Furey, T. S., Roskin, K. M., Pringle, T. H., Zahler, A. M., & Haussler, A. D. (2002) · Genome Research · doi:10.1101/gr.229102 · Cited by 10,400
High-Resolution Profiling of Histone Methylations in the Human Genome
Barski, A., Cuddapah, S., Cui, K., Roh, T.-Y., Schones, D. E., Wang, Z., Wei, G., Chepelev, I., & Zhao, K. (2007) · Cell · doi:10.1016/j.cell.2007.05.009 · Cited by 6,845
Histone H3K27ac separates active from poised enhancers and predicts developmental state
Creyghton, M. P., Cheng, A. W., Welstead, G. G., Kooistra, T., Carey, B. W., Steine, E. J., Hanna, J., Lodato, M. A., Frampton, G. M., Sharp, P. A., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1016071107 · Cited by 4,302
The Role of Chromatin during Transcription
Li, B., Carey, M., & Workman, J. L. (2007) · Cell · doi:10.1016/j.cell.2007.01.015 · Cited by 3,503
Heintzman, N. D., Stuart, R. K., Hon, G., Fu, Y., Ching, C. W., Hawkins, R. D., Barrera, L. O., Van Calcar, S., Qu, C., Ching, K. A., et al. (2007) · Nature Genetics · doi:10.1038/ng1966 · Cited by 3,398
Flagged first, then by citations
Cited by
Sorted by citations
Transcriptional architecture of the mammalian circadian clock
Takahashi, J. S. (2016) · Nature Reviews Genetics · doi:10.1038/nrg.2016.150 · Cited by 2,786
Self-citationA circadian gene expression atlas in mammals: Implications for biology and medicine
Zhang, R., Lahens, N. F., Ballance, H. I., Hughes, M. E., & Hogenesch, J. B. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1408886111 · Cited by 2,304
Post-transcriptional gene regulation by mRNA modifications
Zhao, B. S., Roundtree, I. A., & He, C. (2016) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2016.132 · Cited by 2,469
Molecular architecture of the mammalian circadian clock
Partch, C. L., Green, C. B., & Takahashi, J. S. (2014) · Trends in Cell Biology · doi:10.1016/j.tcb.2013.07.002 · Cited by 1,449
Self-citationMolecular mechanisms and physiological importance of circadian rhythms
Patke, A., Young, M. W., & Axelrod, S. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0179-2 · Cited by 1,388
T cell metabolism drives immunity
Buck, M. D., O’Sullivan, D., & Pearce, E. L. (2015) · The Journal of Experimental Medicine · doi:10.1084/jem.20151159 · Cited by 1,238
Circadian physiology of metabolism
Panda, S. (2016) · Science · doi:10.1126/science.aah4967 · Cited by 1,092
Fasting, Circadian Rhythms, and Time-Restricted Feeding in Healthy Lifespan
Longo, V. D., & Panda, S. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.06.001 · Cited by 1,013
RNA-Methylation-Dependent RNA Processing Controls the Speed of the Circadian Clock
Fustin, J., Doi, M., Yamaguchi, Y., Hayashi, H., Nishimura, S., Yoshida, M., Isagawa, T., Morioka, M. S., Kakeya, H., Manabe, I., et al. (2013) · Cell · doi:10.1016/j.cell.2013.10.026 · Cited by 980
Microbiota Diurnal Rhythmicity Programs Host Transcriptome Oscillations
Thaiss, C. A., Levy, M., Korem, T., Dohnalová, L., Shapiro, H., Jaitin, D. A., David, E., Winter, D. R., Gury-BenAri, M., Tatirovsky, E., et al. (2016) · Cell · doi:10.1016/j.cell.2016.11.003 · Cited by 870
Metabolic Regulation of Gene Expression by Histone Lysine β-Hydroxybutyrylation
Xie, Z., Zhang, D., Chung, D., Tang, Z., Huang, H., Dai, L., Qi, S., Li, J., Colak, G., Chen, Y., et al. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.03.036 · Cited by 744
Self-citationMolecular components of the mammalian circadian clock
Buhr, E. D., & Takahashi, J. S. (2013) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-25950-0_1 · Cited by 738
Self-citationReprogramming of the Circadian Clock by Nutritional Challenge
Eckel‐Mahan, K. L., Patel, V. R., de Mateo, S., Orozco-Solís, R., Ceglia, N., Sahar, S., Dilag-Penilla, S. A., Dyar, K. A., Baldi, P., & Sassone‐Corsi, P. (2013) · Cell · doi:10.1016/j.cell.2013.11.034 · Cited by 732
Time-Restricted Feeding Prevents Obesity and Metabolic Syndrome in Mice Lacking a Circadian Clock
Chaix, A., Lin, T. C., Le, H. D., Chang, M. W., & Panda, S. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.08.004 · Cited by 687
Circadian Clock Proteins and Immunity
Curtis, A. M., Bellet, M. M., Sassone‐Corsi, P., & O'Neill, L. A. J. (2014) · Immunity · doi:10.1016/j.immuni.2014.02.002 · Cited by 661
Circadian time signatures of fitness and disease
Bass, J. T., & Lazar, M. A. (2016) · Science · doi:10.1126/science.aah4965 · Cited by 635
Crosstalk between metabolism and circadian clocks
Reinke, H., & Asher, G. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0096-9 · Cited by 598
Möller-Levet, C. S., Archer, S. N., Bucca, G., Laing, E. E., Slak, A., Kabiljo, R., Lo, J. C. Y., Santhi, N., von Schantz, M., Smith, C. P., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1217154110 · Cited by 576
Genomics of circadian rhythms in health and disease
Rijo‐Ferreira, F., & Takahashi, J. S. (2019) · Genome Medicine · doi:10.1186/s13073-019-0704-0 · Cited by 555
Self-citationInterplay between Metabolism and Epigenetics: A Nuclear Adaptation to Environmental Changes
Etchegaray, J., & Mostoslavsky, R. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.05.029 · Cited by 546
Circadian Mechanisms in Medicine
Allada, R., & Bass, J. (2021) · New England Journal of Medicine · doi:10.1056/nejmra1802337 · Cited by 519
Circadian Homeostasis of Liver Metabolism Suppresses Hepatocarcinogenesis
Kettner, N. M., Voicu, H., Finegold, M. J., Coarfa, C., Sreekumar, A., Putluri, N., Katchy, C. A., Lee, C., Moore, D. D., & Fu, L. (2016) · Cancer Cell · doi:10.1016/j.ccell.2016.10.007 · Cited by 508
“Previous studies have suggested that BMAL1/CLOCK and the PAR-domain basic leucine zipper transcription factor DBP may co-activate Car over a 24 hr period in the liver (Gachon et al., 2006; Koike et al., 2012; Ripperger and Schibler, 2006).”
BackgroundInfluentialSelf-citationHe, B., Nohara, K., Park, N., Park, Y.-S., Guillory, B., Zhao, Z., Garcia, J. M., Koike, N., Lee, C. C., Takahashi, J. S., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.03.007 · Cited by 511
Self-citationCircadian clock genes and the transcriptional architecture of the clock mechanism
Cox, K. H., & Takahashi, J. S. (2019) · Journal of Molecular Endocrinology · doi:10.1530/jme-19-0153 · Cited by 514
Self-citationT H 17 Cell Differentiation Is Regulated by the Circadian Clock
Yu, X., Rollins, D., Ruhn, K. A., Stubblefield, J. J., Green, C. B., Kashiwada, M., Rothman, P. B., Takahashi, J. S., & Hooper, L. V. (2013) · Science · doi:10.1126/science.1243884 · Cited by 451
Self-citationPeek, C. B., Levine, D. C., Cedernaes, J., Taguchi, A., Kobayashi, Y., Tsai, S. J., Bonar, N. A., McNulty, M., Ramsey, K. M., & Bass, J. T. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.09.010 · Cited by 413
Circadian Clocks and Feeding Time Regulate the Oscillations and Levels of Hepatic Triglycerides
Adamovich, Y., Rousso-Noori, L., Zwighaft, Z., Neufeld-Cohen, A., Golik, M., Kraut-Cohen, J., Wang, M., Han, X., & Asher, G. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2013.12.016 · Cited by 410
Hepatic Bmal1 Regulates Rhythmic Mitochondrial Dynamics and Promotes Metabolic Fitness
Jacobi, D., Liu, S., Burkewitz, K., Kory, N., Knudsen, N. H., Alexander, R., Ünlütürk, U., Li, X., Kong, X., Hyde, A. L., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.08.006 · Cited by 419
Self-citationThe emerging link between cancer, metabolism, and circadian rhythms
Masri, S., & Sassone‐Corsi, P. (2018) · Nature Medicine · doi:10.1038/s41591-018-0271-8 · Cited by 418
Time-Restricted Eating to Prevent and Manage Chronic Metabolic Diseases
Chaix, A., Manoogian, E. N. C., Melkani, G. C., & Panda, S. (2019) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-082018-124320 · Cited by 424
Mistimed sleep disrupts circadian regulation of the human transcriptome
Archer, S. N., Laing, E. E., Möller-Levet, C. S., van der Veen, D. R., Bucca, G., Lazar, A. S., Santhi, N., Slak, A., Kabiljo, R., von Schantz, M., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1316335111 · Cited by 386
Robles, M. S., Cox, J., & Mann, M. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004047 · Cited by 383
Pancreatic β cell enhancers regulate rhythmic transcription of genes controlling insulin secretion
Perelis, M., Marcheva, B., Ramsey, K. M., Schipma, M. J., Hutchison, A. L., Taguchi, A., Peek, C. B., Hong, H., Huang, W., Omura, C., et al. (2015) · Science · doi:10.1126/science.aac4250 · Cited by 384
Circadian alignment of early onset caloric restriction promotes longevity in male C57BL/6J mice
Acosta-Rodríguez, V., Rijo-Ferreira, F., Izumo, M., Xu, P., Wight-Carter, M., Green, C. B., & Takahashi, J. S. (2022) · Science · doi:10.1126/science.abk0297 · Cited by 390
Self-citationCircadian System and Glucose Metabolism: Implications for Physiology and Disease
Qian, J., & Scheer, F. A. J. L. (2016) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2016.03.005 · Cited by 370
Medicine in the Fourth Dimension
Cederroth, C. R., Albrecht, U., Bass, J. T., Brown, S. A., Dyhrfjeld‐Johnsen, J., Gachon, F., Green, C. B., Hastings, M. H., Helfrich‐Förster, C., Hogenesch, J. B., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.06.019 · Cited by 374
Self-citationEsnault, C., Stewart, A., Gualdrini, F., East, P., Horswell, S. D., Matthews, N., & Treisman, R. (2014) · Genes & Development · doi:10.1101/gad.239327.114 · Cited by 370
Phosphorylation Is a Central Mechanism for Circadian Control of Metabolism and Physiology
Robles, M. S., Humphrey, S. J., & Mann, M. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.10.004 · Cited by 354
Time-restricted eating for the prevention and management of metabolic diseases
Manoogian, E. N. C., Chow, L. S., Taub, P. R., Laferrère, B., & Panda, S. (2022) · Endocrine Reviews · doi:10.1210/endrev/bnab027 · Cited by 344
The Circadian Protein BMAL1 Regulates Translation in Response to S6K1-Mediated Phosphorylation
Lipton, J. O., Yuan, E. D., Boyle, L. M., Ebrahimi‐Fakhari, D., Kwiatkowski, E. R., Nathan, A., Guettler, T., Davis, F. C., Asara, J. M., & Şahin, M. (2015) · Cell · doi:10.1016/j.cell.2015.04.002 · Cited by 341
Atlas of Circadian Metabolism Reveals System-wide Coordination and Communication between Clocks
Dyar, K. A., Lutter, D., Artati, A., Ceglia, N., Liu, Y., Armenta, D., Jastroch, M., Schneider, S., de Mateo, S., Cervantes, M., et al. (2018) · Cell · doi:10.1016/j.cell.2018.08.042 · Cited by 345
Ballesta, A., Innominato, P. F., Dallmann, R., Rand, D. A. J., & Lévi, F. (2017) · Pharmacological Reviews · doi:10.1124/pr.116.013441 · Cited by 348
MYC and metabolism on the path to cancer
Hsieh, A. L., Walton, Z. E., Altman, B. J., Stine, Z. E., & Dang, C. V. (2015) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2015.08.003 · Cited by 347
Mauvoisin, D., Wang, J., Jouffe, C., Martin, E., Atger, F., Waridel, P., Quadroni, M., Gachon, F., & Naef, F. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1314066111 · Cited by 329
Nascent-Seq reveals novel features of mouse circadian transcriptional regulation
Menet, J. S., Rodriguez, J., Abruzzi, K. C., & Rosbash, M. (2012) · eLife · doi:10.7554/elife.00011 · Cited by 325
Timing of expression of the core clock gene Bmal1 influences its effects on aging and survival
Yang, G., Chen, L., Grant, G. R., Paschos, G. K., Song, W., Musiek, E. S., Lee, V., McLoughlin, S. C., Großer, T., Cotsarelis, G., et al. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aad3305 · Cited by 327
Defining the Independence of the Liver Circadian Clock
Koronowski, K. B., Kinouchi, K., Welz, P.-S., Smith, J. G., Zinna, V. M., Shi, J., Samad, M., Chen, S., Magnan, C. N., Kinchen, J. M., et al. (2019) · Cell · doi:10.1016/j.cell.2019.04.025 · Cited by 320
Gaidatzis, D., Burger, L., Florescu, M., & Stadler, M. B. (2015) · Nature Biotechnology · doi:10.1038/nbt.3269 · Cited by 313
Lane, J. M., Vlasac, I., Anderson, S. G., Kyle, S. D., Dixon, W. G., Bechtold, D. A., Gill, S., Little, M. A., Luik, A., Loudon, A., et al. (2016) · Nature Communications · doi:10.1038/ncomms10889 · Cited by 312
The Genomic Landscape and Pharmacogenomic Interactions of Clock Genes in Cancer Chronotherapy
Ye, Y., Xiang, Y., Ozguc, F. M., Kim, Y.-J., Liu, C., Park, P. K., Hu, Q., Diao, L., Lou, Y., Lin, C., et al. (2018) · Cell Systems · doi:10.1016/j.cels.2018.01.013 · Cited by 312
Self-citationCommunicating clocks shape circadian homeostasis
Koronowski, K. B., & Sassone‐Corsi, P. (2021) · Science · doi:10.1126/science.abd0951 · Cited by 324
Partitioning Circadian Transcription by SIRT6 Leads to Segregated Control of Cellular Metabolism
Masri, S., Rigor, P., Cervantes, M., Ceglia, N., Sebastian, C., Xiao, C., Roqueta-Rivera, M., Deng, C., Osborne, T. F., Mostoslavsky, R., et al. (2014) · Cell · doi:10.1016/j.cell.2014.06.050 · Cited by 292
Core circadian clock genes regulate leukemia stem cells in AML
Puram, R. V., Kowalczyk, M. S., de Boer, C. G., Schneider, R. K., Miller, P. G., McConkey, M., Tothova, Z., Tejero, H., Heckl, D., Järås, M., et al. (2016) · Cell · doi:10.1016/j.cell.2016.03.015 · Cited by 274
Wu, Y., Tang, D., Liu, N., Xiong, W., Huang, H., Li, Y., Ma, Z., Zhao, H., Chen, P., Qi, X., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.09.009 · Cited by 284
Self-citationTargeting Glioblastoma Stem Cells through Disruption of the Circadian Clock
Dong, Z., Zhang, G., Qu, M., Gimple, R. C., Wu, Q., Qiu, Z., Prager, B. C., Wang, X., Kim, L. J. Y., Morton, A. R., et al. (2019) · Cancer Discovery · doi:10.1158/2159-8290.cd-19-0215 · Cited by 293
Self-citationRhythmic Oxygen Levels Reset Circadian Clocks through HIF1α
Adamovich, Y., Ladeuix, B., Golik, M., Koeners, M. P., & Asher, G. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.09.014 · Cited by 283
Circadian Clock Regulation of Hepatic Lipid Metabolism by Modulation of m6A mRNA Methylation
Zhong, X., Yu, J., Frazier, K., Weng, X., Li, Y., Cham, C. M., Dolan, K. T., Zhu, X., Hubert, N., Tao, Y., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.10.068 · Cited by 281
Guidelines for Genome-Scale Analysis of Biological Rhythms
Hughes, M. E., Abruzzi, K. C., Allada, R., Anafi, R. C., Arpat, A. B., Asher, G., Baldi, P., de Bekker, C., Bell‐Pedersen, D., Blau, J., et al. (2017) · Journal of Biological Rhythms · doi:10.1177/0748730417728663 · Cited by 280
Self-citationClocks, cancer, and chronochemotherapy
Sancar, A., & Gelder, R. N. V. (2020) · Science · doi:10.1126/science.abb0738 · Cited by 285
Direct Repression of Evening Genes by CIRCADIAN CLOCK-ASSOCIATED1 in the Arabidopsis Circadian Clock
Kamioka, M., Takao, S., Suzuki, T., Taki, K., Higashiyama, T., Kinoshita, T., & Nakamichi, N. (2016) · The Plant Cell · doi:10.1105/tpc.15.00737 · Cited by 276
Herzog, E. D., Hermanstyne, T. O., Smyllie, N. J., & Hastings, M. H. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a027706 · Cited by 275
Circadian dysfunction induces leptin resistance in mice
Kettner, N. M., Mayo, S. A., Hua, J., Lee, C., Moore, D. D., & Fu, L. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.06.005 · Cited by 260
Self-citationMelatonin feedback on clock genes: a theory involving the proteasome
Vriend, J. P., & Reiter, R. J. (2014) · Journal of Pineal Research · doi:10.1111/jpi.12189 · Cited by 274
Circadian Enhancers Coordinate Multiple Phases of Rhythmic Gene Transcription In Vivo
Fang, B., Everett, L. J., Jager, J., Briggs, E. R., Armour, S. M., Feng, D., Roy, A., Gerhart‐Hines, Z., Sun, Z., & Lazar, M. A. (2014) · Cell · doi:10.1016/j.cell.2014.10.022 · Cited by 269
Genome-wide identification of CCA1 targets uncovers an expanded clock network in Arabidopsis
Nagel, D. H., Doherty, C. J., Pruneda-Paz, J. L., Schmitz, R. J., Ecker, J. R., & Kay, S. A. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1513609112 · Cited by 259
The circadian clock in cancer development and therapy
Fu, L., & Kettner, N. M. (2013) · Progress in Molecular Biology and Translational Science · doi:10.1016/b978-0-12-396971-2.00009-9 · Cited by 251
Vollmers, C., Schmitz, R. J., Nathanson, J. L., Yeo, G. W.-M., Ecker, J. R., & Panda, S. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.11.004 · Cited by 260
Genetic basis of chronotype in humans: insights from three landmark GWAS
Kalmbach, D. A., Schneider, L. D., Cheung, J., Bertrand, S. J., Kariharan, T., Pack, A. I., & Gehrman, P. R. (2017) · Sleep · doi:10.1093/sleep/zsw048 · Cited by 243
Atger, F., Gobet, C., Marquis, J., Martín, E., Wang, J., Weger, B. D., Lefebvre, G. C., Descombes, P., Naef, F., & Gachon, F. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1515308112 · Cited by 254
The forebrain synaptic transcriptome is organized by clocks but its proteome is driven by sleep
Noya, S. B., Colameo, D., Brüning, F., Spinnler, A., Mircsof, D., Opitz, L., Mann, M., Tyagarajan, S. K., Robles, M. S., & Brown, S. A. (2019) · Science · doi:10.1126/science.aav2642 · Cited by 258
CLOCK:BMAL1 is a pioneer-like transcription factorPreprint
Menet, J. S., Pescatore, S., & Rosbash, M. (2014) · Genes & Development · doi:10.1101/gad.228536.113 · Cited by 268
Importance of circadian timing for aging and longevity
Acosta-Rodríguez, V. A., Rijo‐Ferreira, F., Green, C. B., & Takahashi, J. S. (2021) · Nature Communications · doi:10.1038/s41467-021-22922-6 · Cited by 258
Self-citationMacromolecular Assemblies of the Mammalian Circadian Clock
Aryal, R. P., Kwak, P. B., Tamayo, A. G., Gebert, M., Chiu, P., Walz, T., & Weitz, C. J. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.07.017 · Cited by 246
The circadian clock and liver function in health and disease
Mukherji, A., Bailey, S. M., Staels, B., & Baumert, T. F. (2019) · Journal of Hepatology · doi:10.1016/j.jhep.2019.03.020 · Cited by 246
KMT2D Deficiency Impairs Super-Enhancers to Confer a Glycolytic Vulnerability in Lung Cancer
Alam, H., Tang, M., Maitituoheti, M., Dhar, S. S., Kumar, M., Han, C. Y., Ambati, C. R., Amin, S. B., Gu, B., Chen, T.-Y., et al. (2020) · Cancer Cell · doi:10.1016/j.ccell.2020.03.005 · Cited by 243
Ye, R., Selby, C. P., Chiou, Y., Ozkan‐Dagliyan, I., Gaddameedhi, S., & Sancar, A. (2014) · Genes & Development · doi:10.1101/gad.249417.114 · Cited by 255
Circadian timing of metabolism in animal models and humans
Dibner, C., & Schibler, U. (2015) · Journal of Internal Medicine · doi:10.1111/joim.12347 · Cited by 237
Chronopharmacology: New Insights and Therapeutic Implications
Dallmann, R., Brown, S. A., & Gachon, F. (2013) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-011613-135923 · Cited by 259
Circadian rhythms in the absence of the clock gene Bmal1
Ray, S., Valekunja, U. K., Stangherlin, A., Howell, S. A., Snijders, A. P., Damodaran, G., & Reddy, A. B. (2020) · Science · doi:10.1126/science.aaw7365 · Cited by 239
Watanabe, K., Jansen, P. R., Savage, J. E., Nandakumar, P., Wang, X., Agee, M., Aslibekyan, S. W., Auton, A., Bell, R. K., Bryc, K., et al. (2022) · Nature Genetics · doi:10.1038/s41588-022-01124-w · Cited by 240
Honma, S. (2018) · The Journal of Physiological Sciences · doi:10.1007/s12576-018-0597-5 · Cited by 242
Aged Stem Cells Reprogram Their Daily Rhythmic Functions to Adapt to Stress
Solanas, G., Peixoto, F. O., Perdiguero, E., Jardí, M., Ruiz‐Bonilla, V., Datta, D., Symeonidi, A., Castellanos‐Martín, A., Welz, P.-S., Caballero, J. M., et al. (2017) · Cell · doi:10.1016/j.cell.2017.07.035 · Cited by 234
Circadian rhythms of liver physiology and disease: experimental and clinical evidence
Tahara, Y., & Shibata, S. (2016) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2016.8 · Cited by 238
Molecular components of the circadian clock in mammals
Takahashi, J. S. (2015) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.12514 · Cited by 230
Self-citationCell autonomous regulation of herpes and influenza virus infection by the circadian clock
Edgar, R. S., Stangherlin, A., Nagy, A. D., Nicoll, M. P., Efstathiou, S., O'Neill, J. S., & Reddy, A. B. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1601895113 · Cited by 229
Diet-Induced Circadian Enhancer Remodeling Synchronizes Opposing Hepatic Lipid Metabolic Processes
Guan, D., Xiong, Y., Borck, P. C., Jang, C., Doulias, P., Papazyan, R., Fang, B., Jiang, C., Zhang, Y., Briggs, E. R., et al. (2018) · Cell · doi:10.1016/j.cell.2018.06.031 · Cited by 225
Barca‐Mayo, O., Pons‐Espinal, M., Follert, P., Armirotti, A., Berdondini, L., & Tonelli, D. D. P. (2017) · Nature Communications · doi:10.1038/ncomms14336 · Cited by 222
Circadian rhythms in mitochondrial respiration
de Goede, P., Wefers, J., Brombacher, E. C., Schrauwen, P., & Kalsbeek, A. (2018) · Journal of Molecular Endocrinology · doi:10.1530/jme-17-0196 · Cited by 211
Circadian Rhythms, the Molecular Clock, and Skeletal Muscle
Harfmann, B. D., Schroder, E. A., & Esser, K. A. (2015) · Journal of Biological Rhythms · doi:10.1177/0748730414561638 · Cited by 211
Circadian Oscillators: Around the Transcription–Translation Feedback Loop and on to Output
Hurley, J., Loros, J., & Dunlap, J. (2016) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2016.07.009 · Cited by 206
Histone propionylation is a mark of active chromatin
Kebede, A. F., Nieborak, A., Shahidian, L. Z., Gras, S. L., Richter, F. M., Aguilar‐Gómez, D., Baltissen, M. P. A., Mészáros, G., Magliarelli, H. D. F., Taudt, A., et al. (2017) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.3490 · Cited by 215
Circadian actin dynamics drive rhythmic fibroblast mobilization during wound healing
Hoyle, N. P., Seinkmane, E., Putker, M., Feeney, K. A., Krogager, T. P., Chesham, J. E., Bray, L. K., Thomas, J. M., Dunn, K., Blaikley, J., et al. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aal2774 · Cited by 205
mTOR signaling regulates central and peripheral circadian clock function
Ramanathan, C., Kathale, N. D., Liu, D., Lee, C., Freeman, D. A., Hogenesch, J. B., Cao, R., & Liu, A. C. (2018) · PLoS Genetics · doi:10.1371/journal.pgen.1007369 · Cited by 209
Self-citationMartelot, G. L., Canella, D., Symul, L., Migliavacca, E., Gilardi, F., Liechti, R., Martin, O., Harshman, K., Delorenzi, M., Desvergne, B., et al. (2012) · PLoS Biology · doi:10.1371/journal.pbio.1001442 · Cited by 209
Distinct Circadian Signatures in Liver and Gut Clocks Revealed by Ketogenic Diet
Tognini, P., Murakami, M., Liu, Y., Eckel‐Mahan, K. L., Newman, J. C., Verdin, E. M., Baldi, P., & Sassone‐Corsi, P. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.08.015 · Cited by 207
Rev-erbα Dynamically Modulates Chromatin Looping to Control Circadian Gene Transcription
Kim, Y. H., Marhon, S. A., Zhang, Y.-X., Steger, D. J., Won, K.-J., & Lazar, M. (2018) · Science · doi:10.1126/science.aao6891 · Cited by 195
Lananna, B. V., McKee, C. A., King, M. W., Del-Aguila, J. L., Dimitry, J. M., Farias, F. H. G., Nadarajah, C. J., Xiong, D. D., Guo, C., Cammack, A. J., et al. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aax3519 · Cited by 201
Circadian Etiology of Type 2 Diabetes Mellitus
Javeed, N., & Matveyenko, A. V. (2018) · Physiology · doi:10.1152/physiol.00003.2018 · Cited by 219
Tahara, Y., & Shibata, S. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.08.049 · Cited by 198
Extensive Oscillatory Gene Expression during C. elegans Larval Development
Hendriks, G., Gaidatzis, D., Aeschimann, F., & Großhans, H. (2014) · Molecular Cell · doi:10.1016/j.molcel.2013.12.013 · Cited by 193
Metadata
- Authors
- Koike, N., Yoo, S.-H., Huang, H.-C., Kumar, V., Lee, C., Kim, T.-K., & Takahashi, J. S.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Florida State University (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Takahashi, Joseph S.
- Venue
- Science
- Published
- 2012-10-19
- Volume
- 338
- Issue
- 6105
- Pages
- 349-354
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC3694775
- OpenAlex
- W2091531174
- Cited by
- 1,464
- References
- 80
- Citations by year
- 2026: 72 · 2025: 99 · 2024: 93 · 2023: 97 · 2022: 121 · 2021: 112 · 2020: 158 · 2019: 105 · 2018: 109 · 2017: 97 · 2016: 111 · 2015: 102 · 2014: 102 · 2013: 72 · 2012: 13
- FWCI
- 41.23
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Open Access System for Information Sharing (Pohang University of Science and Technology) (submittedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institute on Drug Abuse (F32DA024556)
- National Institute of Neurological Disorders and Stroke (R01NS053616)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
- Keywords
- circadian clock, transcriptional feedback loop, clocks, Bmal1, period gene, RNA polymerase II recruitment, chromatin remodeling, transcription factor binding, de novo transcription, post-transcriptional regulation, mouse liver, chromatin state
- MeSH terms
- Animals, Chromatin, Enhancer Elements, Genetic, Histones, Liver, Male, Mice, Inbred C57BL, RNA Polymerase II, RNA, Messenger, Transcription, Genetic, Transcriptional Activation, Gene Expression Profiling, DNA, Intergenic, Chromatin Assembly and Disassembly, Epigenesis, Genetic, Mice, Genetic Loci, CLOCK Proteins, ARNTL Transcription Factors, Cryptochromes, Period Circadian Proteins, Circadian Clocks
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
