The DOI matches its Crossref record; 80 of the 80 references it cites were found in a registry or an index.
Transcriptional Architecture and Chromatin Landscape of the Core Circadian Clock in Mammals
Open accessAbstract
Transcription Around the Clock: The biological clock that controls daily rhythms in mammalian physiology and behavior is thought to be regulated in large part by transcriptional events (see the Perspective by Doherty and Kay ). Koike et al. (p. 349 ; published online 30 August) produced a comprehensive analysis of these transcriptional events across the entire mouse liver genome over a 24-hour period. Only ∼22% of cycling messenger RNA transcripts were driven by de novo transcription, suggesting that posttranscriptional events also play an important regulatory role in the mammalian clock. Biological timing in organisms can also respond to rhythmic cues from the environment. Morf et al. (p. 379 , published online 23 August) explored how one such cue, cycles in ambient temperature, influence circadian timing in mammalian cells. Cold-inducible RNA–binding protein (CIRP) accumulates when body temperature is low. A systematic search for binding partners of CIRP identified RNA encoding core components of the circadian clock. Loss of CIRP decreased the amplitude of circadian gene expression and cells lacking CIRP adapted more quickly to temperature cycles.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“In the livers of WT mice, BMAL1/CLOCK transcriptional activity is low at ZT2 and 18 but peaks at ZT6 (Koike et al., 2012)”
From Circadian Homeostasis of Liver Metabolism Suppresses Hepatocarcinogenesis (2016) · cites this paper as Koike et al., 2012
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The Sequence Alignment/Map format and SAMtools
Li, H., Handsaker, B., Wysoker, A., Fennell, T., Ruan, J., Homer, N., Marth, G., Abecasis, G., Durbin, R., & 1000 Genome Project Data Processing Subgroup (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp352 · Cited by 62,041
Ultrafast and memory-efficient alignment of short DNA sequences to the human genome.
Langmead, B., Trapnell, C., Pop, M., & Salzberg, S. L. (2009) · Genome Biology · doi:10.1186/gb-2009-10-3-r25 · Cited by 21,849
Model-based Analysis of ChIP-Seq (MACS)
Zhang, Y., Liu, T., Meyer, C. A., Eeckhoute, J., Johnson, D. S., Bernstein, B. E., Nusbaum, C., Myers, R. M., Brown, M., Li, W., et al. (2008) · Genome Biology · doi:10.1186/gb-2008-9-9-r137 · Cited by 18,386
Heinz, S., Benner, C., Spann, N., Bertolino, E., Lin, Y. C., Laslo, P., Cheng, J. X., Murre, C., Singh, H., & Glass, C. K. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.05.004 · Cited by 13,382
TopHat: discovering splice junctions with RNA-Seq
Trapnell, C., Pachter, L. S., & Salzberg, S. L. (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp120 · Cited by 11,682
The Human Genome Browser at UCSC
Kent, W. J., Sugnet, C. W., Furey, T. S., Roskin, K. M., Pringle, T. H., Zahler, A. M., & Haussler, A. D. (2002) · Genome Research · doi:10.1101/gr.229102 · Cited by 10,400
High-Resolution Profiling of Histone Methylations in the Human Genome
Barski, A., Cuddapah, S., Cui, K., Roh, T.-Y., Schones, D. E., Wang, Z., Wei, G., Chepelev, I., & Zhao, K. (2007) · Cell · doi:10.1016/j.cell.2007.05.009 · Cited by 6,845
Histone H3K27ac separates active from poised enhancers and predicts developmental state
Creyghton, M. P., Cheng, A. W., Welstead, G. G., Kooistra, T., Carey, B. W., Steine, E. J., Hanna, J., Lodato, M. A., Frampton, G. M., Sharp, P. A., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1016071107 · Cited by 4,302
The Role of Chromatin during Transcription
Li, B., Carey, M., & Workman, J. L. (2007) · Cell · doi:10.1016/j.cell.2007.01.015 · Cited by 3,503
Heintzman, N. D., Stuart, R. K., Hon, G., Fu, Y., Ching, C. W., Hawkins, R. D., Barrera, L. O., Van Calcar, S., Qu, C., Ching, K. A., et al. (2007) · Nature Genetics · doi:10.1038/ng1966 · Cited by 3,398
Widespread transcription at neuronal activity-regulated enhancers
Kim, T.-K., Hemberg, M., Gray, J. M., Costa, A. M., Bear, D. M., Wu, J., Harmin, D. A., Laptewicz, M., Barbara-Haley, K., Kuersten, S., et al. (2010) · Nature · doi:10.1038/nature09033 · Cited by 2,450
Self-citationYoo, S.-H., Yamazaki, S., Lowrey, P. L., Shimomura, K., Ko, C. H., Buhr, E. D., Siepka, S. M., Hong, H.-K., Oh, W. J., Yoo, O. J., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308709101 · Cited by 2,329
Self-citationCoordinated Transcription of Key Pathways in the Mouse by the Circadian Clock
Panda, S., Antoch, M. P., Miller, B. H., Su, A. I., Schook, A. C., Straume, M., Schultz, P. G., Kay, S. A., Takahashi, J. S., & Hogenesch, J. B. (2002) · Cell · doi:10.1016/s0092-8674(02)00722-5 · Cited by 2,310
Self-citationA unique chromatin signature uncovers early developmental enhancers in humans
Rada-Iglesias, A., Bajpai, R., Swigut, T., Brugmann, S. A., Flynn, R. A., & Wysocka, J. (2011) · Nature · doi:10.1038/nature09692 · Cited by 2,233
Role of the CLOCK Protein in the Mammalian Circadian Mechanism
Gekakis, N., Staknis, D., Nguyen, H. B., Davis, F. C., Wilsbacher, L. D., King, D. P., Takahashi, J. S., & Weitz, C. J. (1998) · Science · doi:10.1126/science.280.5369.1564 · Cited by 2,035
Self-citationA Chromatin Landmark and Transcription Initiation at Most Promoters in Human Cells
Guenther, M. G., Levine, S. S., Boyer, L. A., Jaenisch, R., & Young, R. A. (2007) · Cell · doi:10.1016/j.cell.2007.05.042 · Cited by 2,002
Nascent RNA Sequencing Reveals Widespread Pausing and Divergent Initiation at Human Promoters
Core, L. J., Waterfall, J. J., & Lis, J. T. (2008) · Science · doi:10.1126/science.1162228 · Cited by 1,986
Circadian integration of metabolism and energetics
Bass, J., & Takahashi, J. S. (2010) · Science · doi:10.1126/science.1195027 · Cited by 1,910
Self-citationWebGestalt: an integrated system for exploring gene sets in various biological contexts
Zhang, B., Kirov, S. A., & Snoddy, J. R. (2005) · Nucleic Acids Research · doi:10.1093/nar/gki475 · Cited by 1,803
Mop3 is an essential component of the master circadian pacemaker in mammals.
Bunger, M. K., Wilsbacher, L. D., Moran, S. M., Clendenin, C., Radcliffe, L. A., Hogenesch, J. B., Simon, M. C., Takahashi, J. S., & Bradfield, C. A. (2000) · Cell · doi:10.1016/s0092-8674(00)00205-1 · Cited by 1,621
Self-citationmCRY1 and mCRY2 are essential components of the negative limb of the circadian clock feedback loop
Kume, K., Zylka, M. J., Sriram, S., Shearman, L. P., Weaver, D. R., Jin, X., Maywood, E. S., Hastings, M. H., & Reppert, S. M. (1999) · Cell · doi:10.1016/s0092-8674(00)81014-4 · Cited by 1,617
Extensive and divergent circadian gene expression in liver and heart
Storch, K.-F., Lipan, O., Leykin, I., Viswanathan, N., Davis, F. C., Wong, W. H., & Weitz, C. J. (2002) · Nature · doi:10.1038/nature744 · Cited by 1,509
Positional Cloning of the Mouse Circadian Gene
King, D. P., Zhao, Y., Sangoram, A. M., Wilsbacher, L. D., Tanaka, M., Antoch, M. P., Steeves, T. D. L., Vitaterna, M. H., Kornhauser, J. M., Lowrey, P. L., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80245-7 · Cited by 1,382
Self-citationc-Myc Regulates Transcriptional Pause Release
Rahl, P. B., Lin, C. Y., Seila, A. C., Flynn, R. A., McCuine, S., Burge, C. B., Sharp, P. A., & Young, R. A. (2010) · Cell · doi:10.1016/j.cell.2010.03.030 · Cited by 1,279
Posttranslational Mechanisms Regulate the Mammalian Circadian Clock
Lee, C., Etchegaray, J., Cagampang, F. R. A., Loudon, A. S. I., & Reppert, S. M. (2001) · Cell · doi:10.1016/s0092-8674(01)00610-9 · Cited by 1,174
Self-citationHughes, M. E., Hogenesch, J. B., & Kornacker, K. (2010) · Journal of Biological Rhythms · doi:10.1177/0748730410379711 · Cited by 1,087
Regulation of circadian behaviour and metabolism by REV-ERB-α and REV-ERB-β
Cho, H., Zhao, X., Hatori, M., Yu, R. T., Barish, G. D., Lam, M. T., Chong, L.-W., DiTacchio, L., Atkins, A. R., Glass, C. K., et al. (2012) · Nature · doi:10.1038/nature11048 · Cited by 1,037
A high-resolution map of active promoters in the human genome
Kim, T. H., Barrera, L. O., Zheng, M., Qu, C., Singer, M. A., Richmond, T., Wu, Y., Green, R. D., & Ren, B. (2005) · Nature · doi:10.1038/nature03877 · Cited by 954
Self-citationEnhancer function: new insights into the regulation of tissue-specific gene expression
Ong, C.-T., & Corces, V. G. (2011) · Nature Reviews Genetics · doi:10.1038/nrg2957 · Cited by 929
Circadian Regulator CLOCK Is a Histone Acetyltransferase
Doi, M., Hirayama, J., & Sassone‐Corsi, P. (2006) · Cell · doi:10.1016/j.cell.2006.03.033 · Cited by 910
A transcription factor response element for gene expression during circadian night
Ueda, H. R., Chen, W., Adachi, A. A., Wakamatsu, H., Hayashi, S., Takasugi, T., Nagano, M., Nakahama, K., Suzuki, Y., Sugano, S., et al. (2002) · Nature · doi:10.1038/nature00906 · Cited by 865
Elongation by RNA polymerase II: the short and long of itPreprint
Sims, R. J., Belotserkovskaya, R., & Reinberg, D. (2004) · Genes & Development · doi:10.1101/gad.1235904 · Cited by 709
A circadian rhythm orchestrated by histone deacetylase 3 controls hepatic lipid metabolism
Feng, D., Liu, T., Sun, Z., Bugge, A., Mullican, S. E., Alenghat, T., Liu, X. S., & Lazar, M. A. (2011) · Science · doi:10.1126/science.1198125 · Cited by 701
Harmonics of Circadian Gene Transcription in Mammals
Hughes, M. E., DiTacchio, L., Hayes, K. R., Vollmers, C., Pulivarthy, S. R., Baggs, J. E., Panda, S., & Hogenesch, J. B. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000442 · Cited by 689
Rhythmic histone acetylation underlies transcription in the mammalian circadian clock
Etchegaray, J.-P., Lee, C., Wade, P. A., & Reppert, S. M. (2003) · Nature · doi:10.1038/nature01314 · Cited by 679
Self-citationLight-Independent Role of CRY1 and CRY2 in the Mammalian Circadian Clock
Griffin, E. A., Staknis, D., & Weitz, C. J. (1999) · Science · doi:10.1126/science.286.5440.768 · Cited by 646
Ripperger, J. A., & Schibler, U. (2006) · Nature Genetics · doi:10.1038/ng1738 · Cited by 604
Genetics of Circadian Rhythms in Mammalian Model Organisms
Lowrey, P. L., & Takahashi, J. S. (2011) · Advances in genetics · doi:10.1016/b978-0-12-387690-4.00006-4 · Cited by 601
Self-citationCryptochromes mediate rhythmic repression of the glucocorticoid receptor
Lamia, K. A., Papp, S. J., Yu, R. T., Barish, G. D., Uhlenhaut, N. H., Jonker, J. W., Downes, M., & Evans, R. M. (2011) · Nature · doi:10.1038/nature10700 · Cited by 590
Defining mechanisms that regulate RNA polymerase II transcription in vivo
Fuda, N. J., Ardehali, M. B., & Lis, J. T. (2009) · Nature · doi:10.1038/nature08449 · Cited by 576
NPAS2: an analog of clock operative in the mammalian forebrain
Reick, M., Garcia, J. A., Dudley, C., & McKnight, S. L. (2001) · Science · doi:10.1126/science.1060699 · Cited by 572
Siepka, S. M., Yoo, S. H., Park, J., Song, W., Kumar, V., Hu, Y., Lee, C., & Takahashi, J. S. (2007) · Cell · doi:10.1016/j.cell.2007.04.030 · Cited by 545
Self-citationDeconstructing repression: evolving models of co-repressor action
Perissi, V., Jepsen, K., Glass, C. K., & Rosenfeld, M. G. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2736 · Cited by 532
Rev-erbα and Rev-erbβ coordinately protect the circadian clock and normal metabolic functionPreprint
Bugge, A. K., Feng, D., Everett, L. J., Briggs, E. R., Mullican, S. E., Wang, F., Jager, J., & Lazar, M. A. (2012) · Genes & Development · doi:10.1101/gad.186858.112 · Cited by 514
Gachon, F., Fleury-Olela, F., Schaad, O., Descombes, P., & Schibler, U. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.04.015 · Cited by 513
Busino, L., Bassermann, F. C., Maiolica, A., Lee, C., Nolan, P. M., Godinho, S. I. H., Draetta, G. F., & Pagano, M. (2007) · Science · doi:10.1126/science.1141194 · Cited by 510
Self-citationRey, G., Cesbron, F., Rougemont, J., Reinke, H., Brunner, M., & Naef, F. (2011) · PLoS Biology · doi:10.1371/journal.pbio.1000595 · Cited by 490
A Genome-wide RNAi Screen for Modifiers of the Circadian Clock in Human Cells
Zhang, E. E., Liu, A. C., Hirota, T., Miraglia, L. J., Welch, G. L., Pongsawakul, P. Y., Liu, X., Atwood, A., Huss, J. W., Janes, J. O., et al. (2009) · Cell · doi:10.1016/j.cell.2009.08.031 · Cited by 437
A Molecular Mechanism for Circadian Clock Negative Feedback
Duong, H. A., Robles, M. S., Knutti, D., & Weitz, C. J. (2011) · Science · doi:10.1126/science.1196766 · Cited by 375
Schmutz, I., Ripperger, J. A., Baeriswyl-Aebischer, S., & Albrecht, U. (2010) · Genes & Development · doi:10.1101/gad.564110 · Cited by 361
Ameur, A., Zaghlool, A., Halvardson, J., Wetterbom, A., Gyllensten, U., Cavelier, L., & Feuk, L. (2011) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2143 · Cited by 323
Transcribing RNA Polymerase II Is Phosphorylated at CTD Residue Serine-7
Chapman, R. D., Heidemann, M., Albert, T., Mailhammer, R., Flatley, A., Meisterernst, M., Kremmer, E., & Eick, D. (2007) · Science · doi:10.1126/science.1145977 · Cited by 323
The histone methyltransferase MLL1 permits the oscillation of circadian gene expression
Katada, S., & Sassone‐Corsi, P. (2010) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1961 · Cited by 302
Shirogane, T., Jin, J., Cambronne, X. A., & Harper, J. W. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m502862200 · Cited by 296
Clocks, metabolism, and the epigenome
Feng, D., & Lazar, M. A. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.06.026 · Cited by 271
Nowak, D. E., Tian, B., & Brasier, A. R. (2005) · BioTechniques · doi:10.2144/000112014 · Cited by 256
Post-transcriptional control of circadian rhythms
Kojima, S., Shingle, D. L., & Green, C. B. (2011) · Journal of Cell Science · doi:10.1242/jcs.065771 · Cited by 247
PeakAnalyzer: Genome-wide annotation of chromatin binding and modification loci
Salmon‐Divon, M., Dvinge, H., Koort, K., & Bertone, P. (2010) · BMC Bioinformatics · doi:10.1186/1471-2105-11-415 · Cited by 244
Association of p300 and CBP with Simian Virus 40 Large T Antigen
Eckner, R., Ludlow, J. W., Lill, N. L., Oldread, E., Arany, Z. P., Modjtahedi, N., DeCaprio, J. A., Livingston, D. M., & Morgan, J. A. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.7.3454 · Cited by 242
Chen, R., Schirmer, A. E., Lee, Y., Lee, H.-M., Kumar, V., Yoo, S. H., Takahashi, J. S., & Lee, C. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.10.012 · Cited by 229
Self-citationYang, R., & Su, Z. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btq189 · Cited by 204
Zeng, P.-Y., Vakoc, C. R., Chen, Z., Blobel, G. A., & Berger, S. L. (2006) · BioTechniques · doi:10.2144/000112297 · Cited by 190
β-TrCP1-Mediated Degradation of PERIOD2 Is Essential for Circadian Dynamics
Reischl, S., Vanselow, K., Westermark, P. O., Thierfelder, N., Maier, B., Herzel, H., & Kramer, A. (2007) · Journal of Biological Rhythms · doi:10.1177/0748730407303926 · Cited by 179
Feedback Regulation of Transcriptional Termination by the Mammalian Circadian Clock PERIOD Complex
Padmanabhan, K., Robles, M. S., Westerling, T., & Weitz, C. J. (2012) · Science · doi:10.1126/science.1221592 · Cited by 173
Direct Association between Mouse PERIOD and CKIε Is Critical for a Functioning Circadian Clock
Lee, C., Weaver, D. R., & Reppert, S. M. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.24.2.584-594.2004 · Cited by 160
Self-citationRole for antisense RNA in regulating circadian clock function in Neurospora crassa
Kramer, C., Loros, J., Dunlap, J., & Crosthwaite, S. K. (2003) · Nature · doi:10.1038/nature01427 · Cited by 159
WebGestalt2: an updated and expanded version of the Web-based Gene Set Analysis Toolkit
Duncan, D. T., Prodduturi, N., & Zhang, B. (2010) · BMC Bioinformatics · doi:10.1186/1471-2105-11-s4-p10 · Cited by 147
Hatanaka, F., Matsubara, C., Myung, J., Yoritaka, T., Kamimura, N., Tsutsumi, S., Kanai, A., Suzuki, Y., Sassone‐Corsi, P., Aburatani, H., et al. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.00781-10 · Cited by 140
Plasticity and specificity of the circadian epigenome
Masri, S., & Sassone‐Corsi, P. (2010) · Nature Neuroscience · doi:10.1038/nn.2668 · Cited by 138
Dynamic PER repression mechanisms in the Drosophila circadian clock: from on-DNA to off-DNAPreprint
Menet, J. S., Abruzzi, K. C., Desrochers, J., Rodriguez, J., & Rosbash, M. (2010) · Genes & Development · doi:10.1101/gad.1883910 · Cited by 136
Understanding systems-level properties: timely stories from the study of clocks
Hogenesch, J. B., & Ueda, H. R. (2011) · Nature Reviews Genetics · doi:10.1038/nrg2972 · Cited by 136
Biochemical Analysis of the Canonical Model for the Mammalian Circadian Clock
Ye, R., Selby, C. P., Öztürk, N., Annayev, Y., & Sancar, A. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.254680 · Cited by 132
Jones, J. C., Phatnani, H. P., Haystead, T., MacDonald, J. A., Alam, S. M., & Greenleaf, A. L. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402218200 · Cited by 130
Coactivation of the CLOCK–BMAL1 complex by CBP mediates resetting of the circadian clock
Lee, Y., Lee, J., Kwon, I., Nakajima, Y., Ohmiya, Y., Son, G. H., Lee, K. H., & Kim, K. (2010) · Journal of Cell Science · doi:10.1242/jcs.070300 · Cited by 116
MSOAR 2.0: Incorporating tandem duplications into ortholog assignment based on genome rearrangement
Shi, G., Zhang, L., & Jiang, T. (2010) · BMC Bioinformatics · doi:10.1186/1471-2105-11-10 · Cited by 105
The role of the transcriptional activator protein DBP in circadian liver gene expression
Wuarin, J., Falvey, E., Lavery, D. J., Talbot, D., Schmidt, E., Ossipow, V., Fonjallaz, P., & Schibler, U. (1992) · Journal of Cell Science · doi:10.1242/jcs.1992.supplement_16.15 · Cited by 96
Stratmann, M., Stadler, F., Tamanini, F., van der Horst, G. T. J., & Ripperger, J. A. (2010) · Genes & Development · doi:10.1101/gad.578810 · Cited by 73
CBP/p300 is a cell type-specific modulator of CLOCK/BMAL1-mediated transcription
Hosoda, H., Kato, K., Asano, H., Ito, M., Kato, H., Iwamoto, T., Suzuki, A. Z., Masushige, S., & Kida, S. (2009) · Molecular Brain · doi:10.1186/1756-6606-2-34 · Cited by 69
Spotlight on post-transcriptional control in the circadian system
Staiger, D., & Köster, T. (2010) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-010-0513-5 · Cited by 50
Towards a General Solution to Drawing Area-Proportional Euler Diagrams
Chow, S., & Ruskey, F. (2005) · Electronic Notes in Theoretical Computer Science · doi:10.1016/j.entcs.2005.02.017 · Cited by 32
Cited by
Sorted by citations
Transcriptional architecture of the mammalian circadian clock
Takahashi, J. S. (2016) · Nature Reviews Genetics · doi:10.1038/nrg.2016.150 · Cited by 2,786
Self-citationA circadian gene expression atlas in mammals: Implications for biology and medicine
Zhang, R., Lahens, N. F., Ballance, H. I., Hughes, M. E., & Hogenesch, J. B. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1408886111 · Cited by 2,304
Post-transcriptional gene regulation by mRNA modifications
Zhao, B. S., Roundtree, I. A., & He, C. (2016) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2016.132 · Cited by 2,469
Molecular architecture of the mammalian circadian clock
Partch, C. L., Green, C. B., & Takahashi, J. S. (2014) · Trends in Cell Biology · doi:10.1016/j.tcb.2013.07.002 · Cited by 1,449
Self-citationMolecular mechanisms and physiological importance of circadian rhythms
Patke, A., Young, M. W., & Axelrod, S. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0179-2 · Cited by 1,388
Metadata
- Authors
- Koike, N., Yoo, S.-H., Huang, H.-C., Kumar, V., Lee, C., Kim, T.-K., & Takahashi, J. S.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Florida State University (US)
- Howard Hughes Medical Institute (US)
- Corresponding author
- Takahashi, Joseph S.
- Venue
- Science
- Published
- 2012-10-19
- Volume
- 338
- Issue
- 6105
- Pages
- 349-354
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC3694775
- OpenAlex
- W2091531174
- Cited by
- 1,464
- References
- 80
- Citations by year
- 2026: 72 · 2025: 99 · 2024: 93 · 2023: 97 · 2022: 121 · 2021: 112 · 2020: 158 · 2019: 105 · 2018: 109 · 2017: 97 · 2016: 111 · 2015: 102 · 2014: 102 · 2013: 72 · 2012: 13
- FWCI
- 41.23
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Open Access System for Information Sharing (Pohang University of Science and Technology) (submittedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institute on Drug Abuse (F32DA024556)
- National Institute of Neurological Disorders and Stroke (R01NS053616)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Molecular Biology Research
- Keywords
- circadian clock, transcriptional feedback loop, clocks, Bmal1, period gene, RNA polymerase II recruitment, chromatin remodeling, transcription factor binding, de novo transcription, post-transcriptional regulation, mouse liver, chromatin state
- MeSH terms
- Animals, Chromatin, Enhancer Elements, Genetic, Histones, Liver, Male, Mice, Inbred C57BL, RNA Polymerase II, RNA, Messenger, Transcription, Genetic, Transcriptional Activation, Gene Expression Profiling, DNA, Intergenic, Chromatin Assembly and Disassembly, Epigenesis, Genetic, Mice, Genetic Loci, CLOCK Proteins, ARNTL Transcription Factors, Cryptochromes, Period Circadian Proteins, Circadian Clocks
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
