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The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.

Structural Basis for Hijacking of Cellular LxxLL Motifs by Papillomavirus E6 Oncoproteins

Zanier, Katia, Charbonnier, Sebastian, Sidi, Abdellahi Ould M'hamed Ould, McEwen, Alastair G., Ferrario, Maria Giovanna, Poussin-Courmontagne, Pierre, Cura, Vincent, Brimer, Nicole, Babah, Khaled Ould, Ansari, Tina, Muller, Isabelle, Stote, Roland H., Cavarelli, Jean, Vande Pol, Scott, Travé, Gilles·2013·Science
DOI 10.1126/science.1229934PMC PMC3899395
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Abstract

Targeting HPV: Papillomaviruses infect mammalian epithelial cells and induce cancers, including cervical cancer in humans. Vaccines against human papillomavirus (HPV) can prevent, but not cure, infection. A key viral oncoprotein, E6, acts by binding and inactivating many host proteins. Zanier et al. (p. 694 ) determined high-resolution crystal structures of bovine papillomavirus bound to a peptide from the focal adhesion protein, paxillin, and of HPV bound to a peptide from the ubiquitin ligase E6AP. The structures show that the peptide binds in a pocket formed by two zinc domains and a linker helix, which represents a promising target for therapeutics.

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Metadata

Authors
Zanier, K., Charbonnier, S., Sidi, A. O. M. O., McEwen, A. G., Ferrario, M. G., Poussin-Courmontagne, P., Cura, V., Brimer, N., Babah, K. O., Ansari, T., Muller, I., Stote, R. H., Cavarelli, J., Vande Pol, S., & Travé, G.
Affiliations
  • Biotechnologie et Signalisation Cellulaire UMR 7242, Ecole Supérieure de Biotechnologie de Strasbourg, Boulevard Sébastien Brant, BP 10413, F-67412 Illkirch, France.
  • Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC)/INSERM U964/CNRS UMR 7104/Université de Strasbourg, 1 rue Laurent Fries, BP 10142, F-67404 Illkirch, France.
  • Department of Pathology, University of Virginia, Post Office Box 800904, Charlottesville, VA 22908–0904, USA.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
2013-02-08
Volume
339
Issue
6120
Pages
694-698
ISSN
  • 0036-8075
  • 1095-9203
DOI
10.1126/science.1229934
PMC
PMC3899395
Cited by
222
References
9
Language
en

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CoChat. (2026). Citation check: Structural Basis for Hijacking of Cellular LxxLL Motifs by Papillomavirus E6 Oncoproteins. https://app.cochat.ai/papers/10.1126/science.1229934
The paper
Zanier, K., Charbonnier, S., Sidi, A. O. M. O., McEwen, A. G., Ferrario, M. G., Poussin-Courmontagne, P., Cura, V., Brimer, N., Babah, K. O., Ansari, T., Muller, I., Stote, R. H., Cavarelli, J., Vande Pol, S., & Travé, G. (2013). Structural Basis for Hijacking of Cellular LxxLL Motifs by Papillomavirus E6 Oncoproteins. Science. https://doi.org/10.1126/science.1229934