Assessing Different E3 Ligases for Small Molecule Induced Protein Ubiquitination and Degradation

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HaloPROTACS: Use of Small Molecule PROTACs to Induce Degradation of HaloTag Fusion Proteins

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Enhanced Protein Degradation by Branched Ubiquitin Chains

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Development of Protacs to Target Cancer-promoting Proteins for Ubiquitination and Degradation

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E3 ubiquitin ligases

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USP30 and parkin homeostatically regulate atypical ubiquitin chains on mitochondria

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Defining roles of PARKIN and ubiquitin phosphorylation by PINK1 in mitochondrial quality control using a ubiquitin replacement strategy

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Proteolysis-Targeting Chimeras: Induced Protein Degradation as a Therapeutic Strategy

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Lysine 27 Ubiquitination of the Mitochondrial Transport Protein Miro Is Dependent on Serine 65 of the Parkin Ubiquitin Ligase

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Crystal Structure of Enhanced Green Fluorescent Protein to 1.35 Å Resolution Reveals Alternative Conformations for Glu222

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Development of a Dehalogenase-Based Protein Fusion Tag Capable of Rapid, Selective and Covalent Attachment to Customizable Ligands

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Probes of ubiquitin E3 ligases enable systematic dissection of parkin activation

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Identification of Hydrophobic Tags for the Degradation of Stabilized Proteins

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Detection of Protein Ubiquitination

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Investigating Protein−Ligand Interactions with a Mutant FKBP Possessing a Designed Specificity Pocket

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Structural and Functional Framework for the Autoinhibition of Nedd4-Family Ubiquitin Ligases

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Chimeric ubiquitin ligases inhibit non-small cell lung cancer via negative modulation of EGFR signaling

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Proteolysis-Targeting Chimeras as Therapeutics and Tools for Biological Discovery

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Targeted protein degradation: expanding the toolbox

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Lessons in PROTAC Design from Selective Degradation with a Promiscuous Warhead

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Differential PROTAC substrate specificity dictated by orientation of recruited E3 ligase

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Development of targeted protein degradation therapeutics

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Targeting the C481S ibrutinib-resistance mutation in Bruton’s tyrosine kinase using PROTAC-mediated degradation

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MDM2-Recruiting PROTAC Offers Superior, Synergistic Antiproliferative Activity via Simultaneous Degradation of BRD4 and Stabilization of p53

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Degradation of proteins by PROTACs and other strategies

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<i>In Silico</i> Modeling of PROTAC-Mediated Ternary Complexes: Validation and Application

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FKBP Ligands—Where We Are and Where to Go?

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Rationalizing PROTAC-Mediated Ternary Complex Formation Using Rosetta

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Modulation of Phosphoprotein Activity by Phosphorylation Targeting Chimeras (PhosTACs)

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Antibody-mediated delivery of chimeric protein degraders which target estrogen receptor alpha (ERα)

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PIKES Analysis Reveals Response to Degraders and Key Regulatory Mechanisms of the CRL4 Network

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A novel cereblon modulator for targeted protein degradation

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Unifying Catalysis Framework to Dissect Proteasomal Degradation Paradigms

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Parkin–phosphoubiquitin complex reveals cryptic ubiquitin-binding site required for RBR ligase activity

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Cereblon vs VHL: Hijacking E3 Ligases Against Each Other Using PROTACsPreprint

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Cereblon versus VHL: Hijacking E3 ligases against each other using PROTACs

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Exploiting ubiquitin ligase cereblon as a target for small-molecule compounds in medicine and chemical biology

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