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Reconstructing the DNA Methylation Maps of the Neandertal and the Denisovan
Open accessAbstract
Methylating the Family Tree: DNA sequences show a high level of similarities between humans and ancient hominids but the degree to which there are differences between methylated regions in their genomes that may explain phenotypic differences is unclear. Gokhman et al. (p. 523 , published online 17 April) demonstrate that naturally degraded methylated cytosines in ancient DNA are converted to thymines and can be used to reconstruct ancient methylomes. The results suggest differences in methylation in bone tissues between modern humans and ancient hominids in a set of genes important for limb development.
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The second category of methods for ancient DNA methylation analysis relies on indirect statistical inference based on patterns of post-mortem DNA decay that are ubiquitous in plants and animals.
“The second category of methods for ancient DNA methylation analysis relies on indirect statistical inference based on patterns of post-mortem DNA decay that are ubiquitous in plants 246 and animals 28,29 .”
From Ancient DNA analysis (2021) · cites this paper as [28]
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Metadata
- Authors
- Gokhman, D., Lavi, E., Prüfer, K., Fraga, M. F., Riancho, J. A., Kelso, J., Pääbo, S., Meshorer, E., & Carmel, L.
- Affiliations
- Hebrew University of Jerusalem (IL)
- Max Planck Institute for Evolutionary Anthropology (DE)
- Consejo Superior de Investigaciones Científicas (ES)
- Department of Medicine, Hospital Universitario Marqués de Valdecilla, University of Cantabria, Instituto de Investigación Marqués de Valdecilla, Santander, Spain.
- Corresponding author
- Meshorer, Eran
- Carmel, Liran
- Venue
- Science
- Published
- 2014-05-02
- Volume
- 344
- Issue
- 6183
- Pages
- 523-527
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2000520482
- Cited by
- 221
- References
- 8
- Citations by year
- 2026: 14 · 2025: 10 · 2024: 12 · 2023: 9 · 2022: 8 · 2021: 15 · 2020: 23 · 2019: 30 · 2018: 18 · 2017: 22 · 2016: 22 · 2015: 21 · 2014: 17
- FWCI
- 9.03
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- cc-by-nc-nd
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Consultation of the Doctoral Thesis Database (TESEO) (Ministerio de Educación, Cultura y Deporte) (submittedVersion, cc-by-nc-nd)
- Max Planck Digital Library (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Social Sciences › Anthropology › Pleistocene-Era Hominins and Archaeology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Forensic and Genetic Research
- Keywords
- DNA methylation, Neanderthals, Denisovans, ancient DNA, differentially methylated regions, epigenetic evolution, HoxD cluster, human evolution
- MeSH terms
- Animals, Humans, Genome, Human, Evolution, Molecular, DNA Methylation, Epigenesis, Genetic, Neanderthals
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