The DOI matches its Crossref record.
Absence of Microsomal Triglyceride Transfer Protein in Individuals with Abetalipoproteinemia
Abstract
Abetalipoproteinemia is a human genetic disease that is characterized by a defect in the assembly or secretion of plasma very low density lipoproteins and chylomicrons. The microsomal triglyceride transfer protein (MTP), which is located in the lumen of microsomes isolated from the liver and intestine, has been proposed to function in lipoprotein assembly. MTP activity and the 88-kilodalton component of MTP were present in intestinal biopsy samples from eight control individuals but were absent in four abetalipoproteinemic subjects. This finding suggests that a defect in MTP is the basis for abetalipoproteinemia and that MTP is indeed required for lipoprotein assembly.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
van der Veen, J. N., Kennelly, J. P., Wan, S., Vance, J. E., Vance, D. E., & Jacobs, R. L. (2017) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2017.04.006 · Cited by 1,514
Plasma cholesteryl ester transfer protein
Tall, A. (1993) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)36957-1 · Cited by 953
Mouse models in non‐alcoholic fatty liver disease and steatohepatitis research
Anstee, Q. M., & Goldin, R. D. (2006) · International Journal of Experimental Pathology · doi:10.1111/j.0959-9673.2006.00465.x · Cited by 714
Inhibition of microsomal triglyceride transfer protein in familial hypercholesterolemia
Cuchel, M., Bloedon, L. T., Szapary, P. O., Kolansky, D. M., Wolfe, M. L., Sarkis, A., Millar, J. S., Ikewaki, K., Siegelman, E. S., Gregg, R. E., et al. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa061189 · Cited by 580
Self-citationRegulation of intestinal lipid metabolism: current concepts and relevance to disease
Ko, C.-W., Qu, J., Black, D. D., & Tso, P. (2020) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0250-7 · Cited by 510
Diraison, F., Moulin, P., & Beylot, M. (2003) · Diabetes & Metabolism · doi:10.1016/s1262-3636(07)70061-7 · Cited by 435
Raabe, M., Véniant, M. M., Sullivan, M. A., Zlot, C. H., Björkegren, J., Nielsen, L. B., Wong, J. S., Hamilton, R. L., & Young, S. G. (1999) · Journal of Clinical Investigation · doi:10.1172/jci6576 · Cited by 395
Sharp, D., Blinderman, L., Combs, K. A., Kienzle, B., Ricci, B., Wager-Smith, K., Gil, C. M., Turck, C. W., Boumas, M.-E., Rader, D. J., et al. (1993) · Nature · doi:10.1038/365065a0 · Cited by 393
Self-citationAngptl3 regulates lipid metabolism in mice
Koishi, R., Ando, Y., Ono, M., Shimamura, M., Yasumo, H., Fujiwara, T., Horikoshi, H., & Furukawa, H. (2002) · Nature Genetics · doi:10.1038/ng814 · Cited by 379
Cardiac Lipid Accumulation Associated with Diastolic Dysfunction in Obese Mice
Christoffersen, C., Bollano, E., Lindegaard, M. L. S., Bartels, E. D., Goetze, J. P., Andersen, C. B., & Nielsen, L. B. (2003) · Endocrinology · doi:10.1210/en.2003-0242 · Cited by 375
BasuRay, S., Smagris, E., Cohen, J. C., & Hobbs, H. H. (2017) · Hepatology · doi:10.1002/hep.29273 · Cited by 302
Hashidate-Yoshida, T., Harayama, T., Hishikawa, D., Morimoto, R., Hamano, F., Tokuoka, S. M., Eto, M., Tamura-Nakano, M., Yanobu-Takanashi, R., Mukumoto, Y., et al. (2015) · eLife · doi:10.7554/elife.06328 · Cited by 270
Jiang, X.-C., Qin, S., Qiao, C., Kawano, K., Lin, M., Skold, A., Xiao, X., & Tall, A. R. (2001) · Nature Medicine · doi:10.1038/89977 · Cited by 256
Lipid disorders and mutations in the APOB gene
Whitfield, A. J., Barrett, P. H. R., van Bockxmeer, F. M., & Burnett, J. R. (2004) · Clinical Chemistry · doi:10.1373/clinchem.2004.038026 · Cited by 243
Smagris, E., Gilyard, S., BasuRay, S., Cohen, J. C., & Hobbs, H. H. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.719955 · Cited by 226
Mechanisms for cellular cholesterol transport: Defects and human disease
Ikonen, E. (2006) · Physiological Reviews · doi:10.1152/physrev.00022.2005 · Cited by 229
Inactivation of ANGPTL3 reduces hepatic VLDL-triglyceride secretion
Wang, Y., Gusarova, V., Banfi, S., Gromada, J., Cohen, J. C., & Hobbs, H. H. (2015) · Journal of Lipid Research · doi:10.1194/jlr.m054882 · Cited by 189
The ever-expanding role of degradation in the regulation of apolipoprotein B metabolism
Ginsberg, H. N., & Fisher, E. A. (2009) · Journal of Lipid Research · doi:10.1194/jlr.r800090-jlr200 · Cited by 172
Sundaram, M., & Yao, Z. (2010) · Nutrition & Metabolism · doi:10.1186/1743-7075-7-35 · Cited by 154
Zhang, Y.-L., Hernandez-Ono, A., Siri, P., Weisberg, S., Conlon, D., Graham, M. J., Crooke, R. M., Huang, L.-S., & Ginsberg, H. N. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m604709200 · Cited by 147
Regulated Co-translational Ubiquitination of Apolipoprotein B100
Zhou, M., Fisher, E. A., & Ginsberg, H. N. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.38.24649 · Cited by 139
Intracellular Assembly of VLDL
Olofsson, S.-O., Stillemark-Billton, P., & Asp, L. (2000) · Trends in Cardiovascular Medicine · doi:10.1016/s1050-1738(01)00071-8 · Cited by 132
Monogenic hypocholesterolaemic lipid disorders and apolipoprotein B metabolism
Hooper, A. J., van Bockxmeer, F. M., & Burnett, J. R. (2005) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408360500295113 · Cited by 89
Wang, S., McLeod, R. S., Gordon, D. A., & Yao, Z. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.24.14124 · Cited by 84
Prevalence of ANGPTL3 and APOB Gene Mutations in Subjects With Combined Hypolipidemia
Noto, D., Cefalù, A. B., Valenti, V., Fayer, F., Pinotti, E., Ditta, M., Spina, R., Vigna, G., Yue, P., Kathiresan, S., et al. (2012) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.111.238766 · Cited by 81
Genetic Mutations Affecting Human Lipoproteins, Their Receptors, and Their Enzymes
Zannis, V. I., Kardassis, D., & Zanni, E. E. (1993) · Advances in Human Genetics 21 · doi:10.1007/978-1-4615-3010-7_3 · Cited by 78
Martín-Campos, J. M., Roig, R., Mayoral, C., Martinez, S., Martí, G., Arroyo, J. A., Julve, J., & Blanco-Vaca, F. (2012) · Clinica Chimica Acta · doi:10.1016/j.cca.2011.11.020 · Cited by 65
Cellular signalling by lipoprotein receptors
Herz, J., Gotthardt, M., & Willnow, T. E. (2000) · Current Opinion in Lipidology · doi:10.1097/00041433-200004000-00009 · Cited by 58
Hepatic ABCA1 and VLDL triglyceride production
Liu, M., Chung, S., Shelness, G. S., & Parks, J. S. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2011.09.020 · Cited by 43
Syndromic retinitis pigmentosa.
Karuntu, J. S., Almushattat, H., Nguyen, X.-T.-A., Plomp, A. S., Wanders, R. J. A., Hoyng, C. B., van Schooneveld, M. J., Schalij-Delfos, N. E., Brands, M. M., Leroy, B. P., et al. (2025) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2024.101324 · Cited by 39
Elias, N., Patterson, B. W., & Schonfeld, G. (2000) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.20.5.1309 · Cited by 32
Metadata
- Authors
- Wetterau, J. R., Aggerbeck, L. P., Bouma, M.-E., Eisenberg, C., Munck, A., Hermier, M., Schmitz, J., Gay, G., Rader, D. J., & Gregg, R. E.
- Venue
- Science
- Published
- 1992-11-06
- Volume
- 258
- Issue
- 5084
- Pages
- 999-1001
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2042381594
- Cited by
- 762
- References
- 0
- FWCI
- 22.03
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
